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The map label for this gene is trpG

Identifier: 148659772

GI number: 148659772

Start: 16272

End: 16970

Strand: Direct

Name: trpG

Synonym: MRA_0015

Alternate gene names: 148659772

Gene position: 16272-16970 (Clockwise)

Preceding gene: 148659771

Following gene: 148659781

Centisome position: 0.37

GC content: 63.95

Gene sequence:

>699_bases
ATGCGGATCCTGGTCGTTGACAACTACGACAGCTTCGTGTTCAACCTGGTGCAGTACCTCGGCCAGCTCGGCATCGAGGC
CGAGGTGTGGCGCAACGACGACCACCGGCTATCCGATGAGGCCGCCGTCGCCGGCCAATTCGACGGTGTCCTGCTCAGTC
CCGGTCCGGGTACCCCGGAGCGCGCGGGCGCGTCGGTGAGTATCGTGCACGCGTGTGCGGCAGCACACACCCCTTTGCTG
GGGGTCTGCCTTGGGCACCAAGCCATCGGCGTTGCGTTCGGCGCCACCGTGGACCGTGCGCCCGAGCTATTGCACGGCAA
GACCAGCAGCGTATTCCACACCAATGTCGGTGTGCTACAAGGGCTTCCGGATCCCTTCACGGCCACTCGATACCATTCGT
TGACAATTCTGCCTAAGTCGCTGCCAGCGGTGCTGAGGGTCACGGCCCGCACTAGCAGCGGTGTGATCATGGCCGTGCAG
CACACCGGGCTGCCGATCCACGGTGTCCAGTTCCATCCGGAGTCGATTCTCACCGAGGGCGGGCACCGCATACTGGCCAA
CTGGCTCACCTGCTGCGGATGGACGCAAGACGACACCCTGGTACGTCGGCTGGAAAACGAAGTGCTCACCGCCATCTCAC
CGCACTTCCCAACTTCAACCGCTAGCGCGGGCGAAGCTACTGGCCGAACCTCAGCGTGA

Upstream 100 bases:

>100_bases
AGTCGGCTATGCCGATCCCGTCCGGATGCACTTCGCGCAGCCTGCAGGCCCCTTGGACTACTGAACGACTGCCGGCAGGG
TCAGGCGGTAGCCTGTCACG

Downstream 100 bases:

>100_bases
TGATGCCGTCCCGGTTGACGCCGGTCCCCGCCGGCGGGTTTTGATAGACGACCCGGTTGTGTTGGGAGCCACCGGCGTCG
ACGTCGGCCCCTTTGTCGAG

Product: para-aminobenzoate synthase component II

Products: NA

Alternate protein names: Anthranilate synthase component II; Glutamine amido-transferase

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVAGQFDGVLLSPGPGTPERAGASVSIVHACAAAHTPLL
GVCLGHQAIGVAFGATVDRAPELLHGKTSSVFHTNVGVLQGLPDPFTATRYHSLTILPKSLPAVLRVTARTSSGVIMAVQ
HTGLPIHGVQFHPESILTEGGHRILANWLTCCGWTQDDTLVRRLENEVLTAISPHFPTSTASAGEATGRTSA

Sequences:

>Translated_232_residues
MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVAGQFDGVLLSPGPGTPERAGASVSIVHACAAAHTPLL
GVCLGHQAIGVAFGATVDRAPELLHGKTSSVFHTNVGVLQGLPDPFTATRYHSLTILPKSLPAVLRVTARTSSGVIMAVQ
HTGLPIHGVQFHPESILTEGGHRILANWLTCCGWTQDDTLVRRLENEVLTAISPHFPTSTASAGEATGRTSA
>Mature_232_residues
MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVAGQFDGVLLSPGPGTPERAGASVSIVHACAAAHTPLL
GVCLGHQAIGVAFGATVDRAPELLHGKTSSVFHTNVGVLQGLPDPFTATRYHSLTILPKSLPAVLRVTARTSSGVIMAVQ
HTGLPIHGVQFHPESILTEGGHRILANWLTCCGWTQDDTLVRRLENEVLTAISPHFPTSTASAGEATGRTSA

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI1789760, Length=187, Percent_Identity=50.2673796791444, Blast_Score=184, Evalue=4e-48,
Organism=Escherichia coli, GI1787517, Length=197, Percent_Identity=40.1015228426396, Blast_Score=125, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322638, Length=200, Percent_Identity=42, Blast_Score=161, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6324361, Length=211, Percent_Identity=29.8578199052133, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324878, Length=171, Percent_Identity=28.0701754385965, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPG_MYCTU (Q7DAK6)

Other databases:

- EMBL:   BX842572
- EMBL:   AE000516
- PIR:   C70699
- RefSeq:   NP_334424.1
- RefSeq:   YP_177615.1
- ProteinModelPortal:   Q7DAK6
- EnsemblBacteria:   EBMYCT00000000103
- EnsemblBacteria:   EBMYCT00000070459
- GeneID:   885955
- GeneID:   922462
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0016
- KEGG:   mtu:Rv0013
- TIGR:   MT0016
- TubercuList:   Rv0013
- GeneTree:   EBGT00050000015859
- HOGENOM:   HBG292341
- OMA:   YNVVQYL
- ProtClustDB:   PRK07765
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00566

Pfam domain/function: PF00117 GATase

EC number: =4.1.3.27

Molecular weight: Translated: 24627; Mature: 24627

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS51273 GATASE_TYPE_1; PS00606 B_KETOACYL_SYNTHASE ; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 83-83 ACT_SITE 172-172 ACT_SITE 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVAGQFDGVLLSPGPGTPE
CEEEEEECCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHCCCCCCCEEECCCCCCHH
RAGASVSIVHACAAAHTPLLGVCLGHQAIGVAFGATVDRAPELLHGKTSSVFHTNVGVLQ
HCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHCCCHHCCHHHHCCCCCCEEECCCHHHC
GLPDPFTATRYHSLTILPKSLPAVLRVTARTSSGVIMAVQHTGLPIHGVQFHPESILTEG
CCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCEEEEEECCCCCEECEEECCHHHHHCC
GHRILANWLTCCGWTQDDTLVRRLENEVLTAISPHFPTSTASAGEATGRTSA
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVAGQFDGVLLSPGPGTPE
CEEEEEECCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHCCCCCCCEEECCCCCCHH
RAGASVSIVHACAAAHTPLLGVCLGHQAIGVAFGATVDRAPELLHGKTSSVFHTNVGVLQ
HCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHCCCHHCCHHHHCCCCCCEEECCCHHHC
GLPDPFTATRYHSLTILPKSLPAVLRVTARTSSGVIMAVQHTGLPIHGVQFHPESILTEG
CCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCEEEEEECCCCCEECEEECCHHHHHCC
GHRILANWLTCCGWTQDDTLVRRLENEVLTAISPHFPTSTASAGEATGRTSA
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036