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The map label for this gene is hemC [H]

Identifier: 150401746

GI number: 150401746

Start: 1387922

End: 1388950

Strand: Direct

Name: hemC [H]

Synonym: Maeo_1324

Alternate gene names: 150401746

Gene position: 1387922-1388950 (Clockwise)

Preceding gene: 150401745

Following gene: 150401747

Centisome position: 88.43

GC content: 28.47

Gene sequence:

>1029_bases
ATGGAGACATTAAAAGAACAAACTTTACAGATGGACTATAATGCAAAGTGTTCGTCGATTTACTATATATACTATATAAT
TATTCAAAATGGTTTAATATTTAATGGTTTCAATGGTGGAATTTTGAAAATAATAATAGGAACAAGAGGAAGTAAATTAG
CACTTACTCAAACAAACTATATTAAAGCTCTTTTAGAAAATTTAAATGAAAATATTGATATTGAAGTAAAAATAGTTAAA
ACCACAGGGGATAAAGACCAATCTTCAAAATTATCAGAATTGGGGTTGGGAGTATTTACAAAAGAATTGGATTTAAAAAT
GCTAAATAATGAAATAGATATTGCAGTGCATAGCTTAAAAGATGTCCCTACGGTTTGGAACGAAAATTTAACAATAGCTT
CAACTCCAAAAAGAGAAAGTTATGCCGATTTAATATTGTGGAATAAGGAAGATAATGATATAAATATTGAAAAATGCAAT
GAAAAAGATAATATAATTGTTGGAACATCCAGTATACGAAGACAGGAGTTTTTAAAAATAAAATACCCAAATTTAAAAAC
CAAGTTATTACGGGGGAATGTAGATACTAGATTAAATAAATTAAGAAATAAAGAGTATGACGCCATAATATTGGCAGAAG
CAGGTTTAAATAGATTAAAAATGGATTTATCTGATTTTAACTACGAAAGATTAAATATACTTCCTGCTCCTGCTCAGGGG
GTAGTAGGGGTAGCATCACGAACCGACAATAAAGAAGTAATATCCATATTACAAAAAATAAACCATAAAAAGACATTTTT
AGAGGCACTAGCTGAACGATATGCACTAAGAGAATATGGTGGTGGATGTCAGGCACCTTTCGGAGCTCTCTCAAAATATG
ATGAAGAAAATAAAATATTAAATTTAAAATGTTCCGTAGTAATTGGCAACACAATAAAATCAAAAGAAGAGAATATTAAT
TGTGATATAATGGATATTGAAGGGGCTAAAAATTTAGGCATTAAAATTGGAAAATATATAAAACAATAA

Upstream 100 bases:

>100_bases
CAATATCTTTTGGATATTGAACAAAAGCAAAGCTTTTTTATAATAATATCGATTTGTATAATTGCAATATTTAAAATGTA
TTATTTTTAAATACTAATTT

Downstream 100 bases:

>100_bases
ACAATATAAAGTATTATAATAAAAACAGTAGATTATAATATACTATATAATATATATCTTGCTGCTGTATGTGGTTTATC
TTCGGTCGTTTTCATATATA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
METLKEQTLQMDYNAKCSSIYYIYYIIIQNGLIFNGFNGGILKIIIGTRGSKLALTQTNYIKALLENLNENIDIEVKIVK
TTGDKDQSSKLSELGLGVFTKELDLKMLNNEIDIAVHSLKDVPTVWNENLTIASTPKRESYADLILWNKEDNDINIEKCN
EKDNIIVGTSSIRRQEFLKIKYPNLKTKLLRGNVDTRLNKLRNKEYDAIILAEAGLNRLKMDLSDFNYERLNILPAPAQG
VVGVASRTDNKEVISILQKINHKKTFLEALAERYALREYGGGCQAPFGALSKYDEENKILNLKCSVVIGNTIKSKEENIN
CDIMDIEGAKNLGIKIGKYIKQ

Sequences:

>Translated_342_residues
METLKEQTLQMDYNAKCSSIYYIYYIIIQNGLIFNGFNGGILKIIIGTRGSKLALTQTNYIKALLENLNENIDIEVKIVK
TTGDKDQSSKLSELGLGVFTKELDLKMLNNEIDIAVHSLKDVPTVWNENLTIASTPKRESYADLILWNKEDNDINIEKCN
EKDNIIVGTSSIRRQEFLKIKYPNLKTKLLRGNVDTRLNKLRNKEYDAIILAEAGLNRLKMDLSDFNYERLNILPAPAQG
VVGVASRTDNKEVISILQKINHKKTFLEALAERYALREYGGGCQAPFGALSKYDEENKILNLKCSVVIGNTIKSKEENIN
CDIMDIEGAKNLGIKIGKYIKQ
>Mature_342_residues
METLKEQTLQMDYNAKCSSIYYIYYIIIQNGLIFNGFNGGILKIIIGTRGSKLALTQTNYIKALLENLNENIDIEVKIVK
TTGDKDQSSKLSELGLGVFTKELDLKMLNNEIDIAVHSLKDVPTVWNENLTIASTPKRESYADLILWNKEDNDINIEKCN
EKDNIIVGTSSIRRQEFLKIKYPNLKTKLLRGNVDTRLNKLRNKEYDAIILAEAGLNRLKMDLSDFNYERLNILPAPAQG
VVGVASRTDNKEVISILQKINHKKTFLEALAERYALREYGGGCQAPFGALSKYDEENKILNLKCSVVIGNTIKSKEENIN
CDIMDIEGAKNLGIKIGKYIKQ

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=252, Percent_Identity=36.9047619047619, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI20149500, Length=252, Percent_Identity=36.9047619047619, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI48994974, Length=249, Percent_Identity=40.1606425702811, Blast_Score=157, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6319996, Length=307, Percent_Identity=35.1791530944625, Blast_Score=146, Evalue=5e-36,
Organism=Drosophila melanogaster, GI20130425, Length=252, Percent_Identity=33.7301587301587, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 38647; Mature: 38647

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLKEQTLQMDYNAKCSSIYYIYYIIIQNGLIFNGFNGGILKIIIGTRGSKLALTQTNY
CCCHHHHHEECCCCCCCCEEEEEEEEEEECCEEEECCCCCEEEEEEECCCCEEEEEHHHH
IKALLENLNENIDIEVKIVKTTGDKDQSSKLSELGLGVFTKELDLKMLNNEIDIAVHSLK
HHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHCCCCEEHHHHHHECCCCCEEEEECHH
DVPTVWNENLTIASTPKRESYADLILWNKEDNDINIEKCNEKDNIIVGTSSIRRQEFLKI
CCCHHHCCCEEEEECCCCCCCEEEEEECCCCCCEEEEECCCCCCEEEECCHHCCCCEEEE
KYPNLKTKLLRGNVDTRLNKLRNKEYDAIILAEAGLNRLKMDLSDFNYERLNILPAPAQG
ECCCCEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCEEEEHHHCCEEEEEEECCCCCC
VVGVASRTDNKEVISILQKINHKKTFLEALAERYALREYGGGCQAPFGALSKYDEENKIL
EEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCEE
NLKCSVVIGNTIKSKEENINCDIMDIEGAKNLGIKIGKYIKQ
EEEEEEEECCCCCCCCCCCCEEEEEECCCCCCCEEHHHHHCC
>Mature Secondary Structure
METLKEQTLQMDYNAKCSSIYYIYYIIIQNGLIFNGFNGGILKIIIGTRGSKLALTQTNY
CCCHHHHHEECCCCCCCCEEEEEEEEEEECCEEEECCCCCEEEEEEECCCCEEEEEHHHH
IKALLENLNENIDIEVKIVKTTGDKDQSSKLSELGLGVFTKELDLKMLNNEIDIAVHSLK
HHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHCCCCEEHHHHHHECCCCCEEEEECHH
DVPTVWNENLTIASTPKRESYADLILWNKEDNDINIEKCNEKDNIIVGTSSIRRQEFLKI
CCCHHHCCCEEEEECCCCCCCEEEEEECCCCCCEEEEECCCCCCEEEECCHHCCCCEEEE
KYPNLKTKLLRGNVDTRLNKLRNKEYDAIILAEAGLNRLKMDLSDFNYERLNILPAPAQG
ECCCCEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCEEEEHHHCCEEEEEEECCCCCC
VVGVASRTDNKEVISILQKINHKKTFLEALAERYALREYGGGCQAPFGALSKYDEENKIL
EEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCEE
NLKCSVVIGNTIKSKEENINCDIMDIEGAKNLGIKIGKYIKQ
EEEEEEEECCCCCCCCCCCCEEEEEECCCCCCCEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]