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The map label for this gene is divL [H]

Identifier: 148550792

GI number: 148550792

Start: 265584

End: 266717

Strand: Direct

Name: divL [H]

Synonym: Swit_5356

Alternate gene names: 148550792

Gene position: 265584-266717 (Clockwise)

Preceding gene: 148550791

Following gene: 148550795

Centisome position: 85.61

GC content: 62.61

Gene sequence:

>1134_bases
ATGACGAGTGCGAACCCTCTGCCGAACTGTCTTCTGGTCGACGATCTGGAAGAAAACCTTCTGGCGCTCGAGGCGCTAAT
GGGTGACCAGGGTGTGTCGATCATCAAGGCCCGATCCGGGGAGGAGGCGCTAGAGCTTCTTCTCCAGCACGACGTGGCGC
TCGCCCTGCTCGACGTGCAGATGCCCGGCATGGACGGCTTCGAGCTTGCCGAGTTCATGCGCGCAAGCGAGCGCGCGCGC
GATGTTCCGATCATCTTCCTGACCGCCGGCAGCGCTGACCAGCAACGCCGCTTCCGGGGCTATGAGGCGGGGGCGGTGGA
TTTCCTCCAGAAGCCGATCGAGGCCGATATCCTTCGCTCCAAGGCCCGCATCTTCTTCGACCTCTATCGTCAGCGCCAAA
AAATTGGCGCGCAGCGTGATGCGCTCGAGGAGCTGACCGGCGTGTTGCAGACTGCAGATCGCCGCAAGAATGAGTTTCTG
GCGGTCCTCGCCCATGAACTGCGCAATCCGATCATGGCGATGGGGGCCGGGCTGCACCTGATGGAACGTAGGCCGGATCT
CGAGACAGCCACCATGGTGCGCGGGCAGATGAGCAAATATGTGCGGCATCTTGGCAGCCTGGTCGAGGACCTGCTCGACA
TCGCACGCATCGACCAGGGCAAGATCGCACTCAAGAAGGAACGTCTGCTGCTCCAGGACTTGCTGAGCTTTGCCGTCGAA
GGATCACGCCATCATATCGATGCGGCCAGCCATGAGCTGATCCAGCATGTCGCGCCCAAGCCGATCTGGCTGGAGGCCGA
TCATGCCCGGCTTGCGCAGGTTGTCGGCAATCTCCTCACCAACGCCGCCAAATACACGCCTGCTGGCGGAGAAATTCGCC
TCTCCGCGAGGCGCGAGGAGGATCAGGTGCGCATCGAGGTCGCCGATACGGGCGTCGGCATCCCGGCCGAGATGCAGGCC
CGGATCTTTGATCTGTTCGCCCAGATCGATGGATCGAACCAGCGCACGCAGGAAGGACTTGGGATCGGACTCGCGCTCGT
CAAACAGTTGGTCGAGCTCCACGGCGGGACGATCGCCCTCAAGCGCAGCGCGCCGGGAGAGGGCAGCGTTTTCGAGGTCG
TAGTGCCGCTCTGA

Upstream 100 bases:

>100_bases
CGAGTTCTACCATGCCGACCGCCGCGCTTGCGGCGTGGCCCCAAGCGCGGGCTCAGGATGTGCCCGGCATCATCGCTTAC
CTTCAGACCCTGGTGGCTCC

Downstream 100 bases:

>100_bases
GGCTGGCCGCGACCTTTACGGTTCATCGTCCCCAGCCTCGGCCGCCCCTGCTATTCGCTCCTTCTCGAAGCCATGCATGC
CCCACCACCACTGCAGCGCG

Product: response regulator receiver sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTSANPLPNCLLVDDLEENLLALEALMGDQGVSIIKARSGEEALELLLQHDVALALLDVQMPGMDGFELAEFMRASERAR
DVPIIFLTAGSADQQRRFRGYEAGAVDFLQKPIEADILRSKARIFFDLYRQRQKIGAQRDALEELTGVLQTADRRKNEFL
AVLAHELRNPIMAMGAGLHLMERRPDLETATMVRGQMSKYVRHLGSLVEDLLDIARIDQGKIALKKERLLLQDLLSFAVE
GSRHHIDAASHELIQHVAPKPIWLEADHARLAQVVGNLLTNAAKYTPAGGEIRLSARREEDQVRIEVADTGVGIPAEMQA
RIFDLFAQIDGSNQRTQEGLGIGLALVKQLVELHGGTIALKRSAPGEGSVFEVVVPL

Sequences:

>Translated_377_residues
MTSANPLPNCLLVDDLEENLLALEALMGDQGVSIIKARSGEEALELLLQHDVALALLDVQMPGMDGFELAEFMRASERAR
DVPIIFLTAGSADQQRRFRGYEAGAVDFLQKPIEADILRSKARIFFDLYRQRQKIGAQRDALEELTGVLQTADRRKNEFL
AVLAHELRNPIMAMGAGLHLMERRPDLETATMVRGQMSKYVRHLGSLVEDLLDIARIDQGKIALKKERLLLQDLLSFAVE
GSRHHIDAASHELIQHVAPKPIWLEADHARLAQVVGNLLTNAAKYTPAGGEIRLSARREEDQVRIEVADTGVGIPAEMQA
RIFDLFAQIDGSNQRTQEGLGIGLALVKQLVELHGGTIALKRSAPGEGSVFEVVVPL
>Mature_376_residues
TSANPLPNCLLVDDLEENLLALEALMGDQGVSIIKARSGEEALELLLQHDVALALLDVQMPGMDGFELAEFMRASERARD
VPIIFLTAGSADQQRRFRGYEAGAVDFLQKPIEADILRSKARIFFDLYRQRQKIGAQRDALEELTGVLQTADRRKNEFLA
VLAHELRNPIMAMGAGLHLMERRPDLETATMVRGQMSKYVRHLGSLVEDLLDIARIDQGKIALKKERLLLQDLLSFAVEG
SRHHIDAASHELIQHVAPKPIWLEADHARLAQVVGNLLTNAAKYTPAGGEIRLSARREEDQVRIEVADTGVGIPAEMQAR
IFDLFAQIDGSNQRTQEGLGIGLALVKQLVELHGGTIALKRSAPGEGSVFEVVVPL

Specific function: Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=31.3807531380753, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=33.1877729257642, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=29.7071129707113, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=31.2775330396476, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786783, Length=224, Percent_Identity=30.8035714285714, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI48994928, Length=241, Percent_Identity=28.2157676348548, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790861, Length=211, Percent_Identity=29.8578199052133, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1788713, Length=264, Percent_Identity=28.030303030303, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081816, Length=264, Percent_Identity=28.4090909090909, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=27.9279279279279, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786600, Length=250, Percent_Identity=26.8, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=30.5439330543933, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=25.7383966244726, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=29.535864978903, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788279, Length=242, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787894, Length=267, Percent_Identity=26.9662921348315, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=225, Percent_Identity=26.2222222222222, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082012, Length=114, Percent_Identity=34.2105263157895, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1790551, Length=237, Percent_Identity=24.8945147679325, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41591; Mature: 41459

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSANPLPNCLLVDDLEENLLALEALMGDQGVSIIKARSGEEALELLLQHDVALALLDVQ
CCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHEEEEEE
MPGMDGFELAEFMRASERARDVPIIFLTAGSADQQRRFRGYEAGAVDFLQKPIEADILRS
CCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCCHHHHHHCCHHHHHHHH
KARIFFDLYRQRQKIGAQRDALEELTGVLQTADRRKNEFLAVLAHELRNPIMAMGAGLHL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
MERRPDLETATMVRGQMSKYVRHLGSLVEDLLDIARIDQGKIALKKERLLLQDLLSFAVE
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
GSRHHIDAASHELIQHVAPKPIWLEADHARLAQVVGNLLTNAAKYTPAGGEIRLSARREE
CCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
DQVRIEVADTGVGIPAEMQARIFDLFAQIDGSNQRTQEGLGIGLALVKQLVELHGGTIAL
CEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHCCCEEEE
KRSAPGEGSVFEVVVPL
EECCCCCCCEEEEEECC
>Mature Secondary Structure 
TSANPLPNCLLVDDLEENLLALEALMGDQGVSIIKARSGEEALELLLQHDVALALLDVQ
CCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHEEEEEE
MPGMDGFELAEFMRASERARDVPIIFLTAGSADQQRRFRGYEAGAVDFLQKPIEADILRS
CCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCCHHHHHHCCHHHHHHHH
KARIFFDLYRQRQKIGAQRDALEELTGVLQTADRRKNEFLAVLAHELRNPIMAMGAGLHL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
MERRPDLETATMVRGQMSKYVRHLGSLVEDLLDIARIDQGKIALKKERLLLQDLLSFAVE
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
GSRHHIDAASHELIQHVAPKPIWLEADHARLAQVVGNLLTNAAKYTPAGGEIRLSARREE
CCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
DQVRIEVADTGVGIPAEMQARIFDLFAQIDGSNQRTQEGLGIGLALVKQLVELHGGTIAL
CEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHCCCEEEE
KRSAPGEGSVFEVVVPL
EECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10557274; 11259647 [H]