| Definition | Parabacteroides distasonis ATCC 8503 chromosome, complete genome. |
|---|---|
| Accession | NC_009615 |
| Length | 4,811,379 |
Click here to switch to the map view.
The map label for this gene is lepA
Identifier: 150008111
GI number: 150008111
Start: 1720323
End: 1722110
Strand: Reverse
Name: lepA
Synonym: BDI_1475
Alternate gene names: 150008111
Gene position: 1722110-1720323 (Counterclockwise)
Preceding gene: 150008114
Following gene: 150008109
Centisome position: 35.79
GC content: 48.71
Gene sequence:
>1788_bases ATGAAGAATATCCGCAATTTCTGTATTATTGCTCATATTGACCATGGGAAAAGTACCTTGGCAGACCGTTTGCTTGAGTA TACCAAGACAGTAGAAGGTAAAGACATGCAAGCTCAAGTCCTTGACGACATGGATTTAGAGCGTGAGCGTGGTATTACGA TCAAGAGCCATGCGATCCAGATGAAGTATAATTATAAGGGTGAAGAATATATACTGAACCTGATCGATACTCCGGGGCAC GTGGACTTCTCGTATGAGGTTTCCCGCTCTATCGCCGCCTGCGAGGGTGCGTTGCTGATCGTGGACGCGGCCCAAGGTAT TCAGGCGCAAACCATCTCTAACCTGTATATGGCGATAGAGAATGACTTAGAGATTATTCCGGTGATGAACAAGATTGACT TGCCTAGCGCCATGCCGGAGGAGGTAGAGGACCAGATCGTGGAACTGTTGGGCTGCCCTCGTGAGGATATCTTACGGGCG AGCGGAAAGACAGGCGAGGGAGTGACCGAGATCTTGAATACGATCGTGGAGAAGGTCCCGGCCCCGAAAGGTGATCCGGA GGCCCCGTTGCAGTGTTTGATTTTTGACTCCGTCTTTAATCCGTTCCGTGGTATTATCGCTTACTTCAAGGTGGTAAACG GCGTGATCCGTAAAGGTGACCATGTGAAGTTTATCGCTACAGGAAAAGAGTATGACGCCGACGAGGTAGGTATATTGAAA TTAGATATGTGCCCCCGTGAGGAGATCCGGACGGGAGACGTAGGATATATCATTTCCGGTATCAAGACGTCCCGGGAGGT GCGTGTCGGTGATACGATCACTCATGTGTCTCGCCCGGCTAAAGACGCGATCGCCGGTTTTGAGGAGGTGAAGCCGATGG TCTTCGCCGGTGTCTATCCAATCGATAGCGAGGATTTCGAGAACCTTCGTGCGTCATTGGAGAAATTACAGTTGAACGAC GCTTCCTTGACTTTCCAGCCGGAGAGTTCCGCCGCGCTGGGTTTTGGGTTCCGTTGCGGTTTCTTGGGCTTGTTGCATAT GGAGATTGTTCAGGAGCGTTTGGATCGTGAGTTCAATATGGATGTGATAACCACTGTACCGAACGTTTCTTATATCGTGC ATACAAAGAAAGGGGAGGAGATCGAGGTACATAATCCGGGAGGCTTGCCGGACCCGACCTTGATTGATCATATCGACGAG CCGTTTATCCGTGCTTCCGTGATCACGAACACTACCTATATCGGCCCGATCATGACACTCTGTCTGGGTAAGCGTGGCGT CCTGCTTAAGCAAGAATATATTTCAGGTGATCGTGTCGAGATTCATTATGACTTGCCGTTGGGCGAGATCGTAATCGACT TTTATGATAAGTTGAAGAGTATTTCAAAAGGGTACGCTTCTTTCGATTACCATTTACATGATTTCCGTCCCAGTAAGTTG GCTAAATTAGATATCCTGTTGAACGGTGAGCCGGTAGACGCTTTGTCTACATTGACGCACGTGGATAATAGCGTTACTTT CGGACGTCGTATGTGCGAGAAACTGAAAGAGTTGATCCCCCGCCAGCAATTCGATATCGCTATCCAAGCGGCGATAGGCG CTAAGATTATCGCTCGTGAGACAATTAAGGCTGTCCGTAAAGACGTGACGGCGAAATGTTATGGAGGCGATATCTCCCGT AAGCGTAAATTGCTGGAAAAACAGAAAGAGGGAAAGAAACGAATGAAGCAGATCGGTACGGTAGAAGTTCCGCAAAAAGC GTTCTTGGCCGTATTGAAGCTGGATTAG
Upstream 100 bases:
>100_bases TCTTGTATTGTCATATACTATTAACAACAAATGGTATGCCAAAAGTATAGTATTTAGGCTAAATTTCCTATCTTCGCGTA CCTAAAAATAAATTTGGCAG
Downstream 100 bases:
>100_bases AAAGTCAATGGAATCCGTTCGCTAACTCAATGGATTTATAAAGAAAAGTCAATGGATTCTGTAACGGATTCCATTGACTT TTTTTATATAAATGGGTCAC
Product: GTP-binding protein LepA
Products: NA
Alternate protein names: EF-4; Ribosomal back-translocase LepA
Number of amino acids: Translated: 595; Mature: 595
Protein sequence:
>595_residues MKNIRNFCIIAHIDHGKSTLADRLLEYTKTVEGKDMQAQVLDDMDLERERGITIKSHAIQMKYNYKGEEYILNLIDTPGH VDFSYEVSRSIAACEGALLIVDAAQGIQAQTISNLYMAIENDLEIIPVMNKIDLPSAMPEEVEDQIVELLGCPREDILRA SGKTGEGVTEILNTIVEKVPAPKGDPEAPLQCLIFDSVFNPFRGIIAYFKVVNGVIRKGDHVKFIATGKEYDADEVGILK LDMCPREEIRTGDVGYIISGIKTSREVRVGDTITHVSRPAKDAIAGFEEVKPMVFAGVYPIDSEDFENLRASLEKLQLND ASLTFQPESSAALGFGFRCGFLGLLHMEIVQERLDREFNMDVITTVPNVSYIVHTKKGEEIEVHNPGGLPDPTLIDHIDE PFIRASVITNTTYIGPIMTLCLGKRGVLLKQEYISGDRVEIHYDLPLGEIVIDFYDKLKSISKGYASFDYHLHDFRPSKL AKLDILLNGEPVDALSTLTHVDNSVTFGRRMCEKLKELIPRQQFDIAIQAAIGAKIIARETIKAVRKDVTAKCYGGDISR KRKLLEKQKEGKKRMKQIGTVEVPQKAFLAVLKLD
Sequences:
>Translated_595_residues MKNIRNFCIIAHIDHGKSTLADRLLEYTKTVEGKDMQAQVLDDMDLERERGITIKSHAIQMKYNYKGEEYILNLIDTPGH VDFSYEVSRSIAACEGALLIVDAAQGIQAQTISNLYMAIENDLEIIPVMNKIDLPSAMPEEVEDQIVELLGCPREDILRA SGKTGEGVTEILNTIVEKVPAPKGDPEAPLQCLIFDSVFNPFRGIIAYFKVVNGVIRKGDHVKFIATGKEYDADEVGILK LDMCPREEIRTGDVGYIISGIKTSREVRVGDTITHVSRPAKDAIAGFEEVKPMVFAGVYPIDSEDFENLRASLEKLQLND ASLTFQPESSAALGFGFRCGFLGLLHMEIVQERLDREFNMDVITTVPNVSYIVHTKKGEEIEVHNPGGLPDPTLIDHIDE PFIRASVITNTTYIGPIMTLCLGKRGVLLKQEYISGDRVEIHYDLPLGEIVIDFYDKLKSISKGYASFDYHLHDFRPSKL AKLDILLNGEPVDALSTLTHVDNSVTFGRRMCEKLKELIPRQQFDIAIQAAIGAKIIARETIKAVRKDVTAKCYGGDISR KRKLLEKQKEGKKRMKQIGTVEVPQKAFLAVLKLD >Mature_595_residues MKNIRNFCIIAHIDHGKSTLADRLLEYTKTVEGKDMQAQVLDDMDLERERGITIKSHAIQMKYNYKGEEYILNLIDTPGH VDFSYEVSRSIAACEGALLIVDAAQGIQAQTISNLYMAIENDLEIIPVMNKIDLPSAMPEEVEDQIVELLGCPREDILRA SGKTGEGVTEILNTIVEKVPAPKGDPEAPLQCLIFDSVFNPFRGIIAYFKVVNGVIRKGDHVKFIATGKEYDADEVGILK LDMCPREEIRTGDVGYIISGIKTSREVRVGDTITHVSRPAKDAIAGFEEVKPMVFAGVYPIDSEDFENLRASLEKLQLND ASLTFQPESSAALGFGFRCGFLGLLHMEIVQERLDREFNMDVITTVPNVSYIVHTKKGEEIEVHNPGGLPDPTLIDHIDE PFIRASVITNTTYIGPIMTLCLGKRGVLLKQEYISGDRVEIHYDLPLGEIVIDFYDKLKSISKGYASFDYHLHDFRPSKL AKLDILLNGEPVDALSTLTHVDNSVTFGRRMCEKLKELIPRQQFDIAIQAAIGAKIIARETIKAVRKDVTAKCYGGDISR KRKLLEKQKEGKKRMKQIGTVEVPQKAFLAVLKLD
Specific function: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- transloc
COG id: COG0481
COG function: function code M; Membrane GTPase LepA
Gene ontology:
Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily
Homologues:
Organism=Homo sapiens, GI157426893, Length=601, Percent_Identity=49.7504159733777, Blast_Score=627, Evalue=1e-180, Organism=Homo sapiens, GI94966754, Length=132, Percent_Identity=44.6969696969697, Blast_Score=122, Evalue=1e-27, Organism=Homo sapiens, GI18390331, Length=149, Percent_Identity=39.5973154362416, Blast_Score=106, Evalue=8e-23, Organism=Homo sapiens, GI310132016, Length=109, Percent_Identity=44.0366972477064, Blast_Score=104, Evalue=2e-22, Organism=Homo sapiens, GI310110807, Length=109, Percent_Identity=44.0366972477064, Blast_Score=104, Evalue=2e-22, Organism=Homo sapiens, GI310123363, Length=109, Percent_Identity=44.0366972477064, Blast_Score=104, Evalue=2e-22, Organism=Homo sapiens, GI25306287, Length=133, Percent_Identity=44.3609022556391, Blast_Score=102, Evalue=1e-21, Organism=Homo sapiens, GI19923640, Length=133, Percent_Identity=44.3609022556391, Blast_Score=102, Evalue=1e-21, Organism=Homo sapiens, GI25306283, Length=133, Percent_Identity=44.3609022556391, Blast_Score=101, Evalue=2e-21, Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=39.5833333333333, Blast_Score=101, Evalue=2e-21, Organism=Homo sapiens, GI217272894, Length=133, Percent_Identity=36.0902255639098, Blast_Score=85, Evalue=2e-16, Organism=Homo sapiens, GI217272892, Length=133, Percent_Identity=36.0902255639098, Blast_Score=85, Evalue=2e-16, Organism=Homo sapiens, GI34147630, Length=278, Percent_Identity=28.0575539568345, Blast_Score=76, Evalue=1e-13, Organism=Homo sapiens, GI94966752, Length=93, Percent_Identity=38.7096774193548, Blast_Score=74, Evalue=3e-13, Organism=Homo sapiens, GI53729339, Length=219, Percent_Identity=25.5707762557078, Blast_Score=67, Evalue=7e-11, Organism=Homo sapiens, GI53729337, Length=219, Percent_Identity=25.5707762557078, Blast_Score=67, Evalue=7e-11, Organism=Escherichia coli, GI1788922, Length=595, Percent_Identity=55.7983193277311, Blast_Score=661, Evalue=0.0, Organism=Escherichia coli, GI48994988, Length=517, Percent_Identity=28.8201160541586, Blast_Score=154, Evalue=2e-38, Organism=Escherichia coli, GI1789738, Length=155, Percent_Identity=39.3548387096774, Blast_Score=92, Evalue=1e-19, Organism=Escherichia coli, GI1790835, Length=175, Percent_Identity=32, Blast_Score=91, Evalue=1e-19, Organism=Escherichia coli, GI1789559, Length=232, Percent_Identity=27.5862068965517, Blast_Score=73, Evalue=6e-14, Organism=Escherichia coli, GI1790412, Length=274, Percent_Identity=26.6423357664234, Blast_Score=66, Evalue=8e-12, Organism=Escherichia coli, GI1789737, Length=274, Percent_Identity=26.6423357664234, Blast_Score=65, Evalue=9e-12, Organism=Caenorhabditis elegans, GI17557151, Length=610, Percent_Identity=41.4754098360656, Blast_Score=479, Evalue=1e-135, Organism=Caenorhabditis elegans, GI17533571, Length=145, Percent_Identity=39.3103448275862, Blast_Score=102, Evalue=7e-22, Organism=Caenorhabditis elegans, GI17506493, Length=157, Percent_Identity=38.2165605095541, Blast_Score=100, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17556745, Length=151, Percent_Identity=37.0860927152318, Blast_Score=99, Evalue=8e-21, Organism=Caenorhabditis elegans, GI71988811, Length=133, Percent_Identity=39.0977443609023, Blast_Score=98, Evalue=1e-20, Organism=Caenorhabditis elegans, GI71988819, Length=133, Percent_Identity=39.0977443609023, Blast_Score=98, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17552882, Length=133, Percent_Identity=35.3383458646617, Blast_Score=89, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17556456, Length=248, Percent_Identity=29.0322580645161, Blast_Score=70, Evalue=2e-12, Organism=Saccharomyces cerevisiae, GI6323320, Length=602, Percent_Identity=44.1860465116279, Blast_Score=517, Evalue=1e-147, Organism=Saccharomyces cerevisiae, GI6323098, Length=199, Percent_Identity=36.1809045226131, Blast_Score=119, Evalue=1e-27, Organism=Saccharomyces cerevisiae, GI6324707, Length=225, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=8e-26, Organism=Saccharomyces cerevisiae, GI6320593, Length=225, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=8e-26, Organism=Saccharomyces cerevisiae, GI6322359, Length=114, Percent_Identity=41.2280701754386, Blast_Score=94, Evalue=5e-20, Organism=Saccharomyces cerevisiae, GI6324166, Length=141, Percent_Identity=40.4255319148936, Blast_Score=90, Evalue=1e-18, Organism=Saccharomyces cerevisiae, GI6324761, Length=245, Percent_Identity=26.1224489795918, Blast_Score=71, Evalue=4e-13, Organism=Drosophila melanogaster, GI78706572, Length=601, Percent_Identity=44.7587354409318, Blast_Score=555, Evalue=1e-158, Organism=Drosophila melanogaster, GI24582462, Length=152, Percent_Identity=38.8157894736842, Blast_Score=105, Evalue=8e-23, Organism=Drosophila melanogaster, GI28574573, Length=138, Percent_Identity=42.0289855072464, Blast_Score=104, Evalue=2e-22, Organism=Drosophila melanogaster, GI24585709, Length=149, Percent_Identity=39.5973154362416, Blast_Score=103, Evalue=3e-22, Organism=Drosophila melanogaster, GI24585711, Length=149, Percent_Identity=39.5973154362416, Blast_Score=103, Evalue=4e-22, Organism=Drosophila melanogaster, GI24585713, Length=149, Percent_Identity=39.5973154362416, Blast_Score=103, Evalue=4e-22, Organism=Drosophila melanogaster, GI221458488, Length=137, Percent_Identity=39.4160583941606, Blast_Score=90, Evalue=5e-18, Organism=Drosophila melanogaster, GI21357743, Length=135, Percent_Identity=35.5555555555556, Blast_Score=85, Evalue=1e-16, Organism=Drosophila melanogaster, GI281363316, Length=281, Percent_Identity=27.0462633451957, Blast_Score=78, Evalue=2e-14, Organism=Drosophila melanogaster, GI17864358, Length=281, Percent_Identity=27.0462633451957, Blast_Score=78, Evalue=2e-14, Organism=Drosophila melanogaster, GI28572034, Length=221, Percent_Identity=28.9592760180996, Blast_Score=70, Evalue=4e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): LEPA_PARD8 (A6LC18)
Other databases:
- EMBL: CP000140 - RefSeq: YP_001302854.1 - ProteinModelPortal: A6LC18 - SMR: A6LC18 - STRING: A6LC18 - GeneID: 5306628 - GenomeReviews: CP000140_GR - KEGG: pdi:BDI_1475 - eggNOG: COG0481 - HOGENOM: HBG286375 - OMA: YDSYRGV - ProtClustDB: PRK05433 - BioCyc: PDIS435591:BDI_1475-MONOMER - GO: GO:0006412 - HAMAP: MF_00071 - InterPro: IPR009022 - InterPro: IPR006297 - InterPro: IPR013842 - InterPro: IPR000795 - InterPro: IPR005225 - InterPro: IPR000640 - InterPro: IPR004161 - InterPro: IPR009000 - Gene3D: G3DSA:3.30.70.240 - PRINTS: PR00315 - SMART: SM00838 - TIGRFAMs: TIGR01393 - TIGRFAMs: TIGR00231
Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF06421 LepA_C; SSF54980 EFG_III_V; SSF50447 Translat_factor
EC number: NA
Molecular weight: Translated: 66453; Mature: 66453
Theoretical pI: Translated: 5.45; Mature: 5.45
Prosite motif: PS00301 EFACTOR_GTP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.9 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKNIRNFCIIAHIDHGKSTLADRLLEYTKTVEGKDMQAQVLDDMDLERERGITIKSHAIQ CCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHCCCEEEEEEEE MKYNYKGEEYILNLIDTPGHVDFSYEVSRSIAACEGALLIVDAAQGIQAQTISNLYMAIE EEECCCCHHEEEEEECCCCCCEEEHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCC NDLEIIPVMNKIDLPSAMPEEVEDQIVELLGCPREDILRASGKTGEGVTEILNTIVEKVP CCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHCC APKGDPEAPLQCLIFDSVFNPFRGIIAYFKVVNGVIRKGDHVKFIATGKEYDADEVGILK CCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEE LDMCPREEIRTGDVGYIISGIKTSREVRVGDTITHVSRPAKDAIAGFEEVKPMVFAGVYP ECCCCHHHCCCCCHHHEEECCCCCCEEECCCHHHHHCCCHHHHHCCHHHCCCEEEEEECC IDSEDFENLRASLEKLQLNDASLTFQPESSAALGFGFRCGFLGLLHMEIVQERLDREFNM CCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC DVITTVPNVSYIVHTKKGEEIEVHNPGGLPDPTLIDHIDEPFIRASVITNTTYIGPIMTL EEEEECCCCEEEEEECCCCEEEEECCCCCCCCHHHHHCCCCHHHHHHHCCCHHHHHHHHH CLGKRGVLLKQEYISGDRVEIHYDLPLGEIVIDFYDKLKSISKGYASFDYHLHDFRPSKL HHCCCCCEEEHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEECCEEECCCCCCE AKLDILLNGEPVDALSTLTHVDNSVTFGRRMCEKLKELIPRQQFDIAIQAAIGAKIIARE EEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHCEEEEHHHCHHHHHHH TIKAVRKDVTAKCYGGDISRKRKLLEKQKEGKKRMKQIGTVEVPQKAFLAVLKLD HHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEECC >Mature Secondary Structure MKNIRNFCIIAHIDHGKSTLADRLLEYTKTVEGKDMQAQVLDDMDLERERGITIKSHAIQ CCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHCCCEEEEEEEE MKYNYKGEEYILNLIDTPGHVDFSYEVSRSIAACEGALLIVDAAQGIQAQTISNLYMAIE EEECCCCHHEEEEEECCCCCCEEEHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCC NDLEIIPVMNKIDLPSAMPEEVEDQIVELLGCPREDILRASGKTGEGVTEILNTIVEKVP CCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHCC APKGDPEAPLQCLIFDSVFNPFRGIIAYFKVVNGVIRKGDHVKFIATGKEYDADEVGILK CCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEE LDMCPREEIRTGDVGYIISGIKTSREVRVGDTITHVSRPAKDAIAGFEEVKPMVFAGVYP ECCCCHHHCCCCCHHHEEECCCCCCEEECCCHHHHHCCCHHHHHCCHHHCCCEEEEEECC IDSEDFENLRASLEKLQLNDASLTFQPESSAALGFGFRCGFLGLLHMEIVQERLDREFNM CCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC DVITTVPNVSYIVHTKKGEEIEVHNPGGLPDPTLIDHIDEPFIRASVITNTTYIGPIMTL EEEEECCCCEEEEEECCCCEEEEECCCCCCCCHHHHHCCCCHHHHHHHCCCHHHHHHHHH CLGKRGVLLKQEYISGDRVEIHYDLPLGEIVIDFYDKLKSISKGYASFDYHLHDFRPSKL HHCCCCCEEEHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEECCEEECCCCCCE AKLDILLNGEPVDALSTLTHVDNSVTFGRRMCEKLKELIPRQQFDIAIQAAIGAKIIARE EEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHCEEEEHHHCHHHHHHH TIKAVRKDVTAKCYGGDISRKRKLLEKQKEGKKRMKQIGTVEVPQKAFLAVLKLD HHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA