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The map label for this gene is pepA [H]

Identifier: 150398548

GI number: 150398548

Start: 3558798

End: 3560195

Strand: Direct

Name: pepA [H]

Synonym: Smed_3359

Alternate gene names: 150398548

Gene position: 3558798-3560195 (Clockwise)

Preceding gene: 150398546

Following gene: 150398549

Centisome position: 94.1

GC content: 64.16

Gene sequence:

>1398_bases
ATGGCTCCCTACCAGTTCATCGAGCGGCCATCGCCGTTCAACACAAGCAACGGCAAGACGCTGCCGATCTTTGCGGTGAC
GCCGTCGCATATCGAGACGGGGAGCATCGACCCTATAGCGCTCGACTGGGCGAAGAAGGCCGGCTTCAAGGCGGAATCGG
GCGCGGTGCTGCTTATCCCCTCGGCCGACGGCCAACTCGGCGGCGCGCTGTTCGGTCTGGGCGCCAACCCTTCCGAGGCA
CCATTCCTGACCGGCAAGCTCGCCCGGACGCTCCCTGCCGGCAAATGGCATGTCGAAACGGCGCCTCTCACGGCCAACCG
GCTGGCGCTCGGCTACGGCCTCGGCTCCTATCGTTTCGAGCGCTACAAATCTGCAAAAGCCGAAGCGCCGACGCTGCTCG
TTCCGGCCGATGCCGACGCGGCGGATATCAAGCGCCAGCTCGCTGGCGTCTTCCTCGCCCGCGACCTCATCAACACACCC
ACCAACGACATGGGGCCGGAAGCGTTGGAGGCCGCCTTCCGGGCACTGGCTGCCCATTACAAGGCCGAGGTTTCGGTGGT
CTCGGGCGAAGCGCTGCTCGCGGAGAATTTTCCGCTCGTTCATACGGTCGGCCGCGCCAGTGCCGAAGCGCCGCGGCTTC
TTGAAATGCGCTGGGGCAGGAAAGGGCACAAGAGGGTGACGCTCGTCGGCAAGGGCGTCTGCTTCGACACCGGCGGACTG
GACATCAAGCCGGCCGCATCGATGCTGCTCATGAAGAAGGATATGGGCGGTGCTGCAAACGTCATGGGCCTCGCTCTGAT
GATCATGGATGCCAAACTCAAGGTGGATCTGCGCGTCCTCATCCCGGTGGTCGAGAACTCGATCTCGGCAAACGCCTTCC
GCCCGGGCGACATCTACAAGAGCCGGAAGGGCCTGACCGTGCAGATCGACAACACGGACGCAGAGGGCCGACTGATCCTC
GCCGATGCGCTCGCTTACGCGGACGAGGAGAAGACAGACCTCATTATCGACATGGCGACGCTGACCGGCGCCGCCCGAGT
CGCGCTCGGTCCGGACCTGCCGCCCTTCTTCACCGACGACGAAGATCTCGCCCGCGATCTGGCTGAGGCGAGCCTTACCG
TGGACGATCCGCTCTGGCGGATGCCGCTCTACAAGGGCTACGACAAAGATGTTTCCGCCCGCATCGCCGATCTGACCAAC
GCGCCTTCCGGCGGTATGGCCGGTTCGATCACAGCGGCGCTTTTCCTCAGACGCTTCGTAACGAATGCGAAAAGCTGGGT
TCACTTCGACATTTTCGGCTGGGCACAAGCCGAGCGTCCGCATTCGCCGGTCGGCGGCGAGGCGCAGGCGATCCGGGCGC
TTTATCATCATATCGGGAGGGGCGCGGCCCGCATTTGA

Upstream 100 bases:

>100_bases
TCCCGAACACCCAGCGGCGCAACTTTCACTCCAGCAATAATCTGTTAACCCTAACGGAGCGTTAATCGCGCTTGTTCTTA
TCCGTCAGTCGAGGATTTCC

Downstream 100 bases:

>100_bases
TTCACAAGAGAAACGCTTGCGTAACGATCGGCCGGCTATGCTCCCGCAGCCTTATCCATGCAGGAGTTTCCTTTGCCGGT
CGAACTTACCCCTTCTCAGG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MAPYQFIERPSPFNTSNGKTLPIFAVTPSHIETGSIDPIALDWAKKAGFKAESGAVLLIPSADGQLGGALFGLGANPSEA
PFLTGKLARTLPAGKWHVETAPLTANRLALGYGLGSYRFERYKSAKAEAPTLLVPADADAADIKRQLAGVFLARDLINTP
TNDMGPEALEAAFRALAAHYKAEVSVVSGEALLAENFPLVHTVGRASAEAPRLLEMRWGRKGHKRVTLVGKGVCFDTGGL
DIKPAASMLLMKKDMGGAANVMGLALMIMDAKLKVDLRVLIPVVENSISANAFRPGDIYKSRKGLTVQIDNTDAEGRLIL
ADALAYADEEKTDLIIDMATLTGAARVALGPDLPPFFTDDEDLARDLAEASLTVDDPLWRMPLYKGYDKDVSARIADLTN
APSGGMAGSITAALFLRRFVTNAKSWVHFDIFGWAQAERPHSPVGGEAQAIRALYHHIGRGAARI

Sequences:

>Translated_465_residues
MAPYQFIERPSPFNTSNGKTLPIFAVTPSHIETGSIDPIALDWAKKAGFKAESGAVLLIPSADGQLGGALFGLGANPSEA
PFLTGKLARTLPAGKWHVETAPLTANRLALGYGLGSYRFERYKSAKAEAPTLLVPADADAADIKRQLAGVFLARDLINTP
TNDMGPEALEAAFRALAAHYKAEVSVVSGEALLAENFPLVHTVGRASAEAPRLLEMRWGRKGHKRVTLVGKGVCFDTGGL
DIKPAASMLLMKKDMGGAANVMGLALMIMDAKLKVDLRVLIPVVENSISANAFRPGDIYKSRKGLTVQIDNTDAEGRLIL
ADALAYADEEKTDLIIDMATLTGAARVALGPDLPPFFTDDEDLARDLAEASLTVDDPLWRMPLYKGYDKDVSARIADLTN
APSGGMAGSITAALFLRRFVTNAKSWVHFDIFGWAQAERPHSPVGGEAQAIRALYHHIGRGAARI
>Mature_464_residues
APYQFIERPSPFNTSNGKTLPIFAVTPSHIETGSIDPIALDWAKKAGFKAESGAVLLIPSADGQLGGALFGLGANPSEAP
FLTGKLARTLPAGKWHVETAPLTANRLALGYGLGSYRFERYKSAKAEAPTLLVPADADAADIKRQLAGVFLARDLINTPT
NDMGPEALEAAFRALAAHYKAEVSVVSGEALLAENFPLVHTVGRASAEAPRLLEMRWGRKGHKRVTLVGKGVCFDTGGLD
IKPAASMLLMKKDMGGAANVMGLALMIMDAKLKVDLRVLIPVVENSISANAFRPGDIYKSRKGLTVQIDNTDAEGRLILA
DALAYADEEKTDLIIDMATLTGAARVALGPDLPPFFTDDEDLARDLAEASLTVDDPLWRMPLYKGYDKDVSARIADLTNA
PSGGMAGSITAALFLRRFVTNAKSWVHFDIFGWAQAERPHSPVGGEAQAIRALYHHIGRGAARI

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=350, Percent_Identity=37.7142857142857, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI47155554, Length=384, Percent_Identity=30.7291666666667, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI87082123, Length=306, Percent_Identity=39.2156862745098, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1790710, Length=288, Percent_Identity=37.1527777777778, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17556903, Length=286, Percent_Identity=37.0629370629371, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=215, Percent_Identity=31.6279069767442, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24661038, Length=338, Percent_Identity=33.4319526627219, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI21355725, Length=350, Percent_Identity=33.1428571428571, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI221379063, Length=284, Percent_Identity=33.8028169014084, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI221379062, Length=284, Percent_Identity=33.8028169014084, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI21357381, Length=284, Percent_Identity=33.8028169014084, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI19922386, Length=326, Percent_Identity=27.9141104294479, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20129969, Length=342, Percent_Identity=28.3625730994152, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21355645, Length=341, Percent_Identity=25.2199413489736, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24662223, Length=341, Percent_Identity=25.2199413489736, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24662227, Length=286, Percent_Identity=25.8741258741259, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI161077148, Length=287, Percent_Identity=32.0557491289199, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI20130057, Length=287, Percent_Identity=32.0557491289199, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI20129963, Length=337, Percent_Identity=28.7833827893175, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646701, Length=217, Percent_Identity=34.1013824884793, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24646703, Length=217, Percent_Identity=34.1013824884793, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21358201, Length=217, Percent_Identity=34.1013824884793, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49695; Mature: 49563

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPYQFIERPSPFNTSNGKTLPIFAVTPSHIETGSIDPIALDWAKKAGFKAESGAVLLIP
CCCHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEHHHHCCCCCCCCCEEEEE
SADGQLGGALFGLGANPSEAPFLTGKLARTLPAGKWHVETAPLTANRLALGYGLGSYRFE
CCCCCCCCEEEECCCCCCCCCEEHHHHHHHCCCCCEEEEECCCCCCCEEEECCCCHHHHH
RYKSAKAEAPTLLVPADADAADIKRQLAGVFLARDLINTPTNDMGPEALEAAFRALAAHY
HHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
KAEVSVVSGEALLAENFPLVHTVGRASAEAPRLLEMRWGRKGHKRVTLVGKGVCFDTGGL
HHEEEEEECCEEEECCCCEEEECCCCCCCCCHHHHHHCCCCCCCEEEEEECCEEEECCCC
DIKPAASMLLMKKDMGGAANVMGLALMIMDAKLKVDLRVLIPVVENSISANAFRPGDIYK
CCCHHHHHHEEHHCCCCHHHHHHHHHHEECCCEEEEEEEEEEHHHCCCCCCCCCCCHHHH
SRKGLTVQIDNTDAEGRLILADALAYADEEKTDLIIDMATLTGAARVALGPDLPPFFTDD
CCCCCEEEECCCCCCCEEEEEEHHHHCCCCCCEEEEEEHHHCCCEEEEECCCCCCCCCCH
EDLARDLAEASLTVDDPLWRMPLYKGYDKDVSARIADLTNAPSGGMAGSITAALFLRRFV
HHHHHHHHHCCEEECCCHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
TNAKSWVHFDIFGWAQAERPHSPVGGEAQAIRALYHHIGRGAARI
HCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
APYQFIERPSPFNTSNGKTLPIFAVTPSHIETGSIDPIALDWAKKAGFKAESGAVLLIP
CCHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEHHHHCCCCCCCCCEEEEE
SADGQLGGALFGLGANPSEAPFLTGKLARTLPAGKWHVETAPLTANRLALGYGLGSYRFE
CCCCCCCCEEEECCCCCCCCCEEHHHHHHHCCCCCEEEEECCCCCCCEEEECCCCHHHHH
RYKSAKAEAPTLLVPADADAADIKRQLAGVFLARDLINTPTNDMGPEALEAAFRALAAHY
HHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
KAEVSVVSGEALLAENFPLVHTVGRASAEAPRLLEMRWGRKGHKRVTLVGKGVCFDTGGL
HHEEEEEECCEEEECCCCEEEECCCCCCCCCHHHHHHCCCCCCCEEEEEECCEEEECCCC
DIKPAASMLLMKKDMGGAANVMGLALMIMDAKLKVDLRVLIPVVENSISANAFRPGDIYK
CCCHHHHHHEEHHCCCCHHHHHHHHHHEECCCEEEEEEEEEEHHHCCCCCCCCCCCHHHH
SRKGLTVQIDNTDAEGRLILADALAYADEEKTDLIIDMATLTGAARVALGPDLPPFFTDD
CCCCCEEEECCCCCCCEEEEEEHHHHCCCCCCEEEEEEHHHCCCEEEEECCCCCCCCCCH
EDLARDLAEASLTVDDPLWRMPLYKGYDKDVSARIADLTNAPSGGMAGSITAALFLRRFV
HHHHHHHHHCCEEECCCHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
TNAKSWVHFDIFGWAQAERPHSPVGGEAQAIRALYHHIGRGAARI
HCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]