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The map label for this gene is fabH [H]

Identifier: 150396053

GI number: 150396053

Start: 891795

End: 892766

Strand: Direct

Name: fabH [H]

Synonym: Smed_0829

Alternate gene names: 150396053

Gene position: 891795-892766 (Clockwise)

Preceding gene: 150396052

Following gene: 150396054

Centisome position: 23.58

GC content: 63.17

Gene sequence:

>972_bases
ATGATCCGTTCTGTCGTGCGCGGCTTCGGGGCAGCACTGCCGAAGCGAGTGATGACCAATAAGGAAATGGAATCCAAGGT
CGACACGTCCGACGAATGGATTGTGCAGCGGACCGGCATCCGGCAGCGCTATATCGCAGGCGACGGCGAGACGACTGCCT
CCCTCGGGGAGGCGGCGGCACGCGCGGCGCTCGAGAGAGCCGGACTGACGCCTGATGACATCGATCTGATCATCGTCGCG
ACGTCGACTCCGGACAACACCTTTCCTGCAACGGCGGTCAACATTCAGAATCGCCTCGGCATGCGTCACGGTGCGGCATT
CGATATGCAGGCCGTCTGTTCCGGCTTCGTCTATGCCGTCACGACTGGCGACGCCTATATTCGCGGCGGCCTCGCCACAC
GCGTGCTGGTCATCGGCGCCGAGACTTTTTCGCGTATTCTCGACTGGACGGACCGGACCACCTGCGTTCTCTTCGGCGAC
GGCGCCGGCGCCATCGTCCTCGAAGCGCAGGAGGGTGCCGGGACGAAAGCCGACCGCGGCGTTCTGACGGCGCAACTGCG
CTCCGACGGCGCCCATGGCGACAAGCTTTATGTCGATGGCGGGCCGTCCACGACCGGTACAGTCGGCCATCTCCGGATGG
AAGGGCGCGAGGTCTTCAAGCACGCGGTGGGCATGATCACCGACGTAATCGAAGCGGCTTTCGAAGCCACAGGCACCACG
GCGGACGACATCGACTGGCTCGTTCCGCACCAGGCGAACCGCCGCATCATCGAGGGATCGGCCAAAAAACTCGGGATCCC
TCTCGAAAAGGTTGTGGTTACCGTCGACCTTCATGGAAATACCTCTGCGGCGTCGATTCCGCTCGCGCTTGACGCCGCCG
CTACCGACGGCCGTATCAAGAGGGGCGACCTTGTAATGCTCGAAGCCATGGGCGGAGGCTTCACCTGGGGCTCCGTTTTA
CTGCGCTGGTAA

Upstream 100 bases:

>100_bases
GAACGGCCTCAAGGCCAAGATCGAGGCCGATCTTGCGCGCTATCACGGCGCCCAGGCGTCCGAAGCCCTTCCGCGGGCGT
GAATGATGAGGTTTGATTAG

Downstream 100 bases:

>100_bases
GAAAATAATGAAGTACGGCAGGCGCTTGACCGGAATAGACAAGGGCAATAGTCTTCAATCGCTGATCGGCAGGCCAGACA
TCGGTGGGGGAAGATGAGCG

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MIRSVVRGFGAALPKRVMTNKEMESKVDTSDEWIVQRTGIRQRYIAGDGETTASLGEAAARAALERAGLTPDDIDLIIVA
TSTPDNTFPATAVNIQNRLGMRHGAAFDMQAVCSGFVYAVTTGDAYIRGGLATRVLVIGAETFSRILDWTDRTTCVLFGD
GAGAIVLEAQEGAGTKADRGVLTAQLRSDGAHGDKLYVDGGPSTTGTVGHLRMEGREVFKHAVGMITDVIEAAFEATGTT
ADDIDWLVPHQANRRIIEGSAKKLGIPLEKVVVTVDLHGNTSAASIPLALDAAATDGRIKRGDLVMLEAMGGGFTWGSVL
LRW

Sequences:

>Translated_323_residues
MIRSVVRGFGAALPKRVMTNKEMESKVDTSDEWIVQRTGIRQRYIAGDGETTASLGEAAARAALERAGLTPDDIDLIIVA
TSTPDNTFPATAVNIQNRLGMRHGAAFDMQAVCSGFVYAVTTGDAYIRGGLATRVLVIGAETFSRILDWTDRTTCVLFGD
GAGAIVLEAQEGAGTKADRGVLTAQLRSDGAHGDKLYVDGGPSTTGTVGHLRMEGREVFKHAVGMITDVIEAAFEATGTT
ADDIDWLVPHQANRRIIEGSAKKLGIPLEKVVVTVDLHGNTSAASIPLALDAAATDGRIKRGDLVMLEAMGGGFTWGSVL
LRW
>Mature_323_residues
MIRSVVRGFGAALPKRVMTNKEMESKVDTSDEWIVQRTGIRQRYIAGDGETTASLGEAAARAALERAGLTPDDIDLIIVA
TSTPDNTFPATAVNIQNRLGMRHGAAFDMQAVCSGFVYAVTTGDAYIRGGLATRVLVIGAETFSRILDWTDRTTCVLFGD
GAGAIVLEAQEGAGTKADRGVLTAQLRSDGAHGDKLYVDGGPSTTGTVGHLRMEGREVFKHAVGMITDVIEAAFEATGTT
ADDIDWLVPHQANRRIIEGSAKKLGIPLEKVVVTVDLHGNTSAASIPLALDAAATDGRIKRGDLVMLEAMGGGFTWGSVL
LRW

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family [H]

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=48.2649842271293, Blast_Score=302, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C [H]

EC number: =2.3.1.180 [H]

Molecular weight: Translated: 34213; Mature: 34213

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRSVVRGFGAALPKRVMTNKEMESKVDTSDEWIVQRTGIRQRYIAGDGETTASLGEAAA
CHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEECCCCCEEEECCCCCCHHHHHHHHH
RAALERAGLTPDDIDLIIVATSTPDNTFPATAVNIQNRLGMRHGAAFDMQAVCSGFVYAV
HHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEEEHHHHCCCCCCCCCCHHHHHCCEEEEE
TTGDAYIRGGLATRVLVIGAETFSRILDWTDRTTCVLFGDGAGAIVLEAQEGAGTKADRG
ECCCCEEECCCEEEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCC
VLTAQLRSDGAHGDKLYVDGGPSTTGTVGHLRMEGREVFKHAVGMITDVIEAAFEATGTT
EEEEEECCCCCCCCEEEECCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCC
ADDIDWLVPHQANRRIIEGSAKKLGIPLEKVVVTVDLHGNTSAASIPLALDAAATDGRIK
CCCCCEECCCCCCCEEECCCCHHCCCCHHHEEEEEEECCCCCCCCCEEEEECCCCCCCEE
RGDLVMLEAMGGGFTWGSVLLRW
CCCEEEEEECCCCEEHHHHEECC
>Mature Secondary Structure
MIRSVVRGFGAALPKRVMTNKEMESKVDTSDEWIVQRTGIRQRYIAGDGETTASLGEAAA
CHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEECCCCCEEEECCCCCCHHHHHHHHH
RAALERAGLTPDDIDLIIVATSTPDNTFPATAVNIQNRLGMRHGAAFDMQAVCSGFVYAV
HHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEEEHHHHCCCCCCCCCCHHHHHCCEEEEE
TTGDAYIRGGLATRVLVIGAETFSRILDWTDRTTCVLFGDGAGAIVLEAQEGAGTKADRG
ECCCCEEECCCEEEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCC
VLTAQLRSDGAHGDKLYVDGGPSTTGTVGHLRMEGREVFKHAVGMITDVIEAAFEATGTT
EEEEEECCCCCCCCEEEECCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCC
ADDIDWLVPHQANRRIIEGSAKKLGIPLEKVVVTVDLHGNTSAASIPLALDAAATDGRIK
CCCCCEECCCCCCCEEECCCCHHCCCCHHHEEEEEEECCCCCCCCCEEEEECCCCCCCEE
RGDLVMLEAMGGGFTWGSVLLRW
CCCEEEEEECCCCEEHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]