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The map label for this gene is hisB

Identifier: 148651877

GI number: 148651877

Start: 73612

End: 74238

Strand: Direct

Name: hisB

Synonym: PsycPRwf_0060

Alternate gene names: 148651877

Gene position: 73612-74238 (Clockwise)

Preceding gene: 148651872

Following gene: 148651878

Centisome position: 2.47

GC content: 46.25

Gene sequence:

>627_bases
ATGACTACTGAAATCCACTCAAACCCAGCCAACCGTCCGAATCGTATAGCCAGTGTTGAGCGTAATACCGCTGAGACTCA
AGTCAGCGTCACTGTCAATCTTGATGGGACAGGCCAAGGTAAAATCGATACTGGTGTGCCATTTTTGGACCATATGCTAG
ACCAAATCAAGCGTCATGGTCTATTTGACTTAGACATCACCTGTAAAGGCGATACTTACATTGATGATCACCACAGCATC
GAGGACACCGGCATTACTTTGGGTCAAGCTTTTGCCAAAGCGTTGGGCGACAAAAAGGGCATTCGTCGTTATGGCCACTT
TTATGCGCCATTAGATGAGTCACTAACCCGTGCGGTGGTAGATATTTCTGGTCGTCCAGGGCTGCACATGGACATTCCTT
TTACCCGCTCGCACGTTGGTAATTTTGATGTGGATTTATTCAGCGAATTCTTTTTTGGCTTTGTTAACCATGCGTGGATG
ACAGTGCACTTAGACAACCTTAAGGGTAAAAATAGCCATCACCAGATTGAGTGTACTTTTAAGGCCTTTGCTCGTGCGCT
GCGTATGGCTTGTGAGTATGATGAGCGTGCGCTAAACACGCTACCTTCTACCAAAGAGGCATTGTAA

Upstream 100 bases:

>100_bases
TTAAAGGTAAGGCGTTTGCTATCATCAAGATATCCTATATTCCCTGACGCTATTTGGCGACTGTTTCTTCGTTATTATTT
TATTAGTGAGCCTATTTGCC

Downstream 100 bases:

>100_bases
CTATATGACCAAAATTGCATTGTTAGACTATGGCATGGGCAACCTCCACTCTGCCAGCAAAGCGTTGGCTGCGGTGGGGG
CTGAGGTATCTATTACCAAT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTTEIHSNPANRPNRIASVERNTAETQVSVTVNLDGTGQGKIDTGVPFLDHMLDQIKRHGLFDLDITCKGDTYIDDHHSI
EDTGITLGQAFAKALGDKKGIRRYGHFYAPLDESLTRAVVDISGRPGLHMDIPFTRSHVGNFDVDLFSEFFFGFVNHAWM
TVHLDNLKGKNSHHQIECTFKAFARALRMACEYDERALNTLPSTKEAL

Sequences:

>Translated_208_residues
MTTEIHSNPANRPNRIASVERNTAETQVSVTVNLDGTGQGKIDTGVPFLDHMLDQIKRHGLFDLDITCKGDTYIDDHHSI
EDTGITLGQAFAKALGDKKGIRRYGHFYAPLDESLTRAVVDISGRPGLHMDIPFTRSHVGNFDVDLFSEFFFGFVNHAWM
TVHLDNLKGKNSHHQIECTFKAFARALRMACEYDERALNTLPSTKEAL
>Mature_207_residues
TTEIHSNPANRPNRIASVERNTAETQVSVTVNLDGTGQGKIDTGVPFLDHMLDQIKRHGLFDLDITCKGDTYIDDHHSIE
DTGITLGQAFAKALGDKKGIRRYGHFYAPLDESLTRAVVDISGRPGLHMDIPFTRSHVGNFDVDLFSEFFFGFVNHAWMT
VHLDNLKGKNSHHQIECTFKAFARALRMACEYDERALNTLPSTKEAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=198, Percent_Identity=50.5050505050505, Blast_Score=186, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324776, Length=216, Percent_Identity=38.4259259259259, Blast_Score=155, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_PSYWF (A5WBH9)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001278970.1
- ProteinModelPortal:   A5WBH9
- SMR:   A5WBH9
- STRING:   A5WBH9
- GeneID:   5205115
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_0060
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- BioCyc:   PSP56811:PSYCPRWF_0060-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 23302; Mature: 23171

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEIHSNPANRPNRIASVERNTAETQVSVTVNLDGTGQGKIDTGVPFLDHMLDQIKRHG
CCCCCCCCCCCCCCHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
LFDLDITCKGDTYIDDHHSIEDTGITLGQAFAKALGDKKGIRRYGHFYAPLDESLTRAVV
CEEEEEEECCCCEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHH
DISGRPGLHMDIPFTRSHVGNFDVDLFSEFFFGFVNHAWMTVHLDNLKGKNSHHQIECTF
CCCCCCCEEEECCCHHHHCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEEHH
KAFARALRMACEYDERALNTLPSTKEAL
HHHHHHHHHHHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure 
TTEIHSNPANRPNRIASVERNTAETQVSVTVNLDGTGQGKIDTGVPFLDHMLDQIKRHG
CCCCCCCCCCCCCHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
LFDLDITCKGDTYIDDHHSIEDTGITLGQAFAKALGDKKGIRRYGHFYAPLDESLTRAVV
CEEEEEEECCCCEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHH
DISGRPGLHMDIPFTRSHVGNFDVDLFSEFFFGFVNHAWMTVHLDNLKGKNSHHQIECTF
CCCCCCCEEEECCCHHHHCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEEHH
KAFARALRMACEYDERALNTLPSTKEAL
HHHHHHHHHHHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA