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The map label for this gene is nrdZ

Identifier: 148660339

GI number: 148660339

Start: 662605

End: 664683

Strand: Direct

Name: nrdZ

Synonym: MRA_0577

Alternate gene names: 148660339

Gene position: 662605-664683 (Clockwise)

Preceding gene: 148660338

Following gene: 148660345

Centisome position: 14.99

GC content: 67.39

Gene sequence:

>2079_bases
GTGGGTGTCAGCTGGCCGGCGAAAGTCCGGCGCCGGGATGGAACGCTGGTGCCGTTCGACATCGCGCGGATCGAAGCAGC
GGTGACGCGGGCAGCGCGCGAGGTGGCTTGCGACGACCCCGATATGCCGGGCACCGTAGCGAAAGCCGTCGCCGACGCAC
TCGGGCGCGGTATCGCTCCCGTTGAGGACATTCAGGACTGCGTGGAGGCCCGGCTGGGGGAAGCCGGTCTGGATGACGTG
GCCCGTGTTTACATCATCTACCGGCAGCGGCGCGCCGAGCTGCGGACGGCTAAGGCCTTGCTCGGCGTGCGGGACGAGTT
AAAGCTGAGCTTGGCGGCCGTGACGGTACTGCGCGAGCGCTATCTGCTGCACGACGAGCAGGGCCGGCCGGCCGAGTCGA
CCGGCGAGCTGATGGACCGATCGGCGCGCTGTGTCGCGGCGGCCGAGGACCAGTATGAGCCGGGCTCGTCGAGGCGGTGG
GCCGAGCGGTTCGCCACGCTATTACGCAACCTGGAATTCCTGCCGAATTCGCCCACGTTGATGAACTCTGGCACCGACCT
GGGACTGCTCGCCGGCTGTTTTGTTCTGCCGATTGAGGATTCGCTGCAATCGATCTTTGCGACGCTGGGACAGGCCGCCG
AGCTGCAGCGGGCTGGAGGCGGCACCGGATATGCGTTCAGCCACCTGCGACCCGCCGGGGATCGGGTGGCCTCCACGGGC
GGCACGGCCAGCGGACCGGTGTCGTTTCTACGGCTGTATGACAGTGCCGCGGGTGTGGTCTCCATGGGCGGTCGCCGGCG
TGGCGCCTGTATGGCTGTGCTTGATGTGTCGCACCCGGATATCTGTGATTTCGTCACCGCCAAGGCCGAATCCCCCAGCG
AGCTCCCGCATTTCAACCTATCGGTTGGTGTGACCGACGCGTTCCTGCGGGCCGTCGAACGCAACGGCCTACACCGGCTG
GTCAATCCGCGAACCGGCAAGATCGTCGCGCGGATGCCCGCCGCCGAGCTGTTCGACGCCATCTGCAAAGCCGCGCACGC
CGGTGGCGATCCCGGGCTGGTGTTTCTCGACACGATCAATAGGGCAAACCCGGTGCCGGGGAGAGGCCGCATCGAGGCGA
CCAACCCGTGCGGGGAGGTCCCACTGCTGCCTTACGAGTCATGTAATCTCGGCTCGATCAACCTCGCCCGGATGCTCGCC
GACGGTCGCGTCGACTGGGACCGGCTCGAGGAGGTCGCCGGTGTGGCGGTGCGGTTCCTTGATGACGTCATCGATGTCAG
CCGCTACCCCTTCCCCGAACTGGGTGAGGCGGCCCGCGCCACCCGCAAGATCGGGCTGGGAGTCATGGGTTTGGCGGAAC
TGCTTGCCGCACTGGGTATTCCGTACGACAGTGAAGAAGCCGTGCGGTTAGCCACCCGGCTCATGCGTCGCATACAGCAG
GCGGCGCACACGGCATCGCGGAGGCTGGCCGAAGAGCGGGGCGCATTCCCGGCGTTCACCGATAGCCGGTTCGCGCGGTC
GGGCCCGAGGCGCAACGCACAGGTCACCTCCGTCGCTCCGACGGGCACCATCTCACTGATCGCCGGAACCACCGCGGGCA
TCGAGCCGATGTTCGCTATCGCGTTCACCCGCGCCATCGTCGGCCGGCATCTGCTGGAGGTCAATCCGTGCTTCGACCGA
CTGGCCCGCGATCGGGGCTTTTATCGTGACGAGCTGATCGCCGAGATCGCTCAGCGTGGCGGAGTCCGTGGCTATCCGCG
GCTGCCTGCTGAGGTGCGGGCCGCGTTCCCGACCGCGGCGGAGATCGCGCCGCAGTGGCATCTGCGCATGCAGGCCGCGG
TGCAGCGCCACGTCGAGGCCGCCGTGTCCAAGACGGTCAACTTGCCCGCCACGGCGACGGTCGATGACGTCCGCGCCATC
TATGTGGCCGCCTGGAAGGCAAAGGTCAAGGGCATCACGGTGTATCGCTACGGCAGCCGGGAAGGACAGGTACTGTCCTA
CGCCGCGCCGAAACCGCTACTGGCGCAGGCTGACACGGAGTTCAGCGGCGGCTGTGCGGGCCGCTCCTGCGAGTTCTGA

Upstream 100 bases:

>100_bases
AATGCGGCCGACGAGCGGGCGCAGCATCGGTTCGGCGCGGTTCAGTCGGCGATCCTCCATGCCAGGGGAACGTAGGCGAT
TCGCTCAAGCGACGAAGTCG

Downstream 100 bases:

>100_bases
CGGCGGCTCCCATGGCGCGAGCAGACGCAGAATCGCACAAAATCAGCGATTTTGATGCGATTCTGCGTCTGCTCGCGCAG
GGATCGCAGGGATCACCCCG

Product: putative ribonucleoside-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAPVEDIQDCVEARLGEAGLDDV
ARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRW
AERFATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG
GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRL
VNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLA
DGRVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ
AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTRAIVGRHLLEVNPCFDR
LARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAI
YVAAWKAKVKGITVYRYGSREGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF

Sequences:

>Translated_692_residues
MGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAPVEDIQDCVEARLGEAGLDDV
ARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRW
AERFATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG
GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRL
VNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLA
DGRVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ
AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTRAIVGRHLLEVNPCFDR
LARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAI
YVAAWKAKVKGITVYRYGSREGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF
>Mature_691_residues
GVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAPVEDIQDCVEARLGEAGLDDVA
RVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWA
ERFATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGG
TASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLV
NPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLAD
GRVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQA
AHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTRAIVGRHLLEVNPCFDRL
ARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIY
VAAWKAKVKGITVYRYGSREGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain

Homologues:

Organism=Homo sapiens, GI4506749, Length=552, Percent_Identity=27.3550724637681, Blast_Score=209, Evalue=5e-54,
Organism=Escherichia coli, GI1789030, Length=578, Percent_Identity=27.1626297577855, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI2367133, Length=555, Percent_Identity=22.7027027027027, Blast_Score=106, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17555242, Length=541, Percent_Identity=27.1719038817006, Blast_Score=193, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6322123, Length=661, Percent_Identity=26.6263237518911, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320914, Length=669, Percent_Identity=27.8026905829596, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI17352481, Length=551, Percent_Identity=25.5898366606171, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NRDZ_MYCTU (O53767)

Other databases:

- EMBL:   BX842573
- EMBL:   AE000516
- PIR:   A70933
- RefSeq:   NP_215084.1
- RefSeq:   NP_335005.1
- ProteinModelPortal:   O53767
- SMR:   O53767
- EnsemblBacteria:   EBMYCT00000000981
- EnsemblBacteria:   EBMYCT00000071101
- GeneID:   887666
- GeneID:   924988
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0596
- KEGG:   mtu:Rv0570
- TIGR:   MT0596
- TubercuList:   Rv0570
- GeneTree:   EBGT00050000017700
- HOGENOM:   HBG646512
- OMA:   YNSKEGY
- ProtClustDB:   CLSK790600
- GO:   GO:0005829
- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926
- PANTHER:   PTHR11573
- PRINTS:   PR01183
- TIGRFAMs:   TIGR02504

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN; SSF48168 Ribonucleo_red_N

EC number: =1.17.4.1

Molecular weight: Translated: 74522; Mature: 74391

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS51161 ATP_CONE; PS00089 RIBORED_LARGE

Important sites: ACT_SITE 375-375 ACT_SITE 377-377 ACT_SITE 379-379 BINDING 177-177 BINDING 221-221

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP
CCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL
HHHCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG
ECCCCCHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHCCC
GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL
CCCCCHHHHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCEE
SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN
EECHHHHHHHHHHHCCHHHHCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEEEECC
RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ
HHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI
HHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCCHHHHH
AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA
HHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHH
EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCC
EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF
CCCEEEECCCCCCHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP
CCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL
HHHCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG
ECCCCCHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHCCC
GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL
CCCCCHHHHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCEE
SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN
EECHHHHHHHHHHHCCHHHHCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEEEECC
RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ
HHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI
HHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCCHHHHH
AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA
HHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHH
EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCC
EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF
CCCEEEECCCCCCHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036