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The map label for this gene is prs [H]

Identifier: 150006047

GI number: 150006047

Start: 4403891

End: 4404829

Strand: Direct

Name: prs [H]

Synonym: BVU_3551

Alternate gene names: 150006047

Gene position: 4403891-4404829 (Clockwise)

Preceding gene: 150006046

Following gene: 150006053

Centisome position: 85.29

GC content: 43.13

Gene sequence:

>939_bases
ATGAGCAAAACATCACCTTTTAGGGTATTCTCAGGAACAAATTCGAGATACCTTGCAGAAAAGATTTGCAACAGCCTCGG
TTGCAAATTAGGAAACATGAACATCATGCATTTTGCTGATGGTGAGTTCGCTGTTTCTTATGAAGAATCAATTAGAGGCG
CACATGTTTTTCTAGTTCAATCTACCTTTCCTAACTCTGACAACTTAATGGAACTGCTGCTAATGATTGATGCAGCTAAA
AGAGCCTCTGCAAAAAGCATTGTAGCCGTTATTCCCTACTTTGGATGGGCACGTCAGGACAGAAAAGACAAACCTCGTGT
TTCTATCGGTGCTAAACTGGTAGCCGATCTTCTGAGCGTAGCAGGCATCGACCGTTTAATCACAATGGATTTGCATGCCG
ATCAGATTCAAGGATTCTTTGATGTACCGGTAGACCACCTCTACGCTTCTGGCGTATTCCTGCCTTACATTGAATCATTG
CAACTGGAAGACTTGGTAATCGCAACTCCGGACGTGGGTGGTTCAAAACGCGCCAGCACTTATTCCAAATATTTGGGTGT
ACCCTTGGTACTCTGCAACAAGACGCGCCTGAAAGCCAATGAAGTGGCCACCATGCAAATTATCGGTGATGTAAAAAATA
AAAATGTCATCTTAATTGACGATATGGTAGATACAGCAGGTACTATTACCAAAGCTGCCGATATTATGAAAGAAGCGGGA
GCTATTTCCGTCCGCGCTATCGCTTCTCACTGTGTAATGTCAGGTCCTGCATCCGAACGCGTTCAGAACTCCGGCTTGGA
AGAAATGGTATTTACCGATAGTATTCCTTATGCTAACCGTTGCTCTAAAGTGAAGCAACTGACCATTGCTGATATGTTTG
CTGAAACAATCCGCCGCGTGATGAATAATGAGTCTATCTCTTCACAATACATCATTTAA

Upstream 100 bases:

>100_bases
ACAATAATGAGAAGTTATTTTTAAATTTCTATTTTTAATTTCTAATTATAATACGTACCTTTGCACGCAAATTAACAAAT
AGGTAATATCTATTACAAAA

Downstream 100 bases:

>100_bases
TCTTTATATGATTATAGAAATAAAAGTCCGGACTTTCCCAAGTTCGGACTTTTATTTTAGGGATATTCAGTAAATGTCTC
TAAAAAATAAGATGGCATAT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSKTSPFRVFSGTNSRYLAEKICNSLGCKLGNMNIMHFADGEFAVSYEESIRGAHVFLVQSTFPNSDNLMELLLMIDAAK
RASAKSIVAVIPYFGWARQDRKDKPRVSIGAKLVADLLSVAGIDRLITMDLHADQIQGFFDVPVDHLYASGVFLPYIESL
QLEDLVIATPDVGGSKRASTYSKYLGVPLVLCNKTRLKANEVATMQIIGDVKNKNVILIDDMVDTAGTITKAADIMKEAG
AISVRAIASHCVMSGPASERVQNSGLEEMVFTDSIPYANRCSKVKQLTIADMFAETIRRVMNNESISSQYII

Sequences:

>Translated_312_residues
MSKTSPFRVFSGTNSRYLAEKICNSLGCKLGNMNIMHFADGEFAVSYEESIRGAHVFLVQSTFPNSDNLMELLLMIDAAK
RASAKSIVAVIPYFGWARQDRKDKPRVSIGAKLVADLLSVAGIDRLITMDLHADQIQGFFDVPVDHLYASGVFLPYIESL
QLEDLVIATPDVGGSKRASTYSKYLGVPLVLCNKTRLKANEVATMQIIGDVKNKNVILIDDMVDTAGTITKAADIMKEAG
AISVRAIASHCVMSGPASERVQNSGLEEMVFTDSIPYANRCSKVKQLTIADMFAETIRRVMNNESISSQYII
>Mature_311_residues
SKTSPFRVFSGTNSRYLAEKICNSLGCKLGNMNIMHFADGEFAVSYEESIRGAHVFLVQSTFPNSDNLMELLLMIDAAKR
ASAKSIVAVIPYFGWARQDRKDKPRVSIGAKLVADLLSVAGIDRLITMDLHADQIQGFFDVPVDHLYASGVFLPYIESLQ
LEDLVIATPDVGGSKRASTYSKYLGVPLVLCNKTRLKANEVATMQIIGDVKNKNVILIDDMVDTAGTITKAADIMKEAGA
ISVRAIASHCVMSGPASERVQNSGLEEMVFTDSIPYANRCSKVKQLTIADMFAETIRRVMNNESISSQYII

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=307, Percent_Identity=48.2084690553746, Blast_Score=281, Evalue=7e-76,
Organism=Homo sapiens, GI4506129, Length=305, Percent_Identity=46.8852459016393, Blast_Score=278, Evalue=4e-75,
Organism=Homo sapiens, GI84875539, Length=308, Percent_Identity=46.4285714285714, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI28557709, Length=307, Percent_Identity=46.2540716612378, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI194018537, Length=341, Percent_Identity=34.0175953079179, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI4506133, Length=338, Percent_Identity=32.2485207100592, Blast_Score=167, Evalue=8e-42,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=32.8571428571429, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=32.8571428571429, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=32.8571428571429, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=32.8571428571429, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1787458, Length=310, Percent_Identity=45.8064516129032, Blast_Score=282, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI25149168, Length=307, Percent_Identity=47.2312703583062, Blast_Score=265, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17554702, Length=307, Percent_Identity=47.2312703583062, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI71989924, Length=307, Percent_Identity=47.2312703583062, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17554704, Length=305, Percent_Identity=47.5409836065574, Blast_Score=264, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17570245, Length=335, Percent_Identity=31.044776119403, Blast_Score=168, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6321776, Length=310, Percent_Identity=45.1612903225806, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319403, Length=306, Percent_Identity=43.4640522875817, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6320946, Length=308, Percent_Identity=43.1818181818182, Blast_Score=249, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6322667, Length=198, Percent_Identity=33.8383838383838, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324511, Length=112, Percent_Identity=37.5, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21355239, Length=312, Percent_Identity=49.0384615384615, Blast_Score=287, Evalue=5e-78,
Organism=Drosophila melanogaster, GI45551540, Length=335, Percent_Identity=45.6716417910448, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=31.5492957746479, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=31.5492957746479, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=31.5492957746479, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=31.5492957746479, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI45552010, Length=374, Percent_Identity=31.0160427807487, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24651462, Length=374, Percent_Identity=31.0160427807487, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24651464, Length=374, Percent_Identity=31.0160427807487, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34189; Mature: 34058

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTSPFRVFSGTNSRYLAEKICNSLGCKLGNMNIMHFADGEFAVSYEESIRGAHVFLVQ
CCCCCCEEEECCCCCHHHHHHHHHHHCCEECCEEEEEEECCCEEEEHHHHCCCEEEEEEE
STFPNSDNLMELLLMIDAAKRASAKSIVAVIPYFGWARQDRKDKPRVSIGAKLVADLLSV
ECCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AGIDRLITMDLHADQIQGFFDVPVDHLYASGVFLPYIESLQLEDLVIATPDVGGSKRAST
HCCCCEEEEECCHHHHCCCCCCCHHHHHHCCCHHHHHHCCCCCCEEEECCCCCCCCHHHH
YSKYLGVPLVLCNKTRLKANEVATMQIIGDVKNKNVILIDDMVDTAGTITKAADIMKEAG
HHHHCCCEEEEECCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
AISVRAIASHCVMSGPASERVQNSGLEEMVFTDSIPYANRCSKVKQLTIADMFAETIRRV
CCHHHHHHHHHHCCCCHHHHHHHCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
MNNESISSQYII
HCCCCCCCCCCC
>Mature Secondary Structure 
SKTSPFRVFSGTNSRYLAEKICNSLGCKLGNMNIMHFADGEFAVSYEESIRGAHVFLVQ
CCCCCEEEECCCCCHHHHHHHHHHHCCEECCEEEEEEECCCEEEEHHHHCCCEEEEEEE
STFPNSDNLMELLLMIDAAKRASAKSIVAVIPYFGWARQDRKDKPRVSIGAKLVADLLSV
ECCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AGIDRLITMDLHADQIQGFFDVPVDHLYASGVFLPYIESLQLEDLVIATPDVGGSKRAST
HCCCCEEEEECCHHHHCCCCCCCHHHHHHCCCHHHHHHCCCCCCEEEECCCCCCCCHHHH
YSKYLGVPLVLCNKTRLKANEVATMQIIGDVKNKNVILIDDMVDTAGTITKAADIMKEAG
HHHHCCCEEEEECCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
AISVRAIASHCVMSGPASERVQNSGLEEMVFTDSIPYANRCSKVKQLTIADMFAETIRRV
CCHHHHHHHHHHCCCCHHHHHHHCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
MNNESISSQYII
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12949112 [H]