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The map label for this gene is fadD4 [H]

Identifier: 148659978

GI number: 148659978

Start: 257426

End: 259039

Strand: Direct

Name: fadD4 [H]

Synonym: MRA_0222

Alternate gene names: 148659978

Gene position: 257426-259039 (Clockwise)

Preceding gene: 148659975

Following gene: 148659980

Centisome position: 5.82

GC content: 63.38

Gene sequence:

>1614_bases
TTGCCACGTGGAGAACTTTACAAACGATTTCGGCTGGTGATGGGCGGAATTGCGCCCTGCGGCTCTGGTCGCCGGGCCGC
GACGTACCCTCGGCGCATGCAGATTCGCCCGTATATCGGCGCCGATAAGCCCGCCGTCATCCTGTATCCGTCCGGGACGG
TCATCAGCTTCGACGAGTTGGAGGCCCGCGCCAACCGGTTGGCGCATTGGTTCCGCCAGGCTGGTCTGCGCGAGGACGAC
GTCGTGGCCATCCTGATGGAGAACAACGAGCACGTGCACGCGGTCATGTGGGCGGCTCGCCGCAGCGGGTTGTACTACGT
GCCGATCAATACCCACCTGACCGCCTCCGAGGCCGCCTACATCGTCGACAACAGCGGTGCCAAAGCAATTGTCGGTTCGG
CGGCGCTGCGCGAGACCTGCCACGGCCTGGCCGAACACCTTCCGGGCGGGCTGCCGGACCTGCTGATGCTTGCCGGGGGC
GGTCTGGTCGGCTGGATGACCTACCCGGAATGCGTTGCCGATCAACCAGACACCCCGATCGAGGACGAACGCGAGGGTGA
CCTGCTGCAGTACTCGTCGGGAACGACTGGCCGACCGAAGGGAATCAAACGCGAATTGCCACACGTCTCACCGGATGCGG
CACCCGGGATGATGCCGGCACTGCTCGATTTCTGGATGGACGCCGACTCGGTATATCTGAGTCCCGCGCCGATGTACCAC
ACCGCTCCGTCAGTGTGGACGATGAGCGCACTGGCCGCGGGCGTCACCACCGTCGTGATGGAGAAGTTCGACGCCGAGGG
CGCCCTCGACGCCATCCAGCGCTACCGGGTGACCCACGCGCAATTCGTCCCGGCCATGTTCGTCCGGATGCTGAAACTCC
CTGAAGCAGTTCGTAATTCGTATGACATGTCCAGCCTTAGGCGAGTGATCCACGCGGCCGCTCCATGTCCAGTCCAGATC
AAGGAGCAGATGATTCACTGGTGGGGACCGATCATCGACGAGTACTACGCCTCCTCGGAAGCCAGCGGGTCGACGTTGAT
CACAGCCGAGGATTGGTTGACGCATCCGGGTTCGGTCGGCAAGCCCATACAGGGCGGGGTGCACATCGTGGGCGCCGACG
GCAGCGAGCTGCCGCCGAACCAGCCGGGCGAAATCTATTTCGAGGGCGGGTACCCCTTCGAATACCTCAACGATCCGGCG
AAAACCGCGGCGTCGCGCAACAAGCACGGCTGGGTAACCGTCGGCGACGTCGGCTATCTCGACGACGACGGCTACTTGTT
CCTGACCGGCCGGCGCCACCACATGATCATCTCCGGCGGCGTGAACATCTACCCGCAGGAGGCGGAGAACCTCTTGGTCG
CCCACCCCAAGGTGCTCGACGCGGCGGTGTTCGGCGTTCCCGACGACGAGATGGGTCAACGTGTCATGGCCGCGGTGCAA
ACCGTCGACTCCGCCGATGCCAACGATCAGTTCGCCGGCGAGCTATTAGCCTGGTTACGAGACCGCTTGTCACACTTCAA
GTGTCCAAGGTCGATCGCGTTCGAACCGCAATTGCCGCGCACCGACACCGGAAAGCTCTACAAGAGCGGGCTGGTCGAAA
AATACTCGGTGTGA

Upstream 100 bases:

>100_bases
TCCATGGGCATGGAGCAATACAGCCACGGATCTCCAAGCTTGAGTCCGTCAACGTACGACAGCCCGTCTTGACGGACGCC
TGGAGGATTGACCAGAAGAG

Downstream 100 bases:

>100_bases
CCGATGCTGCCGGGGGCCCGACCTGTCCACCCAGACACCGGCTATATCCCGCCCCGGGCCACCAGTTGTCCGGCTATCAC
GTTGCGCTGGATCTCGTTGG

Product: long-chain-fatty-acid--CoA ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MPRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPYIGADKPAVILYPSGTVISFDELEARANRLAHWFRQAGLREDD
VVAILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAYIVDNSGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAGG
GLVGWMTYPECVADQPDTPIEDEREGDLLQYSSGTTGRPKGIKRELPHVSPDAAPGMMPALLDFWMDADSVYLSPAPMYH
TAPSVWTMSALAAGVTTVVMEKFDAEGALDAIQRYRVTHAQFVPAMFVRMLKLPEAVRNSYDMSSLRRVIHAAAPCPVQI
KEQMIHWWGPIIDEYYASSEASGSTLITAEDWLTHPGSVGKPIQGGVHIVGADGSELPPNQPGEIYFEGGYPFEYLNDPA
KTAASRNKHGWVTVGDVGYLDDDGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHPKVLDAAVFGVPDDEMGQRVMAAVQ
TVDSADANDQFAGELLAWLRDRLSHFKCPRSIAFEPQLPRTDTGKLYKSGLVEKYSV

Sequences:

>Translated_537_residues
MPRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPYIGADKPAVILYPSGTVISFDELEARANRLAHWFRQAGLREDD
VVAILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAYIVDNSGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAGG
GLVGWMTYPECVADQPDTPIEDEREGDLLQYSSGTTGRPKGIKRELPHVSPDAAPGMMPALLDFWMDADSVYLSPAPMYH
TAPSVWTMSALAAGVTTVVMEKFDAEGALDAIQRYRVTHAQFVPAMFVRMLKLPEAVRNSYDMSSLRRVIHAAAPCPVQI
KEQMIHWWGPIIDEYYASSEASGSTLITAEDWLTHPGSVGKPIQGGVHIVGADGSELPPNQPGEIYFEGGYPFEYLNDPA
KTAASRNKHGWVTVGDVGYLDDDGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHPKVLDAAVFGVPDDEMGQRVMAAVQ
TVDSADANDQFAGELLAWLRDRLSHFKCPRSIAFEPQLPRTDTGKLYKSGLVEKYSV
>Mature_536_residues
PRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPYIGADKPAVILYPSGTVISFDELEARANRLAHWFRQAGLREDDV
VAILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAYIVDNSGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAGGG
LVGWMTYPECVADQPDTPIEDEREGDLLQYSSGTTGRPKGIKRELPHVSPDAAPGMMPALLDFWMDADSVYLSPAPMYHT
APSVWTMSALAAGVTTVVMEKFDAEGALDAIQRYRVTHAQFVPAMFVRMLKLPEAVRNSYDMSSLRRVIHAAAPCPVQIK
EQMIHWWGPIIDEYYASSEASGSTLITAEDWLTHPGSVGKPIQGGVHIVGADGSELPPNQPGEIYFEGGYPFEYLNDPAK
TAASRNKHGWVTVGDVGYLDDDGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHPKVLDAAVFGVPDDEMGQRVMAAVQT
VDSADANDQFAGELLAWLRDRLSHFKCPRSIAFEPQLPRTDTGKLYKSGLVEKYSV

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=529, Percent_Identity=27.4102079395085, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI42544132, Length=504, Percent_Identity=27.5793650793651, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI38505220, Length=503, Percent_Identity=27.8330019880716, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI122937307, Length=501, Percent_Identity=27.7445109780439, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI115511026, Length=507, Percent_Identity=27.0216962524655, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI157311624, Length=502, Percent_Identity=26.2948207171315, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI157311622, Length=502, Percent_Identity=26.2948207171315, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI58082049, Length=502, Percent_Identity=26.6932270916335, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI187761345, Length=529, Percent_Identity=25.8979206049149, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI187761343, Length=529, Percent_Identity=25.8979206049149, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI13375727, Length=550, Percent_Identity=23.2727272727273, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI38524616, Length=550, Percent_Identity=25.0909090909091, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI8923896, Length=543, Percent_Identity=23.0202578268877, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI253970489, Length=388, Percent_Identity=24.7422680412371, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788107, Length=535, Percent_Identity=25.4205607476636, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI221142682, Length=511, Percent_Identity=27.3972602739726, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI145693145, Length=501, Percent_Identity=25.3493013972056, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786810, Length=493, Percent_Identity=22.7180527383367, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1790505, Length=525, Percent_Identity=22.8571428571429, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786529, Length=522, Percent_Identity=24.904214559387, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1788595, Length=332, Percent_Identity=27.4096385542169, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994703, Length=535, Percent_Identity=25.607476635514, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71994694, Length=535, Percent_Identity=25.607476635514, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71994690, Length=535, Percent_Identity=25.607476635514, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17531443, Length=503, Percent_Identity=25.2485089463221, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17558820, Length=530, Percent_Identity=26.9811320754717, Blast_Score=149, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI32563687, Length=519, Percent_Identity=25.626204238921, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17559526, Length=514, Percent_Identity=27.2373540856031, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17560308, Length=520, Percent_Identity=25.3846153846154, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17538037, Length=526, Percent_Identity=25.8555133079848, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17557194, Length=531, Percent_Identity=24.4821092278719, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71996755, Length=501, Percent_Identity=23.9520958083832, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17560140, Length=369, Percent_Identity=23.8482384823848, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71985884, Length=369, Percent_Identity=25.7452574525745, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71983001, Length=538, Percent_Identity=23.6059479553903, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71982997, Length=538, Percent_Identity=23.6059479553903, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=363, Percent_Identity=28.6501377410468, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323182, Length=585, Percent_Identity=23.5897435897436, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319264, Length=535, Percent_Identity=23.7383177570093, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21355181, Length=485, Percent_Identity=28.8659793814433, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24581924, Length=554, Percent_Identity=26.3537906137184, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI18859661, Length=496, Percent_Identity=26.008064516129, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24656500, Length=517, Percent_Identity=23.9845261121857, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21358303, Length=478, Percent_Identity=22.1757322175732, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI19922652, Length=522, Percent_Identity=24.5210727969349, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24648257, Length=528, Percent_Identity=23.2954545454545, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI281365686, Length=544, Percent_Identity=24.4485294117647, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24648260, Length=496, Percent_Identity=24.1935483870968, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21356441, Length=447, Percent_Identity=22.5950782997763, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24648253, Length=460, Percent_Identity=24.7826086956522, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21356947, Length=492, Percent_Identity=23.780487804878, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20130357, Length=490, Percent_Identity=24.4897959183673, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24648255, Length=460, Percent_Identity=24.3478260869565, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24653035, Length=485, Percent_Identity=21.0309278350515, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45552801, Length=525, Percent_Identity=24.1904761904762, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45550496, Length=525, Percent_Identity=24.1904761904762, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21355225, Length=391, Percent_Identity=25.3196930946292, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI161076582, Length=503, Percent_Identity=20.675944333996, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24667959, Length=378, Percent_Identity=23.8095238095238, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI62472339, Length=378, Percent_Identity=23.8095238095238, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24667955, Length=378, Percent_Identity=23.8095238095238, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 58890; Mature: 58758

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPYIGADKPAVILYPSGTVISFDEL
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCEEEHHHH
EARANRLAHWFRQAGLREDDVVAILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAY
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEHHHHCCEEEEECCCEEECCCEEE
IVDNSGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAGGGLVGWMTYPECVADQPDTPI
EEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEECCCCHHHCCCCCCCC
EDEREGDLLQYSSGTTGRPKGIKRELPHVSPDAAPGMMPALLDFWMDADSVYLSPAPMYH
CCCCCCCEEEECCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCC
TAPSVWTMSALAAGVTTVVMEKFDAEGALDAIQRYRVTHAQFVPAMFVRMLKLPEAVRNS
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCC
YDMSSLRRVIHAAAPCPVQIKEQMIHWWGPIIDEYYASSEASGSTLITAEDWLTHPGSVG
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCCC
KPIQGGVHIVGADGSELPPNQPGEIYFEGGYPFEYLNDPAKTAASRNKHGWVTVGDVGYL
CCCCCCEEEEECCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHCCCCCCCEEECCCEEE
DDDGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHPKVLDAAVFGVPDDEMGQRVMAAVQ
CCCCEEEEECCCEEEEEECCCEECCCCCCCEEEECCHHHHHHEECCCCHHHHHHHHHHHH
TVDSADANDQFAGELLAWLRDRLSHFKCPRSIAFEPQLPRTDTGKLYKSGLVEKYSV
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCHHCCC
>Mature Secondary Structure 
PRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPYIGADKPAVILYPSGTVISFDEL
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCEEEHHHH
EARANRLAHWFRQAGLREDDVVAILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAY
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEHHHHCCEEEEECCCEEECCCEEE
IVDNSGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAGGGLVGWMTYPECVADQPDTPI
EEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEECCCCHHHCCCCCCCC
EDEREGDLLQYSSGTTGRPKGIKRELPHVSPDAAPGMMPALLDFWMDADSVYLSPAPMYH
CCCCCCCEEEECCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCC
TAPSVWTMSALAAGVTTVVMEKFDAEGALDAIQRYRVTHAQFVPAMFVRMLKLPEAVRNS
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCC
YDMSSLRRVIHAAAPCPVQIKEQMIHWWGPIIDEYYASSEASGSTLITAEDWLTHPGSVG
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCCC
KPIQGGVHIVGADGSELPPNQPGEIYFEGGYPFEYLNDPAKTAASRNKHGWVTVGDVGYL
CCCCCCEEEEECCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHCCCCCCCEEECCCEEE
DDDGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHPKVLDAAVFGVPDDEMGQRVMAAVQ
CCCCEEEEECCCEEEEEECCCEECCCCCCCEEEECCHHHHHHEECCCCHHHHHHHHHHHH
TVDSADANDQFAGELLAWLRDRLSHFKCPRSIAFEPQLPRTDTGKLYKSGLVEKYSV
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA