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The map label for this gene is atpB

Identifier: 148661092

GI number: 148661092

Start: 1461554

End: 1462306

Strand: Direct

Name: atpB

Synonym: MRA_1312

Alternate gene names: 148661092

Gene position: 1461554-1462306 (Clockwise)

Preceding gene: 148661091

Following gene: 148661093

Centisome position: 33.07

GC content: 58.03

Gene sequence:

>753_bases
ATGACTGAGACCATCCTGGCCGCCCAAATCGAGGTCGGCGAGCACCACACGGCCACCTGGCTCGGTATGACGGTCAACAC
CGACACCGTGTTGTCGACGGCGATCGCCGGGTTGATCGTGATCGCGTTGGCCTTTTACCTGCGCGCCAAAGTGACTTCGA
CGGATGTGCCAGGCGGGGTGCAGTTGTTTTTTGAGGCGATCACCATTCAGATGCGCAATCAGGTCGAAAGCGCCATCGGG
ATGCGGATCGCACCCTTCGTGCTGCCGCTGGCGGTGACCATCTTCGTGTTCATCCTGATCTCCAACTGGCTGGCAGTCCT
CCCGGTGCAGTACACCGATAAACACGGGCACACCACCGAGTTGCTCAAATCGGCAGCAGCGGACATCAATTACGTGCTGG
CGCTGGCGCTTTTCGTGTTCGTCTGCTACCACACGGCCGGTATTTGGCGGCGCGGTATTGTCGGACACCCGATCAAGTTG
CTGAAAGGGCACGTGACGCTCCTCGCGCCGATCAACCTTGTCGAAGAAGTCGCCAAGCCAATCTCGTTGTCGCTCCGACT
TTTCGGCAACATTTTCGCCGGCGGCATTCTGGTCGCACTGATCGCGCTCTTTCCCCCCTACATCATGTGGGCGCCCAATG
CGATCTGGAAAGCATTTGACCTGTTCGTCGGCGCAATCCAGGCCTTCATTTTTGCGCTGCTGACAATTTTGTACTTCAGC
CAAGCGATGGAGCTCGAAGAGGAACACCACTAG

Upstream 100 bases:

>100_bases
CTGCCGGTCCTGAAGAAGCTGCGCACTGCGACCGAGGAACCGGTCGCAACTTATTCTTCCAATGGCCAGACCGGGGGATC
GGAAGGAAGGAGCGCCAGCG

Downstream 100 bases:

>100_bases
TACCGGATGCTGGTAACGGCTACCAGAGCCATCAAGGAGGATAAGGAAATGGACCCCACTATCGCTGCCGGCGCCCTCAT
CGGCGGTGGACTGATCATGG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTETILAAQIEVGEHHTATWLGMTVNTDTVLSTAIAGLIVIALAFYLRAKVTSTDVPGGVQLFFEAITIQMRNQVESAIG
MRIAPFVLPLAVTIFVFILISNWLAVLPVQYTDKHGHTTELLKSAAADINYVLALALFVFVCYHTAGIWRRGIVGHPIKL
LKGHVTLLAPINLVEEVAKPISLSLRLFGNIFAGGILVALIALFPPYIMWAPNAIWKAFDLFVGAIQAFIFALLTILYFS
QAMELEEEHH

Sequences:

>Translated_250_residues
MTETILAAQIEVGEHHTATWLGMTVNTDTVLSTAIAGLIVIALAFYLRAKVTSTDVPGGVQLFFEAITIQMRNQVESAIG
MRIAPFVLPLAVTIFVFILISNWLAVLPVQYTDKHGHTTELLKSAAADINYVLALALFVFVCYHTAGIWRRGIVGHPIKL
LKGHVTLLAPINLVEEVAKPISLSLRLFGNIFAGGILVALIALFPPYIMWAPNAIWKAFDLFVGAIQAFIFALLTILYFS
QAMELEEEHH
>Mature_249_residues
TETILAAQIEVGEHHTATWLGMTVNTDTVLSTAIAGLIVIALAFYLRAKVTSTDVPGGVQLFFEAITIQMRNQVESAIGM
RIAPFVLPLAVTIFVFILISNWLAVLPVQYTDKHGHTTELLKSAAADINYVLALALFVFVCYHTAGIWRRGIVGHPIKLL
KGHVTLLAPINLVEEVAKPISLSLRLFGNIFAGGILVALIALFPPYIMWAPNAIWKAFDLFVGAIQAFIFALLTILYFSQ
AMELEEEHH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=212, Percent_Identity=34.9056603773585, Blast_Score=94, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_MYCBO (P63655)

Other databases:

- EMBL:   BX248338
- RefSeq:   NP_854990.1
- ProteinModelPortal:   P63655
- SMR:   P63655
- EnsemblBacteria:   EBMYCT00000015471
- GeneID:   1090621
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1336
- GeneTree:   EBGT00050000016888
- HOGENOM:   HBG734175
- OMA:   LPWWSQF
- ProtClustDB:   PRK05815
- BioCyc:   MBOV233413:MB1336-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 27467; Mature: 27336

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ad4bd04)-; HASH(0x1e357b84)-; HASH(0x1e262aec)-; HASH(0x1e0c93f4)-; HASH(0x1da936ac)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETILAAQIEVGEHHTATWLGMTVNTDTVLSTAIAGLIVIALAFYLRAKVTSTDVPGGV
CCCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
QLFFEAITIQMRNQVESAIGMRIAPFVLPLAVTIFVFILISNWLAVLPVQYTDKHGHTTE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
LLKSAAADINYVLALALFVFVCYHTAGIWRRGIVGHPIKLLKGHVTLLAPINLVEEVAKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHEEHHHHHHHHHHHH
ISLSLRLFGNIFAGGILVALIALFPPYIMWAPNAIWKAFDLFVGAIQAFIFALLTILYFS
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAMELEEEHH
HHHHHHHCCH
>Mature Secondary Structure 
TETILAAQIEVGEHHTATWLGMTVNTDTVLSTAIAGLIVIALAFYLRAKVTSTDVPGGV
CCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
QLFFEAITIQMRNQVESAIGMRIAPFVLPLAVTIFVFILISNWLAVLPVQYTDKHGHTTE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
LLKSAAADINYVLALALFVFVCYHTAGIWRRGIVGHPIKLLKGHVTLLAPINLVEEVAKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHEEHHHHHHHHHHHH
ISLSLRLFGNIFAGGILVALIALFPPYIMWAPNAIWKAFDLFVGAIQAFIFALLTILYFS
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAMELEEEHH
HHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972