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The map label for this gene is dnaZX

Identifier: 148663586

GI number: 148663586

Start: 4173441

End: 4175177

Strand: Reverse

Name: dnaZX

Synonym: MRA_3758

Alternate gene names: 148663586

Gene position: 4175177-4173441 (Counterclockwise)

Preceding gene: 148663587

Following gene: 148663583

Centisome position: 94.46

GC content: 68.57

Gene sequence:

>1737_bases
GTGGCTCTCTACCGCAAGTACCGACCGGCAAGCTTCGCGGAGGTGGTGGGGCAGGAGCACGTCACCGCGCCGCTGTCGGT
GGCGCTGGATGCCGGCCGGATCAACCACGCGTACCTGTTCTCTGGGCCGCGTGGCTGCGGAAAGACGTCGTCAGCGCGTA
TCCTGGCGCGGTCGTTGAACTGTGCGCAGGGCCCTACCGCCAACCCGTGCGGGGTCTGCGAATCCTGCGTTTCGTTGGCG
CCCAACGCCCCCGGCAGCATCGACGTGGTAGAGCTGGATGCCGCCAGCCACGGCGGCGTGGACGACACCCGCGAGCTGCG
GGACCGCGCGTTCTATGCGCCGGTCCAGTCACGGTACCGGGTATTTATCGTCGACGAGGCGCACATGGTGACCACCGCGG
GATTCAACGCGCTGCTCAAGATCGTGGAGGAACCGCCCGAACACCTGATCTTCATATTCGCCACCACCGAACCGGAGAAG
GTACTGCCGACGATTCGGTCGCGCACTCATCACTACCCGTTCCGGCTGCTGCCGCCGCGCACTATGCGGGCGTTGCTCGC
GCGGATCTGCGAGCAGGAGGGCGTCGTCGTCGACGATGCGGTGTACCCGTTGGTGATCCGGGCCGGCGGAGGTTCCCCAC
GGGATACGCTCTCGGTGCTGGACCAATTGCTGGCTGGGGCCGCGGACACCCACGTGACCTACACCCGGGCGCTGGGGCTG
CTGGGTGTCACCGACGTCGCCCTGATCGACGACGCGGTCGACGCACTGGCCGCTTGCGATGCGGCCGCATTGTTCGGGGC
GATCGAATCGGTGATCGATGGCGGACATGACCCTCGGCGTTTCGCTACCGATCTGCTGGAGCGATTCCGCGACCTGATTG
TGCTGCAATCGGTTCCCGACGCGGCATCTCGCGGGGTGGTGGATGCGCCCGAAGACGCGCTGGATCGGATGCGCGAGCAA
GCCGCCCGGATCGGGCGGGCGACCCTGACCCGATATGCCGAGGTGGTGCAGGCCGGGCTAGGCGAGATGCGCGGTGCGAC
CGCGCCGCGTCTGCTGCTGGAAGTGGTTTGCGCGCGACTGCTGCTGCCCTCGGCGAGCGACGCCGAATCGGCACTGTTGC
AGCGGGTCGAACGGATCGAGACCCGGTTGGACATGTCGATCCCGGCGCCGCAAGCCGTACCACGCCCGTCGGCTGCGGCT
GCCGAGCCGAAACACCAGCCCGCGCGTGAACCGAGACCGGTGCTGGCCCCCACACCGGCCTCGAGCGAACCCACCGTGGC
CGCGGTTCGGTCCATGTGGCCGACGGTGCGCGACAAGGTGCGCCTGCGCAGCCGTACCACCGAGGTGATGCTGGCGGGTG
CCACCGTCCGTGCGCTAGAGGACAACACGCTGGTGCTGACCCACGAATCGGCGCCGCTGGCGCGGCGGCTGTCCGAACAG
CGCAACGCCGATGTCCTCGCCGAGGCGCTTAAAGACGCGCTGGGAGTCAACTGGCGGGTGCGGTGTGAGACCGGTGAACC
GGCTGCGGCGGCATCACCCGTCGGCGGGGGAGCGAACGTGGCGACCGCCAAGGCCGTAAACCCTGCCCCCACAGCGAATT
CCACTCAGCGCGACGAAGAGGAGCACATGCTCGCCGAAGCCGGCCGTGGCGACCCGTCGCCGCGTCGCGACCCGGAAGAG
GTTGCACTCGAGCTGCTGCAGAACGAGCTGGGCGCGCGCCGGATAGACAACGCCTAG

Upstream 100 bases:

>100_bases
ACGTGCGCTGAGAGCGGGAACCCGCGCGCCGAAATCACGCCGAACGTTCACATTCGACGCTGCGAACACACTCGTCGCCT
AGGGTCGGTAGCCTGCTGAC

Downstream 100 bases:

>100_bases
GGCTGCCACCAGGGCCGCAGTGGCAAGCTGTCGTCGCCCCGGGGGTCCACCTTGGTCGCCAATACGTGATGTAGCTGCAG
GTTGTTTCGTTCGAAGGCCA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MALYRKYRPASFAEVVGQEHVTAPLSVALDAGRINHAYLFSGPRGCGKTSSARILARSLNCAQGPTANPCGVCESCVSLA
PNAPGSIDVVELDAASHGGVDDTRELRDRAFYAPVQSRYRVFIVDEAHMVTTAGFNALLKIVEEPPEHLIFIFATTEPEK
VLPTIRSRTHHYPFRLLPPRTMRALLARICEQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLLAGAADTHVTYTRALGL
LGVTDVALIDDAVDALAACDAAALFGAIESVIDGGHDPRRFATDLLERFRDLIVLQSVPDAASRGVVDAPEDALDRMREQ
AARIGRATLTRYAEVVQAGLGEMRGATAPRLLLEVVCARLLLPSASDAESALLQRVERIETRLDMSIPAPQAVPRPSAAA
AEPKHQPAREPRPVLAPTPASSEPTVAAVRSMWPTVRDKVRLRSRTTEVMLAGATVRALEDNTLVLTHESAPLARRLSEQ
RNADVLAEALKDALGVNWRVRCETGEPAAAASPVGGGANVATAKAVNPAPTANSTQRDEEEHMLAEAGRGDPSPRRDPEE
VALELLQNELGARRIDNA

Sequences:

>Translated_578_residues
MALYRKYRPASFAEVVGQEHVTAPLSVALDAGRINHAYLFSGPRGCGKTSSARILARSLNCAQGPTANPCGVCESCVSLA
PNAPGSIDVVELDAASHGGVDDTRELRDRAFYAPVQSRYRVFIVDEAHMVTTAGFNALLKIVEEPPEHLIFIFATTEPEK
VLPTIRSRTHHYPFRLLPPRTMRALLARICEQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLLAGAADTHVTYTRALGL
LGVTDVALIDDAVDALAACDAAALFGAIESVIDGGHDPRRFATDLLERFRDLIVLQSVPDAASRGVVDAPEDALDRMREQ
AARIGRATLTRYAEVVQAGLGEMRGATAPRLLLEVVCARLLLPSASDAESALLQRVERIETRLDMSIPAPQAVPRPSAAA
AEPKHQPAREPRPVLAPTPASSEPTVAAVRSMWPTVRDKVRLRSRTTEVMLAGATVRALEDNTLVLTHESAPLARRLSEQ
RNADVLAEALKDALGVNWRVRCETGEPAAAASPVGGGANVATAKAVNPAPTANSTQRDEEEHMLAEAGRGDPSPRRDPEE
VALELLQNELGARRIDNA
>Mature_577_residues
ALYRKYRPASFAEVVGQEHVTAPLSVALDAGRINHAYLFSGPRGCGKTSSARILARSLNCAQGPTANPCGVCESCVSLAP
NAPGSIDVVELDAASHGGVDDTRELRDRAFYAPVQSRYRVFIVDEAHMVTTAGFNALLKIVEEPPEHLIFIFATTEPEKV
LPTIRSRTHHYPFRLLPPRTMRALLARICEQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLLAGAADTHVTYTRALGLL
GVTDVALIDDAVDALAACDAAALFGAIESVIDGGHDPRRFATDLLERFRDLIVLQSVPDAASRGVVDAPEDALDRMREQA
ARIGRATLTRYAEVVQAGLGEMRGATAPRLLLEVVCARLLLPSASDAESALLQRVERIETRLDMSIPAPQAVPRPSAAAA
EPKHQPAREPRPVLAPTPASSEPTVAAVRSMWPTVRDKVRLRSRTTEVMLAGATVRALEDNTLVLTHESAPLARRLSEQR
NADVLAEALKDALGVNWRVRCETGEPAAAASPVGGGANVATAKAVNPAPTANSTQRDEEEHMLAEAGRGDPSPRRDPEEV
ALELLQNELGARRIDNA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=304, Percent_Identity=25, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI31881687, Length=304, Percent_Identity=25, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI6677723, Length=234, Percent_Identity=24.7863247863248, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI194306571, Length=220, Percent_Identity=25, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI194306567, Length=220, Percent_Identity=25, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1786676, Length=360, Percent_Identity=37.7777777777778, Blast_Score=230, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6324039, Length=217, Percent_Identity=27.6497695852535, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO3X_MYCBO (P63976)

