Click here to switch to the map view.

The map label for this gene is parC [H]

Identifier: 150396031

GI number: 150396031

Start: 870115

End: 872391

Strand: Direct

Name: parC [H]

Synonym: Smed_0807

Alternate gene names: 150396031

Gene position: 870115-872391 (Clockwise)

Preceding gene: 150396027

Following gene: 150396032

Centisome position: 23.01

GC content: 61.79

Gene sequence:

>2277_bases
ATGGGACAAAGCCTTTTGCCGCCGTCTGGCGGGGACGACAACATTCAACCGGTTGACCTGAAGGCGGCGCTGGAAGAGCG
CTATCTCGCCTATGCGCTGTCGACCATCATGCATCGCGCCTTGCCGGATGTCCGCGACGGCCTGAAACCGGTCCATCGTC
GGATCATTCACGCCATGAGCGAGATGGGTTTGCGGCCCAATTCCTCGTTCAAGAAATGCGCCCGTATCGTCGGCGACGTC
ATCGGTAAATTCCATCCGCATGGCGACCAGTCCGTTTATGACGCACTGGTGCGCCTCGCGCAGGACTTCTCTCAGCGCTA
TCCGGTCGTCGACGGTCAGGGCAACTTCGGTAATATCGATGGCGACAATGCCGCCGCCTATCGTTACACCGAAGCCAAGA
TGACAGAGGTTGCAGCCCTCCTCCTGGAGGGCATCGATCAGGACGCGGTGGATTTCCGCCCGACCTACAATGAAGAGGAC
CAGGAGCCCACCGTGCTCCCGGGTGCCTTCCCGAACTTGCTGGCCAATGGCGCTTCCGGCATCGCCGTCGGCATGGCGAC
GTCGATCCCGCCGCACAATGCGCATGAACTGTGCGATGCGGCGCTCTACCTCATCCGTCATCCCGACGCGCCACTGGAGG
CGTTGCTGTTCGATCCGGCCAACCCGCAGCGCGGCGGCATCGAAGGGCCGGATTTCCCGACCGGCGGCGTTATCGTCGAG
AGCCGCACCAGCATGATGGAGTCCTATCGGACCGGTCGAGGCGGATTTCGCGTCCGGGCACGCTGGACAGTTGAGGATCT
GGGCCGCGGCGGCTTCCAGATTGTCGTGACTGAAATCCCTTACCAGGTCCAGAAGTCGCGCCTGATCGAAAAGATTGCCG
AGCTGCTCATCGCGCGCAAGCTGCCGCTCCTCGAGGATATCAGAGACGAATCGGCCGAGGACGTCCGCGTCGTTCTCGTG
CCGAAGAGCCGCTCGGTCGATGCCAATATCCTGATGGAATCGCTCTTCAAGCTCACCGAGCTGGAGAGCCGCATTCCACT
CAATATGAACGTGCTTTCCATGGGCCGCGTGCCGCGTGTCATGGCCCTCAACGAGGTCCTCAGCGAATGGCTGGCACATC
GCCGGGAGGTCCTGCAGCGCCGCTCGCGCCATCGGCTCGCCGCGATCGACAGGCGGCTGGAGATTCTCGGCGGCTATCTC
ATCGCCTATCTCAACATCGACGAGGTCATCCGGATCATCCGCGAGGAGGACGAGCCGAAGGCGGTGATGATCGAGCGATT
CGGGCTCACCGACGTCCAGGCCGAAGCGATCCTCAACATGCGGCTGCGCTCGCTGCGCAAGCTCGAAGAGTTCGAGATCC
GCACCGAGTTCGATGCGTTGTCGAAGGAGAAGGCGGAAATCGAAGCGCTGCTCGCCTCCGACGACAAGCAATGGCAGGCG
GTTGCCTGGGAAATCGGCGAGGTCAAGAAGAAATTCGCCAAGGCGACCGAACTCGGCAAGCGCCGCAGCACCTTTGCCGA
TGCGCCCGAGGCGGATGTCGAAGCCATTCAGCAGGCGATGATCGAAAAAGAGCCGATCACCGTGGTCATATCCGAAAAGG
GCTGGATCCGCGCCTTGAAAGGACATATCGCGGACACGACTTCGCTCCAGTTCAAGGACGGCGATGCACTAAAGGTCTCG
TTCCCGGCACAGACTACGGACAAGATCCTCATCTTCACGACGGGCGGGAAGGTCTACACGCTTGGCAGCGACAAATTGCC
GGGCGGGCGAGGCCACGGAGAACCGCTGCGCATCATGGTCGATATGGAAAACGACCAGGACGTGCTGACCGCTTTCGTGC
ACGATCCGGCGCGCAAGCTCGTCGTCTCGTCCACGGCCGGCAACGGCTTCGTCGTCACCGAGAGCGATATCGTCGCCAAT
ACGCGCAAGGGCAAGCAGGTGATGAACGTCAGCATGCCCGACGAGGCCAAGCTGGTGGTTCCGGTCAAGGGCGATCATCT
CGCCGTCGTGGGCGAAAACCGCAAGATGCTCGTCTTTCCGCTGGCACAGGTTCCGGAAATGGCGCGCGGCAAGGGCGTGC
GGCTTCAGCGCTACAAGGATGGCGGCATTTCCGACATCCGTTGCTTCTCGATCGCGGAAGGGCTCACCTGGGAAGACAGT
GCGGGGCGGGTCTTCACCAAGACGAAGGATGAACTGTTAGAGTGGATGGGTGATCGCGCGGGCGCGGGCAGGGTCGTCCC
CAAGGGATTCCCGCGGAGCGGCAAGTTCAACGGATGA

Upstream 100 bases:

>100_bases
ACGCGCGGACGCAGGCAGGGGTCAGCCGCCGATGACGTTCTCCACAGTGCGGTCGCCGGGGATTCTTGCCGATGCGCGCC
TGTTGAGGTAGCAAGGACAC

Downstream 100 bases:

>100_bases
TCCGCAAAACTATGCGCTTGCAAGCGGAGAGCGTTCGTGGATCAATATTGTTGTAAGCGGATGGTCCCCTCCGTCCCGGA
AGCCGCTCTAATGTCCTGCT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 758; Mature: 757

Protein sequence:

>758_residues
MGQSLLPPSGGDDNIQPVDLKAALEERYLAYALSTIMHRALPDVRDGLKPVHRRIIHAMSEMGLRPNSSFKKCARIVGDV
IGKFHPHGDQSVYDALVRLAQDFSQRYPVVDGQGNFGNIDGDNAAAYRYTEAKMTEVAALLLEGIDQDAVDFRPTYNEED
QEPTVLPGAFPNLLANGASGIAVGMATSIPPHNAHELCDAALYLIRHPDAPLEALLFDPANPQRGGIEGPDFPTGGVIVE
SRTSMMESYRTGRGGFRVRARWTVEDLGRGGFQIVVTEIPYQVQKSRLIEKIAELLIARKLPLLEDIRDESAEDVRVVLV
PKSRSVDANILMESLFKLTELESRIPLNMNVLSMGRVPRVMALNEVLSEWLAHRREVLQRRSRHRLAAIDRRLEILGGYL
IAYLNIDEVIRIIREEDEPKAVMIERFGLTDVQAEAILNMRLRSLRKLEEFEIRTEFDALSKEKAEIEALLASDDKQWQA
VAWEIGEVKKKFAKATELGKRRSTFADAPEADVEAIQQAMIEKEPITVVISEKGWIRALKGHIADTTSLQFKDGDALKVS
FPAQTTDKILIFTTGGKVYTLGSDKLPGGRGHGEPLRIMVDMENDQDVLTAFVHDPARKLVVSSTAGNGFVVTESDIVAN
TRKGKQVMNVSMPDEAKLVVPVKGDHLAVVGENRKMLVFPLAQVPEMARGKGVRLQRYKDGGISDIRCFSIAEGLTWEDS
AGRVFTKTKDELLEWMGDRAGAGRVVPKGFPRSGKFNG

Sequences:

>Translated_758_residues
MGQSLLPPSGGDDNIQPVDLKAALEERYLAYALSTIMHRALPDVRDGLKPVHRRIIHAMSEMGLRPNSSFKKCARIVGDV
IGKFHPHGDQSVYDALVRLAQDFSQRYPVVDGQGNFGNIDGDNAAAYRYTEAKMTEVAALLLEGIDQDAVDFRPTYNEED
QEPTVLPGAFPNLLANGASGIAVGMATSIPPHNAHELCDAALYLIRHPDAPLEALLFDPANPQRGGIEGPDFPTGGVIVE
SRTSMMESYRTGRGGFRVRARWTVEDLGRGGFQIVVTEIPYQVQKSRLIEKIAELLIARKLPLLEDIRDESAEDVRVVLV
PKSRSVDANILMESLFKLTELESRIPLNMNVLSMGRVPRVMALNEVLSEWLAHRREVLQRRSRHRLAAIDRRLEILGGYL
IAYLNIDEVIRIIREEDEPKAVMIERFGLTDVQAEAILNMRLRSLRKLEEFEIRTEFDALSKEKAEIEALLASDDKQWQA
VAWEIGEVKKKFAKATELGKRRSTFADAPEADVEAIQQAMIEKEPITVVISEKGWIRALKGHIADTTSLQFKDGDALKVS
FPAQTTDKILIFTTGGKVYTLGSDKLPGGRGHGEPLRIMVDMENDQDVLTAFVHDPARKLVVSSTAGNGFVVTESDIVAN
TRKGKQVMNVSMPDEAKLVVPVKGDHLAVVGENRKMLVFPLAQVPEMARGKGVRLQRYKDGGISDIRCFSIAEGLTWEDS
AGRVFTKTKDELLEWMGDRAGAGRVVPKGFPRSGKFNG
>Mature_757_residues
GQSLLPPSGGDDNIQPVDLKAALEERYLAYALSTIMHRALPDVRDGLKPVHRRIIHAMSEMGLRPNSSFKKCARIVGDVI
GKFHPHGDQSVYDALVRLAQDFSQRYPVVDGQGNFGNIDGDNAAAYRYTEAKMTEVAALLLEGIDQDAVDFRPTYNEEDQ
EPTVLPGAFPNLLANGASGIAVGMATSIPPHNAHELCDAALYLIRHPDAPLEALLFDPANPQRGGIEGPDFPTGGVIVES
RTSMMESYRTGRGGFRVRARWTVEDLGRGGFQIVVTEIPYQVQKSRLIEKIAELLIARKLPLLEDIRDESAEDVRVVLVP
KSRSVDANILMESLFKLTELESRIPLNMNVLSMGRVPRVMALNEVLSEWLAHRREVLQRRSRHRLAAIDRRLEILGGYLI
AYLNIDEVIRIIREEDEPKAVMIERFGLTDVQAEAILNMRLRSLRKLEEFEIRTEFDALSKEKAEIEALLASDDKQWQAV
AWEIGEVKKKFAKATELGKRRSTFADAPEADVEAIQQAMIEKEPITVVISEKGWIRALKGHIADTTSLQFKDGDALKVSF
PAQTTDKILIFTTGGKVYTLGSDKLPGGRGHGEPLRIMVDMENDQDVLTAFVHDPARKLVVSSTAGNGFVVTESDIVANT
RKGKQVMNVSMPDEAKLVVPVKGDHLAVVGENRKMLVFPLAQVPEMARGKGVRLQRYKDGGISDIRCFSIAEGLTWEDSA
GRVFTKTKDELLEWMGDRAGAGRVVPKGFPRSGKFNG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=359, Percent_Identity=22.2841225626741, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789396, Length=678, Percent_Identity=41.4454277286136, Blast_Score=533, Evalue=1e-152,
Organism=Escherichia coli, GI1788562, Length=642, Percent_Identity=38.1619937694704, Blast_Score=410, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI212645657, Length=166, Percent_Identity=33.1325301204819, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17535065, Length=441, Percent_Identity=25.3968253968254, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=361, Percent_Identity=27.4238227146814, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84010; Mature: 83879

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQSLLPPSGGDDNIQPVDLKAALEERYLAYALSTIMHRALPDVRDGLKPVHRRIIHAMS
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
EMGLRPNSSFKKCARIVGDVIGKFHPHGDQSVYDALVRLAQDFSQRYPVVDGQGNFGNID
HCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCC
GDNAAAYRYTEAKMTEVAALLLEGIDQDAVDFRPTYNEEDQEPTVLPGAFPNLLANGASG
CCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCC
IAVGMATSIPPHNAHELCDAALYLIRHPDAPLEALLFDPANPQRGGIEGPDFPTGGVIVE
EEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHEEEECCCCCCCCCCCCCCCCCCCEEEC
SRTSMMESYRTGRGGFRVRARWTVEDLGRGGFQIVVTEIPYQVQKSRLIEKIAELLIARK
CHHHHHHHHHCCCCCEEEEEEEEHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHC
LPLLEDIRDESAEDVRVVLVPKSRSVDANILMESLFKLTELESRIPLNMNVLSMGRVPRV
CCHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHH
MALNEVLSEWLAHRREVLQRRSRHRLAAIDRRLEILGGYLIAYLNIDEVIRIIREEDEPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCCC
AVMIERFGLTDVQAEAILNMRLRSLRKLEEFEIRTEFDALSKEKAEIEALLASDDKQWQA
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VAWEIGEVKKKFAKATELGKRRSTFADAPEADVEAIQQAMIEKEPITVVISEKGWIRALK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
GHIADTTSLQFKDGDALKVSFPAQTTDKILIFTTGGKVYTLGSDKLPGGRGHGEPLRIMV
CCCCCCCEEEECCCCEEEEECCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEE
DMENDQDVLTAFVHDPARKLVVSSTAGNGFVVTESDIVANTRKGKQVMNVSMPDEAKLVV
ECCCCHHHHHHHHHCCHHHEEEEECCCCCEEEECCHHHCCCCCCCEEEECCCCCCCEEEE
PVKGDHLAVVGENRKMLVFPLAQVPEMARGKGVRLQRYKDGGISDIRCFSIAEGLTWEDS
EECCCEEEEEECCCEEEEEEHHHCCHHHCCCCCEEEEECCCCCCCEEEEHHHCCCCCCCC
AGRVFTKTKDELLEWMGDRAGAGRVVPKGFPRSGKFNG
CCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GQSLLPPSGGDDNIQPVDLKAALEERYLAYALSTIMHRALPDVRDGLKPVHRRIIHAMS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
EMGLRPNSSFKKCARIVGDVIGKFHPHGDQSVYDALVRLAQDFSQRYPVVDGQGNFGNID
HCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCC
GDNAAAYRYTEAKMTEVAALLLEGIDQDAVDFRPTYNEEDQEPTVLPGAFPNLLANGASG
CCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCC
IAVGMATSIPPHNAHELCDAALYLIRHPDAPLEALLFDPANPQRGGIEGPDFPTGGVIVE
EEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHEEEECCCCCCCCCCCCCCCCCCCEEEC
SRTSMMESYRTGRGGFRVRARWTVEDLGRGGFQIVVTEIPYQVQKSRLIEKIAELLIARK
CHHHHHHHHHCCCCCEEEEEEEEHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHC
LPLLEDIRDESAEDVRVVLVPKSRSVDANILMESLFKLTELESRIPLNMNVLSMGRVPRV
CCHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHH
MALNEVLSEWLAHRREVLQRRSRHRLAAIDRRLEILGGYLIAYLNIDEVIRIIREEDEPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCCC
AVMIERFGLTDVQAEAILNMRLRSLRKLEEFEIRTEFDALSKEKAEIEALLASDDKQWQA
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VAWEIGEVKKKFAKATELGKRRSTFADAPEADVEAIQQAMIEKEPITVVISEKGWIRALK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
GHIADTTSLQFKDGDALKVSFPAQTTDKILIFTTGGKVYTLGSDKLPGGRGHGEPLRIMV
CCCCCCCEEEECCCCEEEEECCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEE
DMENDQDVLTAFVHDPARKLVVSSTAGNGFVVTESDIVANTRKGKQVMNVSMPDEAKLVV
ECCCCHHHHHHHHHCCHHHEEEEECCCCCEEEECCHHHCCCCCCCEEEECCCCCCCEEEE
PVKGDHLAVVGENRKMLVFPLAQVPEMARGKGVRLQRYKDGGISDIRCFSIAEGLTWEDS
EECCCEEEEEECCCEEEEEEHHHCCHHHCCCCCEEEEECCCCCCCEEEEHHHCCCCCCCC
AGRVFTKTKDELLEWMGDRAGAGRVVPKGFPRSGKFNG
CCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]