Click here to switch to the map view.

The map label for this gene is hisG [H]

Identifier: 148379532

GI number: 148379532

Start: 1697860

End: 1698507

Strand: Direct

Name: hisG [H]

Synonym: CBO1566

Alternate gene names: 148379532

Gene position: 1697860-1698507 (Clockwise)

Preceding gene: 148379531

Following gene: 148379533

Centisome position: 43.68

GC content: 30.09

Gene sequence:

>648_bases
GTGATTACATTGAAAAATGTAAAAATAGCGTTAACCAAAGGTAGACTTGAAAAGAAAGCTATTGAAATATTTAAAACTAT
TAATATTAATACTAGAGAATTAGAGGATAAAGGAAGAAAACTCATTTTTAATTGTGAAAATGAGGAATATAATATAGAGC
TTTTTTTAGTTAAAGCTAAAGATGTAGAAACCTATGTAGAATATGGAGCTGCGGATATCGGTATTGTAGGAAAAGATACT
TTAATGGAAACAAATAAGGAGTTTTATGAAGTTTTAGATCTGAATGTAGGAAAGTGTAAATTTGCTTTAGCGGCTTTGCC
TAGTTTTAAGTTAGATCAAGGATATAATAGGAAAAAGATAGCAACTAAATATCCGAATATAGCAAGGGAATATTTTAGAA
AAAAGGGCATGGATGTGGAATTAATCAAAATAGAAGGCTCCGTAGAATTAGGACCTATTGTAGGGCTTGCAGATGCCATA
GTAGATATTGTAGAAACAGGAAACACTTTAAGAGAAAATGGCTTAGTAGTTGTGGAGGATATATGTGAAATAAGTGCAAG
AATGATAGTAAATAAGGCCAGTATGAAAACGAAAAAGGATGAAATCATAAAAATAATTGAAAATGTAAGTGAGGTAATAA
GGCAATAA

Upstream 100 bases:

>100_bases
AGAAAAACTATTTGTTAAGGATTTAAAATCAGATAAAATAGCTTTTCTAAAGAAAGATGAGATTGAAAATTTGTTAATGT
TGTAATTAATAAGGAAATGG

Downstream 100 bases:

>100_bases
AAAAGAACAAAAATAGGAAAGGGGGGTATTTAGTGAGTTAATGTATTTTTTATATACTCTCTCACTAAAGTTAAAAAATG
ATAAATGTGGTTAAAATAGG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MITLKNVKIALTKGRLEKKAIEIFKTININTRELEDKGRKLIFNCENEEYNIELFLVKAKDVETYVEYGAADIGIVGKDT
LMETNKEFYEVLDLNVGKCKFALAALPSFKLDQGYNRKKIATKYPNIAREYFRKKGMDVELIKIEGSVELGPIVGLADAI
VDIVETGNTLRENGLVVVEDICEISARMIVNKASMKTKKDEIIKIIENVSEVIRQ

Sequences:

>Translated_215_residues
MITLKNVKIALTKGRLEKKAIEIFKTININTRELEDKGRKLIFNCENEEYNIELFLVKAKDVETYVEYGAADIGIVGKDT
LMETNKEFYEVLDLNVGKCKFALAALPSFKLDQGYNRKKIATKYPNIAREYFRKKGMDVELIKIEGSVELGPIVGLADAI
VDIVETGNTLRENGLVVVEDICEISARMIVNKASMKTKKDEIIKIIENVSEVIRQ
>Mature_215_residues
MITLKNVKIALTKGRLEKKAIEIFKTININTRELEDKGRKLIFNCENEEYNIELFLVKAKDVETYVEYGAADIGIVGKDT
LMETNKEFYEVLDLNVGKCKFALAALPSFKLDQGYNRKKIATKYPNIAREYFRKKGMDVELIKIEGSVELGPIVGLADAI
VDIVETGNTLRENGLVVVEDICEISARMIVNKASMKTKKDEIIKIIENVSEVIRQ

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=229, Percent_Identity=31.4410480349345, Blast_Score=97, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320896, Length=189, Percent_Identity=31.2169312169312, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 24339; Mature: 24339

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLKNVKIALTKGRLEKKAIEIFKTININTRELEDKGRKLIFNCENEEYNIELFLVKAK
CEEECCEEEEEECCHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCEEEEEEEEECC
DVETYVEYGAADIGIVGKDTLMETNKEFYEVLDLNVGKCKFALAALPSFKLDQGYNRKKI
CHHHHHHHCCCCEEECCCHHHHHCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHH
ATKYPNIAREYFRKKGMDVELIKIEGSVELGPIVGLADAIVDIVETGNTLRENGLVVVED
HHCCCHHHHHHHHHCCCCEEEEEEECCEEECHHHHHHHHHHHHHHCCCCHHHCCCEEEHH
ICEISARMIVNKASMKTKKDEIIKIIENVSEVIRQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITLKNVKIALTKGRLEKKAIEIFKTININTRELEDKGRKLIFNCENEEYNIELFLVKAK
CEEECCEEEEEECCHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCEEEEEEEEECC
DVETYVEYGAADIGIVGKDTLMETNKEFYEVLDLNVGKCKFALAALPSFKLDQGYNRKKI
CHHHHHHHCCCCEEECCCHHHHHCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHH
ATKYPNIAREYFRKKGMDVELIKIEGSVELGPIVGLADAIVDIVETGNTLRENGLVVVED
HHCCCHHHHHHHHHCCCCEEEEEEECCEEECHHHHHHHHHHHHHHCCCCHHHCCCEEEHH
ICEISARMIVNKASMKTKKDEIIKIIENVSEVIRQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA