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The map label for this gene is emrE [H]

Identifier: 148652469

GI number: 148652469

Start: 796102

End: 796443

Strand: Direct

Name: emrE [H]

Synonym: PsycPRwf_0657

Alternate gene names: 148652469

Gene position: 796102-796443 (Clockwise)

Preceding gene: 148652461

Following gene: 148652474

Centisome position: 26.72

GC content: 45.03

Gene sequence:

>342_bases
ATGTCTCCAACTGCCGTCGCCTATGCCTATTTGGCCGGGGCTATTATCTTTGAAATAACCGGAACCACCTTTTTGGTGAA
GTCGCAAGAATTCACTAAGCTTTATCCCACTTTAGCCACGGTGGTGCTCTATGCTTTTTCTTTTTATTTTTTGACTAAGT
CATTAAGGGGTATTCCGCTTGGTATTGCTTATGCAATGTGGGGCGGGATAGGTATTGTGTTAACAGCTTTGATTGGTCTG
CTGGTATTTAAGCAGAGTATTGATACGCCGGCAGTGATAGGCATTGGCCTGATTGTGACCGGCGTTGTGGTGCTTAATTT
GTTCTCAAGCTCTGTGGGGTAG

Upstream 100 bases:

>100_bases
CTAATGTAGTACAGTCCAACAAATAAAGCAATTTAGCCACATTTATAGGTGCCGCTGGGCTGATCGGTACCTTAAAATTA
CTATAATCGTGGGTGTTTAA

Downstream 100 bases:

>100_bases
GAGGGGGATTAGGGGAAGATCTAAACTCGGCTATCAATAATAACTGGATAGCCTTTGTGCTCAATGACAGTAGCTTTAAC
CCCATATAAATCCTGTATGG

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Efflux-multidrug resistance protein emrE; Ethidium resistance protein; Methyl viologen resistance protein C [H]

Number of amino acids: Translated: 113; Mature: 112

Protein sequence:

>113_residues
MSPTAVAYAYLAGAIIFEITGTTFLVKSQEFTKLYPTLATVVLYAFSFYFLTKSLRGIPLGIAYAMWGGIGIVLTALIGL
LVFKQSIDTPAVIGIGLIVTGVVVLNLFSSSVG

Sequences:

>Translated_113_residues
MSPTAVAYAYLAGAIIFEITGTTFLVKSQEFTKLYPTLATVVLYAFSFYFLTKSLRGIPLGIAYAMWGGIGIVLTALIGL
LVFKQSIDTPAVIGIGLIVTGVVVLNLFSSSVG
>Mature_112_residues
SPTAVAYAYLAGAIIFEITGTTFLVKSQEFTKLYPTLATVVLYAFSFYFLTKSLRGIPLGIAYAMWGGIGIVLTALIGLL
VFKQSIDTPAVIGIGLIVTGVVVLNLFSSSVG

Specific function: Multidrug transporter that expels positively charged hydrophobic drugs across the inner membrane of E.coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. Is involved in the resistanc

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=111, Percent_Identity=46.8468468468468, Blast_Score=103, Evalue=3e-24,
Organism=Escherichia coli, GI1787883, Length=102, Percent_Identity=34.3137254901961, Blast_Score=59, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11944; Mature: 11813

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPTAVAYAYLAGAIIFEITGTTFLVKSQEFTKLYPTLATVVLYAFSFYFLTKSLRGIPL
CCCHHHHHHHHHHHHHHEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
GIAYAMWGGIGIVLTALIGLLVFKQSIDTPAVIGIGLIVTGVVVLNLFSSSVG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPTAVAYAYLAGAIIFEITGTTFLVKSQEFTKLYPTLATVVLYAFSFYFLTKSLRGIPL
CCHHHHHHHHHHHHHHEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
GIAYAMWGGIGIVLTALIGLLVFKQSIDTPAVIGIGLIVTGVVVLNLFSSSVG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1936950; 1320256; 9278503; 7896833; 9050242; 9688273 [H]