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The map label for this gene is ppp

Identifier: 148659777

GI number: 148659777

Start: 22995

End: 24539

Strand: Reverse

Name: ppp

Synonym: MRA_0020

Alternate gene names: 148659777

Gene position: 24539-22995 (Counterclockwise)

Preceding gene: 148659778

Following gene: 148659776

Centisome position: 0.56

GC content: 67.57

Gene sequence:

>1545_bases
GTGGCGCGCGTGACCCTGGTCCTGCGATACGCGGCGCGCAGCGATCGCGGCTTGGTACGCGCCAACAACGAAGACTCGGT
CTACGCTGGGGCACGGCTATTGGCCCTGGCCGACGGCATGGGTGGGCATGCGGCCGGCGAGGTGGCGTCCCAGTTGGTGA
TTGCCGCATTGGCCCATCTCGATGACGACGAGCCCGGTGGCGATCTGCTGGCCAAGCTGGATGCCGCGGTGCGCGCCGGC
AACTCGGCTATCGCAGCGCAAGTCGAGATGGAGCCCGATCTCGAAGGCATGGGTACCACGCTCACCGCAATCCTGTTCGC
GGGCAACCGGCTCGGCCTGGTGCATATCGGTGACTCGCGCGGTTACCTGCTGCGCGACGGTGAGCTGACGCAGATCACCA
AGGACGACACGTTTGTCCAAACGCTGGTCGACGAAGGCCGGATCACCCCGGAGGAGGCGCACAGCCACCCGCAACGCTCG
TTGATCATGCGGGCGTTGACCGGCCATGAGGTCGAACCGACGCTGACCATGCGAGAAGCCCGCGCCGGTGATCGTTACCT
GCTGTGCTCGGACGGGTTGTCCGATCCGGTTAGCGATGAAACTATCCTCGAGGCCCTGCAGATCCCCGAGGTTGCCGAGA
GCGCTCACCGCCTCATTGAACTGGCGCTGCGCGGCGGCGGCCCCGACAACGTCACTGTCGTCGTCGCCGACGTCGTCGAC
TACGACTACGGCCAGACCCAACCGATTCTGGCCGGGGCGGTCTCAGGCGACGACGACCAACTGACCCTGCCCAACACCGC
CGCCGGCCGGGCCTCTGCCATCAGCCAGCGCAAGGAGATCGTTAAACGCGTTCCGCCACAGGCCGATACATTCAGTCGGC
CACGGTGGTCGGGCCGACGGCTAGCATTCGTTGTCGCACTGGTGACCGTGCTGATGACTGCGGGCCTGCTCATTGGTCGC
GCGATCATCCGCAGCAACTACTACGTAGCGGACTACGCCGGCAGCGTGTCCATCATGCGGGGGATTCAAGGGTCGCTACT
GGGCATGTCCCTGCACCAGCCTTACCTGATGGGCTGCCTCAGCCCGCGTAACGAGCTGTCGCAGATCAGCTACGGACAGT
CTGGGGGCCCTCTCGACTGCCATCTGATGAAACTGGAGGATCTGCGACCGCCGGAGCGCGCACAGGTTCGGGCCGGTCTC
CCGGCCGGCACTCTCGATGACGCCATCGGGCAGTTGCGCGAACTGGCGGCCAACTCCCTGCTGCCGCCTTGCCCGGCGCC
GCGTGCCACGTCCCCGCCCGGGCGCCCGGCCCCACCCACCACCAGCGAGACAACCGAACCAAACGTCACCTCCTCGCCAG
CCTCTCCATCACCCACCACCTCCGCGCCGGCCCCCACCGGAACTACTCCTGCCATCCCCACGAGTGCCTCCCCGGCAGCG
CCCGCGTCGCCGCCGACGCCTTGGCCCGTCACCAGCTCGCCGACGATGGCCGCACTTCCGCCACCCCCGCCTCAGCCGGG
CATCGACTGCCGGGCGGCGGCATGA

Upstream 100 bases:

>100_bases
TTGCGCCCGTGACCCGCGCTGGCGACGATGCAGAGCGCAGAGAAGCGGTGGGGGCGCGCCCCCACAAGTGGGGGGTACCC
CCACCCGCTTGCGGGGGAGA

Downstream 100 bases:

>100_bases
CGACACGACTGCAAGCGCCGGTGGCCGTAACGCCCCCGTTGCCGACTCGGCGCAACGCTGAACTGCTGCTGCTGTGCTTT
GCCGCCGTAATCACGTTTGC

Product: putative serine/threonine phosphatase Ppp

Products: NA

Alternate protein names: Mycobacterial Ser/Thr phosphatase; Mstp; Possible serine/threonine phosphatase Ppp

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAG
NSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRS
LIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVD
YDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGR
AIIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGL
PAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSAPAPTGTTPAIPTSASPAA
PASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA

Sequences:

>Translated_514_residues
MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAG
NSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRS
LIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVD
YDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGR
AIIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGL
PAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSAPAPTGTTPAIPTSASPAA
PASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA
>Mature_513_residues
ARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAGN
SAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRSL
IMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVDY
DYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGRA
IIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGLP
AGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSAPAPTGTTPAIPTSASPAAP
ASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA

Specific function: The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (pknA, pknB, pknD, pknE and pknF) and the penicillin-binding protein PBPA

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential). Note=May be localized to the outside of the cell

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSTP_MYCTU (P71588)

Other databases:

- EMBL:   BX842572
- EMBL:   AE000516
- PIR:   H70699
- RefSeq:   NP_214532.1
- RefSeq:   NP_334429.1
- PDB:   1TXO
- PDB:   2CM1
- PDBsum:   1TXO
- PDBsum:   2CM1
- ProteinModelPortal:   P71588
- SMR:   P71588
- PptaseDB:   P3D0410141
- EnsemblBacteria:   EBMYCT00000003854
- EnsemblBacteria:   EBMYCT00000070846
- GeneID:   887070
- GeneID:   922470
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0021
- KEGG:   mtu:Rv0018c
- TIGR:   MT0021
- TubercuList:   Rv0018c
- GeneTree:   EBGT00050000014898
- HOGENOM:   HBG688775
- OMA:   SNNEDSV
- ProtClustDB:   CLSK790196
- InterPro:   IPR015655
- InterPro:   IPR001932
- InterPro:   IPR014045
- Gene3D:   G3DSA:3.60.40.10
- PANTHER:   PTHR13832
- SMART:   SM00331
- SMART:   SM00332

Pfam domain/function: PF00481 PP2C; SSF81606 PP2C-related

EC number: =3.1.3.16

Molecular weight: Translated: 53813; Mature: 53681

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1a2d67d4)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHL
CCEEEEEEEEHHCCCCCEEEECCCCCHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
DDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSR
CCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCC
GYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRSLIMRALTGHEVEPTLTMREA
CEEEECCCEEEEECCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCEEHHHH
RAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVD
CCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECC
YDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRR
CCCCCCCCEEEEECCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
LAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCL
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHCCCCHHCCHHHCCHHHHHHC
SPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGLPAGTLDDAIGQLRELAANSL
CCHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
LPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSAPAPTGTTPAIPTSASPAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA
CCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
ARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHL
CEEEEEEEEHHCCCCCEEEECCCCCHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
DDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSR
CCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCC
GYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRSLIMRALTGHEVEPTLTMREA
CEEEECCCEEEEECCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCEEHHHH
RAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVD
CCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECC
YDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRR
CCCCCCCCEEEEECCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
LAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCL
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHCCCCHHCCHHHCCHHHHHHC
SPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGLPAGTLDDAIGQLRELAANSL
CCHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
LPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSAPAPTGTTPAIPTSASPAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA
CCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036