Click here to switch to the map view.

The map label for this gene is ilvC [H]

Identifier: 150401598

GI number: 150401598

Start: 1241589

End: 1242578

Strand: Direct

Name: ilvC [H]

Synonym: Maeo_1175

Alternate gene names: 150401598

Gene position: 1241589-1242578 (Clockwise)

Preceding gene: 150401591

Following gene: 150401599

Centisome position: 79.11

GC content: 34.65

Gene sequence:

>990_bases
ATGAAAGTATATTATGAAGAAGATGCAAATTATGATGCAGTAAAAGATAAAACAATAGCTGTAATAGGATACGGAAGTCA
AGGAATGGCTCAGTCATGCAATATGAAAGATAGCGGATTAAATGTAATTGTTGGATTAAGACCAAATGGAGCATCATGGG
AAAAGGCAAAAGCAGACGGACATACAGTAATGAGTGTAGAGGAAGCAGCAGAAAAAGCTGATATTATACATATACTCATA
CCCGACGAAGTTCAAAAAGATGTTTATAACAACCAAATAAAACAACATTTAACAGAAGGAAAAACACTTTCATTCTCCCA
CGGATACAATGTTCATTTTAAATATATCGACCCCATAAAAGGAGTAAATGTAATTATGGTGGCTCCAAAATCCCCCGGGG
CAATGGTAAGAAGAACATACACAGAAGGATTTGGTGTTCCAGGATTAGTTTGTGTAGAAAGAGATGAAACAGGAGATGCA
TTAGACATAGCACTTGGAATGGCTAAGGCAGAAGGATTAACAAAAGCAGGAGTAATTAAAACAACATTCAAAGAAGAAAC
AGAAACAGACCTTTTCGGAGAACAAGCTGTTTTATGTGGTGGAGTTACAGAACTTATAAAAGCAGGATTTGATACCCTTG
TTGAAGCTGGATACTCACCAGAGATGGCATATTTTGAAACATGCAATGAGTTAAAATTAATCGTAGATTTAATATACCAA
AAAGGATTGGCTGGAATGTGGAATGATGTATCTAACACAGCAGAATACGGAGGATTTGTTACAAGAGAAAGAGTAATAAA
TGAAGAATCCAGAAAAGCGATGAGAGAAATATTAAAAGAAATCCAAAATGGTAAATTTGCAAGAGATTGGGCATTAGAAA
ATGTAAGTGGAATACCACATTTAAATGCTATGAGAAGATTAGAAGATGAGTCCTTGTTGGAGACAACAGGTAAAAAATTA
AGAAAAATGTGTGGATTACAAAAAGATTAA

Upstream 100 bases:

>100_bases
AATATTGATGGCGAATATAATTAAATAAATACATAGGCGAAAAAATTTACAAAATCAAAGATTTTGAATTTTTTTCCCAC
ATAACAAAGAGAGTGAAACT

Downstream 100 bases:

>100_bases
TTTAATATTAATTATTATATGGTCAATCTTCGGACAATTTCATTACTGTACCACAATAAGCAAAATCTTCATATTACTAA
ATAAAGAAATTTTATTTACA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKVYYEEDANYDAVKDKTIAVIGYGSQGMAQSCNMKDSGLNVIVGLRPNGASWEKAKADGHTVMSVEEAAEKADIIHILI
PDEVQKDVYNNQIKQHLTEGKTLSFSHGYNVHFKYIDPIKGVNVIMVAPKSPGAMVRRTYTEGFGVPGLVCVERDETGDA
LDIALGMAKAEGLTKAGVIKTTFKEETETDLFGEQAVLCGGVTELIKAGFDTLVEAGYSPEMAYFETCNELKLIVDLIYQ
KGLAGMWNDVSNTAEYGGFVTRERVINEESRKAMREILKEIQNGKFARDWALENVSGIPHLNAMRRLEDESLLETTGKKL
RKMCGLQKD

Sequences:

>Translated_329_residues
MKVYYEEDANYDAVKDKTIAVIGYGSQGMAQSCNMKDSGLNVIVGLRPNGASWEKAKADGHTVMSVEEAAEKADIIHILI
PDEVQKDVYNNQIKQHLTEGKTLSFSHGYNVHFKYIDPIKGVNVIMVAPKSPGAMVRRTYTEGFGVPGLVCVERDETGDA
LDIALGMAKAEGLTKAGVIKTTFKEETETDLFGEQAVLCGGVTELIKAGFDTLVEAGYSPEMAYFETCNELKLIVDLIYQ
KGLAGMWNDVSNTAEYGGFVTRERVINEESRKAMREILKEIQNGKFARDWALENVSGIPHLNAMRRLEDESLLETTGKKL
RKMCGLQKD
>Mature_329_residues
MKVYYEEDANYDAVKDKTIAVIGYGSQGMAQSCNMKDSGLNVIVGLRPNGASWEKAKADGHTVMSVEEAAEKADIIHILI
PDEVQKDVYNNQIKQHLTEGKTLSFSHGYNVHFKYIDPIKGVNVIMVAPKSPGAMVRRTYTEGFGVPGLVCVERDETGDA
LDIALGMAKAEGLTKAGVIKTTFKEETETDLFGEQAVLCGGVTELIKAGFDTLVEAGYSPEMAYFETCNELKLIVDLIYQ
KGLAGMWNDVSNTAEYGGFVTRERVINEESRKAMREILKEIQNGKFARDWALENVSGIPHLNAMRRLEDESLLETTGKKL
RKMCGLQKD

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=304, Percent_Identity=35.1973684210526, Blast_Score=152, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=256, Percent_Identity=39.84375, Blast_Score=152, Evalue=5e-38,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36349; Mature: 36349

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYYEEDANYDAVKDKTIAVIGYGSQGMAQSCNMKDSGLNVIVGLRPNGASWEKAKADG
CEEEECCCCCCCCCCCCEEEEEECCCCCCHHCCCCCCCCCEEEEEECCCCCCCCHHCCCC
HTVMSVEEAAEKADIIHILIPDEVQKDVYNNQIKQHLTEGKTLSFSHGYNVHFKYIDPIK
CEEEEHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCCC
GVNVIMVAPKSPGAMVRRTYTEGFGVPGLVCVERDETGDALDIALGMAKAEGLTKAGVIK
CCEEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEE
TTFKEETETDLFGEQAVLCGGVTELIKAGFDTLVEAGYSPEMAYFETCNELKLIVDLIYQ
EHHHCCHHHHHCCCCHHHHCCHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
KGLAGMWNDVSNTAEYGGFVTRERVINEESRKAMREILKEIQNGKFARDWALENVSGIPH
HCCCHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHCCCEEHHHHHHCCCCCCC
LNAMRRLEDESLLETTGKKLRKMCGLQKD
HHHHHHCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKVYYEEDANYDAVKDKTIAVIGYGSQGMAQSCNMKDSGLNVIVGLRPNGASWEKAKADG
CEEEECCCCCCCCCCCCEEEEEECCCCCCHHCCCCCCCCCEEEEEECCCCCCCCHHCCCC
HTVMSVEEAAEKADIIHILIPDEVQKDVYNNQIKQHLTEGKTLSFSHGYNVHFKYIDPIK
CEEEEHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCCC
GVNVIMVAPKSPGAMVRRTYTEGFGVPGLVCVERDETGDALDIALGMAKAEGLTKAGVIK
CCEEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEE
TTFKEETETDLFGEQAVLCGGVTELIKAGFDTLVEAGYSPEMAYFETCNELKLIVDLIYQ
EHHHCCHHHHHCCCCHHHHCCHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
KGLAGMWNDVSNTAEYGGFVTRERVINEESRKAMREILKEIQNGKFARDWALENVSGIPH
HCCCHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHCCCEEHHHHHHCCCCCCC
LNAMRRLEDESLLETTGKKLRKMCGLQKD
HHHHHHCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]