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The map label for this gene is pntAa [H]

Identifier: 148659919

GI number: 148659919

Start: 184982

End: 186082

Strand: Direct

Name: pntAa [H]

Synonym: MRA_0163

Alternate gene names: 148659919

Gene position: 184982-186082 (Clockwise)

Preceding gene: 148659913

Following gene: 148659920

Centisome position: 4.19

GC content: 68.03

Gene sequence:

>1101_bases
ATGACAGATCCGCAGACGCAGAGCACCAGGGTCGGGGTGGTTGCCGAGTCGGGGCCCGACGAACGACGGGTCGCGCTGGT
TCCCAAGGCGGTCGCGTCGCTGGTGAACCGTGGTGTGGCGGTCGTGGTCGAGGCCGGTGCGGGCGAGCGCGCGCTGCTTC
CCGATGAGCTCTACACCGCTGTCGGTGCCAGCATCGGGGATGCTTGGGCCGCCGACGTCGTTGTCAAGGTCGCGCCGCCG
ACGGCGGCGGAGGTCGGCCGGTTGCGCGGTGGGCAGACACTGATCGGCTTTCTAGCGCCCCGTAATGCTGACAACTCGAT
CGGCGCGCTGACCCAGGCCGGGGTGCAGGCGTTCGCGCTCGAGGCCATCCCGCGCATCTCGCGGGCGCAGGTGATGGACG
CGCTGTCGTCGCAAGCCAACGTGTCTGGGTATAAGGCTGTGCTGCTCGCGGCCTCGGAATCGACCCGGTTCTTTCCGATG
CTGACGACGGCGGCCGGAACGGTGAAGCCGGCCACGGTGCTGGTGCTCGGCGTCGGCGTGGCCGGCCTGCAGGCGCTGGC
GACGGCCAAACGGCTAGGCGCGCGCACCACGGGCTACGATGTGCGTCCCGAGGTGGCCGACCAGGTCCGATCGGTGGGCG
CTCAATGGCTTGATTTGGGCATCTCAGCGTCCGGTGAGGGCGGTTACGCCCGCGAACTGACCGACGACGAGCGCGCCCAG
CAGCAAAAGGCATTGGAAGAAGCGATCAGTGGCTTCGACGTGGTGATCACCACCGCGCTGGTGCCGGGCCGCCCGGCGCC
AACGTTGGTGACCGCCGCTGCAGTGGAAGCGATGAAGCCTGGCAGCGTGGTGGTGGATCTCGCCGGCGAGACGGGCGGCA
ACTGCGAATTGACCGAGCCCGGCCGGACAGTCGTCAAGCACGACGTCACCATTGCCGCACCGCTGAACCTGCCGGCCACG
ATGCCCGAGCACGCCAGCGAGCTCTACAGCAAGAACATCACCGCGCTACTCGACTTGTTGATCAAAGACGGCAGGCTGGC
CCCGGACTTCGACGACGAGGTGATTGCCCAGTCGTGTGTCACCCGCGGGAAGGACTCCTAG

Upstream 100 bases:

>100_bases
CTCGGCATCCGAGTATGGCCAGGAAATACCGCTCTGGTAGCCCGGTAGGGTGTCTGAGCAAATCTATCGGCGTTCAGTAA
GGAAAGTGGATGTACGCGCC

Downstream 100 bases:

>100_bases
ATGTACAACGAATTGTTGGAGAACCTGGCGATCCTGGTGCTGTCCGGATTCGTCGGGTTCGCGGTGATCTCGAAAGTGCC
CAACACGTTGCACACCCCGC

Product: putative NAD(P) transhydrogenase subunit alpha PntAa

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVEAGAGERALLPDELYTAVGASIGDAWAADVVVKVAPP
TAAEVGRLRGGQTLIGFLAPRNADNSIGALTQAGVQAFALEAIPRISRAQVMDALSSQANVSGYKAVLLAASESTRFFPM
LTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTTGYDVRPEVADQVRSVGAQWLDLGISASGEGGYARELTDDERAQ
QQKALEEAISGFDVVITTALVPGRPAPTLVTAAAVEAMKPGSVVVDLAGETGGNCELTEPGRTVVKHDVTIAAPLNLPAT
MPEHASELYSKNITALLDLLIKDGRLAPDFDDEVIAQSCVTRGKDS

Sequences:

>Translated_366_residues
MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVEAGAGERALLPDELYTAVGASIGDAWAADVVVKVAPP
TAAEVGRLRGGQTLIGFLAPRNADNSIGALTQAGVQAFALEAIPRISRAQVMDALSSQANVSGYKAVLLAASESTRFFPM
LTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTTGYDVRPEVADQVRSVGAQWLDLGISASGEGGYARELTDDERAQ
QQKALEEAISGFDVVITTALVPGRPAPTLVTAAAVEAMKPGSVVVDLAGETGGNCELTEPGRTVVKHDVTIAAPLNLPAT
MPEHASELYSKNITALLDLLIKDGRLAPDFDDEVIAQSCVTRGKDS
>Mature_365_residues
TDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVEAGAGERALLPDELYTAVGASIGDAWAADVVVKVAPPT
AAEVGRLRGGQTLIGFLAPRNADNSIGALTQAGVQAFALEAIPRISRAQVMDALSSQANVSGYKAVLLAASESTRFFPML
TTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTTGYDVRPEVADQVRSVGAQWLDLGISASGEGGYARELTDDERAQQ
QKALEEAISGFDVVITTALVPGRPAPTLVTAAAVEAMKPGSVVVDLAGETGGNCELTEPGRTVVKHDVTIAAPLNLPATM
PEHASELYSKNITALLDLLIKDGRLAPDFDDEVIAQSCVTRGKDS

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=360, Percent_Identity=42.2222222222222, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI122939153, Length=360, Percent_Identity=42.2222222222222, Blast_Score=248, Evalue=6e-66,
Organism=Escherichia coli, GI1787887, Length=361, Percent_Identity=41.8282548476454, Blast_Score=270, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17550456, Length=358, Percent_Identity=44.1340782122905, Blast_Score=288, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 37694; Mature: 37563

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVEAGAGERALLPDELYTA
CCCCCCCCCEEEEEECCCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHH
VGASIGDAWAADVVVKVAPPTAAEVGRLRGGQTLIGFLAPRNADNSIGALTQAGVQAFAL
HCCCCCCHHHEEEEEEECCCCHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
EAIPRISRAQVMDALSSQANVSGYKAVLLAASESTRFFPMLTTAAGTVKPATVLVLGVGV
HHHCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCEEEEECCCH
AGLQALATAKRLGARTTGYDVRPEVADQVRSVGAQWLDLGISASGEGGYARELTDDERAQ
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCHHHHH
QQKALEEAISGFDVVITTALVPGRPAPTLVTAAAVEAMKPGSVVVDLAGETGGNCELTEP
HHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEECCC
GRTVVKHDVTIAAPLNLPATMPEHASELYSKNITALLDLLIKDGRLAPDFDDEVIAQSCV
CCEEEEECEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
TRGKDS
HCCCCC
>Mature Secondary Structure 
TDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVEAGAGERALLPDELYTA
CCCCCCCCEEEEEECCCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHH
VGASIGDAWAADVVVKVAPPTAAEVGRLRGGQTLIGFLAPRNADNSIGALTQAGVQAFAL
HCCCCCCHHHEEEEEEECCCCHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
EAIPRISRAQVMDALSSQANVSGYKAVLLAASESTRFFPMLTTAAGTVKPATVLVLGVGV
HHHCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCEEEEECCCH
AGLQALATAKRLGARTTGYDVRPEVADQVRSVGAQWLDLGISASGEGGYARELTDDERAQ
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCHHHHH
QQKALEEAISGFDVVITTALVPGRPAPTLVTAAAVEAMKPGSVVVDLAGETGGNCELTEP
HHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEECCC
GRTVVKHDVTIAAPLNLPATMPEHASELYSKNITALLDLLIKDGRLAPDFDDEVIAQSCV
CCEEEEECEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
TRGKDS
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]