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The map label for this gene is macA [H]

Identifier: 152969468

GI number: 152969468

Start: 1018806

End: 1019921

Strand: Direct

Name: macA [H]

Synonym: KPN_00911

Alternate gene names: 152969468

Gene position: 1018806-1019921 (Clockwise)

Preceding gene: 152969467

Following gene: 152969469

Centisome position: 19.17

GC content: 59.23

Gene sequence:

>1116_bases
ATGAAAGTGAAGGGAAAACGCAGGACCGTCTGGTGGCTGTTGGCGATCGTTGTGCTGGGGCTGGCTATCTGGGGATGGCG
GATCCTCAATGCGCCGCTGCCGAACTACCAGACGCTGGTAGTTCGCAAAGGGGATCTTCAGCAGAGCGTGCTGGCCACCG
GCAAACTGGATGCCCTGCGAAAAGTTGACGTCGGCGCCCAGGTCAGCGGACAGCTGAAAACGCTGCACGTCAATATTGGC
GATAAGGTTAAAAAGGATCAGTTGCTGGGGGTTATCGATCCGGAGCAGGCGCAAAACCAGATTAAAGAGGTGGAAGCGAC
GCTCATGGAGCTGCGCGCCCAGCTCAATCAGGCGCGCGCGGAGAGCAAACTGGCGCAAGTGACTCTGGCCCGTCAGCAGC
AGCTGGCGCAGCGCCAGCTGGTCTCGCGGCAGGACCTTGATACCGCGGCCACCGATTTGGCGGTGAAACAGGCGCAGATC
GGCACTATTGAAGCGCAAATAAAGCGTAACCAGGCGACGCTCGATACGGCGAAGACCAACCTCGATTACACGCGGATCCT
GGCGCCGATGGCCGGCGAAGTGACGCAAATTACCACCCTGCAGGGACAGACAGTGATCGCCGCCCAGCAGGCGCCTAACA
TTCTGACGCTGGCGGATCTCAGCACCATGCTGGTTAAAGCGCAGGTCTCTGAAGCGGATGTCATCCACCTCAGACCGGGG
CAAAAAGCGTGGTTTACCGTGCTGGGCGACCCGCTTACCCGTTATGAAGGTAAACTGAAAGACATTCTGCCGACGCCGGA
AAAAGTGAATGACGCCATCTTCTATTATGCCCGCTTCGAGGTACCGAACCCGCAGGGGATCCTGCGCCTCGACATGACCG
CGCAGGTGCACATTCAGCTGGCTGAGGTGAAGAACGTGATTACTATCCCGCTGAGCGCCCTGGGCGACGCGGTAGGCGAT
AACCGCTACCACGTTCGACTGTTGCGCACCGGTGAGGTCAAAGAGCGTGAGGTTATCATTGGCGCCCGCAATGATACCGA
CGTCGCAGTGGTGCAAGGTCTGGAAGAGGGCGACGAAGTGATCGTCGGCGAGAGCGCGAGCGGGGCGGCAAAATGA

Upstream 100 bases:

>100_bases
TAAACAAAACCTCATTGACGCGAAAAATGGGTGTCCTGTTGCCAACGGGTTTCGATAGAATCACCGCCTGGAGCGGCAGG
GAAACAGCAGGAATCGGAAT

Downstream 100 bases:

>100_bases
CGGCGCTGCTTGAGCTGCGAGATATACGTCGCAGCTATCCTTCCGGCGACGGCAGCGTTGAGGTCCTGAAGGGGATCACC
CTCAGCATCCATGCGGGTGA

Product: macrolide transporter subunit MacA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MKVKGKRRTVWWLLAIVVLGLAIWGWRILNAPLPNYQTLVVRKGDLQQSVLATGKLDALRKVDVGAQVSGQLKTLHVNIG
DKVKKDQLLGVIDPEQAQNQIKEVEATLMELRAQLNQARAESKLAQVTLARQQQLAQRQLVSRQDLDTAATDLAVKQAQI
GTIEAQIKRNQATLDTAKTNLDYTRILAPMAGEVTQITTLQGQTVIAAQQAPNILTLADLSTMLVKAQVSEADVIHLRPG
QKAWFTVLGDPLTRYEGKLKDILPTPEKVNDAIFYYARFEVPNPQGILRLDMTAQVHIQLAEVKNVITIPLSALGDAVGD
NRYHVRLLRTGEVKEREVIIGARNDTDVAVVQGLEEGDEVIVGESASGAAK

Sequences:

>Translated_371_residues
MKVKGKRRTVWWLLAIVVLGLAIWGWRILNAPLPNYQTLVVRKGDLQQSVLATGKLDALRKVDVGAQVSGQLKTLHVNIG
DKVKKDQLLGVIDPEQAQNQIKEVEATLMELRAQLNQARAESKLAQVTLARQQQLAQRQLVSRQDLDTAATDLAVKQAQI
GTIEAQIKRNQATLDTAKTNLDYTRILAPMAGEVTQITTLQGQTVIAAQQAPNILTLADLSTMLVKAQVSEADVIHLRPG
QKAWFTVLGDPLTRYEGKLKDILPTPEKVNDAIFYYARFEVPNPQGILRLDMTAQVHIQLAEVKNVITIPLSALGDAVGD
NRYHVRLLRTGEVKEREVIIGARNDTDVAVVQGLEEGDEVIVGESASGAAK
>Mature_371_residues
MKVKGKRRTVWWLLAIVVLGLAIWGWRILNAPLPNYQTLVVRKGDLQQSVLATGKLDALRKVDVGAQVSGQLKTLHVNIG
DKVKKDQLLGVIDPEQAQNQIKEVEATLMELRAQLNQARAESKLAQVTLARQQQLAQRQLVSRQDLDTAATDLAVKQAQI
GTIEAQIKRNQATLDTAKTNLDYTRILAPMAGEVTQITTLQGQTVIAAQQAPNILTLADLSTMLVKAQVSEADVIHLRPG
QKAWFTVLGDPLTRYEGKLKDILPTPEKVNDAIFYYARFEVPNPQGILRLDMTAQVHIQLAEVKNVITIPLSALGDAVGD
NRYHVRLLRTGEVKEREVIIGARNDTDVAVVQGLEEGDEVIVGESASGAAK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=366, Percent_Identity=82.7868852459016, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI87082036, Length=315, Percent_Identity=27.3015873015873, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789929, Length=295, Percent_Identity=25.0847457627119, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790519, Length=239, Percent_Identity=28.0334728033473, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081951, Length=199, Percent_Identity=31.6582914572864, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40724; Mature: 40724

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKGKRRTVWWLLAIVVLGLAIWGWRILNAPLPNYQTLVVRKGDLQQSVLATGKLDALR
CCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEECCCHHHHHHHHCCHHHHH
KVDVGAQVSGQLKTLHVNIGDKVKKDQLLGVIDPEQAQNQIKEVEATLMELRAQLNQARA
HCCCCCCCCCCEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESKLAQVTLARQQQLAQRQLVSRQDLDTAATDLAVKQAQIGTIEAQIKRNQATLDTAKTN
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHCC
LDYTRILAPMAGEVTQITTLQGQTVIAAQQAPNILTLADLSTMLVKAQVSEADVIHLRPG
CCHHHHHHCCCCCCEEEEEECCCEEEEECCCCCEEEEHHHHHHHHHEECCCCCEEEECCC
QKAWFTVLGDPLTRYEGKLKDILPTPEKVNDAIFYYARFEVPNPQGILRLDMTAQVHIQL
CCEEEEEECCHHHHHCCCHHHCCCCCCCCCCEEEEEEEEECCCCCCEEEEECEEEEEEEE
AEVKNVITIPLSALGDAVGDNRYHVRLLRTGEVKEREVIIGARNDTDVAVVQGLEEGDEV
EHHCCEEEEEHHHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCCCCCCEEECCCCCCEE
IVGESASGAAK
EEECCCCCCCC
>Mature Secondary Structure
MKVKGKRRTVWWLLAIVVLGLAIWGWRILNAPLPNYQTLVVRKGDLQQSVLATGKLDALR
CCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEECCCHHHHHHHHCCHHHHH
KVDVGAQVSGQLKTLHVNIGDKVKKDQLLGVIDPEQAQNQIKEVEATLMELRAQLNQARA
HCCCCCCCCCCEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESKLAQVTLARQQQLAQRQLVSRQDLDTAATDLAVKQAQIGTIEAQIKRNQATLDTAKTN
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHCC
LDYTRILAPMAGEVTQITTLQGQTVIAAQQAPNILTLADLSTMLVKAQVSEADVIHLRPG
CCHHHHHHCCCCCCEEEEEECCCEEEEECCCCCEEEEHHHHHHHHHEECCCCCEEEECCC
QKAWFTVLGDPLTRYEGKLKDILPTPEKVNDAIFYYARFEVPNPQGILRLDMTAQVHIQL
CCEEEEEECCHHHHHCCCHHHCCCCCCCCCCEEEEEEEEECCCCCCEEEEECEEEEEEEE
AEVKNVITIPLSALGDAVGDNRYHVRLLRTGEVKEREVIIGARNDTDVAVVQGLEEGDEV
EHHCCEEEEEHHHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCCCCCCEEECCCCCCEE
IVGESASGAAK
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]