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The map label for this gene is cobS [H]

Identifier: 150401603

GI number: 150401603

Start: 1246552

End: 1247343

Strand: Direct

Name: cobS [H]

Synonym: Maeo_1180

Alternate gene names: 150401603

Gene position: 1246552-1247343 (Clockwise)

Preceding gene: 150401602

Following gene: 150401605

Centisome position: 79.42

GC content: 30.81

Gene sequence:

>792_bases
ATGTTAAAAAAAATAATAAATGGAATTGATGCCATAAGAGGTTTAATGGCATTTATGACCAAAATACCCATGGGAAATTT
TAAAAGTGGTTTTAAAGAGATGTCTCATCATTATACATTTATTATTTTTATTGGTCTTTTTATTGGATTAATTGGAGCTC
CATGTTCATATCCATTTTATTATTTTGATATAGGAGGCATTATTGTTGGAGTTGTGGTTCTTTTTGTTATGTTGTATATT
CAAGGATTTCATCATGTAGATGGTTTGGGGGACTATGGGGACGCCTGGATGGTAATGGGAGCTCCCGAAAAAAAATTAAT
AGTAATGAGAGATAAATATATGGGAGTTGGAGCTTTTGCATTTATATTTTTTGTGGAGCTCCTATCTATATCCGCAATAT
CCGCAATATATTTAAATTCTACATTTTTACAATTTGTAAAATTAATAATTTTGGCAGAAGGCTGTTCCCGATTAGGTAGC
TTATGCTGTGCAAGTTTGGGAGCTCCTTCAAATAGTGGCACAGGAAGGTATTTTATTGAAAATACTAAAAAAATTCATTT
ATTTATTGGAATAATTATATTATTATTCATAAGCTATTTAATTGGAATTTTTAAAATTGGTTTAATGGCTGTGGCTGTGG
CTGTGCTGGTTGGAATAGTCATTGTAAAAAGTTCAAAAAAATCTTTTGGATGTATCACGGGGGATATACTGGGAGCTTCC
TGTGAGATAACAAGGGCATTTGTGTTATTAATAATGGTTTTTTTGATAAATATTAATATGGGCATAATATAA

Upstream 100 bases:

>100_bases
AAAAATGCAGAGGACACCGTAAGTCAATATAAAATAAAGGATATATATGAAGCTGTGGATATTATAAAAAATTTAGTATC
TTCAAATGAACCGTGAAAAT

Downstream 100 bases:

>100_bases
AAAATAAAATAAAAAATAAATTATGCTTTACATATTATTTTATCAACACATACGGAACTATCTTTTCCTTTTACCTTTAA
TTCTCCATTGTCGATATAAA

Product: cobalamin 5'-phosphate synthase

Products: GMP; adenosylcobalamin

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MLKKIINGIDAIRGLMAFMTKIPMGNFKSGFKEMSHHYTFIIFIGLFIGLIGAPCSYPFYYFDIGGIIVGVVVLFVMLYI
QGFHHVDGLGDYGDAWMVMGAPEKKLIVMRDKYMGVGAFAFIFFVELLSISAISAIYLNSTFLQFVKLIILAEGCSRLGS
LCCASLGAPSNSGTGRYFIENTKKIHLFIGIIILLFISYLIGIFKIGLMAVAVAVLVGIVIVKSSKKSFGCITGDILGAS
CEITRAFVLLIMVFLININMGII

Sequences:

>Translated_263_residues
MLKKIINGIDAIRGLMAFMTKIPMGNFKSGFKEMSHHYTFIIFIGLFIGLIGAPCSYPFYYFDIGGIIVGVVVLFVMLYI
QGFHHVDGLGDYGDAWMVMGAPEKKLIVMRDKYMGVGAFAFIFFVELLSISAISAIYLNSTFLQFVKLIILAEGCSRLGS
LCCASLGAPSNSGTGRYFIENTKKIHLFIGIIILLFISYLIGIFKIGLMAVAVAVLVGIVIVKSSKKSFGCITGDILGAS
CEITRAFVLLIMVFLININMGII
>Mature_263_residues
MLKKIINGIDAIRGLMAFMTKIPMGNFKSGFKEMSHHYTFIIFIGLFIGLIGAPCSYPFYYFDIGGIIVGVVVLFVMLYI
QGFHHVDGLGDYGDAWMVMGAPEKKLIVMRDKYMGVGAFAFIFFVELLSISAISAIYLNSTFLQFVKLIILAEGCSRLGS
LCCASLGAPSNSGTGRYFIENTKKIHLFIGIIILLFISYLIGIFKIGLMAVAVAVLVGIVIVKSSKKSFGCITGDILGAS
CEITRAFVLLIMVFLININMGII

Specific function: Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) [H]

COG id: COG0368

COG function: function code H; Cobalamin-5-phosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobS family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003805 [H]

Pfam domain/function: PF02654 CobS [H]

EC number: 2.7.8.26

Molecular weight: Translated: 28742; Mature: 28742

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLKKIINGIDAIRGLMAFMTKIPMGNFKSGFKEMSHHYTFIIFIGLFIGLIGAPCSYPFY
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
YFDIGGIIVGVVVLFVMLYIQGFHHVDGLGDYGDAWMVMGAPEKKLIVMRDKYMGVGAFA
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEECCCCCHHHHH
FIFFVELLSISAISAIYLNSTFLQFVKLIILAEGCSRLGSLCCASLGAPSNSGTGRYFIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEC
NTKKIHLFIGIIILLFISYLIGIFKIGLMAVAVAVLVGIVIVKSSKKSFGCITGDILGAS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHCCCC
CEITRAFVLLIMVFLININMGII
HHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: adenosylcobinamide-GDP; alpha-ribazole

Specific reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]