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The map label for this gene is hisD [H]

Identifier: 148379533

GI number: 148379533

Start: 1698585

End: 1699889

Strand: Direct

Name: hisD [H]

Synonym: CBO1567

Alternate gene names: 148379533

Gene position: 1698585-1699889 (Clockwise)

Preceding gene: 148379532

Following gene: 148379534

Centisome position: 43.7

GC content: 31.95

Gene sequence:

>1305_bases
ATGATAAATGTGGTTAAAATAGGTGAAGACAATAAAAAACAGTGCATGAATAATTTGAAAAGCAGGTCAAAAAAAGTACA
AAAAGATGTAATTACTTCTGTAAAAAAAATACTAGGGGACATAAATGAAGATGGGGATAAAGCATTAATAAAATATACTA
ATAAGTTTGATAGTAAAAAAATAAATTTAGAAAATATTAGAGTTACTTCAGAAGAGATAAAAAAGGCTTATGAATTAGTT
GATGAAAAATTTATAAAGGCTATAAAAATTGCTAAAGAAAATATATTGTTTTATCATGAGAAGCAAAAACAAAGATCATG
GATGGTAACAAAGGAAGATGGAATAATTTTAGGTCAGCAAATTAGAGCTCTAGAGACTGTAGGTATATACGTTTCAGGAG
GAACAGCAGCTTATCCTTCTTCAGTATTAATGAACACCCTTCCAGCTAAAGTAGCAGGAGTAGAAAAAATAGTTATGATA
ACTCCTCCTTCTAAGGATGGGAGTGTAAATCCTAATATTTTAGTAGCTGCTAATATTGCAGGGGTTGATGAAATATATAA
AGCAGGAGGAGCACAAGGAATAGGAGCTTTAGCTTATGGAACAAAAATCATACCAAAGGTGGATAAAATAGTAGGTCCAG
GTAATATATATGTGGCTATGGCCAAAAGAAGTGTTTATGGCTTTGTGGATATAGATATGATAGCAGGACCTAGTGAAATT
TTGATTATAGCAGATGAAAGTTCTGATCCTAAATTTATAGCAGCAGATTTTATGTCTCAAGCTGAGCATGATGTATTGGC
ATCCTCAATGTTAGTTACTACCTCTGAGAGATTAGCACAAAAGGTAAAAGACCAATTAAACATACAGATAAAAAATCTTT
CAAGGAAAGAAATAATACGTACATCTATTAAAGATTATGGTGCTATTTTTGTAGTAGATAATTTAGAAGAAGCTATAGAA
CTTGCTAATGATATATCCCCAGAACATTTAGAGGTTATGACAGAAGACCCCTTCACTATTTTAGGACAAATTAAAAATGC
AGGTTCTGTATTCTTAGGTAAATATGCTCCAGAACCATTAGGGGATTATATGGCAGGACCAAATCATGTATTGCCTACTA
GCGGAAGTGCAAGATTTTTTTCACCTCTTTCAGTAGATGATTATATTAAGAAATCAAGTTTCACATATTACACCAAAAGG
GCATTGGAAAAAGTAAAGGATGTTACTGTAACCATTGCTGAAACAGAGGGATTAACTGCCCATGCAAATTCCATAAGAGT
GAGATTTGATAATAATAATTTTTGA

Upstream 100 bases:

>100_bases
TAAGTGAGGTAATAAGGCAATAAAAAAGAACAAAAATAGGAAAGGGGGGTATTTAGTGAGTTAATGTATTTTTTATATAC
TCTCTCACTAAAGTTAAAAA

Downstream 100 bases:

>100_bases
TTTTAGGAAGATGTTAAGTTTAAATTGAAGATTTAAAAGTGGTAATTAATAGATAAATAGTAGTTTAATATGTTTCCTAT
AAAAATACAATTGGAACAGT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MINVVKIGEDNKKQCMNNLKSRSKKVQKDVITSVKKILGDINEDGDKALIKYTNKFDSKKINLENIRVTSEEIKKAYELV
DEKFIKAIKIAKENILFYHEKQKQRSWMVTKEDGIILGQQIRALETVGIYVSGGTAAYPSSVLMNTLPAKVAGVEKIVMI
TPPSKDGSVNPNILVAANIAGVDEIYKAGGAQGIGALAYGTKIIPKVDKIVGPGNIYVAMAKRSVYGFVDIDMIAGPSEI
LIIADESSDPKFIAADFMSQAEHDVLASSMLVTTSERLAQKVKDQLNIQIKNLSRKEIIRTSIKDYGAIFVVDNLEEAIE
LANDISPEHLEVMTEDPFTILGQIKNAGSVFLGKYAPEPLGDYMAGPNHVLPTSGSARFFSPLSVDDYIKKSSFTYYTKR
ALEKVKDVTVTIAETEGLTAHANSIRVRFDNNNF

Sequences:

>Translated_434_residues
MINVVKIGEDNKKQCMNNLKSRSKKVQKDVITSVKKILGDINEDGDKALIKYTNKFDSKKINLENIRVTSEEIKKAYELV
DEKFIKAIKIAKENILFYHEKQKQRSWMVTKEDGIILGQQIRALETVGIYVSGGTAAYPSSVLMNTLPAKVAGVEKIVMI
TPPSKDGSVNPNILVAANIAGVDEIYKAGGAQGIGALAYGTKIIPKVDKIVGPGNIYVAMAKRSVYGFVDIDMIAGPSEI
LIIADESSDPKFIAADFMSQAEHDVLASSMLVTTSERLAQKVKDQLNIQIKNLSRKEIIRTSIKDYGAIFVVDNLEEAIE
LANDISPEHLEVMTEDPFTILGQIKNAGSVFLGKYAPEPLGDYMAGPNHVLPTSGSARFFSPLSVDDYIKKSSFTYYTKR
ALEKVKDVTVTIAETEGLTAHANSIRVRFDNNNF
>Mature_434_residues
MINVVKIGEDNKKQCMNNLKSRSKKVQKDVITSVKKILGDINEDGDKALIKYTNKFDSKKINLENIRVTSEEIKKAYELV
DEKFIKAIKIAKENILFYHEKQKQRSWMVTKEDGIILGQQIRALETVGIYVSGGTAAYPSSVLMNTLPAKVAGVEKIVMI
TPPSKDGSVNPNILVAANIAGVDEIYKAGGAQGIGALAYGTKIIPKVDKIVGPGNIYVAMAKRSVYGFVDIDMIAGPSEI
LIIADESSDPKFIAADFMSQAEHDVLASSMLVTTSERLAQKVKDQLNIQIKNLSRKEIIRTSIKDYGAIFVVDNLEEAIE
LANDISPEHLEVMTEDPFTILGQIKNAGSVFLGKYAPEPLGDYMAGPNHVLPTSGSARFFSPLSVDDYIKKSSFTYYTKR
ALEKVKDVTVTIAETEGLTAHANSIRVRFDNNNF

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=426, Percent_Identity=36.8544600938967, Blast_Score=290, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6319819, Length=420, Percent_Identity=37.3809523809524, Blast_Score=280, Evalue=4e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47747; Mature: 47747

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVVKIGEDNKKQCMNNLKSRSKKVQKDVITSVKKILGDINEDGDKALIKYTNKFDSKK
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCE
INLENIRVTSEEIKKAYELVDEKFIKAIKIAKENILFYHEKQKQRSWMVTKEDGIILGQQ
EEHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEECCCCEEEHHH
IRALETVGIYVSGGTAAYPSSVLMNTLPAKVAGVEKIVMITPPSKDGSVNPNILVAANIA
HHEEEEEEEEEECCCCCCCHHHHHHHCCHHHCCCEEEEEEECCCCCCCCCCCEEEEEECC
GVDEIYKAGGAQGIGALAYGTKIIPKVDKIVGPGNIYVAMAKRSVYGFVDIDMIAGPSEI
CHHHHHHCCCCCCCCHHHHCCCCCCCHHHHCCCCCEEEEEECCCEEEEEEEEEECCCCEE
LIIADESSDPKFIAADFMSQAEHDVLASSMLVTTSERLAQKVKDQLNIQIKNLSRKEIIR
EEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHH
TSIKDYGAIFVVDNLEEAIELANDISPEHLEVMTEDPFTILGQIKNAGSVFLGKYAPEPL
HHHHHCCEEEEECCHHHHHHHHHCCCCCCEEEECCCCCEEHHHHCCCCCEEEECCCCCCH
GDYMAGPNHVLPTSGSARFFSPLSVDDYIKKSSFTYYTKRALEKVKDVTVTIAETEGLTA
HHHCCCCCCCCCCCCCCCEECCCCHHHHHHHCCCHHHHHHHHHHHHCEEEEEEECCCCEE
HANSIRVRFDNNNF
ECCEEEEEECCCCC
>Mature Secondary Structure
MINVVKIGEDNKKQCMNNLKSRSKKVQKDVITSVKKILGDINEDGDKALIKYTNKFDSKK
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCE
INLENIRVTSEEIKKAYELVDEKFIKAIKIAKENILFYHEKQKQRSWMVTKEDGIILGQQ
EEHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEECCCCEEEHHH
IRALETVGIYVSGGTAAYPSSVLMNTLPAKVAGVEKIVMITPPSKDGSVNPNILVAANIA
HHEEEEEEEEEECCCCCCCHHHHHHHCCHHHCCCEEEEEEECCCCCCCCCCCEEEEEECC
GVDEIYKAGGAQGIGALAYGTKIIPKVDKIVGPGNIYVAMAKRSVYGFVDIDMIAGPSEI
CHHHHHHCCCCCCCCHHHHCCCCCCCHHHHCCCCCEEEEEECCCEEEEEEEEEECCCCEE
LIIADESSDPKFIAADFMSQAEHDVLASSMLVTTSERLAQKVKDQLNIQIKNLSRKEIIR
EEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHH
TSIKDYGAIFVVDNLEEAIELANDISPEHLEVMTEDPFTILGQIKNAGSVFLGKYAPEPL
HHHHHCCEEEEECCHHHHHHHHHCCCCCCEEEECCCCCEEHHHHCCCCCEEEECCCCCCH
GDYMAGPNHVLPTSGSARFFSPLSVDDYIKKSSFTYYTKRALEKVKDVTVTIAETEGLTA
HHHCCCCCCCCCCCCCCCEECCCCHHHHHHHCCCHHHHHHHHHHHHCEEEEEEECCCCEE
HANSIRVRFDNNNF
ECCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]