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The map label for this gene is accD4 [H]

Identifier: 148663667

GI number: 148663667

Start: 4262826

End: 4264394

Strand: Reverse

Name: accD4 [H]

Synonym: MRA_3839

Alternate gene names: 148663667

Gene position: 4264394-4262826 (Counterclockwise)

Preceding gene: 148663668

Following gene: 148663655

Centisome position: 96.48

GC content: 65.97

Gene sequence:

>1569_bases
GTGACCGTCACCGAGCCGGTTCTGCATACCACCGCCGAGAAGCTGGCGGAGCTGCGCGAACGCCTGGAGTTGGCCAAGGA
ACCCGGCGGTGAGAAGGCCGCCGCCAAGCGCGACAAGAAGGGCATCCCGAGTGCCCGCGCCCGCATCTACGAGCTGGTCG
ATCCGGGTAGCTTCATGGAGATCGGAGCGCTGTGCCGCACCCCCGGTGACCCCAACGCGCTCTACGGGGACGGCGTGGTC
ACCGGACATGGCCTCATCAACGGCCGGCCGGTCGGCGTGTTCTCGCACGACCAAACCGTGTTCGGCGGCACCGTCGGGGA
GATGTTTGGCCGCAAGGTGGCCCGGCTGATGGAGTGGTGCGCGATGGTCGGCTGCCCGATCGTCGGCATCAACGACTCCG
GCGGCGCCCGCATCCAAGACGCCGTCACCTCGCTGGCCTGGTACGCCGAGCTGGGGCGCCGCCACGAACTGCTCAGTGGG
CTGGTGCCGCAGATCTCCATCATTTTGGGCAAATGCGCTGGGGGAGCGGTGTATTCGCCGATCCAGACCGATCTGGTGGT
GGCGGTGCGCGACCAGGGTTACATGTTCGTCACCGGCCCCGACGTCATCAAGGACGTCACCGGTGAGGACGTCAGCCTCG
ACGAGCTGGGGGGCGCCGACCACCAGGCGAGCTACGGCAACATCCATCAGGTGGTGGAGTCCGAGGCCGCCGCATACCAG
TACGTGCGGGACTTTCTGTCGTTTCTGCCGTCCAACTGCTTCGACAAACCGCCGGTCGTCAACCCCGGGCTGGAACCCGA
AATCACCGGCCACGATCTGGAACTCGACTCGATCGTGCCGGACTCGGACAACATGGCCTACGACATGCACGAGGTCCTGC
TGCGGATCTTCGACGACGGCGACTTCCTCGACGTCGCTGCCCAGGCCGGGCAGGCGATCATCACCGGCTACGCGCGGGTG
GACGGGCGGACCGTTGGTGTGGTGGCCAACCAGCCCATGCACATGTCGGGGGCGATCGACAACGAGGCGTCCGACAAGGC
CGCACGGTTCATCCGGTTTAGCGACGCGTTCGACATCCCGCTGGTGTTCGTCGTGGACACACCGGGGTTTTTGCCCGGGG
TGGAACAGGAAAAGAACGGGATCATCAAGCGCGGTGGGAGGTTCTTGTACGCGGTGGTCGAGGCTGATGTGCCGAAGGTG
ACGATCACCATCCGCAAGTCCTACGGCGGTGCCTACGCGGTGATGGGGTCCAAGCAGCTGACCGCCGACCTGAACTTCGC
CTGGCCCACCGCGCGCATCGCGGTGATCGGCGCCGACGGGGCCGCGCAGTTGCTGATGAAGCGTTTCCCGGACCCGAATG
CGCCGGAGGCGCAAGCGATCCGGAAGAGCTTCGTCGAGAATTACAACCTCAACATGGCGATCCCGTGGATCGCCGCCGAG
CGCGGGTTCATCGATGCCGTCATCGACCCGCATGAGACCCGGCTGCTGTTGCGCAAGTCGATGCACCTGCTGCGGGACAA
GCAGCTGTGGTGGCGGGTGGGCCGCAAGCACGGCCTGATCCCGGTCTAG

Upstream 100 bases:

>100_bases
TTCAGGCCATCGACGAGCCGATCATCGCCAAGGTGGGCGAACACATGAGCCGCGCGTTGGGGCAGATCGAGGCCGATCGA
ACAAGTGAGGTAGGCAAGCA

Downstream 100 bases:

>100_bases
CTGGGTAGCGCGAGCAGACGTAAAAGCCCCCAAATTCGGTACGAATTGGGCTCTACTGACTGATCTGTGGGTGGTTGTGT
CGGCCTGGCAGGGTGGGGCG

Product: propionyl-CoA carboxylase subunit beta AccD4

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MTVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPSARARIYELVDPGSFMEIGALCRTPGDPNALYGDGVV
TGHGLINGRPVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMVGCPIVGINDSGGARIQDAVTSLAWYAELGRRHELLSG
LVPQISIILGKCAGGAVYSPIQTDLVVAVRDQGYMFVTGPDVIKDVTGEDVSLDELGGADHQASYGNIHQVVESEAAAYQ
YVRDFLSFLPSNCFDKPPVVNPGLEPEITGHDLELDSIVPDSDNMAYDMHEVLLRIFDDGDFLDVAAQAGQAIITGYARV
DGRTVGVVANQPMHMSGAIDNEASDKAARFIRFSDAFDIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKV
TITIRKSYGGAYAVMGSKQLTADLNFAWPTARIAVIGADGAAQLLMKRFPDPNAPEAQAIRKSFVENYNLNMAIPWIAAE
RGFIDAVIDPHETRLLLRKSMHLLRDKQLWWRVGRKHGLIPV

Sequences:

>Translated_522_residues
MTVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPSARARIYELVDPGSFMEIGALCRTPGDPNALYGDGVV
TGHGLINGRPVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMVGCPIVGINDSGGARIQDAVTSLAWYAELGRRHELLSG
LVPQISIILGKCAGGAVYSPIQTDLVVAVRDQGYMFVTGPDVIKDVTGEDVSLDELGGADHQASYGNIHQVVESEAAAYQ
YVRDFLSFLPSNCFDKPPVVNPGLEPEITGHDLELDSIVPDSDNMAYDMHEVLLRIFDDGDFLDVAAQAGQAIITGYARV
DGRTVGVVANQPMHMSGAIDNEASDKAARFIRFSDAFDIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKV
TITIRKSYGGAYAVMGSKQLTADLNFAWPTARIAVIGADGAAQLLMKRFPDPNAPEAQAIRKSFVENYNLNMAIPWIAAE
RGFIDAVIDPHETRLLLRKSMHLLRDKQLWWRVGRKHGLIPV
>Mature_521_residues
TVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPSARARIYELVDPGSFMEIGALCRTPGDPNALYGDGVVT
GHGLINGRPVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMVGCPIVGINDSGGARIQDAVTSLAWYAELGRRHELLSGL
VPQISIILGKCAGGAVYSPIQTDLVVAVRDQGYMFVTGPDVIKDVTGEDVSLDELGGADHQASYGNIHQVVESEAAAYQY
VRDFLSFLPSNCFDKPPVVNPGLEPEITGHDLELDSIVPDSDNMAYDMHEVLLRIFDDGDFLDVAAQAGQAIITGYARVD
GRTVGVVANQPMHMSGAIDNEASDKAARFIRFSDAFDIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKVT
ITIRKSYGGAYAVMGSKQLTADLNFAWPTARIAVIGADGAAQLLMKRFPDPNAPEAQAIRKSFVENYNLNMAIPWIAAER
GFIDAVIDPHETRLLLRKSMHLLRDKQLWWRVGRKHGLIPV

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=533, Percent_Identity=44.0900562851782, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI295821216, Length=553, Percent_Identity=42.49547920434, Blast_Score=411, Evalue=1e-114,
Organism=Homo sapiens, GI11545863, Length=501, Percent_Identity=32.3353293413174, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI25147362, Length=529, Percent_Identity=42.7221172022684, Blast_Score=410, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI25147359, Length=529, Percent_Identity=42.7221172022684, Blast_Score=410, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17552936, Length=501, Percent_Identity=29.940119760479, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24586065, Length=529, Percent_Identity=30.0567107750473, Blast_Score=213, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56680; Mature: 56549

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPSARARIYELVDPGSFME
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
IGALCRTPGDPNALYGDGVVTGHGLINGRPVGVFSHDQTVFGGTVGEMFGRKVARLMEWC
HHHHHCCCCCCCCEECCCEEECCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHH
AMVGCPIVGINDSGGARIQDAVTSLAWYAELGRRHELLSGLVPQISIILGKCAGGAVYSP
HHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IQTDLVVAVRDQGYMFVTGPDVIKDVTGEDVSLDELGGADHQASYGNIHQVVESEAAAYQ
CCCCEEEEEECCCEEEEECHHHHHHCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHH
YVRDFLSFLPSNCFDKPPVVNPGLEPEITGHDLELDSIVPDSDNMAYDMHEVLLRIFDDG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCC
DFLDVAAQAGQAIITGYARVDGRTVGVVANQPMHMSGAIDNEASDKAARFIRFSDAFDIP
CHHHHHHHCCCEEEEEEEEECCEEEEEEECCCEEECCCCCCCCHHHHHHEEEECCCCCCC
LVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQL
EEEEEECCCCCCCCCHHHCCHHHCCCEEEEEEEECCCCEEEEEEEECCCCEEEEECCCEE
TADLNFAWPTARIAVIGADGAAQLLMKRFPDPNAPEAQAIRKSFVENYNLNMAIPWIAAE
EEECEECCCCEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECC
RGFIDAVIDPHETRLLLRKSMHLLRDKQLWWRVGRKHGLIPV
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPSARARIYELVDPGSFME
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
IGALCRTPGDPNALYGDGVVTGHGLINGRPVGVFSHDQTVFGGTVGEMFGRKVARLMEWC
HHHHHCCCCCCCCEECCCEEECCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHH
AMVGCPIVGINDSGGARIQDAVTSLAWYAELGRRHELLSGLVPQISIILGKCAGGAVYSP
HHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IQTDLVVAVRDQGYMFVTGPDVIKDVTGEDVSLDELGGADHQASYGNIHQVVESEAAAYQ
CCCCEEEEEECCCEEEEECHHHHHHCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHH
YVRDFLSFLPSNCFDKPPVVNPGLEPEITGHDLELDSIVPDSDNMAYDMHEVLLRIFDDG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCC
DFLDVAAQAGQAIITGYARVDGRTVGVVANQPMHMSGAIDNEASDKAARFIRFSDAFDIP
CHHHHHHHCCCEEEEEEEEECCEEEEEEECCCEEECCCCCCCCHHHHHHEEEECCCCCCC
LVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQL
EEEEEECCCCCCCCCHHHCCHHHCCCEEEEEEEECCCCEEEEEEEECCCCEEEEECCCEE
TADLNFAWPTARIAVIGADGAAQLLMKRFPDPNAPEAQAIRKSFVENYNLNMAIPWIAAE
EEECEECCCCEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECC
RGFIDAVIDPHETRLLLRKSMHLLRDKQLWWRVGRKHGLIPV
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]