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The map label for this gene is pepA [H]

Identifier: 150395990

GI number: 150395990

Start: 823801

End: 825294

Strand: Direct

Name: pepA [H]

Synonym: Smed_0766

Alternate gene names: 150395990

Gene position: 823801-825294 (Clockwise)

Preceding gene: 150395983

Following gene: 150395991

Centisome position: 21.78

GC content: 62.52

Gene sequence:

>1494_bases
ATGCCGACGAAATTTGAGTTCTCTTTCAGTAAATCCCACCGCCCGGCGGGCGGCGTCGCGGTTCTCCTGCAGGCTGCAGG
TGCCAAAGAAGCAGCCGGTGCCGCCGTTGCCGATCCGGAGAGCGTTCTTGCCAAGGCAGCGAAGATCGGCAAGTTCACAG
GCAAAGCACTCTCGACCCTCGACGTCATTGCCCCGCACGGTTCGCCGGCAGATCGCATCGTGCTTCTCGGCGTTGGCCAC
GCGGCCGGAATGGGCGATCACGACTGGTTGAAGGCCGGTGGCGCCGCGGCCGCGAAATTGCGGTCCGCCGAAAAGATCAC
GGTCTTTCTCGACGCTCCCGGCATTGAGGTCACCGGCAAGGCAGCCGCGGACTTCGCCCTTGGGATGGAGATGAACGCCT
ACAGCTTCGAGAGCTACAAGACCCGGAAATCGGATGATGAGCCGAAGACGACACAGAAACCGGTCAAGGTCACCATCGTC
ACCGCCACTGTGATCGCCGCGAAAAAGGCATTCGGGACCGCCCAGGCGGTTGGTGAGGGTGTGTTTCTGGCGCGCGACCT
CGTCAACGAGCCCGCCAACGTCCTCGGCCCCGTGGAGTTCGCCGCGCGTGCCAAGGAACTGGAAAAACTTGGCGTCGAGG
TCGAGATCCTGACCGAGCGGGAGATGAAGAAGCTCGGCATGGGCGCACTTCTCGGCGTGGCACAGGGTTCGTCCCGCCCG
CCGCGGCTTGTCGTCATGCAATGGAAAGGCGGTAAGGCCAAGGACAAGTCCGTCGCCTTCATCGGCAAGGGCGTTGTCTT
CGACACGGGCGGCATCTCCATCAAGCCCGCTTCCGGCATGGAGGACATGAAGGGCGACATGGGCGGAGCGGCGGCAGTGA
CCGGCCTCATGCATGTCCTTGCCGCACGCAAGGCGGCCGTCAACGCGATCGGCATCATCGGCCTGGTCGAGAATATGCCC
GACGGAAGCGCACAGAGACCGGGAGACATCGTGACGTCGATGTCCGGGCAGACGATCGAGGTGATCAACACCGATGCCGA
AGGCAGACTCGTTCTGGGCGATGCTCTCTGGTACTGCAATGACCGGTTCAAGCCGCAGCTGATGATCGATCTTGCAACGC
TGACGGGCGCAATCATGGTGGCGCTCAGCAATCATTACGCCGGATTGTTTTCGAACGACGACCGCCTGGCCGAGCAGTTG
CTTGCGGCCGGTCTCGTCACGCAGGAGCGGCTGTGGCGGATGCCGCTCGGCAAGGAATATGACAAGATGATCGATAGCAA
GTTCGCCGATATGAAGAACACCGGCGGCAGGCACGGCGGCTCGGTCACCGCGGCGCAGTTCCTGAAGCGGTTCGTCAAGG
ATACGCCCTGGGCGCATCTCGATATCGCCGGCACCGCAATGGGATCTCCCACCGACGAGCTCAACCAGTCCTGGGGCTCT
GGTTTCGGCGTTCGCCTTCTCGACCAGCTGGTGCGTGCGAACTACGAATCGTGA

Upstream 100 bases:

>100_bases
GGCCCACAGCTTCGATCGCCGCCGACGTCACGAATGTCGGTCACTGTAGCCGTCCGGTAACAGGCCGGACGCCGCCGTAA
GAAAGTGCCTGGAGTCCTGC

Downstream 100 bases:

>100_bases
GAGTTCGCCCGAGATCGGAATGACCGAAGTTCTTTTCTACCACCTGACGGAATCCAAGCTCGAGGACGCTTTGCCGCCGC
TGCTCGACAAGAGCATTGAG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MPTKFEFSFSKSHRPAGGVAVLLQAAGAKEAAGAAVADPESVLAKAAKIGKFTGKALSTLDVIAPHGSPADRIVLLGVGH
AAGMGDHDWLKAGGAAAAKLRSAEKITVFLDAPGIEVTGKAAADFALGMEMNAYSFESYKTRKSDDEPKTTQKPVKVTIV
TATVIAAKKAFGTAQAVGEGVFLARDLVNEPANVLGPVEFAARAKELEKLGVEVEILTEREMKKLGMGALLGVAQGSSRP
PRLVVMQWKGGKAKDKSVAFIGKGVVFDTGGISIKPASGMEDMKGDMGGAAAVTGLMHVLAARKAAVNAIGIIGLVENMP
DGSAQRPGDIVTSMSGQTIEVINTDAEGRLVLGDALWYCNDRFKPQLMIDLATLTGAIMVALSNHYAGLFSNDDRLAEQL
LAAGLVTQERLWRMPLGKEYDKMIDSKFADMKNTGGRHGGSVTAAQFLKRFVKDTPWAHLDIAGTAMGSPTDELNQSWGS
GFGVRLLDQLVRANYES

Sequences:

>Translated_497_residues
MPTKFEFSFSKSHRPAGGVAVLLQAAGAKEAAGAAVADPESVLAKAAKIGKFTGKALSTLDVIAPHGSPADRIVLLGVGH
AAGMGDHDWLKAGGAAAAKLRSAEKITVFLDAPGIEVTGKAAADFALGMEMNAYSFESYKTRKSDDEPKTTQKPVKVTIV
TATVIAAKKAFGTAQAVGEGVFLARDLVNEPANVLGPVEFAARAKELEKLGVEVEILTEREMKKLGMGALLGVAQGSSRP
PRLVVMQWKGGKAKDKSVAFIGKGVVFDTGGISIKPASGMEDMKGDMGGAAAVTGLMHVLAARKAAVNAIGIIGLVENMP
DGSAQRPGDIVTSMSGQTIEVINTDAEGRLVLGDALWYCNDRFKPQLMIDLATLTGAIMVALSNHYAGLFSNDDRLAEQL
LAAGLVTQERLWRMPLGKEYDKMIDSKFADMKNTGGRHGGSVTAAQFLKRFVKDTPWAHLDIAGTAMGSPTDELNQSWGS
GFGVRLLDQLVRANYES
>Mature_496_residues
PTKFEFSFSKSHRPAGGVAVLLQAAGAKEAAGAAVADPESVLAKAAKIGKFTGKALSTLDVIAPHGSPADRIVLLGVGHA
AGMGDHDWLKAGGAAAAKLRSAEKITVFLDAPGIEVTGKAAADFALGMEMNAYSFESYKTRKSDDEPKTTQKPVKVTIVT
ATVIAAKKAFGTAQAVGEGVFLARDLVNEPANVLGPVEFAARAKELEKLGVEVEILTEREMKKLGMGALLGVAQGSSRPP
RLVVMQWKGGKAKDKSVAFIGKGVVFDTGGISIKPASGMEDMKGDMGGAAAVTGLMHVLAARKAAVNAIGIIGLVENMPD
GSAQRPGDIVTSMSGQTIEVINTDAEGRLVLGDALWYCNDRFKPQLMIDLATLTGAIMVALSNHYAGLFSNDDRLAEQLL
AAGLVTQERLWRMPLGKEYDKMIDSKFADMKNTGGRHGGSVTAAQFLKRFVKDTPWAHLDIAGTAMGSPTDELNQSWGSG
FGVRLLDQLVRANYES

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=406, Percent_Identity=37.192118226601, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI47155554, Length=316, Percent_Identity=33.5443037974684, Blast_Score=145, Evalue=9e-35,
Organism=Escherichia coli, GI1790710, Length=338, Percent_Identity=45.8579881656805, Blast_Score=295, Evalue=6e-81,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=38.5579937304075, Blast_Score=197, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17556903, Length=313, Percent_Identity=31.9488817891374, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=155, Percent_Identity=31.6129032258064, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20129969, Length=293, Percent_Identity=34.8122866894198, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24662227, Length=287, Percent_Identity=36.5853658536585, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24661038, Length=295, Percent_Identity=37.9661016949153, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI21355725, Length=282, Percent_Identity=37.5886524822695, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161077148, Length=291, Percent_Identity=34.020618556701, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI20130057, Length=291, Percent_Identity=34.020618556701, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI21355645, Length=289, Percent_Identity=33.2179930795848, Blast_Score=182, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24662223, Length=289, Percent_Identity=33.2179930795848, Blast_Score=182, Evalue=7e-46,
Organism=Drosophila melanogaster, GI19922386, Length=287, Percent_Identity=33.4494773519164, Blast_Score=175, Evalue=7e-44,
Organism=Drosophila melanogaster, GI20129963, Length=378, Percent_Identity=31.4814814814815, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI221379063, Length=308, Percent_Identity=33.4415584415584, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI221379062, Length=308, Percent_Identity=33.4415584415584, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21357381, Length=308, Percent_Identity=33.4415584415584, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24646701, Length=314, Percent_Identity=27.3885350318471, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646703, Length=314, Percent_Identity=27.3885350318471, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21358201, Length=314, Percent_Identity=27.3885350318471, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52254; Mature: 52123

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTKFEFSFSKSHRPAGGVAVLLQAAGAKEAAGAAVADPESVLAKAAKIGKFTGKALSTL
CCCEEEEEECCCCCCCCCCEEEEECCCCCHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHH
DVIAPHGSPADRIVLLGVGHAAGMGDHDWLKAGGAAAAKLRSAEKITVFLDAPGIEVTGK
EEECCCCCCCCEEEEEECCCCCCCCCHHHHHCCCHHHHHHCCCCEEEEEEECCCCEEECC
AAADFALGMEMNAYSFESYKTRKSDDEPKTTQKPVKVTIVTATVIAAKKAFGTAQAVGEG
CHHHHEECCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHCHHHHHCCC
VFLARDLVNEPANVLGPVEFAARAKELEKLGVEVEILTEREMKKLGMGALLGVAQGSSRP
HHHHHHHHCCCHHHHCHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCHHEEEECCCCCCC
PRLVVMQWKGGKAKDKSVAFIGKGVVFDTGGISIKPASGMEDMKGDMGGAAAVTGLMHVL
CEEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCCCCHHHHHHHHHHHH
AARKAAVNAIGIIGLVENMPDGSAQRPGDIVTSMSGQTIEVINTDAEGRLVLGDALWYCN
HHHHHHHHHHHHEEHHHCCCCCCCCCCCHHEECCCCCEEEEEECCCCCEEEEECEEEEEC
DRFKPQLMIDLATLTGAIMVALSNHYAGLFSNDDRLAEQLLAAGLVTQERLWRMPLGKEY
CCCCCEEEEEHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
DKMIDSKFADMKNTGGRHGGSVTAAQFLKRFVKDTPWAHLDIAGTAMGSPTDELNQSWGS
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCC
GFGVRLLDQLVRANYES
CCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
PTKFEFSFSKSHRPAGGVAVLLQAAGAKEAAGAAVADPESVLAKAAKIGKFTGKALSTL
CCEEEEEECCCCCCCCCCEEEEECCCCCHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHH
DVIAPHGSPADRIVLLGVGHAAGMGDHDWLKAGGAAAAKLRSAEKITVFLDAPGIEVTGK
EEECCCCCCCCEEEEEECCCCCCCCCHHHHHCCCHHHHHHCCCCEEEEEEECCCCEEECC
AAADFALGMEMNAYSFESYKTRKSDDEPKTTQKPVKVTIVTATVIAAKKAFGTAQAVGEG
CHHHHEECCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHCHHHHHCCC
VFLARDLVNEPANVLGPVEFAARAKELEKLGVEVEILTEREMKKLGMGALLGVAQGSSRP
HHHHHHHHCCCHHHHCHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCHHEEEECCCCCCC
PRLVVMQWKGGKAKDKSVAFIGKGVVFDTGGISIKPASGMEDMKGDMGGAAAVTGLMHVL
CEEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCCCCHHHHHHHHHHHH
AARKAAVNAIGIIGLVENMPDGSAQRPGDIVTSMSGQTIEVINTDAEGRLVLGDALWYCN
HHHHHHHHHHHHEEHHHCCCCCCCCCCCHHEECCCCCEEEEEECCCCCEEEEECEEEEEC
DRFKPQLMIDLATLTGAIMVALSNHYAGLFSNDDRLAEQLLAAGLVTQERLWRMPLGKEY
CCCCCEEEEEHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
DKMIDSKFADMKNTGGRHGGSVTAAQFLKRFVKDTPWAHLDIAGTAMGSPTDELNQSWGS
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCC
GFGVRLLDQLVRANYES
CCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]