Click here to switch to the map view.

The map label for this gene is yeiA [H]

Identifier: 148380778

GI number: 148380778

Start: 2988552

End: 2989787

Strand: Reverse

Name: yeiA [H]

Synonym: CBO2819

Alternate gene names: 148380778

Gene position: 2989787-2988552 (Counterclockwise)

Preceding gene: 148380779

Following gene: 148380777

Centisome position: 76.92

GC content: 33.01

Gene sequence:

>1236_bases
ATGAAAAGAAGAGATCTTTCCATAGAATTTTGTGGAGTAAAGTGTGAAAATCCATTTTTCTTATCATCATCACCAGTAGG
AAACTGTTACGAAATGTGTGCTAAAGCTTTAGAAATTGGTTGGGGAGGTATAGTATTTAAAACTATAGGCTTCTTCATTG
CAAATGAAGTTTCTCCACGTTTTGATAATTTAGAAAAAGAAGGAACTTCATTTTTAGGTTTTAAAAATATGGAGCAAATA
GCAGAACACTCACTAGAAGAAAACTTAGAAGCTATGAAAAGACTAAAACAAAATTATCCCAATAAAGTTTTAGTGGCTTC
AATAATGGGACAAAATGAAAAAGAGTGGGAAGAACTTGCAAAACTTGTTACAGAAGTGGGAGCAGATATAATAGAATGTA
ACTTTTCATGTCCACAAATGACTAGTAGCGCCATGGGATCAGATGTGGGACAAAATCCACAATTAGTTAAAAAATATTGT
GAAGCAGTAAGAAGAGGAACTGATATTCCAATACTAGCTAAAATGACTCCGAACATAGGAGATATGAGTGTGCCGGCAAT
AGCCTCTATAGAAGGTGGAGCAACAGGTATAGCTACAATAAATACAATTAAGTGTATTACAGGAGTGGACTTAGATAAAT
TTATAGGATATCCTATTGTAAATGGAAAATCATCAATTTCAGGATACTCAGGAAAAGCAGTAAAACCAATAGCTTTAAGA
TTTATACAACAATTAGTAACAGATGGAAGGCTTAAAAGTGTTCCAATAAGTGGTATAGGTGGAATAGAAACTTGGGAAGA
TGCCGCGGAATTTATATTGTTAGGATCAAGAAACTTGCAAGTAACTACTGCTGTAATGCAATATGGATATAGAATAGTAG
AAGATATGATAGAAGGTCTTTCATATTATATGAAAGAAAAAGGCTTTGAAAAATTAGAAGATATGGTGGGATTAGCAAAT
AAAAACATAATTCCAGCAGAGGATTTAGATAGGGGATATATTGTGTACCCGAAATTTAATGAAGAAAACTGTGTAGGTTG
CGGAAGATGCTATATATCTTGCTATGATGGTGGACATCAAGCAATCAAATGGGATGGTAAAAATAGAAAACCTATATTAG
AGAAAGAAAACTGTGTAGGATGTCATTTATGTGCTAATGTGTGTCCAGTACAATGTATATCAAAAGGAGAAATAGAGTTT
AAAAAGGATGAAATAGCTAGAGAGATAATAGTTTAA

Upstream 100 bases:

>100_bases
TTGAAGGAGATAAAACTGTTGTAAATGCTGTAAAAGAAGGAAAAGAAGCAGCAAAGGCCATAGCAAAATATTTATTAGCT
AAGAAAGAAGGTGTAAGATA

Downstream 100 bases:

>100_bases
TATAAATTTATTATCTTTTATGCCTGGTACCTTTTGTGAAAATTTAATAATTTTATAAACAGATTAAAAACCACTTATAA
TTAGTGGTTTTTAATCTGTT

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MKRRDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKALEIGWGGIVFKTIGFFIANEVSPRFDNLEKEGTSFLGFKNMEQI
AEHSLEENLEAMKRLKQNYPNKVLVASIMGQNEKEWEELAKLVTEVGADIIECNFSCPQMTSSAMGSDVGQNPQLVKKYC
EAVRRGTDIPILAKMTPNIGDMSVPAIASIEGGATGIATINTIKCITGVDLDKFIGYPIVNGKSSISGYSGKAVKPIALR
FIQQLVTDGRLKSVPISGIGGIETWEDAAEFILLGSRNLQVTTAVMQYGYRIVEDMIEGLSYYMKEKGFEKLEDMVGLAN
KNIIPAEDLDRGYIVYPKFNEENCVGCGRCYISCYDGGHQAIKWDGKNRKPILEKENCVGCHLCANVCPVQCISKGEIEF
KKDEIAREIIV

Sequences:

>Translated_411_residues
MKRRDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKALEIGWGGIVFKTIGFFIANEVSPRFDNLEKEGTSFLGFKNMEQI
AEHSLEENLEAMKRLKQNYPNKVLVASIMGQNEKEWEELAKLVTEVGADIIECNFSCPQMTSSAMGSDVGQNPQLVKKYC
EAVRRGTDIPILAKMTPNIGDMSVPAIASIEGGATGIATINTIKCITGVDLDKFIGYPIVNGKSSISGYSGKAVKPIALR
FIQQLVTDGRLKSVPISGIGGIETWEDAAEFILLGSRNLQVTTAVMQYGYRIVEDMIEGLSYYMKEKGFEKLEDMVGLAN
KNIIPAEDLDRGYIVYPKFNEENCVGCGRCYISCYDGGHQAIKWDGKNRKPILEKENCVGCHLCANVCPVQCISKGEIEF
KKDEIAREIIV
>Mature_411_residues
MKRRDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKALEIGWGGIVFKTIGFFIANEVSPRFDNLEKEGTSFLGFKNMEQI
AEHSLEENLEAMKRLKQNYPNKVLVASIMGQNEKEWEELAKLVTEVGADIIECNFSCPQMTSSAMGSDVGQNPQLVKKYC
EAVRRGTDIPILAKMTPNIGDMSVPAIASIEGGATGIATINTIKCITGVDLDKFIGYPIVNGKSSISGYSGKAVKPIALR
FIQQLVTDGRLKSVPISGIGGIETWEDAAEFILLGSRNLQVTTAVMQYGYRIVEDMIEGLSYYMKEKGFEKLEDMVGLAN
KNIIPAEDLDRGYIVYPKFNEENCVGCGRCYISCYDGGHQAIKWDGKNRKPILEKENCVGCHLCANVCPVQCISKGEIEF
KKDEIAREIIV

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=323, Percent_Identity=34.984520123839, Blast_Score=186, Evalue=2e-47,
Organism=Escherichia coli, GI87082059, Length=404, Percent_Identity=72.5247524752475, Blast_Score=626, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984108, Length=323, Percent_Identity=37.1517027863777, Blast_Score=201, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322633, Length=325, Percent_Identity=24.9230769230769, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24640763, Length=313, Percent_Identity=36.4217252396166, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI18858217, Length=313, Percent_Identity=36.4217252396166, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 45386; Mature: 45386

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKALEIGWGGIVFKTIGFFIANEVSPR
CCCCCCEEEEECEEECCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCH
FDNLEKEGTSFLGFKNMEQIAEHSLEENLEAMKRLKQNYPNKVLVASIMGQNEKEWEELA
HHCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHCCCHHHHHHHH
KLVTEVGADIIECNFSCPQMTSSAMGSDVGQNPQLVKKYCEAVRRGTDIPILAKMTPNIG
HHHHHHCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCC
DMSVPAIASIEGGATGIATINTIKCITGVDLDKFIGYPIVNGKSSISGYSGKAVKPIALR
CCCCCCEEECCCCCCCEEEEHHHHHHCCCCHHHHCCCCEECCCCCCCCCCCCCCHHHHHH
FIQQLVTDGRLKSVPISGIGGIETWEDAAEFILLGSRNLQVTTAVMQYGYRIVEDMIEGL
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHEEEECCCCCEEHHHHHHHHHHHHHHHHHHH
SYYMKEKGFEKLEDMVGLANKNIIPAEDLDRGYIVYPKFNEENCVGCGRCYISCYDGGHQ
HHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCC
AIKWDGKNRKPILEKENCVGCHLCANVCPVQCISKGEIEFKKDEIAREIIV
EEEECCCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCCEECHHHHHHHHCC
>Mature Secondary Structure
MKRRDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKALEIGWGGIVFKTIGFFIANEVSPR
CCCCCCEEEEECEEECCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCH
FDNLEKEGTSFLGFKNMEQIAEHSLEENLEAMKRLKQNYPNKVLVASIMGQNEKEWEELA
HHCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHCCCHHHHHHHH
KLVTEVGADIIECNFSCPQMTSSAMGSDVGQNPQLVKKYCEAVRRGTDIPILAKMTPNIG
HHHHHHCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCC
DMSVPAIASIEGGATGIATINTIKCITGVDLDKFIGYPIVNGKSSISGYSGKAVKPIALR
CCCCCCEEECCCCCCCEEEEHHHHHHCCCCHHHHCCCCEECCCCCCCCCCCCCCHHHHHH
FIQQLVTDGRLKSVPISGIGGIETWEDAAEFILLGSRNLQVTTAVMQYGYRIVEDMIEGL
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHEEEECCCCCEEHHHHHHHHHHHHHHHHHHH
SYYMKEKGFEKLEDMVGLANKNIIPAEDLDRGYIVYPKFNEENCVGCGRCYISCYDGGHQ
HHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCC
AIKWDGKNRKPILEKENCVGCHLCANVCPVQCISKGEIEFKKDEIAREIIV
EEEECCCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCCEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]