Other databases:

- EMBL:   BX248347
- RefSeq:   NP_857386.1
- ProteinModelPortal:   P63976
- SMR:   P63976
- EnsemblBacteria:   EBMYCT00000017387
- GeneID:   1093383
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3748c
- GeneTree:   EBGT00050000014856
- HOGENOM:   HBG729459
- OMA:   EARKDEL
- ProtClustDB:   PRK14952
- BioCyc:   MBOV233413:MB3748C-MONOMER
- BRENDA:   2.7.7.7
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- SMART:   SM00382
- TIGRFAMs:   TIGR02397

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; SSF48019 Pol_clamp_load_C

EC number: =2.7.7.7

Molecular weight: Translated: 61924; Mature: 61793

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALYRKYRPASFAEVVGQEHVTAPLSVALDAGRINHAYLFSGPRGCGKTSSARILARSLN
CCCCCCCCCCHHHHHHCHHHCCCCHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHCC
CAQGPTANPCGVCESCVSLAPNAPGSIDVVELDAASHGGVDDTRELRDRAFYAPVQSRYR
CCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEE
VFIVDEAHMVTTAGFNALLKIVEEPPEHLIFIFATTEPEKVLPTIRSRTHHYPFRLLPPR
EEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEECCHH
TMRALLARICEQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLLAGAADTHVTYTRALGL
HHHHHHHHHHHHCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
LGVTDVALIDDAVDALAACDAAALFGAIESVIDGGHDPRRFATDLLERFRDLIVLQSVPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
AASRGVVDAPEDALDRMREQAARIGRATLTRYAEVVQAGLGEMRGATAPRLLLEVVCARL
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LLPSASDAESALLQRVERIETRLDMSIPAPQAVPRPSAAAAEPKHQPAREPRPVLAPTPA
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SSEPTVAAVRSMWPTVRDKVRLRSRTTEVMLAGATVRALEDNTLVLTHESAPLARRLSEQ
CCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEEECCCEEEEEECCCHHHHHHHHH
RNADVLAEALKDALGVNWRVRCETGEPAAAASPVGGGANVATAKAVNPAPTANSTQRDEE
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHH
EHMLAEAGRGDPSPRRDPEEVALELLQNELGARRIDNA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHCCCC
>Mature Secondary Structure 
ALYRKYRPASFAEVVGQEHVTAPLSVALDAGRINHAYLFSGPRGCGKTSSARILARSLN
CCCCCCCCCHHHHHHCHHHCCCCHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHCC
CAQGPTANPCGVCESCVSLAPNAPGSIDVVELDAASHGGVDDTRELRDRAFYAPVQSRYR
CCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEE
VFIVDEAHMVTTAGFNALLKIVEEPPEHLIFIFATTEPEKVLPTIRSRTHHYPFRLLPPR
EEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEECCHH
TMRALLARICEQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLLAGAADTHVTYTRALGL
HHHHHHHHHHHHCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
LGVTDVALIDDAVDALAACDAAALFGAIESVIDGGHDPRRFATDLLERFRDLIVLQSVPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
AASRGVVDAPEDALDRMREQAARIGRATLTRYAEVVQAGLGEMRGATAPRLLLEVVCARL
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LLPSASDAESALLQRVERIETRLDMSIPAPQAVPRPSAAAAEPKHQPAREPRPVLAPTPA
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SSEPTVAAVRSMWPTVRDKVRLRSRTTEVMLAGATVRALEDNTLVLTHESAPLARRLSEQ
CCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEEECCCEEEEEECCCHHHHHHHHH
RNADVLAEALKDALGVNWRVRCETGEPAAAASPVGGGANVATAKAVNPAPTANSTQRDEE
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHH
EHMLAEAGRGDPSPRRDPEEVALELLQNELGARRIDNA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972