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The map label for this gene is hemL

Identifier: 150401631

GI number: 150401631

Start: 1276079

End: 1277377

Strand: Direct

Name: hemL

Synonym: Maeo_1208

Alternate gene names: 150401631

Gene position: 1276079-1277377 (Clockwise)

Preceding gene: 150401630

Following gene: 150401635

Centisome position: 81.3

GC content: 31.95

Gene sequence:

>1299_bases
ATGGACAATACCATAATAAATTTAAATTTGGAAAAATCAAAAAAATTATTTGAAGAATCTCAGAAATATCTTGTAAAAGG
AGTAAATAGTCCAGTTAGGTATTTTAAGCCATTTCCATTTTTCGTGAATAATGCAAAAGATTATTATTTGGTTGATGTTG
ATGGAAATAAATATATTGATTACTGTCTAGCCTATGGTCCTGCTGTATTGGGGCATGCAAATGAAAATATAGCAAATGCC
GTAATTGAGCAATTGAAACATGGAACTGCATATGGTTGTCCAACAGAAAAAGAAATTACACTTGCAAAAGAGATAATAAA
AAGAATGCCATGTGCTGAAATGGTAAGATTTGTAAATTCTGGAACAGAGGCTACAATGAGTGCCATTAGGTTAGCCAGAG
GAATAACTAAAAGAAATAAAATAATAAAATTTGATGGGGCATATCATGGAGCTCATGATTATGTGCTTGTGAAAAGTGGT
AGCGGGGCTTTAACACATGGAGCTCCCAACTCTCCTGGTATTCCTGAGGACACTACAAAACATACAATATTAGCCCCATT
CAATGATAAGGATGCAATCGTGGAAATAATAAAAAATAATAAAGACGAAATTGCCTGTATTATTGTTGAGCCAGTTATGG
GAAATGTTGGTTGTATCCCTCCAAGAGAGGATTATTTAAAGTTTTTAAGAGAAATTACGGAAGAAAATAATATAATTTTA
ATATTTGATGAGGTAATTACTGGATTTAGAATTGCCAAAGGGGGAGCTCAGGAATATTATGGTGTTGTTCCAGATTTGGC
AACAGTTGGTAAAATTATGGGGGGCGGTTTTCCAATTGGTGCAATAGTTGGTAAAAAGGAGTTAATGGAAAATTTCTCAC
CGAATGGAACAATATATCAAGCTGGAACATTTAATGGAAATCCCATATCCATGACAGCAGGTATTGAAACTCTAAAAAAT
CTTGATGATAATTTTTATAGCACAACTTCAAAATCGGCAAAAAAATTAAGTGATTTTATTGGGGAAACAGCAGAAAAACA
CAATATACCACATAAAGTTTATACCGTAGCTTCAATGTTTCAAATATATTTCAATGAAGAAGAAGTAGTTAATTACGATA
TAGCAAAAAATAGCAATACAGATTTATTTATGAAATATTTCTATGGATTAATGGAAAATGGAGTATTTATAGCACCCTCA
CAATTTGAATGCTGTTTTACATCTATAAAGCACACAGACGATGTTATAAATACAACTATGGATGCCATTGAAGAAGTATT
TAAAAAAATTACTCGATAA

Upstream 100 bases:

>100_bases
AAAACAATGGTTAGGAACAGGGGGAACTTCTTATTTCTTTACTGCAATAGTATTTTGGATTATATCATTTAATGGAGTTA
TCTGTTTATAAGGTGAAAAT

Downstream 100 bases:

>100_bases
TTTTCAAATCAAATTATTAGATAGAAGCGAAGCTTCTATTTTTAATTATAAATAATTTGTAAATATTAAAACTCCGAAGA
ATTTCTATAATCATAAAAAT

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MDNTIINLNLEKSKKLFEESQKYLVKGVNSPVRYFKPFPFFVNNAKDYYLVDVDGNKYIDYCLAYGPAVLGHANENIANA
VIEQLKHGTAYGCPTEKEITLAKEIIKRMPCAEMVRFVNSGTEATMSAIRLARGITKRNKIIKFDGAYHGAHDYVLVKSG
SGALTHGAPNSPGIPEDTTKHTILAPFNDKDAIVEIIKNNKDEIACIIVEPVMGNVGCIPPREDYLKFLREITEENNIIL
IFDEVITGFRIAKGGAQEYYGVVPDLATVGKIMGGGFPIGAIVGKKELMENFSPNGTIYQAGTFNGNPISMTAGIETLKN
LDDNFYSTTSKSAKKLSDFIGETAEKHNIPHKVYTVASMFQIYFNEEEVVNYDIAKNSNTDLFMKYFYGLMENGVFIAPS
QFECCFTSIKHTDDVINTTMDAIEEVFKKITR

Sequences:

>Translated_432_residues
MDNTIINLNLEKSKKLFEESQKYLVKGVNSPVRYFKPFPFFVNNAKDYYLVDVDGNKYIDYCLAYGPAVLGHANENIANA
VIEQLKHGTAYGCPTEKEITLAKEIIKRMPCAEMVRFVNSGTEATMSAIRLARGITKRNKIIKFDGAYHGAHDYVLVKSG
SGALTHGAPNSPGIPEDTTKHTILAPFNDKDAIVEIIKNNKDEIACIIVEPVMGNVGCIPPREDYLKFLREITEENNIIL
IFDEVITGFRIAKGGAQEYYGVVPDLATVGKIMGGGFPIGAIVGKKELMENFSPNGTIYQAGTFNGNPISMTAGIETLKN
LDDNFYSTTSKSAKKLSDFIGETAEKHNIPHKVYTVASMFQIYFNEEEVVNYDIAKNSNTDLFMKYFYGLMENGVFIAPS
QFECCFTSIKHTDDVINTTMDAIEEVFKKITR
>Mature_432_residues
MDNTIINLNLEKSKKLFEESQKYLVKGVNSPVRYFKPFPFFVNNAKDYYLVDVDGNKYIDYCLAYGPAVLGHANENIANA
VIEQLKHGTAYGCPTEKEITLAKEIIKRMPCAEMVRFVNSGTEATMSAIRLARGITKRNKIIKFDGAYHGAHDYVLVKSG
SGALTHGAPNSPGIPEDTTKHTILAPFNDKDAIVEIIKNNKDEIACIIVEPVMGNVGCIPPREDYLKFLREITEENNIIL
IFDEVITGFRIAKGGAQEYYGVVPDLATVGKIMGGGFPIGAIVGKKELMENFSPNGTIYQAGTFNGNPISMTAGIETLKN
LDDNFYSTTSKSAKKLSDFIGETAEKHNIPHKVYTVASMFQIYFNEEEVVNYDIAKNSNTDLFMKYFYGLMENGVFIAPS
QFECCFTSIKHTDDVINTTMDAIEEVFKKITR

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=323, Percent_Identity=27.5541795665635, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI37574042, Length=339, Percent_Identity=28.023598820059, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI226442705, Length=339, Percent_Identity=26.8436578171091, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI226442709, Length=303, Percent_Identity=28.0528052805281, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI13994255, Length=344, Percent_Identity=27.3255813953488, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI24119277, Length=344, Percent_Identity=26.7441860465116, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI284507298, Length=295, Percent_Identity=25.4237288135593, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=46.7136150234742, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1789016, Length=373, Percent_Identity=31.6353887399464, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1787560, Length=346, Percent_Identity=31.5028901734104, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1788044, Length=297, Percent_Identity=32.6599326599327, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789759, Length=286, Percent_Identity=30.0699300699301, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI145693181, Length=373, Percent_Identity=29.7587131367292, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1786991, Length=302, Percent_Identity=24.5033112582781, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71992977, Length=401, Percent_Identity=26.9326683291771, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=326, Percent_Identity=26.0736196319018, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI25144274, Length=140, Percent_Identity=31.4285714285714, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=357, Percent_Identity=25.2100840336134, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324432, Length=346, Percent_Identity=28.6127167630058, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21357415, Length=334, Percent_Identity=25.1497005988024, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI161085790, Length=326, Percent_Identity=26.3803680981595, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28574759, Length=326, Percent_Identity=26.3803680981595, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_META3 (A6UWB3)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001325397.1
- ProteinModelPortal:   A6UWB3
- SMR:   A6UWB3
- STRING:   A6UWB3
- GeneID:   5326788
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_1208
- eggNOG:   arNOG04972
- HOGENOM:   HBG725944
- OMA:   NENAVRD
- ProtClustDB:   PRK00062
- BioCyc:   MAEO419665:MAEO_1208-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 48066; Mature: 48066

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNTIINLNLEKSKKLFEESQKYLVKGVNSPVRYFKPFPFFVNNAKDYYLVDVDGNKYID
CCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEECCCCEEEEEEECCCHHHH
YCLAYGPAVLGHANENIANAVIEQLKHGTAYGCPTEKEITLAKEIIKRMPCAEMVRFVNS
HHHHHCCHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHC
GTEATMSAIRLARGITKRNKIIKFDGAYHGAHDYVLVKSGSGALTHGAPNSPGIPEDTTK
CHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCC
HTILAPFNDKDAIVEIIKNNKDEIACIIVEPVMGNVGCIPPREDYLKFLREITEENNIIL
CEEEECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEE
IFDEVITGFRIAKGGAQEYYGVVPDLATVGKIMGGGFPIGAIVGKKELMENFSPNGTIYQ
EEHHHHCCEEEECCCCHHHHCCCCCHHHHHHHHCCCCCHHHHHCHHHHHHCCCCCCCEEE
AGTFNGNPISMTAGIETLKNLDDNFYSTTSKSAKKLSDFIGETAEKHNIPHKVYTVASMF
CCCCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QIYFNEEEVVNYDIAKNSNTDLFMKYFYGLMENGVFIAPSQFECCFTSIKHTDDVINTTM
HHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHH
DAIEEVFKKITR
HHHHHHHHHHCC
>Mature Secondary Structure
MDNTIINLNLEKSKKLFEESQKYLVKGVNSPVRYFKPFPFFVNNAKDYYLVDVDGNKYID
CCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEECCCCEEEEEEECCCHHHH
YCLAYGPAVLGHANENIANAVIEQLKHGTAYGCPTEKEITLAKEIIKRMPCAEMVRFVNS
HHHHHCCHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHC
GTEATMSAIRLARGITKRNKIIKFDGAYHGAHDYVLVKSGSGALTHGAPNSPGIPEDTTK
CHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCC
HTILAPFNDKDAIVEIIKNNKDEIACIIVEPVMGNVGCIPPREDYLKFLREITEENNIIL
CEEEECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEE
IFDEVITGFRIAKGGAQEYYGVVPDLATVGKIMGGGFPIGAIVGKKELMENFSPNGTIYQ
EEHHHHCCEEEECCCCHHHHCCCCCHHHHHHHHCCCCCHHHHHCHHHHHHCCCCCCCEEE
AGTFNGNPISMTAGIETLKNLDDNFYSTTSKSAKKLSDFIGETAEKHNIPHKVYTVASMF
CCCCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QIYFNEEEVVNYDIAKNSNTDLFMKYFYGLMENGVFIAPSQFECCFTSIKHTDDVINTTM
HHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHH
DAIEEVFKKITR
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA