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The map label for this gene is prcB

Identifier: 148823321

GI number: 148823321

Start: 2383118

End: 2383993

Strand: Reverse

Name: prcB

Synonym: TBFG_12142

Alternate gene names: 148823321

Gene position: 2383993-2383118 (Counterclockwise)

Preceding gene: 148823322

Following gene: 148823320

Centisome position: 53.88

GC content: 63.58

Gene sequence:

>876_bases
GTGACCTGGCCGTTGCCCGATCGCCTGTCCATTAATTCACTCTCTGGAACACCCGCTGTAGACCTATCTTCTTTCACTGA
CTTCCTGCGCCGCCAGGCGCCGGAGTTGCTGCCGGCAAGCATCAGCGGCGGTGCGCCACTCGCAGGCGGCGATGCGCAAC
TGCCGCACGGCACCACCATTGTCGCGCTGAAATACCCCGGCGGTGTTGTCATGGCGGGTGACCGGCGTTCGACGCAGGGC
AACATGATTTCTGGGCGTGATGTGCGCAAGGTGTATATCACCGATGACTACACCGCTACCGGCATCGCTGGCACGGCTGC
GGTCGCGGTTGAGTTTGCCCGGCTGTATGCCGTGGAACTTGAGCACTACGAGAAGCTCGAGGGTGTGCCGCTGACGTTTG
CCGGCAAAATCAACCGGCTGGCGATTATGGTGCGTGGCAATCTGGCGGCCGCGATGCAGGGTCTGCTGGCGTTGCCGTTG
CTGGCGGGCTACGACATTCATGCGTCTGACCCGCAGAGCGCGGGTCGTATCGTTTCGTTCGACGCCGCCGGCGGTTGGAA
CATCGAGGAAGAGGGCTATCAGGCGGTGGGCTCGGGTTCGCTGTTCGCGAAGTCGTCGATGAAGAAGTTGTATTCGCAGG
TTACCGACGGTGATTCGGGGCTGCGGGTGGCGGTCGAGGCGCTCTACGACGCCGCCGACGACGACTCCGCCACCGGCGGT
CCGGACCTGGTGCGGGGCATCTTTCCGACGGCGGTGATCATCGACGCCGACGGGGCGGTTGACGTGCCGGAGAGCCGGAT
TGCCGAATTGGCCCGCGCGATCATCGAAAGCCGTTCGGGTGCGGATACTTTCGGCTCCGATGGCGGTGAGAAGTGA

Upstream 100 bases:

>100_bases
AGCTGACCGAGGAGACCGACGATCTGCTCGACGAAATCGACGACGTCCTCGAGGAGAACGCCGAGGACTTCGTCCGCGCA
TACGTCCAAAAGGGCGGACA

Downstream 100 bases:

>100_bases
GTTTTCCGTATTTCATCTCGCCTGAGCAGGCGATGCGCGAGCGCAGCGAGTTGGCGCGTAAGGGCATTGCGCGGGCCAAA
AGCGTGGTGGCGCTGGCCTA

Product: proteasome beta subunit prcB

Products: NA

Alternate protein names: 20S proteasome beta subunit; Proteasome core protein PrcB

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTWPLPDRLSINSLSGTPAVDLSSFTDFLRRQAPELLPASISGGAPLAGGDAQLPHGTTIVALKYPGGVVMAGDRRSTQG
NMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPL
LAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGG
PDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSGADTFGSDGGEK

Sequences:

>Translated_291_residues
MTWPLPDRLSINSLSGTPAVDLSSFTDFLRRQAPELLPASISGGAPLAGGDAQLPHGTTIVALKYPGGVVMAGDRRSTQG
NMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPL
LAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGG
PDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSGADTFGSDGGEK
>Mature_290_residues
TWPLPDRLSINSLSGTPAVDLSSFTDFLRRQAPELLPASISGGAPLAGGDAQLPHGTTIVALKYPGGVVMAGDRRSTQGN
MISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLL
AGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGP
DLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSGADTFGSDGGEK

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB_MYCBO (Q7TZ13)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855783.1
- HSSP:   Q9P996
- ProteinModelPortal:   Q7TZ13
- SMR:   Q7TZ13
- MEROPS:   T01.005
- EnsemblBacteria:   EBMYCT00000015825
- GeneID:   1091165
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2134c
- GeneTree:   EBGT00050000016799
- HOGENOM:   HBG322409
- OMA:   FQVELEH
- ProtClustDB:   CLSK872008
- BioCyc:   MBOV233413:MB2134C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_02113_B
- InterPro:   IPR022483
- InterPro:   IPR001353
- TIGRFAMs:   TIGR03690

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 30305; Mature: 30174

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 58-58

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWPLPDRLSINSLSGTPAVDLSSFTDFLRRQAPELLPASISGGAPLAGGDAQLPHGTTI
CCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEE
VALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVEL
EEEECCCCEEEECCCCCCCCCEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
EHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSF
HHHHHHCCCCEEEECCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
DAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGG
ECCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCC
PDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSGADTFGSDGGEK
HHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TWPLPDRLSINSLSGTPAVDLSSFTDFLRRQAPELLPASISGGAPLAGGDAQLPHGTTI
CCCCCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEE
VALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVEL
EEEECCCCEEEECCCCCCCCCEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
EHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSF
HHHHHHCCCCEEEECCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
DAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGG
ECCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCC
PDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSGADTFGSDGGEK
HHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972