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The map label for this gene is betA [C]

Identifier: 148661066

GI number: 148661066

Start: 1431372

End: 1432958

Strand: Direct

Name: betA [C]

Synonym: MRA_1287

Alternate gene names: 148661066

Gene position: 1431372-1432958 (Clockwise)

Preceding gene: 148661065

Following gene: 148661071

Centisome position: 32.38

GC content: 65.28

Gene sequence:

>1587_bases
ATGGACACTCAGAGCGACTACGTCGTGGTCGGTACCGGCTCAGCCGGGGCGGTTGTGGCCAGCCGGCTTAGCACCGATCC
GGCCACGACGGTGGTGGCCCTGGAGGCGGGGCCGCGTGACAAGAACAGATTCATCGGCGTCCCAGCGGCGTTTTCCAAGC
TGTTCCGCAGCGAGATCGACTGGGATTACCTAACCGAACCGCAGCCGGAGCTCGACGGCCGCGAAATCTATTGGCCTCGT
GGCAAGGTGCTCGGTGGCTCGTCGTCCATGAACGCAATGATGTGGGTGCGTGGATTCGCATCAGACTACGATGAGTGGGC
CGCGCGAGCCGGTCCGCGGTGGTCGTACGCCGACGTGCTCGGCTACTTTCGCCGCATCGAGAACGTCACCGCTGCCTGGC
ACTTTGTCAGCGGTGACGACAGCGGAGTAACCGGTCCGTTGCATATTTCCCGGCAACGCAGCCCAAGATCGGTGACCGCA
GCGTGGCTGGCAGCCGCACGTGAGTGCGGATTTGCCGCTGCGCGGCCGAATTCCCCTCGACCGGAAGGCTTTTGCGAGAC
CGTCGTCACCCAGCGCCGCGGTGCTCGATTCAGTACTGCCGACGCCTATCTGAAGCCCGCGATGCGCCGTAAAAACCTCC
GTGTGCTTACCGGCGCCACTGCTACCCGGGTGGTCATCGACGGCGACCGGGCCGTCGGCGTGGAATACCAAAGCGACGGT
CAAACCCGCATCGTCTACGCCCGCCGCGAGGTGGTGCTCTGCGCTGGTGCCGTCAACAGCCCTCAGCTGCTGATGCTCTC
CGGCATCGGCGACCGCGACCACCTCGCCGAACACGACATCGACACCGTTTACCACGCGCCCGAGGTCGGGTGCAACCTGC
TCGATCATCTCGTCACGGTGCTGGGTTTCGACGTCGAAAAGGACAGCTTGTTTGCCGCCGAGAAGCCCGGCCAGTTGATC
AGCTACTTACTGCGACGCCGCGGCATGCTCACCTCCAACGTCGGCGAGGCGTACGGATTTGTCCGCAGCCGACCCGAACT
GAAGCTGCCCGATTTGGAGTTGATTTTTGCCCCGGCGCCGTTTTACGACGAAGCGCTGGTTCCACCGGCTGGTCACGGTG
TGGTATTCGGCCCGATTCTGGTCGCGCCGCAAAGCCGTGGCCAGATCACGCTGCGGTCCGCCGATCCGCATGCCAAGCCT
GTCATCGAACCGCGTTACCTGTCCGATCTCGGTGGCGTAGACCGGGCCGCCATGATGGCGGGCCTGCGGATATGCGCGCG
GATCGCGCAGGCCCGCCCGCTCAGAGATCTCCTTGGGTCCATCGCGCGACCGCGCAACAGCACCGAGCTGGACGAGGCCA
CTCTCGAGTTGGCGCTGGCCACTTGTTCGCACACCCTGTACCACCCGATGGGCACCTGCCGCATGGGCAGCGACGAGGCC
AGCGTGGTGGATCCGCAGCTGCGGGTCCGCGGTGTCGACGGACTCCGCGTCGCCGACGCGTCGGTGATGCCCAGCACGGT
TCGTGGGCATACGCATGCGCCGTCGGTGCTGATCGGGGAGAAGGCCGCCGACTTAATCCGCAGCTGA

Upstream 100 bases:

>100_bases
TGATCGTGCTGACGTGCAGTCCCACCCGATACGGCGGTGTCAAAGGAGCGCACCGCATCGATCTGGACGCCATACAGTGA
GCCCGAAACGGGGACATGCG

Downstream 100 bases:

>100_bases
GCTGGTCGCCGCCGGCTCAGCGTCGCATGAACCCGATGGCGGTGTAGTCCAGGTCTGCCAGACCCGTCGCGCCGAAGTTG
GCCAGCGTGCTGCGGACCGC

Product: putative dehydrogenase FAD flavoprotein GMC oxidoreductase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPR
GKVLGGSSSMNAMMWVRGFASDYDEWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTA
AWLAAARECGFAAARPNSPRPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDGDRAVGVEYQSDG
QTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQLI
SYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAPFYDEALVPPAGHGVVFGPILVAPQSRGQITLRSADPHAKP
VIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSDEA
SVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS

Sequences:

>Translated_528_residues
MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPR
GKVLGGSSSMNAMMWVRGFASDYDEWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTA
AWLAAARECGFAAARPNSPRPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDGDRAVGVEYQSDG
QTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQLI
SYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAPFYDEALVPPAGHGVVFGPILVAPQSRGQITLRSADPHAKP
VIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSDEA
SVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS
>Mature_528_residues
MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPR
GKVLGGSSSMNAMMWVRGFASDYDEWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTA
AWLAAARECGFAAARPNSPRPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDGDRAVGVEYQSDG
QTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQLI
SYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAPFYDEALVPPAGHGVVFGPILVAPQSRGQITLRSADPHAKP
VIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSDEA
SVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family

Homologues:

Organism=Homo sapiens, GI217272839, Length=546, Percent_Identity=40.1098901098901, Blast_Score=347, Evalue=2e-95,
Organism=Escherichia coli, GI1786503, Length=545, Percent_Identity=38.1651376146789, Blast_Score=298, Evalue=5e-82,
Organism=Caenorhabditis elegans, GI17532301, Length=557, Percent_Identity=34.2908438061041, Blast_Score=305, Evalue=6e-83,
Organism=Drosophila melanogaster, GI24642042, Length=564, Percent_Identity=37.5886524822695, Blast_Score=327, Evalue=2e-89,
Organism=Drosophila melanogaster, GI45549471, Length=571, Percent_Identity=36.9527145359019, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI45551458, Length=571, Percent_Identity=36.9527145359019, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI24642055, Length=569, Percent_Identity=36.3796133567663, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24650267, Length=569, Percent_Identity=36.0281195079086, Blast_Score=299, Evalue=2e-81,
Organism=Drosophila melanogaster, GI17137792, Length=552, Percent_Identity=36.7753623188406, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI24642059, Length=563, Percent_Identity=35.7015985790409, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24642048, Length=569, Percent_Identity=33.9191564147627, Blast_Score=291, Evalue=7e-79,
Organism=Drosophila melanogaster, GI24642039, Length=566, Percent_Identity=34.2756183745583, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI18859995, Length=569, Percent_Identity=32.688927943761, Blast_Score=256, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24642037, Length=570, Percent_Identity=34.2105263157895, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24642051, Length=563, Percent_Identity=33.0373001776199, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24642035, Length=571, Percent_Identity=31.8739054290718, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI18859993, Length=566, Percent_Identity=31.8021201413428, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24642057, Length=584, Percent_Identity=27.9109589041096, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24645930, Length=574, Percent_Identity=28.5714285714286, Blast_Score=145, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1279_MYCTU (P64263)

Other databases:

- EMBL:   BX842576
- EMBL:   AE000516
- PIR:   G70755
- RefSeq:   NP_215795.1
- RefSeq:   NP_335763.1
- ProteinModelPortal:   P64263
- EnsemblBacteria:   EBMYCT00000002176
- EnsemblBacteria:   EBMYCT00000071181
- GeneID:   887002
- GeneID:   923187
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1316
- KEGG:   mtu:Rv1279
- TIGR:   MT1316
- TubercuList:   Rv1279
- GeneTree:   EBGT00050000015739
- HOGENOM:   HBG734713
- OMA:   ADYDEWA
- ProtClustDB:   CLSK791075
- GO:   GO:0005829
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867
- PIRSF:   PIRSF000137

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 57332; Mature: 57332

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00623 GMC_OXRED_1; PS00624 GMC_OXRED_2

Important sites: ACT_SITE 468-468

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFIGVPAAFSKLFRSEID
CCCCCCEEEEECCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCEEECHHHHHHHHHHCCC
WDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMMWVRGFASDYDEWAARAGPRWSYADVL
CCCCCCCCCCCCCCEEECCCCCEECCCCCCCHHHHHHHHHCCHHHHHHCCCCCCCHHHHH
GYFRRIENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSPR
HHHHHHHCCEEEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
PEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDGDRAVGVEYQSDG
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCEEEEEEECCCEEEEEECCCC
QTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTV
CEEEEEEEEEEEEEECCCCCCCEEEEECCCCHHHHHHCCCHHHHCCCHHHHHHHHHHHHH
LGFDVEKDSLFAAEKPGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAP
HCCCCCCCCEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCC
FYDEALVPPAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRAAMMA
CCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHH
GLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSDEA
HHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS
CEECCCCEEECCCCCEEECCCCCCHHHCCCCCCCCEEECCHHHHHHCC
>Mature Secondary Structure
MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFIGVPAAFSKLFRSEID
CCCCCCEEEEECCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCEEECHHHHHHHHHHCCC
WDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMMWVRGFASDYDEWAARAGPRWSYADVL
CCCCCCCCCCCCCCEEECCCCCEECCCCCCCHHHHHHHHHCCHHHHHHCCCCCCCHHHHH
GYFRRIENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSPR
HHHHHHHCCEEEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
PEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDGDRAVGVEYQSDG
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCEEEEEEECCCEEEEEECCCC
QTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTV
CEEEEEEEEEEEEEECCCCCCCEEEEECCCCHHHHHHCCCHHHHCCCHHHHHHHHHHHHH
LGFDVEKDSLFAAEKPGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAP
HCCCCCCCCEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCC
FYDEALVPPAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRAAMMA
CCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHH
GLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSDEA
HHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS
CEECCCCEEECCCCCEEECCCCCCHHHCCCCCCCCEEECCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036