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The map label for this gene is hemL

Identifier: 148643293

GI number: 148643293

Start: 1235225

End: 1236496

Strand: Reverse

Name: hemL

Synonym: Msm_1233

Alternate gene names: 148643293

Gene position: 1236496-1235225 (Counterclockwise)

Preceding gene: 148643294

Following gene: 148643292

Centisome position: 66.72

GC content: 34.43

Gene sequence:

>1272_bases
ATGTTTTCCAAAGATTTATTCCAAGAATCCAAAAAATTCATTCCTGGGGGAGTTAGCTCTCCAGTTCGTGCATTTGAACC
ATATCCATTTTTTGTTAAAAAAGCTAGCGGTTCAAAAATATATGATGTTGATGGAAATAAGTATATTGACCACTGTTTGG
CTTATGGTCCTTTAATACTTGGTCATGCTGATCCTAAAGTAGTTAGGGAAGTGTCCAATCAGTTAACAATCGGGTCTGCT
TATGGTACTCCAACTGAAAATGAAATCATTTTAGCAAAAGAAGTTGTTGACAGAATACCTAGTGCTGAAATGGTAAGATT
TGTAAATAGTGGTGGAGAAGCTACTATGAGTGCTATAAGATTAGCCCGTGGTTTTACAGGTAAAGATAAAATTATTAAAT
TTGACGGTGCGTATCATGGTGCTCATGATTATACATTAGTTAAAGGAGAACCTGGTAAATCTTGTGTTCCAGATACTAAA
GGAATTCCTCTTGATACAGCTAAAAATACCTATTCTGTACCTTTCAATGATGAAGAAGCTTTAAGTGATTTGATCCAAAA
AGATGGTGATAACATAGCTTGTCTTATTATGGAGGTAGTTATGGGTAACATTGGTTGTATTGAACCTAAAAAAGGATTTT
TGGAATTTGTAAGAAAAATTACTGAAGAAAATAATATTTTATTAATATTTGATGAAGTTATAACTGGTTTCAGATTAGCT
AGAGGTGGAGCTCAGGAATATTATGGTGTAACTCCTGATTTAACTACAATGGGTAAAATTGTAGGTGGAGGTTTGCCTAT
GGGTGCCTTTGCAGGTAAAAAAGAAATAATGGAATTAATAGCACCTAATGGACCAGTTTATCAGGCTGGTACTTTCAGCG
GTAATCCAATATCTGTTCAGGCAGGAATATCTACATTAAAACAGTTGGATAATCAGTTCTACAAAGATTTGGAAAGAAAA
GGAAACTTTTTAAGAAGCAATATTCAGTCAATTATTGATGAACAGGGGTATAATATTACTCCTGTGGGCTGCGGATCAAT
GTTCCAGATATATTTCAACCCTGCTCCAGTTTATAATAATGACGATGCCCATAATTCTGATGCAAAAAGATTCTTGAGAT
ACTTTAGAGCATTATTAAAAGAAGGGGTTTTCATTCCTCCAAGTCAATTTGAATGTAACTTTATTTCAAGTGCTCACAGT
ATGGAGGACTTAACACAAACTGCAGAAGCTATTGAAGTAGCTTTGGAAGTGGCTTTTAAGAAAAAAGGATAG

Upstream 100 bases:

>100_bases
TTCAAATATTCCAAATATTATTGTTGAAGGCCCTAAAGGTGGAACACCAATAGCTGTGGCTTGTGTAAACTCTTTAATTC
AAAATTTATAATGTGATAAT

Downstream 100 bases:

>100_bases
TGTCATCTATTTGACATTATTTTTTAATTTATTTTATCAACAATTTAACCATCAATCCATATGTTTAAAAATATTTTATA
AGATTTAGCTAAATTATTTA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MFSKDLFQESKKFIPGGVSSPVRAFEPYPFFVKKASGSKIYDVDGNKYIDHCLAYGPLILGHADPKVVREVSNQLTIGSA
YGTPTENEIILAKEVVDRIPSAEMVRFVNSGGEATMSAIRLARGFTGKDKIIKFDGAYHGAHDYTLVKGEPGKSCVPDTK
GIPLDTAKNTYSVPFNDEEALSDLIQKDGDNIACLIMEVVMGNIGCIEPKKGFLEFVRKITEENNILLIFDEVITGFRLA
RGGAQEYYGVTPDLTTMGKIVGGGLPMGAFAGKKEIMELIAPNGPVYQAGTFSGNPISVQAGISTLKQLDNQFYKDLERK
GNFLRSNIQSIIDEQGYNITPVGCGSMFQIYFNPAPVYNNDDAHNSDAKRFLRYFRALLKEGVFIPPSQFECNFISSAHS
MEDLTQTAEAIEVALEVAFKKKG

Sequences:

>Translated_423_residues
MFSKDLFQESKKFIPGGVSSPVRAFEPYPFFVKKASGSKIYDVDGNKYIDHCLAYGPLILGHADPKVVREVSNQLTIGSA
YGTPTENEIILAKEVVDRIPSAEMVRFVNSGGEATMSAIRLARGFTGKDKIIKFDGAYHGAHDYTLVKGEPGKSCVPDTK
GIPLDTAKNTYSVPFNDEEALSDLIQKDGDNIACLIMEVVMGNIGCIEPKKGFLEFVRKITEENNILLIFDEVITGFRLA
RGGAQEYYGVTPDLTTMGKIVGGGLPMGAFAGKKEIMELIAPNGPVYQAGTFSGNPISVQAGISTLKQLDNQFYKDLERK
GNFLRSNIQSIIDEQGYNITPVGCGSMFQIYFNPAPVYNNDDAHNSDAKRFLRYFRALLKEGVFIPPSQFECNFISSAHS
MEDLTQTAEAIEVALEVAFKKKG
>Mature_423_residues
MFSKDLFQESKKFIPGGVSSPVRAFEPYPFFVKKASGSKIYDVDGNKYIDHCLAYGPLILGHADPKVVREVSNQLTIGSA
YGTPTENEIILAKEVVDRIPSAEMVRFVNSGGEATMSAIRLARGFTGKDKIIKFDGAYHGAHDYTLVKGEPGKSCVPDTK
GIPLDTAKNTYSVPFNDEEALSDLIQKDGDNIACLIMEVVMGNIGCIEPKKGFLEFVRKITEENNILLIFDEVITGFRLA
RGGAQEYYGVTPDLTTMGKIVGGGLPMGAFAGKKEIMELIAPNGPVYQAGTFSGNPISVQAGISTLKQLDNQFYKDLERK
GNFLRSNIQSIIDEQGYNITPVGCGSMFQIYFNPAPVYNNDDAHNSDAKRFLRYFRALLKEGVFIPPSQFECNFISSAHS
MEDLTQTAEAIEVALEVAFKKKG

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=352, Percent_Identity=26.4204545454545, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI37574042, Length=324, Percent_Identity=28.7037037037037, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI24119277, Length=333, Percent_Identity=28.8288288288288, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI226442709, Length=289, Percent_Identity=29.4117647058824, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI226442705, Length=327, Percent_Identity=28.1345565749235, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI13994255, Length=362, Percent_Identity=26.5193370165746, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI284507298, Length=162, Percent_Identity=30.8641975308642, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786349, Length=415, Percent_Identity=45.5421686746988, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1789016, Length=392, Percent_Identity=30.6122448979592, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1788044, Length=340, Percent_Identity=29.7058823529412, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787560, Length=349, Percent_Identity=29.2263610315186, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI145693181, Length=317, Percent_Identity=30.5993690851735, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789759, Length=330, Percent_Identity=28.7878787878788, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786991, Length=293, Percent_Identity=25.5972696245734, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71992977, Length=317, Percent_Identity=30.2839116719243, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=340, Percent_Identity=26.4705882352941, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=165, Percent_Identity=29.0909090909091, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=355, Percent_Identity=24.5070422535211, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324432, Length=324, Percent_Identity=25.6172839506173, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21356575, Length=343, Percent_Identity=26.2390670553936, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357415, Length=325, Percent_Identity=26.1538461538462, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_METS3 (A5UML0)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001273806.1
- ProteinModelPortal:   A5UML0
- SMR:   A5UML0
- STRING:   A5UML0
- GeneID:   5216017
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_1233
- eggNOG:   arNOG04972
- HOGENOM:   HBG725944
- OMA:   IMELIAP
- ProtClustDB:   PRK00062
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46375; Mature: 46375

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSKDLFQESKKFIPGGVSSPVRAFEPYPFFVKKASGSKIYDVDGNKYIDHCLAYGPLIL
CCCHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHCCEEE
GHADPKVVREVSNQLTIGSAYGTPTENEIILAKEVVDRIPSAEMVRFVNSGGEATMSAIR
CCCCHHHHHHHHHCEEEECCCCCCCCCCEEEHHHHHHHCCHHHHHHHHHCCCHHHHHHHH
LARGFTGKDKIIKFDGAYHGAHDYTLVKGEPGKSCVPDTKGIPLDTAKNTYSVPFNDEEA
HHHCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCHHH
LSDLIQKDGDNIACLIMEVVMGNIGCIEPKKGFLEFVRKITEENNILLIFDEVITGFRLA
HHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHH
RGGAQEYYGVTPDLTTMGKIVGGGLPMGAFAGKKEIMELIAPNGPVYQAGTFSGNPISVQ
CCCCHHHCCCCCCHHHHHHHHCCCCCCHHHCCHHHHHHHHCCCCCEEECCCCCCCCEEEH
AGISTLKQLDNQFYKDLERKGNFLRSNIQSIIDEQGYNITPVGCGSMFQIYFNPAPVYNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCC
DDAHNSDAKRFLRYFRALLKEGVFIPPSQFECNFISSAHSMEDLTQTAEAIEVALEVAFK
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKG
CCC
>Mature Secondary Structure
MFSKDLFQESKKFIPGGVSSPVRAFEPYPFFVKKASGSKIYDVDGNKYIDHCLAYGPLIL
CCCHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHCCEEE
GHADPKVVREVSNQLTIGSAYGTPTENEIILAKEVVDRIPSAEMVRFVNSGGEATMSAIR
CCCCHHHHHHHHHCEEEECCCCCCCCCCEEEHHHHHHHCCHHHHHHHHHCCCHHHHHHHH
LARGFTGKDKIIKFDGAYHGAHDYTLVKGEPGKSCVPDTKGIPLDTAKNTYSVPFNDEEA
HHHCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCHHH
LSDLIQKDGDNIACLIMEVVMGNIGCIEPKKGFLEFVRKITEENNILLIFDEVITGFRLA
HHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHH
RGGAQEYYGVTPDLTTMGKIVGGGLPMGAFAGKKEIMELIAPNGPVYQAGTFSGNPISVQ
CCCCHHHCCCCCCHHHHHHHHCCCCCCHHHCCHHHHHHHHCCCCCEEECCCCCCCCEEEH
AGISTLKQLDNQFYKDLERKGNFLRSNIQSIIDEQGYNITPVGCGSMFQIYFNPAPVYNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCC
DDAHNSDAKRFLRYFRALLKEGVFIPPSQFECNFISSAHSMEDLTQTAEAIEVALEVAFK
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA