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The map label for this gene is bioF [H]

Identifier: 150005676

GI number: 150005676

Start: 3985915

End: 3987102

Strand: Direct

Name: bioF [H]

Synonym: BVU_3166

Alternate gene names: 150005676

Gene position: 3985915-3987102 (Clockwise)

Preceding gene: 150005674

Following gene: 150005677

Centisome position: 77.2

GC content: 42.93

Gene sequence:

>1188_bases
ATGGGATTATTACAAGACAAGTTAAGTAAATTCAGATTGCCTCAACTATACATGGAAAGAGGCGTTTACCCTTATTTTCG
TGAGATAGACAGCCATCAGGATACAGAGGTTATCATGGATGGTAAAAAGGTGCTGATGTTTGGCTCCAACTCATATATGG
GGTTAACCTACGATGAACGGATTATTGAAGCAGCTGTTGCTGCAACCCGTAAATATGGTACAGGTTGTGCAGGTTCACGC
TTCTTGAATGGTACGCTTGACCTGCACGTTCAGTTAGAAAAGGAATTGGCGGAATTCGTAGGGAAAGATGATGCATTGGT
TTATTCTACCGGTTTTACTGTAAATGAGGGTGTGGTATCTTGCCTGACAGACCGCAATGACTACATTATCTGTGATGACC
GTGACCATGCTTCCATCGTAGACGGACGTCGCCTTTCTTTCTCCACCCAGTTGAAATACAAGCACAATGATATGGAAGCC
CTTGAGAAAGAACTTCAGAAGTGTAAACCGGAATCTGTGAAACTGATTGTGGTGGACGGGGTTTTCTCTATGGAAGGTGA
TTTGGCTAACTTGCCTGAGATTGTTCGTTTGAAAGACAAATACAATGCAAGTATCATGGTGGATGAAGCACACGGCTTGG
GTGTGTTCGGTCGTGACGGGCGAGGTGTCTGTGATCACTTCGGACTGACAGATCAGGTAGATGTTATTATGGGTACATTC
TCAAAGTCACTGGCTTCTATCGGTGGTTTTGTTGCTGCGGATAAAGATACAATCAACTGGTTGCGTCACAACTCACGTTC
ATATATATTCTCTGCAAGTAATACTCCTGCTGCAACAGCTGCTGCACGTGCTGCACTTCATATCCTCAAGAGTGAGCCCG
AACGTCGTGAGAATTTGTGGAAGATTACAAATTATGCTTTGGATTGTTTCCGTCAGGCCGGTTTTGAAATCGGTGATACT
GAAAGTCCGATTATTCCACTTTATGTTCGTGATACGGATAAGACATTCGAAGTGACTAAACTGGCATTTGACGAGGGTAT
ATTTATTAATCCTGTTATTCCACCGGCTTGTGCACCACAAGATACTTTGGTGCGTGTTGCTTTGATGGCTACTCATACAA
AGGAACAAGTTGACTATGCTGTGGATAAACTGACTAAATGCTTTAAGAAGTTGGAAATCATAAAGTAA

Upstream 100 bases:

>100_bases
CAGCCTGTTTTGACGGGAACACCTTGAAAACAGAATGTATTAGTGAGTTTATATACATTATTTTAAAGTAGGCCGACGAG
GCTTACATATACAATAGGAT

Downstream 100 bases:

>100_bases
GATATCACAGGTTGCCTTTACAAAGGCAACCTGTTTTTTTATTATGTATTATTGTCTATCTTTGTATCCGCTTTACTTGA
AAAGGACATGAATCGGATAA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MGLLQDKLSKFRLPQLYMERGVYPYFREIDSHQDTEVIMDGKKVLMFGSNSYMGLTYDERIIEAAVAATRKYGTGCAGSR
FLNGTLDLHVQLEKELAEFVGKDDALVYSTGFTVNEGVVSCLTDRNDYIICDDRDHASIVDGRRLSFSTQLKYKHNDMEA
LEKELQKCKPESVKLIVVDGVFSMEGDLANLPEIVRLKDKYNASIMVDEAHGLGVFGRDGRGVCDHFGLTDQVDVIMGTF
SKSLASIGGFVAADKDTINWLRHNSRSYIFSASNTPAATAAARAALHILKSEPERRENLWKITNYALDCFRQAGFEIGDT
ESPIIPLYVRDTDKTFEVTKLAFDEGIFINPVIPPACAPQDTLVRVALMATHTKEQVDYAVDKLTKCFKKLEIIK

Sequences:

>Translated_395_residues
MGLLQDKLSKFRLPQLYMERGVYPYFREIDSHQDTEVIMDGKKVLMFGSNSYMGLTYDERIIEAAVAATRKYGTGCAGSR
FLNGTLDLHVQLEKELAEFVGKDDALVYSTGFTVNEGVVSCLTDRNDYIICDDRDHASIVDGRRLSFSTQLKYKHNDMEA
LEKELQKCKPESVKLIVVDGVFSMEGDLANLPEIVRLKDKYNASIMVDEAHGLGVFGRDGRGVCDHFGLTDQVDVIMGTF
SKSLASIGGFVAADKDTINWLRHNSRSYIFSASNTPAATAAARAALHILKSEPERRENLWKITNYALDCFRQAGFEIGDT
ESPIIPLYVRDTDKTFEVTKLAFDEGIFINPVIPPACAPQDTLVRVALMATHTKEQVDYAVDKLTKCFKKLEIIK
>Mature_394_residues
GLLQDKLSKFRLPQLYMERGVYPYFREIDSHQDTEVIMDGKKVLMFGSNSYMGLTYDERIIEAAVAATRKYGTGCAGSRF
LNGTLDLHVQLEKELAEFVGKDDALVYSTGFTVNEGVVSCLTDRNDYIICDDRDHASIVDGRRLSFSTQLKYKHNDMEAL
EKELQKCKPESVKLIVVDGVFSMEGDLANLPEIVRLKDKYNASIMVDEAHGLGVFGRDGRGVCDHFGLTDQVDVIMGTFS
KSLASIGGFVAADKDTINWLRHNSRSYIFSASNTPAATAAARAALHILKSEPERRENLWKITNYALDCFRQAGFEIGDTE
SPIIPLYVRDTDKTFEVTKLAFDEGIFINPVIPPACAPQDTLVRVALMATHTKEQVDYAVDKLTKCFKKLEIIK

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=392, Percent_Identity=31.6326530612245, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=32.4712643678161, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI4758668, Length=361, Percent_Identity=33.7950138504155, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI119220554, Length=364, Percent_Identity=34.0659340659341, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI83977442, Length=367, Percent_Identity=27.7929155313352, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI83977440, Length=367, Percent_Identity=27.7929155313352, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI83977444, Length=367, Percent_Identity=27.7929155313352, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI4502025, Length=371, Percent_Identity=29.6495956873315, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI40316939, Length=371, Percent_Identity=29.6495956873315, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI5454084, Length=269, Percent_Identity=36.0594795539033, Blast_Score=166, Evalue=5e-41,
Organism=Escherichia coli, GI1790046, Length=378, Percent_Identity=36.5079365079365, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI1786993, Length=350, Percent_Identity=31.4285714285714, Blast_Score=178, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71994529, Length=379, Percent_Identity=33.7730870712401, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI32566772, Length=362, Percent_Identity=31.4917127071823, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17560912, Length=355, Percent_Identity=33.2394366197183, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17560914, Length=355, Percent_Identity=33.2394366197183, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71982617, Length=383, Percent_Identity=31.331592689295, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71982625, Length=383, Percent_Identity=31.331592689295, Blast_Score=168, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6320267, Length=365, Percent_Identity=33.4246575342466, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320438, Length=425, Percent_Identity=28.4705882352941, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323954, Length=278, Percent_Identity=31.6546762589928, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24662918, Length=382, Percent_Identity=34.0314136125654, Blast_Score=234, Evalue=5e-62,
Organism=Drosophila melanogaster, GI17136286, Length=361, Percent_Identity=32.409972299169, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24653280, Length=324, Percent_Identity=33.3333333333333, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24653276, Length=324, Percent_Identity=33.3333333333333, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24653278, Length=324, Percent_Identity=33.3333333333333, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI17137420, Length=378, Percent_Identity=26.984126984127, Blast_Score=162, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 44189; Mature: 44058

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLQDKLSKFRLPQLYMERGVYPYFREIDSHQDTEVIMDGKKVLMFGSNSYMGLTYDER
CCCHHHHHHHCCCHHHHHHCCCCHHHHHHCCCCCCEEEECCCEEEEECCCCEEECCHHHH
IIEAAVAATRKYGTGCAGSRFLNGTLDLHVQLEKELAEFVGKDDALVYSTGFTVNEGVVS
HHHHHHHHHHHCCCCCCCCEEECCEEEEEEEEHHHHHHHHCCCCEEEEEECCEECCCHHH
CLTDRNDYIICDDRDHASIVDGRRLSFSTQLKYKHNDMEALEKELQKCKPESVKLIVVDG
HEECCCCEEEECCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEEEC
VFSMEGDLANLPEIVRLKDKYNASIMVDEAHGLGVFGRDGRGVCDHFGLTDQVDVIMGTF
EEECCCCCCCCCHHHEECCCCCCEEEEECCCCCCEECCCCCCHHHHCCCCCHHHHHHHHH
SKSLASIGGFVAADKDTINWLRHNSRSYIFSASNTPAATAAARAALHILKSEPERRENLW
HHHHHHHCCEEECCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHH
KITNYALDCFRQAGFEIGDTESPIIPLYVRDTDKTFEVTKLAFDEGIFINPVIPPACAPQ
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCEEECCCCCCCCCCH
DTLVRVALMATHTKEQVDYAVDKLTKCFKKLEIIK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GLLQDKLSKFRLPQLYMERGVYPYFREIDSHQDTEVIMDGKKVLMFGSNSYMGLTYDER
CCHHHHHHHCCCHHHHHHCCCCHHHHHHCCCCCCEEEECCCEEEEECCCCEEECCHHHH
IIEAAVAATRKYGTGCAGSRFLNGTLDLHVQLEKELAEFVGKDDALVYSTGFTVNEGVVS
HHHHHHHHHHHCCCCCCCCEEECCEEEEEEEEHHHHHHHHCCCCEEEEEECCEECCCHHH
CLTDRNDYIICDDRDHASIVDGRRLSFSTQLKYKHNDMEALEKELQKCKPESVKLIVVDG
HEECCCCEEEECCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEEEC
VFSMEGDLANLPEIVRLKDKYNASIMVDEAHGLGVFGRDGRGVCDHFGLTDQVDVIMGTF
EEECCCCCCCCCHHHEECCCCCCEEEEECCCCCCEECCCCCCHHHHCCCCCHHHHHHHHH
SKSLASIGGFVAADKDTINWLRHNSRSYIFSASNTPAATAAARAALHILKSEPERRENLW
HHHHHHHCCEEECCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHH
KITNYALDCFRQAGFEIGDTESPIIPLYVRDTDKTFEVTKLAFDEGIFINPVIPPACAPQ
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCEEECCCCCCCCCCH
DTLVRVALMATHTKEQVDYAVDKLTKCFKKLEIIK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]