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The map label for this gene is aroB [H]

Identifier: 150396020

GI number: 150396020

Start: 854958

End: 856481

Strand: Direct

Name: aroB [H]

Synonym: Smed_0796

Alternate gene names: 150396020

Gene position: 854958-856481 (Clockwise)

Preceding gene: 150396019

Following gene: 150396026

Centisome position: 22.61

GC content: 61.68

Gene sequence:

>1524_bases
ATGGTCGAATCTGAAGCGCAGGGGCGTCTGCCCGGTATCCGCCCGGTCTCCGTTGTGGATATCGGTTCCAACTCCATTCG
TCTTGTCGTCTATGAAGGGTTGAGCCGTTCGCCGGCGATGCTGTTCAACGAGAAAGTAATGTGCGGCCTCGGCAAGGGGA
TCGATGCCACCGGCCGCATGGAGGAGGAAAGCGTGGCAAGGGCGCTAAGGGCGCTGCATCGCTTTCGTGCGCTCTCGAAC
CAGGCGCGAGCGACCAAAATGTATGTGCTGGCAACCGCGGCGGCACGGGAGGCCACCAACGGCGCGGCCTTCATAGAAAG
AGCGGAAGCCATCCTCGGCGAAAAGGTGAAGATCCTGAGCGGTGAGGAAGAGGCCTATTATTCGGCCATGGGGATCGTCA
GCGGTTATCACGAGCCGGACGGTGTGGTCGGGGACCTCGGCGGCGGTTCGCTCGAGCTTGTCGATGTAAGCGGCAAACGT
ATCGGCAAAGGCATAACCCTGCCGCTGGGCGGCATTCGTCTGTTCGAACACTCGAGCGGCTCGCTCAGCAGGGCGCGAAC
CTGGGTTCGCAAGTTCATGAAGGATGCCGAGGTCCTGAAGAAGGGGACCGCACGCACGTTCTATGCCGTGGGCGGAACGT
GGCGAGCGATCGCCAAGCTGCATATGGAGATGCGCAACTATCCGCTGCATATGATGCAGGGCTACGAGATCCCCTATGAC
GAGGCAATGGCGGTTCTTGCCGAAGTGATCGAGCCGAAGAACGTCAAGCCATCCGCCTATGCAACGATCTCCAAGAGCCG
CAGGGCACTCTTGCCCTTCGGCGCGGTGACGATGCAGGAGGCGATCTCCATCATGAAACCCGAGCGCATCTCTTTCTCCG
CGCTCGGTGTCCGCGAGGGATATCTTTTTTCGCTGCTTCCCGAAAAGGCGCGCCAGCAGGACCCGCTGCTGACGGCTGCC
AATGAAATCGCCATTCTTCGCGCCCGCTCGCCCGAGCATGCGCGCGAGCTCGCCGAGTGGACGGGCCGTCTCGTACCGTT
CTTCGGTGTGGAGGAAACGGAGGAGGAAAGGCGCTACCGTCAGGCCGCCTGCCTGTTGGCCGATATCAGCTGGCGGGCGC
ATCCGGACTATCGCGGCCTGCAGGCGTTGAATATCATTTCCCACTCGGCCTTCACGGGAATCACGCATGCGGGGCGCGCC
TATATCGCGCTTGCGAACTATTACCGCTTCGAAGGGCCAAACGACGATGGCGCCACCAGCCCGCTCACGGCCATCACGAC
GCCGCGCCTCCTCGAACTCGCAAAGCTCCTGGGTGGGTTGTTGCGCGTCGCCTATCTCTTTTCGGCTTCCATGCCGGGGG
TAGCGCGCCATCTCACGCTTAGACGGTCCACGAAGCCCGATATCGATCTCGAATTCGTCGTCCCGGCAGCCTATGCCGAT
TTCGAAGGCGAACGCCTCGACGGCCGGCTCCAGCAGCTCGGTAAGCTGACGGGCAAGAAACTCGCTTTCTGCTTCGAGCG
CTAG

Upstream 100 bases:

>100_bases
ACCAATCCGAGCCTTTCGGGTCGGGGTGAGGCTTTGAAATCCAGTGCACCGAAGCTGATCGCCGGCTGGAAGGGCGGCTG
GCGCGAGTAAACGGAATTGC

Downstream 100 bases:

>100_bases
AAATCGCGAAAAACGCTAGCATCTTTCGCGCGGGAATCTGCCTCATCCGCCTGCCGACACGTTCTCCCCGCACGCGGTTG
CATGCGGGGAGAGGGTGGCG

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: 3-dehydroquinate synthase; Unknown phosphatase [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MVESEAQGRLPGIRPVSVVDIGSNSIRLVVYEGLSRSPAMLFNEKVMCGLGKGIDATGRMEEESVARALRALHRFRALSN
QARATKMYVLATAAAREATNGAAFIERAEAILGEKVKILSGEEEAYYSAMGIVSGYHEPDGVVGDLGGGSLELVDVSGKR
IGKGITLPLGGIRLFEHSSGSLSRARTWVRKFMKDAEVLKKGTARTFYAVGGTWRAIAKLHMEMRNYPLHMMQGYEIPYD
EAMAVLAEVIEPKNVKPSAYATISKSRRALLPFGAVTMQEAISIMKPERISFSALGVREGYLFSLLPEKARQQDPLLTAA
NEIAILRARSPEHARELAEWTGRLVPFFGVEETEEERRYRQAACLLADISWRAHPDYRGLQALNIISHSAFTGITHAGRA
YIALANYYRFEGPNDDGATSPLTAITTPRLLELAKLLGGLLRVAYLFSASMPGVARHLTLRRSTKPDIDLEFVVPAAYAD
FEGERLDGRLQQLGKLTGKKLAFCFER

Sequences:

>Translated_507_residues
MVESEAQGRLPGIRPVSVVDIGSNSIRLVVYEGLSRSPAMLFNEKVMCGLGKGIDATGRMEEESVARALRALHRFRALSN
QARATKMYVLATAAAREATNGAAFIERAEAILGEKVKILSGEEEAYYSAMGIVSGYHEPDGVVGDLGGGSLELVDVSGKR
IGKGITLPLGGIRLFEHSSGSLSRARTWVRKFMKDAEVLKKGTARTFYAVGGTWRAIAKLHMEMRNYPLHMMQGYEIPYD
EAMAVLAEVIEPKNVKPSAYATISKSRRALLPFGAVTMQEAISIMKPERISFSALGVREGYLFSLLPEKARQQDPLLTAA
NEIAILRARSPEHARELAEWTGRLVPFFGVEETEEERRYRQAACLLADISWRAHPDYRGLQALNIISHSAFTGITHAGRA
YIALANYYRFEGPNDDGATSPLTAITTPRLLELAKLLGGLLRVAYLFSASMPGVARHLTLRRSTKPDIDLEFVVPAAYAD
FEGERLDGRLQQLGKLTGKKLAFCFER
>Mature_507_residues
MVESEAQGRLPGIRPVSVVDIGSNSIRLVVYEGLSRSPAMLFNEKVMCGLGKGIDATGRMEEESVARALRALHRFRALSN
QARATKMYVLATAAAREATNGAAFIERAEAILGEKVKILSGEEEAYYSAMGIVSGYHEPDGVVGDLGGGSLELVDVSGKR
IGKGITLPLGGIRLFEHSSGSLSRARTWVRKFMKDAEVLKKGTARTFYAVGGTWRAIAKLHMEMRNYPLHMMQGYEIPYD
EAMAVLAEVIEPKNVKPSAYATISKSRRALLPFGAVTMQEAISIMKPERISFSALGVREGYLFSLLPEKARQQDPLLTAA
NEIAILRARSPEHARELAEWTGRLVPFFGVEETEEERRYRQAACLLADISWRAHPDYRGLQALNIISHSAFTGITHAGRA
YIALANYYRFEGPNDDGATSPLTAITTPRLLELAKLLGGLLRVAYLFSASMPGVARHLTLRRSTKPDIDLEFVVPAAYAD
FEGERLDGRLQQLGKLTGKKLAFCFER

Specific function: Conversion Of Pppgpp To Ppgpp. Guanosine Pentaphosphate (Pppgpp) Is A Cytoplasmic Signaling Molecule Which Together With Ppgpp Controls The "Stringent Response", An Adaptive Process That Allows Bacteria To Respond To Amino Acid Starvation, Resulting In T

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=180, Percent_Identity=28.3333333333333, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788848, Length=410, Percent_Identity=23.1707317073171, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321185, Length=435, Percent_Identity=26.8965517241379, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002658
- InterPro:   IPR016037
- InterPro:   IPR003695 [H]

Pfam domain/function: PF01761 DHQ_synthase; PF02541 Ppx-GppA [H]

EC number: =4.2.3.4 [H]

Molecular weight: Translated: 55754; Mature: 55754

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVESEAQGRLPGIRPVSVVDIGSNSIRLVVYEGLSRSPAMLFNEKVMCGLGKGIDATGRM
CCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHCCHHHEECCCCCCCCCCC
EEESVARALRALHRFRALSNQARATKMYVLATAAAREATNGAAFIERAEAILGEKVKILS
CHHHHHHHHHHHHHHHHHHCHHHHHEEEEEEEHHHHHCCCCHHHHHHHHHHHCCCEEEEC
GEEEAYYSAMGIVSGYHEPDGVVGDLGGGSLELVDVSGKRIGKGITLPLGGIRLFEHSSG
CCHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEECCCCCCCCCEEECCCCEEEEECCCC
SLSRARTWVRKFMKDAEVLKKGTARTFYAVGGTWRAIAKLHMEMRNYPLHMMQGYEIPYD
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHCCCCCCHH
EAMAVLAEVIEPKNVKPSAYATISKSRRALLPFGAVTMQEAISIMKPERISFSALGVREG
HHHHHHHHHHCCCCCCCCHHEEHHCCCCEECCCCHHHHHHHHHHCCCCCCCEEEECCCCC
YLFSLLPEKARQQDPLLTAANEIAILRARSPEHARELAEWTGRLVPFFGVEETEEERRYR
HHHHHCCHHHHCCCCCEEECCCEEEEECCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHH
QAACLLADISWRAHPDYRGLQALNIISHSAFTGITHAGRAYIALANYYRFEGPNDDGATS
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHEEECCCCCCCCCC
PLTAITTPRLLELAKLLGGLLRVAYLFSASMPGVARHLTLRRSTKPDIDLEFVVPAAYAD
CCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEECCCCCCCCEEEEEEEHHCC
FEGERLDGRLQQLGKLTGKKLAFCFER
CCCCHHHHHHHHHHHHCCCHHHHEECC
>Mature Secondary Structure
MVESEAQGRLPGIRPVSVVDIGSNSIRLVVYEGLSRSPAMLFNEKVMCGLGKGIDATGRM
CCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHCCHHHEECCCCCCCCCCC
EEESVARALRALHRFRALSNQARATKMYVLATAAAREATNGAAFIERAEAILGEKVKILS
CHHHHHHHHHHHHHHHHHHCHHHHHEEEEEEEHHHHHCCCCHHHHHHHHHHHCCCEEEEC
GEEEAYYSAMGIVSGYHEPDGVVGDLGGGSLELVDVSGKRIGKGITLPLGGIRLFEHSSG
CCHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEECCCCCCCCCEEECCCCEEEEECCCC
SLSRARTWVRKFMKDAEVLKKGTARTFYAVGGTWRAIAKLHMEMRNYPLHMMQGYEIPYD
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHCCCCCCHH
EAMAVLAEVIEPKNVKPSAYATISKSRRALLPFGAVTMQEAISIMKPERISFSALGVREG
HHHHHHHHHHCCCCCCCCHHEEHHCCCCEECCCCHHHHHHHHHHCCCCCCCEEEECCCCC
YLFSLLPEKARQQDPLLTAANEIAILRARSPEHARELAEWTGRLVPFFGVEETEEERRYR
HHHHHCCHHHHCCCCCEEECCCEEEEECCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHH
QAACLLADISWRAHPDYRGLQALNIISHSAFTGITHAGRAYIALANYYRFEGPNDDGATS
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHEEECCCCCCCCCC
PLTAITTPRLLELAKLLGGLLRVAYLFSASMPGVARHLTLRRSTKPDIDLEFVVPAAYAD
CCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEECCCCCCCCEEEEEEEHHCC
FEGERLDGRLQQLGKLTGKKLAFCFER
CCCCHHHHHHHHHHHHCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]