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The map label for this gene is 148659910

Identifier: 148659910

GI number: 148659910

Start: 173570

End: 174502

Strand: Direct

Name: 148659910

Synonym: MRA_0153

Alternate gene names: NA

Gene position: 173570-174502 (Clockwise)

Preceding gene: 148659909

Following gene: 148659911

Centisome position: 3.93

GC content: 66.88

Gene sequence:

>933_bases
ATGCGCACCCATGACGACACCTGGGATATCAAGACCAGCGTCGGCGCCACCGCAGTGATGGTGGCTGCTGCCCGGGCCGT
CGAAACCGACCGGCCCGACCCGCTGATCCGCGATCCCTACGCCAGACTGCTCGTCACCAACGCCGGGGCCGGCGCCATTT
GGGAAGCCATGCTCGACCCAACACTGGTAGCCAAGGCGGCTGCCATCGATGCCGAAACCGCGGCCATCGTCGCCTATCTG
CGCAGCTACCAAGCGGTGCGGACCAACTTCTTCGATACCTACTTCGCCAGCGCTGTCGCCGCCGGAATCCGGCAGGTAGT
GATTCTGGCGTCCGGACTGGATTCCCGCGCCTATCGCCTGGACTGGCCCGCCGGAACCATCGTGTATGAGATCGATCAAC
CCAAGGTGCTTTCCTACAAGTCCACGACGCTGGCGGAAAACGGGGTAACGCCGTCGGCTGGTCGCCGTGAGGTGCCCGCC
GACCTGCGCCAGGACTGGCCCGCCGCGCTGCGTGATGCCGGGTTTGACCCGACGGCACGCACGGCGTGGTTGGCCGAGGG
GCTGTTGATGTACCTACCGGCCGAGGCCCAGGACCGGCTGTTCACCCAGGTCGGCGCCGTGAGCGTGGCGGGCAGCCGGA
TCGCGGCCGAGACTGCGCCGGTGCACGGCGAAGAGCGGCGAGCAGAAATGCGGGCACGGTTCAAGAAAGTGGCCGATGTG
CTCGGTATCGAGCAGACCATCGACGTGCAGGAACTGGTCTACCACGACCAGGATCGGGCGTCCGTTGCCGACTGGCTCAC
CGATCACGGTTGGCGGGCCCGATCCCAACGTGCGCCCGACGAGATGCGCCGCGTGGGTCGCTGGGTTGAGGGGGTGCCGA
TGGCGGACGACCCGACTGCGTTCGCCGAGTTTGTCACCGCAGAGCGGTTGTAG

Upstream 100 bases:

>100_bases
GACCGTCCGCACCACGTTGCTGCGAGGGCGTCTGGTCACACCCGCTCAACCGGCGTGACACCGGCATCACGAGAACCAGA
GGGAGCACAGGATGAGCGCC

Downstream 100 bases:

>100_bases
CGAGCGCATCCGACTGACCTTATATATCCGGATATATGGCTGGATCTTTTCTATTGCTGGTTCAACCGGGTGACTAGGAT
CGCGGTTATCACCGATGAGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLLVTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYL
RSYQAVRTNFFDTYFASAVAAGIRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTLAENGVTPSAGRREVPA
DLRQDWPAALRDAGFDPTARTAWLAEGLLMYLPAEAQDRLFTQVGAVSVAGSRIAAETAPVHGEERRAEMRARFKKVADV
LGIEQTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMRRVGRWVEGVPMADDPTAFAEFVTAERL

Sequences:

>Translated_310_residues
MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLLVTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYL
RSYQAVRTNFFDTYFASAVAAGIRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTLAENGVTPSAGRREVPA
DLRQDWPAALRDAGFDPTARTAWLAEGLLMYLPAEAQDRLFTQVGAVSVAGSRIAAETAPVHGEERRAEMRARFKKVADV
LGIEQTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMRRVGRWVEGVPMADDPTAFAEFVTAERL
>Mature_310_residues
MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLLVTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYL
RSYQAVRTNFFDTYFASAVAAGIRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTLAENGVTPSAGRREVPA
DLRQDWPAALRDAGFDPTARTAWLAEGLLMYLPAEAQDRLFTQVGAVSVAGSRIAAETAPVHGEERRAEMRARFKKVADV
LGIEQTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMRRVGRWVEGVPMADDPTAFAEFVTAERL

Specific function: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity

COG id: COG3315

COG function: function code Q; O-Methyltransferase involved in polyketide biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPF0677 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y146_MYCTU (P96823)

Other databases:

- EMBL:   BX842572
- EMBL:   AE000516
- PIR:   E70617
- RefSeq:   NP_214660.1
- RefSeq:   NP_334564.1
- ProteinModelPortal:   P96823
- SMR:   P96823
- EnsemblBacteria:   EBMYCT00000002142
- EnsemblBacteria:   EBMYCT00000069340
- GeneID:   886849
- GeneID:   923025
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0154
- KEGG:   mtu:Rv0146
- TIGR:   MT0154
- TubercuList:   Rv0146
- GeneTree:   EBGT00050000015698
- HOGENOM:   HBG570783
- OMA:   LAYKSAT
- ProtClustDB:   CLSK790300
- GO:   GO:0005829
- InterPro:   IPR011610
- InterPro:   IPR007213
- TIGRFAMs:   TIGR00027

Pfam domain/function: PF04072 LCM

EC number: NA

Molecular weight: Translated: 34017; Mature: 34017

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: BINDING 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLLVTNAGAGAIWEAMLDP
CCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHEEEECCCCHHHHHHHHCH
TLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTYFASAVAAGIRQVVILASGLDSRAYRL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
DWPAGTIVYEIDQPKVLSYKSTTLAENGVTPSAGRREVPADLRQDWPAALRDAGFDPTAR
ECCCCEEEEECCCCCEEEECCHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHCCCCCCHH
TAWLAEGLLMYLPAEAQDRLFTQVGAVSVAGSRIAAETAPVHGEERRAEMRARFKKVADV
HHHHHCCHHEECCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LGIEQTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMRRVGRWVEGVPMADDPTA
HCCHHHCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHH
FAEFVTAERL
HHHHHHHHCC
>Mature Secondary Structure
MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLLVTNAGAGAIWEAMLDP
CCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHEEEECCCCHHHHHHHHCH
TLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTYFASAVAAGIRQVVILASGLDSRAYRL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
DWPAGTIVYEIDQPKVLSYKSTTLAENGVTPSAGRREVPADLRQDWPAALRDAGFDPTAR
ECCCCEEEEECCCCCEEEECCHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHCCCCCCHH
TAWLAEGLLMYLPAEAQDRLFTQVGAVSVAGSRIAAETAPVHGEERRAEMRARFKKVADV
HHHHHCCHHEECCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LGIEQTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMRRVGRWVEGVPMADDPTA
HCCHHHCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHH
FAEFVTAERL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036