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The map label for this gene is ilvC [H]

Identifier: 148827857

GI number: 148827857

Start: 1220043

End: 1221521

Strand: Direct

Name: ilvC [H]

Synonym: CGSHiGG_06705

Alternate gene names: 148827857

Gene position: 1220043-1221521 (Clockwise)

Preceding gene: 148827853

Following gene: 148827860

Centisome position: 64.65

GC content: 39.89

Gene sequence:

>1479_bases
ATGGCTAACTATTTCAACACTTTAAATTTACGTCAAAAATTAGACCAATTAGGTCGTTGTCGTTTTATGGATCGCGAAGA
ATTTGCAGATGAAGCAAACTTCTTAAAAGGCAAAAAAATCGTTATCGTGGGCTGTGGTGCGCAAGGTTTAAACCAAGGTT
TGAATATGCGTGATTCTGGCTTAGATATTAGCTATGCCTTACGCCCTGAAGCAATTGCAGAAAAACGTGCATCATTCCAA
CGTGCAACCGAAAATGGTTTTAAAGTGGGTACTTATGAAGAATTAATCCCAACTGCAGATTTAGTCGTAAACTTAACACC
AGACAAACAACACTCTAAAGTGGTTGCTGATGTGATGCCTTTAATGAAAAAAGACTCTGCATTTGGTTATTCACACGGTT
TCAACATTGTTGAAGTAGGCGAAGAAATTCGTAAAGACATTACTGTTGTGATGGTTGCACCAAAATGTCCAGGTACTGAA
GTACGTGAAGAATACAAACGTGGTTTCGGTGTACCAACATTAATTGCGGTTCACCCAGAAAATGATCCGAAAGGCGAAGG
CTTGGCGATCGCGAAAGCTTGGGCTGCTGCAACTGGCGGTCATAAAGCAGGTGTTTTAGAATCTTCATTCGTGGCAGAAG
TAAAATCTGACTTAATGGGTGAGCAAACTATCCTTTGCGGTATGTTACAAGCAGGTTCTATCGTATGTTATGACAAATTA
GTGGCAGATGGTAAAGATCCAGCATACGCAGGTAAATTAATCCAATACGGTTGGGAAACCATTACCGAAGCGTTAAAACA
AGGTGGTATCACATTAATGATGGATCGCCTATCAAACAGCGCAAAATTACGAGCATTTGAACTTGCTGAACAAATTAAAA
AAAGCCTTGGTTTCTTATATTACAAACACATGGATGACATCGTCAGCGGTCACTTCTCTGCAACCATGATGGCAGACTGG
GAAAATGACGATAAAGATTTATTCGCATGGCGTGAAGCAACAGGTAAAACAGCCTTTGAAAATGCACCAAAATATGATGG
CAAAATTAGCGAACAAGAATACTTTGATAACGGCGTATTAATGATTGCAATGGTTAAAGCTGGTGTAGAATTAGCCTTTG
ATGCGATGGTTGCAAGCGGTATTTATGAAGAATCAGCTTACTACGAATCACTTCACGAATTACCATTAATTGCGAACACT
ATTGCTCGTAAACGCTTATACGAAATGAACGTGGTAATTTCAGATACTGCAGAATATGGTAACTACTTATTCTCTAACGT
AGCGACCCCAATTCTTGCAAAAGAAATTATCCCTAACCTTCAAAAAGGCGATTTGGGCGAGCCAACTCCAGCAGTGGAAG
TCGATAACATTACCTTACGTGCTGTAAACGATGCAATTCGCAACCACCCTGTTGAATTAATCGGTCAAGAATTACGTGGT
TATATGACGGATATGAAACGTATCGCTGTTGCAGGTTAA

Upstream 100 bases:

>100_bases
TACGCAACAACAAAAAATCCTATAATCAAACCATAACAAAAAAAATAATGCAAACACAACATCATACAATTATCAACCTT
ACACAATTAAGGACAAAAAA

Downstream 100 bases:

>100_bases
TGTTAAATTGAACTGAATTAAAAACCGACTTTATCAATATAAAGTTGGTTTTTTCATAGATAAAATTAATCATAAAAATG
CACCTTAATTACAACATGCA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MANYFNTLNLRQKLDQLGRCRFMDREEFADEANFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEKRASFQ
RATENGFKVGTYEELIPTADLVVNLTPDKQHSKVVADVMPLMKKDSAFGYSHGFNIVEVGEEIRKDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGLAIAKAWAAATGGHKAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKL
VADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELAEQIKKSLGFLYYKHMDDIVSGHFSATMMADW
ENDDKDLFAWREATGKTAFENAPKYDGKISEQEYFDNGVLMIAMVKAGVELAFDAMVASGIYEESAYYESLHELPLIANT
IARKRLYEMNVVISDTAEYGNYLFSNVATPILAKEIIPNLQKGDLGEPTPAVEVDNITLRAVNDAIRNHPVELIGQELRG
YMTDMKRIAVAG

Sequences:

>Translated_492_residues
MANYFNTLNLRQKLDQLGRCRFMDREEFADEANFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEKRASFQ
RATENGFKVGTYEELIPTADLVVNLTPDKQHSKVVADVMPLMKKDSAFGYSHGFNIVEVGEEIRKDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGLAIAKAWAAATGGHKAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKL
VADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELAEQIKKSLGFLYYKHMDDIVSGHFSATMMADW
ENDDKDLFAWREATGKTAFENAPKYDGKISEQEYFDNGVLMIAMVKAGVELAFDAMVASGIYEESAYYESLHELPLIANT
IARKRLYEMNVVISDTAEYGNYLFSNVATPILAKEIIPNLQKGDLGEPTPAVEVDNITLRAVNDAIRNHPVELIGQELRG
YMTDMKRIAVAG
>Mature_491_residues
ANYFNTLNLRQKLDQLGRCRFMDREEFADEANFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEKRASFQR
ATENGFKVGTYEELIPTADLVVNLTPDKQHSKVVADVMPLMKKDSAFGYSHGFNIVEVGEEIRKDITVVMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPKGEGLAIAKAWAAATGGHKAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLV
ADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELAEQIKKSLGFLYYKHMDDIVSGHFSATMMADWE
NDDKDLFAWREATGKTAFENAPKYDGKISEQEYFDNGVLMIAMVKAGVELAFDAMVASGIYEESAYYESLHELPLIANTI
ARKRLYEMNVVISDTAEYGNYLFSNVATPILAKEIIPNLQKGDLGEPTPAVEVDNITLRAVNDAIRNHPVELIGQELRGY
MTDMKRIAVAG

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=492, Percent_Identity=80.8943089430894, Blast_Score=807, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=280, Percent_Identity=31.4285714285714, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 54279; Mature: 54147

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNTLNLRQKLDQLGRCRFMDREEFADEANFLKGKKIVIVGCGAQGLNQGLNMRDSG
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHCCCCCCCCC
LDISYALRPEAIAEKRASFQRATENGFKVGTYEELIPTADLVVNLTPDKQHSKVVADVMP
CCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHHH
LMKKDSAFGYSHGFNIVEVGEEIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGLAIAKAWAAATGGHKAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKL
CCCCCCCEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEHHH
VADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELAEQIKKSLGFLY
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
YKHMDDIVSGHFSATMMADWENDDKDLFAWREATGKTAFENAPKYDGKISEQEYFDNGVL
HHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHCCCEE
MIAMVKAGVELAFDAMVASGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYG
EEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEEEECCHHHH
NYLFSNVATPILAKEIIPNLQKGDLGEPTPAVEVDNITLRAVNDAIRNHPVELIGQELRG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCEEEEHHHHHHHCCCHHHHHHHHHH
YMTDMKRIAVAG
HHHHHHHHHCCC
>Mature Secondary Structure 
ANYFNTLNLRQKLDQLGRCRFMDREEFADEANFLKGKKIVIVGCGAQGLNQGLNMRDSG
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHCCCCCCCCC
LDISYALRPEAIAEKRASFQRATENGFKVGTYEELIPTADLVVNLTPDKQHSKVVADVMP
CCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHHH
LMKKDSAFGYSHGFNIVEVGEEIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGLAIAKAWAAATGGHKAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKL
CCCCCCCEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEHHH
VADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELAEQIKKSLGFLY
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
YKHMDDIVSGHFSATMMADWENDDKDLFAWREATGKTAFENAPKYDGKISEQEYFDNGVL
HHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHCCCEE
MIAMVKAGVELAFDAMVASGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYG
EEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEEEECCHHHH
NYLFSNVATPILAKEIIPNLQKGDLGEPTPAVEVDNITLRAVNDAIRNHPVELIGQELRG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCEEEEHHHHHHHCCCHHHHHHHHHH
YMTDMKRIAVAG
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA