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The map label for this gene is acr1 [H]

Identifier: 148660316

GI number: 148660316

Start: 639342

End: 640349

Strand: Reverse

Name: acr1 [H]

Synonym: MRA_0554

Alternate gene names: 148660316

Gene position: 640349-639342 (Counterclockwise)

Preceding gene: 148660317

Following gene: 148660315

Centisome position: 14.49

GC content: 65.48

Gene sequence:

>1008_bases
CTGGAGCCCGTTTCCGCGCTATTTCTAACGCGGCCGTTCGCCGAGGCTGTAGTTGCCGAGCAGAAGCCCGACGAGTGGGA
CACCACAGTAACTACAGGCTCGGCAAAACTAGACTCCCCAGCTGTGAGCAAAAGACCGCTGCGCTGGTTGACTGAACAAA
TCACATTGGCCGGCATGCGGCCACCAATTTCGCCGCAACTGCTGATCAACCGGCCCGCGATGCAACCCGTCGACCTCACC
GGCAAGCGCATCCTGCTCACCGGCGCGTCGTCAGGCATCGGTGCGGCCGCGACCAAACAGTTCGGACTGCACCGCGCCGT
CGTGGTTGCCGTCGCGCGCCGTAAGGATCTGCTGGATGCGGTGGCGGACCGGATCACCGGCGACGGCGGCACGGCGATGT
CGCTCCCCTGCGACCTCTCGGACATGGAAGCGATCGACGCGCTGGTCGAAGACGTCGAAAAGCGCATCGGCGGGATCGAC
ATCCTGATCAACAATGCCGGCCGGTCGATCCGGCGGCCGCTGGCCGAGTCGCTGGAACGCTGGCACGACGTCGAGCGCAC
CATGGTGCTCAACTACTATGCCCCGCTGCGGCTTATCCGCGGGCTTGCACCCGGGATGCTCGAGCGTGGCGACGGCCATA
TCATCAATGTCGCCACCTGGGGCGTGTTGTCGGAGGCTTCGCCGCTGTTCTCGGTGTACAACGCATCGAAGGCCGCACTG
TCGGCGGTGAGCCGGATCATCGAAACCGAGTGGGGTAGTCAGGGCGTGCATTCGACGACGCTGTACTACCCGCTGGTGGC
AACTCCGATGATTGCGCCGACGAAGGCCTACGACGGGCTGCCGGCGCTGACCGCCGCGGAAGCCGCCGAGTGGATGGTCA
CCGCCGCCCGCACCCGACCGGTGCGGATCGCGCCTCGGGTTGCCGTCGCCGTCAACGCGCTGGACAGCATCGGTCCCCGC
TGGGTCAATGCACTCATGCAGCGCCGCAACGAACAGCTCAACCCTTGA

Upstream 100 bases:

>100_bases
TGGGTCAGCAACTGTTTGCCGGTGAGGCCACCCGCCTGGCCTACATGACCGACGAGGCCGTCGAAGGCCGCGACGCCTTC
CTACAGAAGCGTCCCCCCGA

Downstream 100 bases:

>100_bases
ACCGGGTCCCGGCCTGCCGACCCTCGGCCGCCGGCGTGCCGCTACGTGATAGACACAGGGCCATGGAAATCCTGGCCAGC
CGGATGCTACTTCGGCCGGC

Product: short chain dehydrogenase

Products: D-Gluconate; Nicotinamide adenine dinucleotide phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MEPVSALFLTRPFAEAVVAEQKPDEWDTTVTTGSAKLDSPAVSKRPLRWLTEQITLAGMRPPISPQLLINRPAMQPVDLT
GKRILLTGASSGIGAAATKQFGLHRAVVVAVARRKDLLDAVADRITGDGGTAMSLPCDLSDMEAIDALVEDVEKRIGGID
ILINNAGRSIRRPLAESLERWHDVERTMVLNYYAPLRLIRGLAPGMLERGDGHIINVATWGVLSEASPLFSVYNASKAAL
SAVSRIIETEWGSQGVHSTTLYYPLVATPMIAPTKAYDGLPALTAAEAAEWMVTAARTRPVRIAPRVAVAVNALDSIGPR
WVNALMQRRNEQLNP

Sequences:

>Translated_335_residues
MEPVSALFLTRPFAEAVVAEQKPDEWDTTVTTGSAKLDSPAVSKRPLRWLTEQITLAGMRPPISPQLLINRPAMQPVDLT
GKRILLTGASSGIGAAATKQFGLHRAVVVAVARRKDLLDAVADRITGDGGTAMSLPCDLSDMEAIDALVEDVEKRIGGID
ILINNAGRSIRRPLAESLERWHDVERTMVLNYYAPLRLIRGLAPGMLERGDGHIINVATWGVLSEASPLFSVYNASKAAL
SAVSRIIETEWGSQGVHSTTLYYPLVATPMIAPTKAYDGLPALTAAEAAEWMVTAARTRPVRIAPRVAVAVNALDSIGPR
WVNALMQRRNEQLNP
>Mature_335_residues
MEPVSALFLTRPFAEAVVAEQKPDEWDTTVTTGSAKLDSPAVSKRPLRWLTEQITLAGMRPPISPQLLINRPAMQPVDLT
GKRILLTGASSGIGAAATKQFGLHRAVVVAVARRKDLLDAVADRITGDGGTAMSLPCDLSDMEAIDALVEDVEKRIGGID
ILINNAGRSIRRPLAESLERWHDVERTMVLNYYAPLRLIRGLAPGMLERGDGHIINVATWGVLSEASPLFSVYNASKAAL
SAVSRIIETEWGSQGVHSTTLYYPLVATPMIAPTKAYDGLPALTAAEAAEWMVTAARTRPVRIAPRVAVAVNALDSIGPR
WVNALMQRRNEQLNP

Specific function: Catalyzes the NADPH-dependent reduction of long chain acyl-CoA to the corresponding aldehyde [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI126723191, Length=192, Percent_Identity=30.7291666666667, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI20149619, Length=186, Percent_Identity=30.6451612903226, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI7706318, Length=209, Percent_Identity=32.0574162679426, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI32483357, Length=197, Percent_Identity=28.9340101522843, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503817, Length=221, Percent_Identity=28.5067873303167, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI210032110, Length=184, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI7705855, Length=204, Percent_Identity=27.4509803921569, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI142976729, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI7705925, Length=193, Percent_Identity=29.5336787564767, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI40807363, Length=255, Percent_Identity=25.8823529411765, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI32455239, Length=186, Percent_Identity=30.6451612903226, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI5031765, Length=186, Percent_Identity=30.6451612903226, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1790717, Length=204, Percent_Identity=28.4313725490196, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787820, Length=227, Percent_Identity=29.0748898678414, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082100, Length=193, Percent_Identity=26.9430051813472, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787905, Length=142, Percent_Identity=30.9859154929577, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1787335, Length=200, Percent_Identity=28.5, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789208, Length=198, Percent_Identity=28.7878787878788, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=263, Percent_Identity=29.6577946768061, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17508895, Length=208, Percent_Identity=28.8461538461538, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=219, Percent_Identity=27.3972602739726, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17567345, Length=198, Percent_Identity=28.2828282828283, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71997099, Length=198, Percent_Identity=32.3232323232323, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=222, Percent_Identity=26.5765765765766, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=196, Percent_Identity=30.1020408163265, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=226, Percent_Identity=25.2212389380531, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=226, Percent_Identity=24.3362831858407, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=172, Percent_Identity=29.6511627906977, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=188, Percent_Identity=28.7234042553192, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=175, Percent_Identity=29.7142857142857, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=236, Percent_Identity=23.728813559322, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21358495, Length=189, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI116007236, Length=227, Percent_Identity=29.0748898678414, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28571387, Length=226, Percent_Identity=31.858407079646, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640492, Length=255, Percent_Identity=24.3137254901961, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648944, Length=225, Percent_Identity=29.3333333333333, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28571526, Length=180, Percent_Identity=34.4444444444444, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI116007238, Length=176, Percent_Identity=29.5454545454545, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648693, Length=228, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355889, Length=228, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357041, Length=194, Percent_Identity=29.3814432989691, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24584744, Length=213, Percent_Identity=28.169014084507, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28574402, Length=213, Percent_Identity=28.169014084507, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24643142, Length=193, Percent_Identity=30.5699481865285, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.69 [C]

Molecular weight: Translated: 36224; Mature: 36224

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPVSALFLTRPFAEAVVAEQKPDEWDTTVTTGSAKLDSPAVSKRPLRWLTEQITLAGMR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
PPISPQLLINRPAMQPVDLTGKRILLTGASSGIGAAATKQFGLHRAVVVAVARRKDLLDA
CCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VADRITGDGGTAMSLPCDLSDMEAIDALVEDVEKRIGGIDILINNAGRSIRRPLAESLER
HHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHH
WHDVERTMVLNYYAPLRLIRGLAPGMLERGDGHIINVATWGVLSEASPLFSVYNASKAAL
HHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEEECCHHHCCCHHHHHHHHHHHHH
SAVSRIIETEWGSQGVHSTTLYYPLVATPMIAPTKAYDGLPALTAAEAAEWMVTAARTRP
HHHHHHHHHCCCCCCCCCCEEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
VRIAPRVAVAVNALDSIGPRWVNALMQRRNEQLNP
EEECCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEPVSALFLTRPFAEAVVAEQKPDEWDTTVTTGSAKLDSPAVSKRPLRWLTEQITLAGMR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
PPISPQLLINRPAMQPVDLTGKRILLTGASSGIGAAATKQFGLHRAVVVAVARRKDLLDA
CCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VADRITGDGGTAMSLPCDLSDMEAIDALVEDVEKRIGGIDILINNAGRSIRRPLAESLER
HHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHH
WHDVERTMVLNYYAPLRLIRGLAPGMLERGDGHIINVATWGVLSEASPLFSVYNASKAAL
HHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEEECCHHHCCCHHHHHHHHHHHHH
SAVSRIIETEWGSQGVHSTTLYYPLVATPMIAPTKAYDGLPALTAAEAAEWMVTAARTRP
HHHHHHHHHCCCCCCCCCCEEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
VRIAPRVAVAVNALDSIGPRWVNALMQRRNEQLNP
EEECCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+; NADH; NADP+; NADPH [C]

Metal ions: Mn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.02 {NADP+}} 20 {D-gluconate}} 0.006 {NADPH}} 0.9 {5-keto-D-gluconate}} [C]

Substrates: 5-Dehydro-D-gluconate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]

Specific reaction: 5-Dehydro-D-gluconate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced <==> D-Gluconate + Nicotinamide adenine dinucleotide phosphate [C]

General reaction: Redox reaction [C]

Inhibitor: Cd2+; Cs2+; Cu2+; Divalent metal ions; Hg2+; Ni2+; p-Chloromercuribenzoate; Sn2+; Sulfhydryl reagents [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA