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The map label for this gene is devS

Identifier: 148824326

GI number: 148824326

Start: 3510652

End: 3512388

Strand: Reverse

Name: devS

Synonym: TBFG_13153

Alternate gene names: 148824326

Gene position: 3512388-3510652 (Counterclockwise)

Preceding gene: 148824327

Following gene: 148824324

Centisome position: 79.39

GC content: 63.96

Gene sequence:

>1737_bases
ATGACAACAGGGGGCCTCGTCGACGAAAACGACGGCGCCGCAATGCGTCCACTGCGTCACACGCTCTCCCAACTACGCCT
GCACGAGCTGCTGGTCGAGGTGCAGGACCGGGTCGAGCAGATCGTCGAGGGCCGGGACCGCCTCGATGGTCTGGTGGAGG
CCATGCTCGTGGTCACAGCGGGCCTGGACCTGGAGGCAACCCTACGCGCTATCGTGCATTCAGCGACCAGCCTTGTCGAT
GCGCGCTATGGCGCTATGGAGGTGCACGACCGGCAGCATCGGGTATTGCACTTTGTCTATGAAGGCATCGACGAGGAGAC
CGTTCGGCGGATCGGCCACCTACCGAAAGGCCTAGGCGTCATCGGGCTGCTCATCGAAGATCCCAAACCGTTACGGCTGG
ACGATGTTTCTGCGCACCCGGCCTCGATTGGTTTTCCGCCGTATCATCCGCCGATGCGTACCTTCCTCGGGGTACCGGTT
CGGGTGCGCGATGAATCGTTCGGCACTCTGTACCTGACTGACAAGACCAACGGGCAACCGTTCAGCGACGACGACGAGGT
TCTGGTCCAGGCGCTGGCGGCCGCCGCGGGTATCGCAGTCGCGAATGCCCGGCTCTACCAGCAGGCTAAGGCGCGTCAGT
CGTGGATCGAGGCCACCCGTGACATCGCCACCGAGTTGTTGTCCGGCACCGAACCCGCGACGGTGTTCCGGCTTGTCGCC
GCGGAGGCGCTCAAGCTGACGGCGGCTGACGCTGCCCTGGTAGCCGTTCCCGTCGACGAGGACATGCCTGCCGCTGACGT
GGGGGAGCTGCTGGTGATTGAAACAGTCGGCAGCGCTGTGGCTTCCATTGTTGGGCGAACGATTCCGGTGGCGGGCGCGG
TGCTGCGGGAGGTCTTCGTCAACGGCATTCCGCGACGGGTCGACCGGGTCGATTTGGAAGGCCTGGACGAACTGGCCGAC
GCAGGTCCGGCGCTGCTGTTGCCGCTGCGGGCCAGAGGTACCGTAGCGGGTGTCGTTGTTGTGCTGAGTCAAGGCGGTCC
AGGGGCTTTCACCGACGAACAACTCGAGATGATGGCCGCGTTCGCCGACCAGGCCGCGCTGGCTTGGCAATTGGCCACTT
CGCAACGTCGGATGCGCGAACTCGACGTACTGACCGACCGGGATCGTATCGCCCGTGACCTCCATGACCATGTCATCCAG
CGGCTCTTCGCGATTGGCCTGGCTTTGCAGGGTGCTGTCCCGCACGAACGTAATCCTGAAGTGCAGCAACGACTCTCGGA
CGTGGTAGACGATCTGCAAGACGTTATACAGGAAATCCGGACCACCATTTATGACCTGCACGGAGCATCGCAGGGTATCA
CTCGGCTCCGGCAGCGAATCGATGCGGCCGTAGCCCAATTTGCCGACTCGGGGTTGCGCACCAGCGTTCAATTCGTGGGT
CCATTGTCGGTGGTCGACAGCGCGCTCGCCGATCAGGCCGAGGCGGTGGTTCGGGAAGCGGTCAGCAACGCGGTTCGCCA
TGCGAAGGCCAGCACGTTGACCGTCCGGGTCAAAGTCGACGACGACTTGTGCATCGAGGTGACCGACAACGGCCGCGGGC
TGCCCGACGAGTTCACCGGAAGCGGCTTAACGAACCTGCGGCAGCGGGCAGAGCAGGCCGGCGGCGAATTCACCCTCGCG
AGCGTACCGGGCGCGAGCGGAACAGTGCTGCGATGGTCAGCACCGTTGTCGCAGTAG

Upstream 100 bases:

>100_bases
ACGTGTCGCGGTTGCTGGCCAAGCTGGGCATGGAACGTCGGACGCAAGCCGCGGTATTCGCGACGGAGTTGAAGCGCTCG
CGGCCACCCGGTGATGGACC

Downstream 100 bases:

>100_bases
CTCTTCCGGCCACTCAACGACCTGGGACAGTTCGCGCCGTGGCGTCGGTGGCAACGGGTCGGCATTGATCGGTGCCCAAC
CCACTCGCAGCAGCATCTGG

Product: two component system sensor histidine kinase devS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVD
ARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPV
RVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVA
AEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLDELAD
AGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQ
RLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVG
PLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGEFTLA
SVPGASGTVLRWSAPLSQ

Sequences:

>Translated_578_residues
MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVD
ARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPV
RVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVA
AEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLDELAD
AGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQ
RLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVG
PLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGEFTLA
SVPGASGTVLRWSAPLSQ
>Mature_577_residues
TTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDA
RYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPVR
VRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAA
EALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLDELADA
GPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQR
LFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVGP
LSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGEFTLAS
VPGASGTVLRWSAPLSQ

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaer

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1788812, Length=208, Percent_Identity=28.3653846153846, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787474, Length=256, Percent_Identity=27.734375, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DEVS_MYCTU (P95194)

Other databases:

- EMBL:   BX842582
- EMBL:   AE000516
- EMBL:   U22037
- PIR:   E70645
- RefSeq:   NP_217648.1
- RefSeq:   NP_337742.1
- PDB:   2W3D
- PDB:   2W3E
- PDB:   2W3F
- PDB:   2W3G
- PDB:   2W3H
- PDBsum:   2W3D
- PDBsum:   2W3E
- PDBsum:   2W3F
- PDBsum:   2W3G
- PDBsum:   2W3H
- ProteinModelPortal:   P95194
- EnsemblBacteria:   EBMYCT00000001904
- EnsemblBacteria:   EBMYCT00000072883
- GeneID:   888829
- GeneID:   923423
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3218
- KEGG:   mtu:Rv3132c
- TIGR:   MT3218
- TubercuList:   Rv3132c
- GeneTree:   EBGT00050000014831
- HOGENOM:   HBG322367
- OMA:   RIGHLPE
- ProtClustDB:   CLSK791572
- GO:   GO:0005737
- GO:   GO:0040007
- InterPro:   IPR016030
- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712
- InterPro:   IPR005467
- Gene3D:   G3DSA:1.20.1200.10
- Gene3D:   G3DSA:3.30.565.10
- SMART:   SM00065
- SMART:   SM00387

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3; SSF55874 ATP_bd_ATPase

EC number: =2.7.13.3

Molecular weight: Translated: 62241; Mature: 62110

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGV
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCE
IGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQP
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCCEEEEEECCCCCC
FSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGAVLREVFV
HHHHHHEECCCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHH
NGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAA
CCCCHHHHHCCCCCHHHHHCCCCEEEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHHHH
FADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPE
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
VQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
PLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCCCC
SGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ
CCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCC
>Mature Secondary Structure 
TTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGV
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCE
IGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQP
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCCEEEEEECCCCCC
FSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGAVLREVFV
HHHHHHEECCCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHH
NGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAA
CCCCHHHHHCCCCCHHHHHCCCCEEEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHHHH
FADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPE
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
VQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
PLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCCCC
SGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ
CCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036