Click here to switch to the map view.

The map label for this gene is hgdC [H]

Identifier: 148379520

GI number: 148379520

Start: 1686963

End: 1687724

Strand: Direct

Name: hgdC [H]

Synonym: CBO1553

Alternate gene names: 148379520

Gene position: 1686963-1687724 (Clockwise)

Preceding gene: 148379519

Following gene: 148379521

Centisome position: 43.4

GC content: 32.15

Gene sequence:

>762_bases
ATGAGATTGTTAGGAATAGACCTTGGAAGTAGAGAAGTTAAGATTGTTTTAATGGAAAACAATATTATAGTTCAAAAGAA
AAAAGTAAGTACCATGAAATTTTATAGAGATTACTGTAGCTTTCATGGCAAGATTGTAGTAGATTTAGAAAAACTTAATA
TAGAAGGAATAGATAAAGCGATATCAACGGGTTATGGAAAAAATAATACGGATTTAGAATTTTTTACACCTATAAATGAG
ATAAAAGCCCATGTTTATGGTGGGATCTATCAAAGTAATTTAAAGGATTTTATACTTTTAGATGTAGGTGGTCAGGACGT
TAAGGTGGTAAAGGTAGAAAAGGGTGTTGCAACAGATTTGGAGCTTAATGAAAAATGTGCTGCTTCCTGTGGAAGATACT
TGGAGAATATGGCAAATGTACTTGAAATATCCCTAGATGAAATGAGCCAGTACTCGGAAAATCCCGTGGATTTAAATTCC
ACCTGTGCAGTATTTTCTGAATCAGAATTAATTGGAAAAATAGCCGAAGGGGTACACATAGAAAGGTTATGTGCTGGGGT
TAATTACTCTTTGTATAAAAGGCTACAACCTCTTTTAAGTAAGTTTAGGGGGAAGAAATTAGTTATAACCGGTGGTGTTG
CAAATAACCATTCAATAAAAAAATATTTAAATAATGATTATGAAGAAATAGTATCCGTAAAAGATCCTCAGTTTAATGGG
GCTATTGGATGTTGTTATTACGGAAGCAAATTTTTAAAATAA

Upstream 100 bases:

>100_bases
AATTTTTATCTTAATATATTGTTGGATTTAAAGCAAAAGTAATAGACGGTATATAAAAGAAGTTCATGTTTTCTTTATAT
TTAGCGAAGGAGGGGAATTA

Downstream 100 bases:

>100_bases
ACTTAGGAGGAAAAAACATGTATACTTTAAAAGTAGAACATAATTTTGATAGTGCTCATTTTCTTGCAGGTTATGAAGGT
AAATGTGGAAATATTCATGG

Product: 2-hydroxyglutaryl-CoA dehydratase component A

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MRLLGIDLGSREVKIVLMENNIIVQKKKVSTMKFYRDYCSFHGKIVVDLEKLNIEGIDKAISTGYGKNNTDLEFFTPINE
IKAHVYGGIYQSNLKDFILLDVGGQDVKVVKVEKGVATDLELNEKCAASCGRYLENMANVLEISLDEMSQYSENPVDLNS
TCAVFSESELIGKIAEGVHIERLCAGVNYSLYKRLQPLLSKFRGKKLVITGGVANNHSIKKYLNNDYEEIVSVKDPQFNG
AIGCCYYGSKFLK

Sequences:

>Translated_253_residues
MRLLGIDLGSREVKIVLMENNIIVQKKKVSTMKFYRDYCSFHGKIVVDLEKLNIEGIDKAISTGYGKNNTDLEFFTPINE
IKAHVYGGIYQSNLKDFILLDVGGQDVKVVKVEKGVATDLELNEKCAASCGRYLENMANVLEISLDEMSQYSENPVDLNS
TCAVFSESELIGKIAEGVHIERLCAGVNYSLYKRLQPLLSKFRGKKLVITGGVANNHSIKKYLNNDYEEIVSVKDPQFNG
AIGCCYYGSKFLK
>Mature_253_residues
MRLLGIDLGSREVKIVLMENNIIVQKKKVSTMKFYRDYCSFHGKIVVDLEKLNIEGIDKAISTGYGKNNTDLEFFTPINE
IKAHVYGGIYQSNLKDFILLDVGGQDVKVVKVEKGVATDLELNEKCAASCGRYLENMANVLEISLDEMSQYSENPVDLNS
TCAVFSESELIGKIAEGVHIERLCAGVNYSLYKRLQPLLSKFRGKKLVITGGVANNHSIKKYLNNDYEEIVSVKDPQFNG
AIGCCYYGSKFLK

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=255, Percent_Identity=30.1960784313725, Blast_Score=103, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 28290; Mature: 28290

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLGIDLGSREVKIVLMENNIIVQKKKVSTMKFYRDYCSFHGKIVVDLEKLNIEGIDKA
CEEEEECCCCCEEEEEEEECCEEEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHH
ISTGYGKNNTDLEFFTPINEIKAHVYGGIYQSNLKDFILLDVGGQDVKVVKVEKGVATDL
HHCCCCCCCCCEEEECCHHHHHHHHHCCHHHCCCCEEEEEEECCCCEEEEEECCCCCCCC
ELNEKCAASCGRYLENMANVLEISLDEMSQYSENPVDLNSTCAVFSESELIGKIAEGVHI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHCCCCH
ERLCAGVNYSLYKRLQPLLSKFRGKKLVITGGVANNHSIKKYLNNDYEEIVSVKDPQFNG
HHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHCCCHHHHHCCCCCCCCC
AIGCCYYGSKFLK
CEEEEECCHHHCC
>Mature Secondary Structure
MRLLGIDLGSREVKIVLMENNIIVQKKKVSTMKFYRDYCSFHGKIVVDLEKLNIEGIDKA
CEEEEECCCCCEEEEEEEECCEEEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHH
ISTGYGKNNTDLEFFTPINEIKAHVYGGIYQSNLKDFILLDVGGQDVKVVKVEKGVATDL
HHCCCCCCCCCEEEECCHHHHHHHHHCCHHHCCCCEEEEEEECCCCEEEEEECCCCCCCC
ELNEKCAASCGRYLENMANVLEISLDEMSQYSENPVDLNSTCAVFSESELIGKIAEGVHI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHCCCCH
ERLCAGVNYSLYKRLQPLLSKFRGKKLVITGGVANNHSIKKYLNNDYEEIVSVKDPQFNG
HHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHCCCHHHHHCCCCCCCCC
AIGCCYYGSKFLK
CEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]