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The map label for this gene is lldD1

Identifier: 148660469

GI number: 148660469

Start: 794641

End: 795831

Strand: Direct

Name: lldD1

Synonym: MRA_0702

Alternate gene names: 148660469

Gene position: 794641-795831 (Clockwise)

Preceding gene: 148660468

Following gene: 148660470

Centisome position: 17.98

GC content: 65.32

Gene sequence:

>1191_bases
GTGGCCGAAGCGTGGTTTGAAACGGTAGCCATCGCGCAGCAACGCGCGAAGCGGAGGCTGCCGAAATCGGTTTACTCGTC
CCTGATTGCGGCCAGTGAAAAGGGAATCACGGTCGCCGACAATGTCGCAGCATTCAGCGAGCTCGGGTTCGCGCCGCACG
TCATCGGGGCGACAGATAAACGTGACTTGTCGACGACCGTTATGGGGCAAGAAGTTTCGTTGCCAGTGATTATTTCGCCG
ACCGGTGTTCAGGCGGTCGATCCCGGCGGTGAAGTCGCCGTCGCGCGGGCCGCGGCCGCCCGGGGTACTGTGATGGGATT
GTCCTCGTTTGCCAGCAAGCCGATCGAGGAGGTCATTGCCGCCAACCCCAAGACCTTCTTCCAGGTCTACTGGCAGGGCG
GGCGCGACGCGCTCGCTGAACGCGTCGAACGGGCGCGGCAGGCCGGCGCGGTCGGCCTGGTCGTCACCACCGACTGGACG
TTCTCGCACGGGCGCGACTGGGGCAGCCCCAAGATCCCCGAAGAGATGAACTTGAAGACCATCCTGCGGCTATCCCCGGA
GGCGATCACCCGGCCGAGGTGGTTGTGGAAGTTCGCCAAGACGCTACGGCCACCGGACCTACGGGTGCCCAACCAGGGCC
GGCGCGGCGAGCCCGGCCCACCGTTCTTCGCAGCCTACGGCGAATGGATGGCAACACCTCCGCCGACCTGGGAAGATATC
GGCTGGCTGCGCGAACTGTGGGGCGGACCGTTCATGCTCAAGGGCGTCATGCGGGTCGACGATGCCAAAAGAGCTGTGGA
TGCCGGGGTTTCGGCGATCTCGGTATCCAACCATGGTGGCAACAATTTGGATGGGACGCCAGCATCGATCCGGGCCCTGC
CCGCGGTCTCGGCGGCGGTCGGCGATCAGGTCGAAGTGTTGCTCGACGGCGGCATCCGGCGGGGCAGCGATGTCGTCAAG
GCGGTGGCGCTGGGCGCGCGCGCGGTAATGATTGGTCGCGCTTACCTGTGGGGCTTGGCCGCCAACGGCCAAGCCGGGGT
CGAGAATGTACTCGACATCCTGCGCGGTGGTATCGACTCGGCTCTGATGGGTCTCGGGCATGCCTCTGTCCATGACCTCA
GCCCAGCCGACATCCTCGTTCCCACCGGGTTCATCCGCGACCTGGGTGTGCCCTCCCGACGGGACGTTTAG

Upstream 100 bases:

>100_bases
GCGCCGACCACTCCCGCGGTCGGCGCGTCAGCAAACCGGTGCCCCTGACGCTGTCGATGCGGCCACCCAAGCGCCCGTGC
AATGAAAGTCCGGTGTAGCC

Downstream 100 bases:

>100_bases
CCGGATGTTGAGCTGGGCCCAAATTGGGGTTGGCCCTCCCATTACCACAGAGATGCTCGCGACGGAATGACGTTTTTAGA
AATTCTGATACGGGCGTGGC

Product: FMN-dependent alpha-hydroxy acid dehydrogenase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MAEAWFETVAIAQQRAKRRLPKSVYSSLIAASEKGITVADNVAAFSELGFAPHVIGATDKRDLSTTVMGQEVSLPVIISP
TGVQAVDPGGEVAVARAAAARGTVMGLSSFASKPIEEVIAANPKTFFQVYWQGGRDALAERVERARQAGAVGLVVTTDWT
FSHGRDWGSPKIPEEMNLKTILRLSPEAITRPRWLWKFAKTLRPPDLRVPNQGRRGEPGPPFFAAYGEWMATPPPTWEDI
GWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAVSAAVGDQVEVLLDGGIRRGSDVVK
AVALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDSALMGLGHASVHDLSPADILVPTGFIRDLGVPSRRDV

Sequences:

>Translated_396_residues
MAEAWFETVAIAQQRAKRRLPKSVYSSLIAASEKGITVADNVAAFSELGFAPHVIGATDKRDLSTTVMGQEVSLPVIISP
TGVQAVDPGGEVAVARAAAARGTVMGLSSFASKPIEEVIAANPKTFFQVYWQGGRDALAERVERARQAGAVGLVVTTDWT
FSHGRDWGSPKIPEEMNLKTILRLSPEAITRPRWLWKFAKTLRPPDLRVPNQGRRGEPGPPFFAAYGEWMATPPPTWEDI
GWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAVSAAVGDQVEVLLDGGIRRGSDVVK
AVALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDSALMGLGHASVHDLSPADILVPTGFIRDLGVPSRRDV
>Mature_395_residues
AEAWFETVAIAQQRAKRRLPKSVYSSLIAASEKGITVADNVAAFSELGFAPHVIGATDKRDLSTTVMGQEVSLPVIISPT
GVQAVDPGGEVAVARAAAARGTVMGLSSFASKPIEEVIAANPKTFFQVYWQGGRDALAERVERARQAGAVGLVVTTDWTF
SHGRDWGSPKIPEEMNLKTILRLSPEAITRPRWLWKFAKTLRPPDLRVPNQGRRGEPGPPFFAAYGEWMATPPPTWEDIG
WLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAVSAAVGDQVEVLLDGGIRRGSDVVKA
VALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDSALMGLGHASVHDLSPADILVPTGFIRDLGVPSRRDV

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain

Homologues:

Organism=Homo sapiens, GI11068137, Length=372, Percent_Identity=38.1720430107527, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI54234014, Length=368, Percent_Identity=33.9673913043478, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI7705393, Length=368, Percent_Identity=33.9673913043478, Blast_Score=196, Evalue=3e-50,
Organism=Escherichia coli, GI1790033, Length=366, Percent_Identity=34.4262295081967, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI193208036, Length=361, Percent_Identity=34.0720221606648, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI32566217, Length=278, Percent_Identity=29.136690647482, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323587, Length=390, Percent_Identity=28.7179487179487, Blast_Score=146, Evalue=5e-36,
Organism=Drosophila melanogaster, GI78707188, Length=378, Percent_Identity=31.4814814814815, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI281363140, Length=378, Percent_Identity=31.4814814814815, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI78707190, Length=378, Percent_Identity=31.4814814814815, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LLDD1_MYCTU (P95040)

Other databases:

- EMBL:   BX842574
- EMBL:   AE000516
- PIR:   A70641
- RefSeq:   NP_215208.1
- RefSeq:   NP_335136.1
- HSSP:   P05414
- ProteinModelPortal:   P95040
- SMR:   P95040
- EnsemblBacteria:   EBMYCT00000002905
- EnsemblBacteria:   EBMYCT00000069734
- GeneID:   888310
- GeneID:   926009
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0721
- KEGG:   mtu:Rv0694
- TIGR:   MT0721
- TubercuList:   Rv0694
- GeneTree:   EBGT00050000016192
- HOGENOM:   HBG517781
- OMA:   LIVTTDW
- ProtClustDB:   CLSK871846
- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000138

Pfam domain/function: PF01070 FMN_dh

EC number: =1.1.2.3

Molecular weight: Translated: 42162; Mature: 42030

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH_1; PS51349 FMN_HYDROXY_ACID_DH_2

Important sites: ACT_SITE 278-278 BINDING 108-108 BINDING 128-128 BINDING 130-130 BINDING 156-156 BINDING 165-165 BINDING 254-254

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAWFETVAIAQQRAKRRLPKSVYSSLIAASEKGITVADNVAAFSELGFAPHVIGATDK
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCCEECCCCCC
RDLSTTVMGQEVSLPVIISPTGVQAVDPGGEVAVARAAAARGTVMGLSSFASKPIEEVIA
CCCHHHCCCCCCCCEEEECCCCCEEECCCCCEEHHHHHHHCCHHHHHHHHHCCCHHHHHH
ANPKTFFQVYWQGGRDALAERVERARQAGAVGLVVTTDWTFSHGRDWGSPKIPEEMNLKT
CCCHHEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHH
ILRLSPEAITRPRWLWKFAKTLRPPDLRVPNQGRRGEPGPPFFAAYGEWMATPPPTWEDI
HEEECHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHH
GWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAVSAAV
HHHHHHHCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
GDQVEVLLDGGIRRGSDVVKAVALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDS
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHCCHHH
ALMGLGHASVHDLSPADILVPTGFIRDLGVPSRRDV
HHHHCCCCCCCCCCCCCEEECCHHHHHCCCCCCCCC
>Mature Secondary Structure 
AEAWFETVAIAQQRAKRRLPKSVYSSLIAASEKGITVADNVAAFSELGFAPHVIGATDK
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCCEECCCCCC
RDLSTTVMGQEVSLPVIISPTGVQAVDPGGEVAVARAAAARGTVMGLSSFASKPIEEVIA
CCCHHHCCCCCCCCEEEECCCCCEEECCCCCEEHHHHHHHCCHHHHHHHHHCCCHHHHHH
ANPKTFFQVYWQGGRDALAERVERARQAGAVGLVVTTDWTFSHGRDWGSPKIPEEMNLKT
CCCHHEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHH
ILRLSPEAITRPRWLWKFAKTLRPPDLRVPNQGRRGEPGPPFFAAYGEWMATPPPTWEDI
HEEECHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHH
GWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAVSAAV
HHHHHHHCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
GDQVEVLLDGGIRRGSDVVKAVALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDS
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHCCHHH
ALMGLGHASVHDLSPADILVPTGFIRDLGVPSRRDV
HHHHCCCCCCCCCCCCCEEECCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036