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The map label for this gene is fdh [H]

Identifier: 148550781

GI number: 148550781

Start: 253592

End: 254791

Strand: Direct

Name: fdh [H]

Synonym: Swit_5345

Alternate gene names: 148550781

Gene position: 253592-254791 (Clockwise)

Preceding gene: 148550780

Following gene: 148550784

Centisome position: 81.74

GC content: 62.33

Gene sequence:

>1200_bases
ATGAAGGCGATCACCTGGCACGGCAAGCACGACGTACGCTGCGACACGGTCGACGATCCCGCGATCGTCAATCCGCGCGA
TGCGATCATCCGCGTGACCTCCACCGCGATCTGCGGGTCGGACCTGCATCTTTATGACGGCTATATCCCGACGATGCAGA
AGGGCGACATTCTCGGCCACGAGTTCATGGGCGAAGTGGTCGAGGCCGGGCCCAAGAGCAGCCTCAACACCGGACAGCGC
GTCGTCGTGCCGTTCACCATCTCGTGCGGCAGCTGCTACCACTGTTCGAAGACGCAATATTCAGCCTGCGAGAATGCGAA
CCCGGCCGACAACCAGGATATCGGGCGCGAGGGCTATGGCCATCCGATGCCCGGCCTGTTCGGCTACAGCCACATGACCG
GAGGCTATGCCGGCGGGCAGGCCGAATATGTCCGCGTGCCCTTCTCTGATGTCGGCCCGCTCGTTATTCCTGACGAGAGC
ATCCCGGACGACAAGGTGCTGTTCCTCTCGGACATCCTTCCTACGGGCTGGATGGCGGCGGAGAATGCCGAGATCGAGCC
GGGCGACACAGTGGCGGTCTGGGGCTGCGGTCCGGTCGGCCTGTTCGCGGTGCAGTCGGCTTTCCTGATGGGCGCCGAGC
GGGTTATCGCGATCGATCATTTCCCGCACCGCCTCGAACTTGCGCGCAAATTCGGTGCCGAGACTGTCAATTTCGAAGAG
AGCAAAGTTTACGAGGCGCTGATGGAGATGACGGGCGGGATCGGCCCCGACGCGGCTATCGATTGCGTGGGTCTTGAGGC
GCACGGCGCCTTTGCCGACAATATCATCGACCAAATCAAGGCTTCTACCTTCCTTGGGACCGATCGCATCCACGCCATCC
GGCAGGTGATCCTGGCGACCCGCAAGGGCGGGCGTGTCTCGATGCCCGCCGTCTATGGCGGCTTCGTCGACAAGTTCCCC
TTGGGCGCGCTGATGGAGAAGGGCCTGACCCTCAAGACCGGCCAGACGCATGTGCAGCGCTATCTGCAGCCTCTCTATGC
CGCGATCGCGGAGGACAAGATCGATTCAACCTTCCTTATCAGCCACCGCATGGCGCTCGAGGATGGGCCACTCGGCTATC
AGAAATTCCACGACGAGCAGGACAGCTACACGAAGATCGTTTTGAAGCCAGGGCAGGCAGCGGGCGCAACGGCTGCCTGA

Upstream 100 bases:

>100_bases
GGCGCGACCTGCGCCGGTTCAAGCAGCTTATGGAAACCGGCGAAATCGCCACGAACGCGCGCAATCCGCGCATCCTCGCA
GGAGAAGGAAAGTAAGCGCG

Downstream 100 bases:

>100_bases
CGCTGCACATACGCCTTGTCACACGCCCGCGAGCGCGTCGATGGAAGCCTGTACGTTCTCGTAAGTATAGGGCTTGGTCA
GGGTCCGGGCGCCGGCATGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKAITWHGKHDVRCDTVDDPAIVNPRDAIIRVTSTAICGSDLHLYDGYIPTMQKGDILGHEFMGEVVEAGPKSSLNTGQR
VVVPFTISCGSCYHCSKTQYSACENANPADNQDIGREGYGHPMPGLFGYSHMTGGYAGGQAEYVRVPFSDVGPLVIPDES
IPDDKVLFLSDILPTGWMAAENAEIEPGDTVAVWGCGPVGLFAVQSAFLMGAERVIAIDHFPHRLELARKFGAETVNFEE
SKVYEALMEMTGGIGPDAAIDCVGLEAHGAFADNIIDQIKASTFLGTDRIHAIRQVILATRKGGRVSMPAVYGGFVDKFP
LGALMEKGLTLKTGQTHVQRYLQPLYAAIAEDKIDSTFLISHRMALEDGPLGYQKFHDEQDSYTKIVLKPGQAAGATAA

Sequences:

>Translated_399_residues
MKAITWHGKHDVRCDTVDDPAIVNPRDAIIRVTSTAICGSDLHLYDGYIPTMQKGDILGHEFMGEVVEAGPKSSLNTGQR
VVVPFTISCGSCYHCSKTQYSACENANPADNQDIGREGYGHPMPGLFGYSHMTGGYAGGQAEYVRVPFSDVGPLVIPDES
IPDDKVLFLSDILPTGWMAAENAEIEPGDTVAVWGCGPVGLFAVQSAFLMGAERVIAIDHFPHRLELARKFGAETVNFEE
SKVYEALMEMTGGIGPDAAIDCVGLEAHGAFADNIIDQIKASTFLGTDRIHAIRQVILATRKGGRVSMPAVYGGFVDKFP
LGALMEKGLTLKTGQTHVQRYLQPLYAAIAEDKIDSTFLISHRMALEDGPLGYQKFHDEQDSYTKIVLKPGQAAGATAA
>Mature_399_residues
MKAITWHGKHDVRCDTVDDPAIVNPRDAIIRVTSTAICGSDLHLYDGYIPTMQKGDILGHEFMGEVVEAGPKSSLNTGQR
VVVPFTISCGSCYHCSKTQYSACENANPADNQDIGREGYGHPMPGLFGYSHMTGGYAGGQAEYVRVPFSDVGPLVIPDES
IPDDKVLFLSDILPTGWMAAENAEIEPGDTVAVWGCGPVGLFAVQSAFLMGAERVIAIDHFPHRLELARKFGAETVNFEE
SKVYEALMEMTGGIGPDAAIDCVGLEAHGAFADNIIDQIKASTFLGTDRIHAIRQVILATRKGGRVSMPAVYGGFVDKFP
LGALMEKGLTLKTGQTHVQRYLQPLYAAIAEDKIDSTFLISHRMALEDGPLGYQKFHDEQDSYTKIVLKPGQAAGATAA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=365, Percent_Identity=28.4931506849315, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI71565154, Length=269, Percent_Identity=28.2527881040892, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4501933, Length=338, Percent_Identity=27.5147928994083, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501929, Length=365, Percent_Identity=26.5753424657534, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI71565152, Length=302, Percent_Identity=27.4834437086093, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI156523966, Length=241, Percent_Identity=29.4605809128631, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4501939, Length=241, Percent_Identity=29.4605809128631, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI156627571, Length=407, Percent_Identity=24.5700245700246, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI71743840, Length=261, Percent_Identity=26.8199233716475, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI262073058, Length=261, Percent_Identity=26.8199233716475, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786825, Length=402, Percent_Identity=46.0199004975124, Blast_Score=355, Evalue=2e-99,
Organism=Escherichia coli, GI1790045, Length=370, Percent_Identity=26.7567567567568, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87082125, Length=265, Percent_Identity=29.0566037735849, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI226510992, Length=339, Percent_Identity=25.3687315634218, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1787863, Length=235, Percent_Identity=28.936170212766, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786552, Length=249, Percent_Identity=30.5220883534137, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790718, Length=216, Percent_Identity=27.3148148148148, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788075, Length=276, Percent_Identity=27.8985507246377, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788073, Length=244, Percent_Identity=25.8196721311475, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788407, Length=246, Percent_Identity=28.0487804878049, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=316, Percent_Identity=26.2658227848101, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=318, Percent_Identity=26.7295597484277, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=289, Percent_Identity=26.643598615917, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=417, Percent_Identity=29.2565947242206, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=330, Percent_Identity=31.2121212121212, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=424, Percent_Identity=27.122641509434, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17137530, Length=276, Percent_Identity=28.9855072463768, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17737895, Length=271, Percent_Identity=28.4132841328413, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 43025; Mature: 43025

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAITWHGKHDVRCDTVDDPAIVNPRDAIIRVTSTAICGSDLHLYDGYIPTMQKGDILGH
CCCEEECCCCCCCCCCCCCCCEECCCHHEEEEEEHEECCCCCEEECCCCCCCCCCCCCCH
EFMGEVVEAGPKSSLNTGQRVVVPFTISCGSCYHCSKTQYSACENANPADNQDIGREGYG
HHHHHHHHCCCCCCCCCCCEEEEEEEECCCCEECCCCCHHHHCCCCCCCCCCCCCCCCCC
HPMPGLFGYSHMTGGYAGGQAEYVRVPFSDVGPLVIPDESIPDDKVLFLSDILPTGWMAA
CCCCCCCCCHHCCCCCCCCCCEEEECCCCCCCCEEECCCCCCCCCEEEEHHCCCCCCEEC
ENAEIEPGDTVAVWGCGPVGLFAVQSAFLMGAERVIAIDHFPHRLELARKFGAETVNFEE
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCCCH
SKVYEALMEMTGGIGPDAAIDCVGLEAHGAFADNIIDQIKASTFLGTDRIHAIRQVILAT
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RKGGRVSMPAVYGGFVDKFPLGALMEKGLTLKTGQTHVQRYLQPLYAAIAEDKIDSTFLI
CCCCCEECCHHHCCCHHHCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHCCCCEEEE
SHRMALEDGPLGYQKFHDEQDSYTKIVLKPGQAAGATAA
EEHEECCCCCCCHHHHCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKAITWHGKHDVRCDTVDDPAIVNPRDAIIRVTSTAICGSDLHLYDGYIPTMQKGDILGH
CCCEEECCCCCCCCCCCCCCCEECCCHHEEEEEEHEECCCCCEEECCCCCCCCCCCCCCH
EFMGEVVEAGPKSSLNTGQRVVVPFTISCGSCYHCSKTQYSACENANPADNQDIGREGYG
HHHHHHHHCCCCCCCCCCCEEEEEEEECCCCEECCCCCHHHHCCCCCCCCCCCCCCCCCC
HPMPGLFGYSHMTGGYAGGQAEYVRVPFSDVGPLVIPDESIPDDKVLFLSDILPTGWMAA
CCCCCCCCCHHCCCCCCCCCCEEEECCCCCCCCEEECCCCCCCCCEEEEHHCCCCCCEEC
ENAEIEPGDTVAVWGCGPVGLFAVQSAFLMGAERVIAIDHFPHRLELARKFGAETVNFEE
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCCCH
SKVYEALMEMTGGIGPDAAIDCVGLEAHGAFADNIIDQIKASTFLGTDRIHAIRQVILAT
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RKGGRVSMPAVYGGFVDKFPLGALMEKGLTLKTGQTHVQRYLQPLYAAIAEDKIDSTFLI
CCCCCEECCHHHCCCHHHCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHCCCCEEEE
SHRMALEDGPLGYQKFHDEQDSYTKIVLKPGQAAGATAA
EEHEECCCCCCCHHHHCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]