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The map label for this gene is gloB [H]

Identifier: 148663540

GI number: 148663540

Start: 4125704

End: 4126498

Strand: Reverse

Name: gloB [H]

Synonym: MRA_3712

Alternate gene names: 148663540

Gene position: 4126498-4125704 (Counterclockwise)

Preceding gene: 148663541

Following gene: 148663537

Centisome position: 93.36

GC content: 65.03

Gene sequence:

>795_bases
ATGTCGAAGACAGCTGAGTCGCTGACCCATCCCGCCTACGGCCAGCTGCGCGCGGTCACCGACACCGCGTCGGTCCTGTT
GGCCGACAACCCCGGTTTGCTGACGTTGGACGGCACCAACACCTGGGTGCTGCGCGGCCCGCTCAGTGACGAGCTGGTCG
TTGTCGATCCAGGCCCGGACGACGACGAGCACCTGGCACGGGTTGCCGCGCTTGGCCGCATCGCGTTGGTACTGATCAGT
CATCGTCATGGCGACCACACCAGCGGCATCGACAAACTGGTCGCGCTGACCGGGGCGCCGGTACGGGCCGCGGATCCGCA
GTTCTTGCGACGTGATGGGGAGACGCTGACCGACGGGGAAGTGATCGACGTTGCCGGGTTAACCATTACCGTGTTGGCCA
CCCCTGGCCACACCGCAGATTCGCTGTCATTTGTCCTCGACGACGCCGTGTTGACCGCCGACACCGTGTTGGGTTGCGGG
ACCACCGTCATCGACAAGGAAGACGGCAGCCTAGCCGACTACTTGGAATCGCTGCACCGGCTGCGTGGCCTGGGCCGGCG
GACCGTGCTGCCGGGGCACGGGCCGGACTTGCTCGACCTGGAAGCGATTGCATCGGGATACCTGCTGCACCGGCACGAAC
GTCTGGAGCAGATACGCGCCGCGTTGCGGGATCTCGGTGACGACGCCACGGTCCGCGAGGTCGTCGAACACGTCTACCTC
GACGTTGACGAAAAGCTTTGGAATGCGGCCGAATGGTCGGTGCAGGCACAACTGGACTATCTGCGGACTCGGTAG

Upstream 100 bases:

>100_bases
CGATAGCGGCGCGCATGCGCGTTCGGCGGTCGGCGTATCCGAGCTACCGTTGGATGCGCCGGTGGAAGTCGAGTTGATCG
TGGAGGTCGGCTAGCGGCCG

Downstream 100 bases:

>100_bases
CGCGAGCAGCCGCACAATCGCACAAAATCCGTCGTTTGCGTGCGACTCTGTGTCTGCTGGGCGTGAGGAAGCTAGCTCGC
TCGGTTGCGCCCGCGCGGCG

Product: putative hydrolase

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVAALGRIALVLIS
HRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCG
TTVIDKEDGSLADYLESLHRLRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL
DVDEKLWNAAEWSVQAQLDYLRTR

Sequences:

>Translated_264_residues
MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVAALGRIALVLIS
HRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCG
TTVIDKEDGSLADYLESLHRLRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL
DVDEKLWNAAEWSVQAQLDYLRTR
>Mature_263_residues
SKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPDDDEHLARVAALGRIALVLISH
RHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGEVIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGT
TVIDKEDGSLADYLESLHRLRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYLD
VDEKLWNAAEWSVQAQLDYLRTR

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI7705793, Length=248, Percent_Identity=33.0645161290323, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17537503, Length=253, Percent_Identity=30.8300395256917, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI193205216, Length=253, Percent_Identity=30.8300395256917, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI20129357, Length=263, Percent_Identity=27.3764258555133, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 28490; Mature: 28359

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD
CCCCHHHHCCCCCCCEEEEECCEEEEEECCCCEEEECCCCEEEEECCCCCCEEEECCCCC
DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE
CHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCC
VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR
EEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHH
LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL
HHCCCCCEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
DVDEKLWNAAEWSVQAQLDYLRTR
CCHHHHHCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVLRGPLSDELVVVDPGPD
CCCHHHHCCCCCCCEEEEECCEEEEEECCCCEEEECCCCEEEEECCCCCCEEEECCCCC
DDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVRAADPQFLRRDGETLTDGE
CHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCC
VIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCGTTVIDKEDGSLADYLESLHR
EEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHH
LRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQIRAALRDLGDDATVREVVEHVYL
HHCCCCCEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
DVDEKLWNAAEWSVQAQLDYLRTR
CCHHHHHCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA