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The map label for this gene is uxuR [C]

Identifier: 148660262

GI number: 148660262

Start: 586005

End: 586733

Strand: Direct

Name: uxuR [C]

Synonym: MRA_0501

Alternate gene names: 148660262

Gene position: 586005-586733 (Clockwise)

Preceding gene: 148660258

Following gene: 148660264

Centisome position: 13.26

GC content: 69.68

Gene sequence:

>729_bases
TTGGTTGAGCCAATGAACCAGTCAAGTGTCTTTCAGCCGCCGGATCGGCAGCGGGTGGATGAGCGGATCGCGACGACGAT
CGCCGACGCCATCCTCGACGGCGTCTTCCCGCCGGGCTCGACCCTGCCGCCCGAGCGAGACCTGGCAGAGCGGCTCGGTG
TCAACCGCACCTCGCTACGCCAGGGTCTGGCGCGACTGCAACAGATGGGCCTGATCGAGGTGCGGCACGGCAGCGGCAGT
GTGGTCCGTGACCCCGAGGGGCTCACCCATCCCGCGGTGGTCGAGGCGCTGGTGCGCAAACTGGGCCCCGACTTCCTCGT
CGAGTTGCTGGAGATCCGCGCGGCGTTAGGCCCGTTGATTGGCCGCCTGGCGGCCGCCCGGAGCACGCCCGAGGATGCCG
AGGCGTTGTGTGCGGCGCTGGAAGTGGTGCAACAGGCGGACACGGCCGCGGCGCGGCAGGCAGCCGATCTTGCCTACTTC
CGGGTGCTCATCCACAGCACTCGCAACCGCGCATTGGGGTTGCTCTACCGCTGGGTGGAGCACGCCTTCGGCGGCCGCGA
GCATGCGCTCACCGGGGCCTACGACGACGCGGACCCAGTGTTGACCGACCTGCGGGCGATCAACGGGGCGGTGCTGGCCG
GTGACCCGGCGGCCGCTGCCGCGACCGTCGAGGCGTATCTGAACGCCAGTGCGCTGCGCATGGTCAAGTCCTACCGCGAC
CGCGCTTAG

Upstream 100 bases:

>100_bases
GCGCCCGGCTGCACCGCGCCACCGCGGCAAGGCCGCCGACCGCGTTTCATCGTCCACTGCGGCACCTCCTGCTGGCTGAG
TTGTCGATTCGCCCACTATA

Downstream 100 bases:

>100_bases
CTACTGGGCCGCACGCGTCGCCGGATGTACGGCGATGAGCCCTAATTGACTGCGGCGCTTGCACATTGCTGCGAGTTCCC
CATAGGCCTTCTCCCCGAGT

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MVEPMNQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPERDLAERLGVNRTSLRQGLARLQQMGLIEVRHGSGS
VVRDPEGLTHPAVVEALVRKLGPDFLVELLEIRAALGPLIGRLAAARSTPEDAEALCAALEVVQQADTAAARQAADLAYF
RVLIHSTRNRALGLLYRWVEHAFGGREHALTGAYDDADPVLTDLRAINGAVLAGDPAAAAATVEAYLNASALRMVKSYRD
RA

Sequences:

>Translated_242_residues
MVEPMNQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPERDLAERLGVNRTSLRQGLARLQQMGLIEVRHGSGS
VVRDPEGLTHPAVVEALVRKLGPDFLVELLEIRAALGPLIGRLAAARSTPEDAEALCAALEVVQQADTAAARQAADLAYF
RVLIHSTRNRALGLLYRWVEHAFGGREHALTGAYDDADPVLTDLRAINGAVLAGDPAAAAATVEAYLNASALRMVKSYRD
RA
>Mature_242_residues
MVEPMNQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPERDLAERLGVNRTSLRQGLARLQQMGLIEVRHGSGS
VVRDPEGLTHPAVVEALVRKLGPDFLVELLEIRAALGPLIGRLAAARSTPEDAEALCAALEVVQQADTAAARQAADLAYF
RVLIHSTRNRALGLLYRWVEHAFGGREHALTGAYDDADPVLTDLRAINGAVLAGDPAAAAATVEAYLNASALRMVKSYRD
RA

Specific function: Repressor For The Uxurba Operon. [C]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1790780, Length=232, Percent_Identity=29.3103448275862, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786303, Length=224, Percent_Identity=32.1428571428571, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787436, Length=153, Percent_Identity=33.9869281045752, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790032, Length=234, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI48994955, Length=159, Percent_Identity=28.3018867924528, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789353, Length=176, Percent_Identity=31.25, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y494_MYCTU (P67739)

Other databases:

- EMBL:   BX842573
- EMBL:   AE000516
- PIR:   A70745
- RefSeq:   NP_215008.2
- RefSeq:   NP_334923.1
- ProteinModelPortal:   P67739
- EnsemblBacteria:   EBMYCT00000002847
- EnsemblBacteria:   EBMYCT00000072854
- GeneID:   887166
- GeneID:   923883
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0514
- KEGG:   mtu:Rv0494
- TIGR:   MT0514
- TubercuList:   Rv0494
- GeneTree:   EBGT00050000014626
- HOGENOM:   HBG565415
- OMA:   AKLAMWR
- ProtClustDB:   CLSK799714
- GO:   GO:0005622
- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00035
- SMART:   SM00895
- SMART:   SM00345

Pfam domain/function: PF07729 FCD; PF00392 GntR

EC number: NA

Molecular weight: Translated: 26015; Mature: 26015

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEPMNQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPERDLAERLGVNRTSLR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHH
QGLARLQQMGLIEVRHGSGSVVRDPEGLTHPAVVEALVRKLGPDFLVELLEIRAALGPLI
HHHHHHHHCCCEEEECCCCCEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
GRLAAARSTPEDAEALCAALEVVQQADTAAARQAADLAYFRVLIHSTRNRALGLLYRWVE
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAFGGREHALTGAYDDADPVLTDLRAINGAVLAGDPAAAAATVEAYLNASALRMVKSYRD
HHHCCCHHCCCCCCCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHC
RA
CC
>Mature Secondary Structure
MVEPMNQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPERDLAERLGVNRTSLR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHH
QGLARLQQMGLIEVRHGSGSVVRDPEGLTHPAVVEALVRKLGPDFLVELLEIRAALGPLI
HHHHHHHHCCCEEEECCCCCEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
GRLAAARSTPEDAEALCAALEVVQQADTAAARQAADLAYFRVLIHSTRNRALGLLYRWVE
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAFGGREHALTGAYDDADPVLTDLRAINGAVLAGDPAAAAATVEAYLNASALRMVKSYRD
HHHCCCHHCCCCCCCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHC
RA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036