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The map label for this gene is ribD [H]

Identifier: 150396042

GI number: 150396042

Start: 881361

End: 882557

Strand: Direct

Name: ribD [H]

Synonym: Smed_0818

Alternate gene names: 150396042

Gene position: 881361-882557 (Clockwise)

Preceding gene: 150396041

Following gene: 150396043

Centisome position: 23.3

GC content: 63.32

Gene sequence:

>1197_bases
ATGGTTAAGCCGGCGCACGAAGACGAGCGGTTCATGGCGGCGGCGCTGCGCCTTTCGAGGCGCAATCTTGGTCGGACTGG
CACCAATCCCTCTGTCGGCTGCGTGATCGTAAACGAGGGAATGATTGTTGGCCGCGCGGTGACGGCGTCCGGCGGGCGAC
CGCATGCCGAGACGCAGGCGCTTGCCGAGGCGGGCGAGAAGGCGAGGGGAGCGACGGCATATGTCACGCTCGAACCCTGT
TCGCATCACGGCAAGACCCCGCCCTGCACGGATGCGCTGATTGCTTCCGGAGTCGCTCGTGTCGTGGTCGCCATCCTCGA
CCCCGACGAACGCGTTGCCGGTCGCGGCATTGTGCTGCTTCGCGAAGCGGGAATAGCGGTCGATATCGGCGTCCTCCGCG
AGGAGGGCGAGCGTGCGCTCCAGGCATACCTTATGCGGCAGTGCAAGAAGCGCCCGCATGTGACTCTGAAGCTTGCGGTT
TCCAACGATGGCATGATCGGTCGAAGGGGCGAAGGGCAGGTAAGGATTACCGGCGCGGTTTCCCGCGCTCAGGTACAGAT
ATTGCGTGCCGAAACCGACGCGATCCTCGTCGGCATCGGCACGGCGAGCGCTGACGATCCGGAACTTACGGTGCGCATGC
AGGGGCTTGAAGACCGATCGCCCGTGCGGATCGTGCTTGACCGCCGGCTTGAGTTGCCGATCGAGTCGAAACTGGTGCGG
TCGGCTGGCGAAGTTTCGTTGATCGTCGTTGCGGGTGATGCAGGCTCACCTTCTCCGCGCATGCGGGTAGAAGGTGAGCG
AAGGGCGGATGAGGGGCAGGTAAGCGGCGTGTCATTGCCCCTCACCCCGACCCTCTCTCCGGTTGCCGGGAGAGGGGGCG
ACTACGAAGCCCGCCGGGATGTGCTCGTATCGGCCGGTGTGGAAATCCTGAACGCTGACAACATCCCGGATCTGCTGGCT
GCGCTTGCCTCGCGCGGCATCTCCTCTCTTCTCGTCGAAGGTGGGAGCAGCGCGGCGCGCGCCTTTCTCGATGTGGAGCT
GGTCGATCGTATCTTGCTCTTCACCGGCCCGTCTCCCATTGGCAAAGGTGGCATACCATCCCCATTTCAGCGAAGGTCCG
TACCGGCGGGCTTCACGCTCCAGCGTACCGCACGTTACGGCGACGATATTTTTGAAGAGTATGAGAGAGATATCTGA

Upstream 100 bases:

>100_bases
TATCGCGATTTCTCCCACGCGGAGGATTTCGAGAAGGTCATCGCGGAAATCAGCGCAAAGATCGCACGCGATCCTGGCGA
GTAGGCCGGAGGCGAAAGGC

Downstream 100 bases:

>100_bases
TGTTCACAGGCATTATTACCGACATCGGCACCGTCGAGAAGGTCACGCCGCTCAGGGAGGGCGCGAAGCTCCGCGTTGCC
ACGAATTACGATCCGAAGAC

Product: riboflavin biosynthesis protein RibD

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MVKPAHEDERFMAAALRLSRRNLGRTGTNPSVGCVIVNEGMIVGRAVTASGGRPHAETQALAEAGEKARGATAYVTLEPC
SHHGKTPPCTDALIASGVARVVVAILDPDERVAGRGIVLLREAGIAVDIGVLREEGERALQAYLMRQCKKRPHVTLKLAV
SNDGMIGRRGEGQVRITGAVSRAQVQILRAETDAILVGIGTASADDPELTVRMQGLEDRSPVRIVLDRRLELPIESKLVR
SAGEVSLIVVAGDAGSPSPRMRVEGERRADEGQVSGVSLPLTPTLSPVAGRGGDYEARRDVLVSAGVEILNADNIPDLLA
ALASRGISSLLVEGGSSAARAFLDVELVDRILLFTGPSPIGKGGIPSPFQRRSVPAGFTLQRTARYGDDIFEEYERDI

Sequences:

>Translated_398_residues
MVKPAHEDERFMAAALRLSRRNLGRTGTNPSVGCVIVNEGMIVGRAVTASGGRPHAETQALAEAGEKARGATAYVTLEPC
SHHGKTPPCTDALIASGVARVVVAILDPDERVAGRGIVLLREAGIAVDIGVLREEGERALQAYLMRQCKKRPHVTLKLAV
SNDGMIGRRGEGQVRITGAVSRAQVQILRAETDAILVGIGTASADDPELTVRMQGLEDRSPVRIVLDRRLELPIESKLVR
SAGEVSLIVVAGDAGSPSPRMRVEGERRADEGQVSGVSLPLTPTLSPVAGRGGDYEARRDVLVSAGVEILNADNIPDLLA
ALASRGISSLLVEGGSSAARAFLDVELVDRILLFTGPSPIGKGGIPSPFQRRSVPAGFTLQRTARYGDDIFEEYERDI
>Mature_398_residues
MVKPAHEDERFMAAALRLSRRNLGRTGTNPSVGCVIVNEGMIVGRAVTASGGRPHAETQALAEAGEKARGATAYVTLEPC
SHHGKTPPCTDALIASGVARVVVAILDPDERVAGRGIVLLREAGIAVDIGVLREEGERALQAYLMRQCKKRPHVTLKLAV
SNDGMIGRRGEGQVRITGAVSRAQVQILRAETDAILVGIGTASADDPELTVRMQGLEDRSPVRIVLDRRLELPIESKLVR
SAGEVSLIVVAGDAGSPSPRMRVEGERRADEGQVSGVSLPLTPTLSPVAGRGGDYEARRDVLVSAGVEILNADNIPDLLA
ALASRGISSLLVEGGSSAARAFLDVELVDRILLFTGPSPIGKGGIPSPFQRRSVPAGFTLQRTARYGDDIFEEYERDI

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=367, Percent_Identity=38.4196185286104, Blast_Score=225, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 42203; Mature: 42203

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKPAHEDERFMAAALRLSRRNLGRTGTNPSVGCVIVNEGMIVGRAVTASGGRPHAETQA
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCEEEEEEEECCCCCCCHHHHH
LAEAGEKARGATAYVTLEPCSHHGKTPPCTDALIASGVARVVVAILDPDERVAGRGIVLL
HHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHCCHHHEEEEEECCCHHHCCCCEEEE
REAGIAVDIGVLREEGERALQAYLMRQCKKRPHVTLKLAVSNDGMIGRRGEGQVRITGAV
EECCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEECC
SRAQVQILRAETDAILVGIGTASADDPELTVRMQGLEDRSPVRIVLDRRLELPIESKLVR
CEEEEEEEEECCCEEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHH
SAGEVSLIVVAGDAGSPSPRMRVEGERRADEGQVSGVSLPLTPTLSPVAGRGGDYEARRD
CCCCEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHH
VLVSAGVEILNADNIPDLLAALASRGISSLLVEGGSSAARAFLDVELVDRILLFTGPSPI
HHHHCCEEEECCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHEEHEEECCCCC
GKGGIPSPFQRRSVPAGFTLQRTARYGDDIFEEYERDI
CCCCCCCCHHHCCCCCCCEEHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MVKPAHEDERFMAAALRLSRRNLGRTGTNPSVGCVIVNEGMIVGRAVTASGGRPHAETQA
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCEEEEEEEECCCCCCCHHHHH
LAEAGEKARGATAYVTLEPCSHHGKTPPCTDALIASGVARVVVAILDPDERVAGRGIVLL
HHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHCCHHHEEEEEECCCHHHCCCCEEEE
REAGIAVDIGVLREEGERALQAYLMRQCKKRPHVTLKLAVSNDGMIGRRGEGQVRITGAV
EECCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEECC
SRAQVQILRAETDAILVGIGTASADDPELTVRMQGLEDRSPVRIVLDRRLELPIESKLVR
CEEEEEEEEECCCEEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHH
SAGEVSLIVVAGDAGSPSPRMRVEGERRADEGQVSGVSLPLTPTLSPVAGRGGDYEARRD
CCCCEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHH
VLVSAGVEILNADNIPDLLAALASRGISSLLVEGGSSAARAFLDVELVDRILLFTGPSPI
HHHHCCEEEECCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHEEHEEECCCCC
GKGGIPSPFQRRSVPAGFTLQRTARYGDDIFEEYERDI
CCCCCCCCHHHCCCCCCCEEHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]