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The map label for this gene is argH

Identifier: 150401591

GI number: 150401591

Start: 1226623

End: 1228086

Strand: Direct

Name: argH

Synonym: Maeo_1168

Alternate gene names: 150401591

Gene position: 1226623-1228086 (Clockwise)

Preceding gene: 150401588

Following gene: 150401598

Centisome position: 78.15

GC content: 30.33

Gene sequence:

>1464_bases
ATGCAAAAAAATAATGAAAATATATTGAGGAGAGGGAGATTGGGGAGCTCCACAAAAAAGGAAGTTATGAATTATATGAC
TAGTTTAAGTTTTGATAAAGAAATATTTGAAAGTGATATATTTTGCGACATAGCCCATACAAAAATGCTAATGGAACAAA
ATATTATTTTGGAAGAGGATGGAATTAAAATAATAAATGAATTAAAAAAAATATATAATAATGGAATGGATTGTTTAAAT
CTTGACCCATCTCTTGACGATATACATATGGTAATAGAAAGTGAATTAATAAAAAACCTCGGAGAAGATGTTGCTGGAAG
AATGCACACAGGAAGAAGTAGAAATGATGAAGTGGCAACAGATTTAAGAATGGCATTAAGGGATAAAATACTAACAATAT
TAAAATTATTAATAAATATGCAAAAAAATATATTAAATCTTGCAAAAGAGCATAAAGAAACACTAACTATTGGATATACT
CATTTACAACATGCTCAACCAATAACATTTGGACATCATCTTTTAAGTTATGCTTCTCCGATGGAGCGGGATATATTGAG
ATTAATAGACACCTATAAGCGAGTAAATATCTGTCCTCTTGGAAGTGGGGCATTTGCTACAACTGGATTTAATATTAATA
GAAATGCCACAAAAGAATTATTGGGCTTTGATAGTGTTATTGAGAATTCTATGGACGGAGTGGCATCAAGGGATTTTATA
TTGGAAACTATGGCAAATTTATCAATATTGGGAACAAATCTCTCAAAAATTTGTGAGGAAATGGTGCTTTTCTCCTCCTG
TGAATTTGGGACTATTGATTTGGCTAATGAATATACTTCAACATCATCAATAATGCCACAGAAAAAGAATCCTGATGTTG
CAGAAATTGCAAGGGCAAAATTATCTACATTAAATGGAAACCTTGTAACTGTGCTTACAATATTAAAGGCACTTCCAAAT
ACATATAACCGGGATTTACAGGAAATAAGTCCCCATTTGTGGGATAGTGTATATACCACAATTGACACTCTAAAAATAAT
AGATGGAATGATTTCAACAATAAAAGTAAATGCCGATAGAATGAAGGAATTAACGGAGAAAAATTATTCCACAGCAACAG
AATTGGCTGATACACTTGTGAGGGAATGCAATATTCCATTTAGGACGGCACATGGTATTGTGGGGGAAGTTGTAAGGCTA
TCAATTGAAAATAATAAAAATATGAATGAAGTAATTAGGGATGTTTTGGATAAATTTAATTTGAAACTTGATGATTCAAA
AATAGAAAAAGCATTAAATCCTATGGAAAATGTAAAAATGAGAAAAGTTATTGGGGGTCCAGCTCCTGAGGAAGTAGAAA
GAGCCATAAATTCATATTATAGTAGAATAGAAAATTACGAAAAAGAAGTAAATGATAAAATTGAAAAGATTGAAATTATT
AAAAATAATTTATTGAATTTATAA

Upstream 100 bases:

>100_bases
AATTATTATTATAATATTATATATTTGTTAATTATATATGTATGTTATATTATGTATTTATGTTATTTTATATTATTATA
ATAATTTAGGTGAATGAATT

Downstream 100 bases:

