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The map label for this gene is fadR [C]

Identifier: 148660355

GI number: 148660355

Start: 685720

End: 686442

Strand: Direct

Name: fadR [C]

Synonym: MRA_0593

Alternate gene names: 148660355

Gene position: 685720-686442 (Clockwise)

Preceding gene: 148660353

Following gene: 148660356

Centisome position: 15.51

GC content: 62.79

Gene sequence:

>723_bases
ATGGCGCTGCAGCCGGTGACTCGCCGATCGGTGCCCGAAGAGGTCTTCGAGCAGATCGCTACCGATGTGCTCACCGGCGA
GATGCCGCCCGGCGAGGCGTTGCCCAGCGAGCGTCGGTTGGCTGAGTTGCTCGGAGTGTCGCGACCCGCGGTCCGCGAGG
CGCTCAAACGGCTGTCGGCCGCAGGTCTGGTCGAGGTGCGTCAGGGCGACGTCACCACCGTGCGTGACTTCCGGCGGCAC
GCCGGCCTGGATCTGTTGCCCCGATTGTTGTTTCGCAACGGTGAGCTGGATATCTCCGTCGTCCGCAGCATCCTCGAGGC
CCGGCTGCGCAATTTTCCGAAGGTCGCGGAACTAGCGGCCGAACGGAACGAGCCCGAGTTGGCGGAATTGCTGCAGGATT
CGCTGCGTGCGCTGGACACTGAGGAAGATCCGATCGTGTGGCAACGCCACACGCTCGACTTTTGGGATCATGTGGTCGAC
AGCGCCGGTTCGATCGTAGATCGATTGATGTACAACGCATTTCGTGCTGCTTACGAGCCGACGCTAGCTGCTCTGACCAC
CACGATGACCGCTGCGGCTAAGCGTCCGTCGGACTACCGGAAACTCGCGGATGCGATCTGCTCAGGTGATCCCACCGGAG
CGAAGAAAGCCGCCCAAGACCTACTCGAACTTGCGAACACATCGTTGATGGCCGTACTCGTTAGCCAGGCGAGTCGGCAA
TGA

Upstream 100 bases:

>100_bases
GGTGCCGTTTCGCGGCTCCGCGGACAACTTAGCCCGATAACTGCGTGGGGTGTCGGTCTGACCACTTGACGTCTTACCAA
TCTTCATTCACACTGGGCGC

Downstream 100 bases:

>100_bases
CCACCCACGCCGTGATCATCACCTATCTCCGCGACCAGACGCAGCCCGCCGTCGATGCGATCGGCGGGTTCTACCGGACA
TGCGTACTGACTGGCAAGGC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MALQPVTRRSVPEEVFEQIATDVLTGEMPPGEALPSERRLAELLGVSRPAVREALKRLSAAGLVEVRQGDVTTVRDFRRH
AGLDLLPRLLFRNGELDISVVRSILEARLRNFPKVAELAAERNEPELAELLQDSLRALDTEEDPIVWQRHTLDFWDHVVD
SAGSIVDRLMYNAFRAAYEPTLAALTTTMTAAAKRPSDYRKLADAICSGDPTGAKKAAQDLLELANTSLMAVLVSQASRQ

Sequences:

>Translated_240_residues
MALQPVTRRSVPEEVFEQIATDVLTGEMPPGEALPSERRLAELLGVSRPAVREALKRLSAAGLVEVRQGDVTTVRDFRRH
AGLDLLPRLLFRNGELDISVVRSILEARLRNFPKVAELAAERNEPELAELLQDSLRALDTEEDPIVWQRHTLDFWDHVVD
SAGSIVDRLMYNAFRAAYEPTLAALTTTMTAAAKRPSDYRKLADAICSGDPTGAKKAAQDLLELANTSLMAVLVSQASRQ
>Mature_239_residues
ALQPVTRRSVPEEVFEQIATDVLTGEMPPGEALPSERRLAELLGVSRPAVREALKRLSAAGLVEVRQGDVTTVRDFRRHA
GLDLLPRLLFRNGELDISVVRSILEARLRNFPKVAELAAERNEPELAELLQDSLRALDTEEDPIVWQRHTLDFWDHVVDS
AGSIVDRLMYNAFRAAYEPTLAALTTTMTAAAKRPSDYRKLADAICSGDPTGAKKAAQDLLELANTSLMAVLVSQASRQ

Specific function: Multifunctional Regulator Of Fatty Acid Metabolism. Represses Transcription Of At Least Eight Genes Required For Fatty Acid Transport And Beta-Oxidation Among Which Fada, Fadb, Fadd, Fadl And Fade. Activates Transcription Of At Least Three Genes Required

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787436, Length=113, Percent_Identity=32.7433628318584, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y586_MYCTU (P67741)

Other databases:

- EMBL:   BX842574
- EMBL:   AE000516
- PIR:   E70907
- RefSeq:   NP_215100.1
- RefSeq:   NP_335025.1
- ProteinModelPortal:   P67741
- EnsemblBacteria:   EBMYCT00000001148
- EnsemblBacteria:   EBMYCT00000070519
- GeneID:   887754
- GeneID:   925010
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0615
- KEGG:   mtu:Rv0586
- TIGR:   MT0615
- TubercuList:   Rv0586
- GeneTree:   EBGT00050000014626
- HOGENOM:   HBG700007
- ProtClustDB:   CLSK790614
- GO:   GO:0005622
- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00035
- SMART:   SM00895
- SMART:   SM00345

Pfam domain/function: PF07729 FCD; PF00392 GntR

EC number: NA

Molecular weight: Translated: 26510; Mature: 26378

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQPVTRRSVPEEVFEQIATDVLTGEMPPGEALPSERRLAELLGVSRPAVREALKRLSA
CCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
AGLVEVRQGDVTTVRDFRRHAGLDLLPRLLFRNGELDISVVRSILEARLRNFPKVAELAA
HCHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
ERNEPELAELLQDSLRALDTEEDPIVWQRHTLDFWDHVVDSAGSIVDRLMYNAFRAAYEP
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLAALTTTMTAAAKRPSDYRKLADAICSGDPTGAKKAAQDLLELANTSLMAVLVSQASRQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALQPVTRRSVPEEVFEQIATDVLTGEMPPGEALPSERRLAELLGVSRPAVREALKRLSA
CCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
AGLVEVRQGDVTTVRDFRRHAGLDLLPRLLFRNGELDISVVRSILEARLRNFPKVAELAA
HCHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
ERNEPELAELLQDSLRALDTEEDPIVWQRHTLDFWDHVVDSAGSIVDRLMYNAFRAAYEP
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLAALTTTMTAAAKRPSDYRKLADAICSGDPTGAKKAAQDLLELANTSLMAVLVSQASRQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA; DNA [C]

Specific reaction: Activates transcription of at least two genes required for unsaturated fatty acid biosynthesis; activates the iclR gene encoding the transcription regulator of the aceBAKoperon which in turn encodes the glyoxylate shunt enzymes Protein + DNA = Protein-DN

General reaction: NA

Inhibitor: Fatty acyl CoA compounds [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036