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The map label for this gene is glcR [H]

Identifier: 148379578

GI number: 148379578

Start: 1751554

End: 1752303

Strand: Reverse

Name: glcR [H]

Synonym: CBO1616

Alternate gene names: 148379578

Gene position: 1752303-1751554 (Counterclockwise)

Preceding gene: 148379581

Following gene: 148379577

Centisome position: 45.08

GC content: 28.53

Gene sequence:

>750_bases
ATGAATAAAATATTAGAATATTTAAAAATAAATAAACGGATAAAAGTAGATGAAATATGTAAAATGTGTAATGTATCCAG
AGATACAGCAAGACGCGACCTTGTAAATCTTGAAAAAGAAGGAGCAATCCTTCGAACTCATGGTGGTGCTATATTACCTA
ATACGAGAGGTAAAGTAAAAAACTATGAGGACCGACTTCTTACTTATCCAACTGAAAAAAAACTTATAGCAAAACTTGCA
ACATCTTTAATCAAAAATACAGATAAATTAATAATGGACTCCTCAACTACAGTACAAATTTTTGCAGAAATGCTTGAAGT
AGAAAATTTATCTGTTATAACCAATTCAATAAATTTAGCACATAGATTATCGAAAAAAGCTAATATAGACATTCATTTAT
TAGGAGGAATTTTAGATTGTGAATATAAATTTTTATATGGTCCTAGTACCATAGATATGCTTTCCAATTATTTTGCTGAT
AAAGCATGTATAGGAGCCCTCGGAATATCAGAAAAAGGTATAACTGTGGCACATGCAGAAGATGCTTCTGTTATGAAAAA
AATGATTGAACAATCTAATGAAACTATAGTTCTAGTAGACCACAGCAAATTTGGAAATAATGGTTTTTTTAAAGTATGTG
ATTTATGTGATATTGATTTAATAGTTACAGATAAACTGCCAAATAAAGATTTGACTAAAATATTTGAAGAAAATAACATA
GACATTATGGCTGTAAATGAGAAAGGTTAA

Upstream 100 bases:

>100_bases
AAAAAGCTTATAAGGACTTGAAAGTTTACTTAAAATAACTTATAATTAAATTATTAAGTTTCTACTGTGGAGGTTTAAAA
TATTGTATCAGGAAGAAAGA

Downstream 100 bases:

>100_bases
GGTGGATAATGATGAAGTTAATAGCATTAGATTTAGATGGTACTCTATTAAATAATAAAAGTATAATAAGTAATGAAAAT
GCAGCTGCCATTAGATATGC

Product: DeoR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MNKILEYLKINKRIKVDEICKMCNVSRDTARRDLVNLEKEGAILRTHGGAILPNTRGKVKNYEDRLLTYPTEKKLIAKLA
TSLIKNTDKLIMDSSTTVQIFAEMLEVENLSVITNSINLAHRLSKKANIDIHLLGGILDCEYKFLYGPSTIDMLSNYFAD
KACIGALGISEKGITVAHAEDASVMKKMIEQSNETIVLVDHSKFGNNGFFKVCDLCDIDLIVTDKLPNKDLTKIFEENNI
DIMAVNEKG

Sequences:

>Translated_249_residues
MNKILEYLKINKRIKVDEICKMCNVSRDTARRDLVNLEKEGAILRTHGGAILPNTRGKVKNYEDRLLTYPTEKKLIAKLA
TSLIKNTDKLIMDSSTTVQIFAEMLEVENLSVITNSINLAHRLSKKANIDIHLLGGILDCEYKFLYGPSTIDMLSNYFAD
KACIGALGISEKGITVAHAEDASVMKKMIEQSNETIVLVDHSKFGNNGFFKVCDLCDIDLIVTDKLPNKDLTKIFEENNI
DIMAVNEKG
>Mature_249_residues
MNKILEYLKINKRIKVDEICKMCNVSRDTARRDLVNLEKEGAILRTHGGAILPNTRGKVKNYEDRLLTYPTEKKLIAKLA
TSLIKNTDKLIMDSSTTVQIFAEMLEVENLSVITNSINLAHRLSKKANIDIHLLGGILDCEYKFLYGPSTIDMLSNYFAD
KACIGALGISEKGITVAHAEDASVMKKMIEQSNETIVLVDHSKFGNNGFFKVCDLCDIDLIVTDKLPNKDLTKIFEENNI
DIMAVNEKG

Specific function: Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789829, Length=243, Percent_Identity=30.8641975308642, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1788069, Length=237, Percent_Identity=32.4894514767932, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1789059, Length=246, Percent_Identity=30.0813008130081, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789519, Length=249, Percent_Identity=27.710843373494, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI87082344, Length=242, Percent_Identity=26.4462809917355, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI226510968, Length=247, Percent_Identity=29.9595141700405, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789170, Length=225, Percent_Identity=27.5555555555556, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787540, Length=247, Percent_Identity=28.3400809716599, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790753, Length=232, Percent_Identity=27.1551724137931, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787063, Length=249, Percent_Identity=26.1044176706827, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790635, Length=243, Percent_Identity=22.2222222222222, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 27885; Mature: 27885

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKILEYLKINKRIKVDEICKMCNVSRDTARRDLVNLEKEGAILRTHGGAILPNTRGKVK
CHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCEECCCCCCCCC
NYEDRLLTYPTEKKLIAKLATSLIKNTDKLIMDSSTTVQIFAEMLEVENLSVITNSINLA
CCCCCEEECCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCEEEHHHHHHH
HRLSKKANIDIHLLGGILDCEYKFLYGPSTIDMLSNYFADKACIGALGISEKGITVAHAE
HHHHHHCCCEEEEECCEEECCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
DASVMKKMIEQSNETIVLVDHSKFGNNGFFKVCDLCDIDLIVTDKLPNKDLTKIFEENNI
CHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHCCCE
DIMAVNEKG
EEEEECCCC
>Mature Secondary Structure
MNKILEYLKINKRIKVDEICKMCNVSRDTARRDLVNLEKEGAILRTHGGAILPNTRGKVK
CHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCEECCCCCCCCC
NYEDRLLTYPTEKKLIAKLATSLIKNTDKLIMDSSTTVQIFAEMLEVENLSVITNSINLA
CCCCCEEECCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCEEEHHHHHHH
HRLSKKANIDIHLLGGILDCEYKFLYGPSTIDMLSNYFADKACIGALGISEKGITVAHAE
HHHHHHCCCEEEEECCEEECCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
DASVMKKMIEQSNETIVLVDHSKFGNNGFFKVCDLCDIDLIVTDKLPNKDLTKIFEENNI
CHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHCCCE
DIMAVNEKG
EEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]