>100_bases
ATATTTATAAATTATTTTTTATTATCTGTTTTATAGTATGCCATACCACAAGGAGCTCCGAACATACATAATAATTATAA
ATTATTATTTTTTGAATTAA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MQKNNENILRRGRLGSSTKKEVMNYMTSLSFDKEIFESDIFCDIAHTKMLMEQNIILEEDGIKIINELKKIYNNGMDCLN
LDPSLDDIHMVIESELIKNLGEDVAGRMHTGRSRNDEVATDLRMALRDKILTILKLLINMQKNILNLAKEHKETLTIGYT
HLQHAQPITFGHHLLSYASPMERDILRLIDTYKRVNICPLGSGAFATTGFNINRNATKELLGFDSVIENSMDGVASRDFI
LETMANLSILGTNLSKICEEMVLFSSCEFGTIDLANEYTSTSSIMPQKKNPDVAEIARAKLSTLNGNLVTVLTILKALPN
TYNRDLQEISPHLWDSVYTTIDTLKIIDGMISTIKVNADRMKELTEKNYSTATELADTLVRECNIPFRTAHGIVGEVVRL
SIENNKNMNEVIRDVLDKFNLKLDDSKIEKALNPMENVKMRKVIGGPAPEEVERAINSYYSRIENYEKEVNDKIEKIEII
KNNLLNL

Sequences:

>Translated_487_residues
MQKNNENILRRGRLGSSTKKEVMNYMTSLSFDKEIFESDIFCDIAHTKMLMEQNIILEEDGIKIINELKKIYNNGMDCLN
LDPSLDDIHMVIESELIKNLGEDVAGRMHTGRSRNDEVATDLRMALRDKILTILKLLINMQKNILNLAKEHKETLTIGYT
HLQHAQPITFGHHLLSYASPMERDILRLIDTYKRVNICPLGSGAFATTGFNINRNATKELLGFDSVIENSMDGVASRDFI
LETMANLSILGTNLSKICEEMVLFSSCEFGTIDLANEYTSTSSIMPQKKNPDVAEIARAKLSTLNGNLVTVLTILKALPN
TYNRDLQEISPHLWDSVYTTIDTLKIIDGMISTIKVNADRMKELTEKNYSTATELADTLVRECNIPFRTAHGIVGEVVRL
SIENNKNMNEVIRDVLDKFNLKLDDSKIEKALNPMENVKMRKVIGGPAPEEVERAINSYYSRIENYEKEVNDKIEKIEII
KNNLLNL
>Mature_487_residues
MQKNNENILRRGRLGSSTKKEVMNYMTSLSFDKEIFESDIFCDIAHTKMLMEQNIILEEDGIKIINELKKIYNNGMDCLN
LDPSLDDIHMVIESELIKNLGEDVAGRMHTGRSRNDEVATDLRMALRDKILTILKLLINMQKNILNLAKEHKETLTIGYT
HLQHAQPITFGHHLLSYASPMERDILRLIDTYKRVNICPLGSGAFATTGFNINRNATKELLGFDSVIENSMDGVASRDFI
LETMANLSILGTNLSKICEEMVLFSSCEFGTIDLANEYTSTSSIMPQKKNPDVAEIARAKLSTLNGNLVTVLTILKALPN
TYNRDLQEISPHLWDSVYTTIDTLKIIDGMISTIKVNADRMKELTEKNYSTATELADTLVRECNIPFRTAHGIVGEVVRL
SIENNKNMNEVIRDVLDKFNLKLDDSKIEKALNPMENVKMRKVIGGPAPEEVERAINSYYSRIENYEKEVNDKIEKIEII
KNNLLNL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=404, Percent_Identity=33.9108910891089, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI68303542, Length=404, Percent_Identity=33.9108910891089, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI68303547, Length=408, Percent_Identity=31.3725490196078, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI68303549, Length=404, Percent_Identity=30.9405940594059, Blast_Score=212, Evalue=8e-55,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=34.7921225382932, Blast_Score=293, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17553882, Length=211, Percent_Identity=28.9099526066351, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI32565146, Length=211, Percent_Identity=28.9099526066351, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321806, Length=472, Percent_Identity=34.1101694915254, Blast_Score=257, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6324993, Length=192, Percent_Identity=29.6875, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221473854, Length=445, Percent_Identity=33.2584269662921, Blast_Score=241, Evalue=8e-64,
Organism=Drosophila melanogaster, GI78706858, Length=445, Percent_Identity=33.2584269662921, Blast_Score=241, Evalue=8e-64,
Organism=Drosophila melanogaster, GI24662684, Length=212, Percent_Identity=27.8301886792453, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_META3 (A6UW73)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001325357.1
- ProteinModelPortal:   A6UW73
- SMR:   A6UW73
- STRING:   A6UW73
- GeneID:   5327710
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_1168
- eggNOG:   arNOG04975
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BioCyc:   MAEO419665:MAEO_1168-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 55209; Mature: 55209

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKNNENILRRGRLGSSTKKEVMNYMTSLSFDKEIFESDIFCDIAHTKMLMEQNIILEED
CCCCCHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
GIKIINELKKIYNNGMDCLNLDPSLDDIHMVIESELIKNLGEDVAGRMHTGRSRNDEVAT
CHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
DLRMALRDKILTILKLLINMQKNILNLAKEHKETLTIGYTHLQHAQPITFGHHLLSYASP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHCCCCCHHHHHHHHHCCH
MERDILRLIDTYKRVNICPLGSGAFATTGFNINRNATKELLGFDSVIENSMDGVASRDFI
HHHHHHHHHHHHHHCEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
LETMANLSILGTNLSKICEEMVLFSSCEFGTIDLANEYTSTSSIMPQKKNPDVAEIARAK
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEECCHHHCCHHHCCCCCCCCCHHHHHHHH
LSTLNGNLVTVLTILKALPNTYNRDLQEISPHLWDSVYTTIDTLKIIDGMISTIKVNADR
HHHCCCCHHHHHHHHHHCCCHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
MKELTEKNYSTATELADTLVRECNIPFRTAHGIVGEVVRLSIENNKNMNEVIRDVLDKFN
HHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCC
LKLDDSKIEKALNPMENVKMRKVIGGPAPEEVERAINSYYSRIENYEKEVNDKIEKIEII
CCCCHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNNLLNL
HHHHCCC
>Mature Secondary Structure
MQKNNENILRRGRLGSSTKKEVMNYMTSLSFDKEIFESDIFCDIAHTKMLMEQNIILEED
CCCCCHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
GIKIINELKKIYNNGMDCLNLDPSLDDIHMVIESELIKNLGEDVAGRMHTGRSRNDEVAT
CHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
DLRMALRDKILTILKLLINMQKNILNLAKEHKETLTIGYTHLQHAQPITFGHHLLSYASP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHCCCCCHHHHHHHHHCCH
MERDILRLIDTYKRVNICPLGSGAFATTGFNINRNATKELLGFDSVIENSMDGVASRDFI
HHHHHHHHHHHHHHCEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
LETMANLSILGTNLSKICEEMVLFSSCEFGTIDLANEYTSTSSIMPQKKNPDVAEIARAK
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEECCHHHCCHHHCCCCCCCCCHHHHHHHH
LSTLNGNLVTVLTILKALPNTYNRDLQEISPHLWDSVYTTIDTLKIIDGMISTIKVNADR
HHHCCCCHHHHHHHHHHCCCHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
MKELTEKNYSTATELADTLVRECNIPFRTAHGIVGEVVRLSIENNKNMNEVIRDVLDKFN
HHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCC
LKLDDSKIEKALNPMENVKMRKVIGGPAPEEVERAINSYYSRIENYEKEVNDKIEKIEII
CCCCHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNNLLNL
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA