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The map label for this gene is queD [H]

Identifier: 148379521

GI number: 148379521

Start: 1687742

End: 1688173

Strand: Direct

Name: queD [H]

Synonym: CBO1554

Alternate gene names: 148379521

Gene position: 1687742-1688173 (Clockwise)

Preceding gene: 148379520

Following gene: 148379522

Centisome position: 43.42

GC content: 32.18

Gene sequence:

>432_bases
ATGTATACTTTAAAAGTAGAACATAATTTTGATAGTGCTCATTTTCTTGCAGGTTATGAAGGTAAATGTGGAAATATTCA
TGGACACAGATGGAAGGTTGAAATTCAGGTTCAGGCAGAATCATTAGTACAAGGTGGTCAACTTGACGGGATGATAATAG
ACTTTGGAGACTTAAAAAAAGATGTTAAATCTATGGTAGATTATTATGATCATGCACTTATAATAGAGAAGGGAACTATG
AGGGGGCAATCATTAAGCTCATTAAAGGAGGATGGATTTCGTATAATAGAAGTTAATTTTAGACCAACAGCGGAAAATTT
TGCAGCTTTTTTCTATAAAATTATGAAGGATAGAGGATATAATGTAAAAAGTACTACAGTTTATGAAACACCTAATAATA
GTGCTACCTATGAAGAAAGTGGGGTAATTTAA

Upstream 100 bases:

>100_bases
ATGAAGAAATAGTATCCGTAAAAGATCCTCAGTTTAATGGGGCTATTGGATGTTGTTATTACGGAAGCAAATTTTTAAAA
TAAACTTAGGAGGAAAAAAC

Downstream 100 bases:

>100_bases
AATGGATTTTAAGGTGGTTGAAAGGTTTGTAAGCATAAATGGAGAAGGAAGGCGTTGTGGACAACTGGCTATATTCATAA
GATTCGCGGGTTGTAATTTA

Product: putative 6-pyruvoyl tetrahydropterin synthase

Products: 6-pyruvoyl-5,6,7,8-tetrahydropterin; triphosphate

Alternate protein names: CPH4 synthase; Queuosine biosynthesis protein queD [H]

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MYTLKVEHNFDSAHFLAGYEGKCGNIHGHRWKVEIQVQAESLVQGGQLDGMIIDFGDLKKDVKSMVDYYDHALIIEKGTM
RGQSLSSLKEDGFRIIEVNFRPTAENFAAFFYKIMKDRGYNVKSTTVYETPNNSATYEESGVI

Sequences:

>Translated_143_residues
MYTLKVEHNFDSAHFLAGYEGKCGNIHGHRWKVEIQVQAESLVQGGQLDGMIIDFGDLKKDVKSMVDYYDHALIIEKGTM
RGQSLSSLKEDGFRIIEVNFRPTAENFAAFFYKIMKDRGYNVKSTTVYETPNNSATYEESGVI
>Mature_143_residues
MYTLKVEHNFDSAHFLAGYEGKCGNIHGHRWKVEIQVQAESLVQGGQLDGMIIDFGDLKKDVKSMVDYYDHALIIEKGTM
RGQSLSSLKEDGFRIIEVNFRPTAENFAAFFYKIMKDRGYNVKSTTVYETPNNSATYEESGVI

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde [H]

COG id: COG0720

COG function: function code H; 6-pyruvoyl-tetrahydropterin synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTPS family. QueD subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007116
- InterPro:   IPR007115 [H]

Pfam domain/function: PF01242 PTPS [H]

EC number: 4.2.3.12

Molecular weight: Translated: 16243; Mature: 16243

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTLKVEHNFDSAHFLAGYEGKCGNIHGHRWKVEIQVQAESLVQGGQLDGMIIDFGDLKK
CEEEEEECCCCCEEEEECCCCCCCCCCCEEEEEEEEEEEHHHHCCCCCCEEEEEHHHHHH
DVKSMVDYYDHALIIEKGTMRGQSLSSLKEDGFRIIEVNFRPTAENFAAFFYKIMKDRGY
HHHHHHHHHCCEEEEECCCCCCCHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHCCC
NVKSTTVYETPNNSATYEESGVI
CCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MYTLKVEHNFDSAHFLAGYEGKCGNIHGHRWKVEIQVQAESLVQGGQLDGMIIDFGDLKK
CEEEEEECCCCCEEEEECCCCCCCCCCCEEEEEEEEEEEHHHHCCCCCCEEEEEHHHHHH
DVKSMVDYYDHALIIEKGTMRGQSLSSLKEDGFRIIEVNFRPTAENFAAFFYKIMKDRGY
HHHHHHHHHCCEEEEECCCCCCCHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHCCC
NVKSTTVYETPNNSATYEESGVI
CCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin

Specific reaction: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]