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The map label for this gene is lytC [H]

Identifier: 148379305

GI number: 148379305

Start: 1447275

End: 1448729

Strand: Direct

Name: lytC [H]

Synonym: CBO1326

Alternate gene names: 148379305

Gene position: 1447275-1448729 (Clockwise)

Preceding gene: 148379304

Following gene: 148379307

Centisome position: 37.23

GC content: 29.0

Gene sequence:

>1455_bases
ATGAAAAAGATTATGGCGTTGGTAATTTCATCGGCTATAGTATTAGGAGGAAAGGGTGTAGCAGGAGCAAAAGGAGATTA
TAATGTAAATAGAATAAGTGGAAAAAATAGATATGAAACATCAATAAATATAGCTAAGCATTATAATAGTGAAAAGTTTG
AAAATGTAATCATAGCAAATGGAAATGACTTCCCTGATGCTTTGGCTGGATCTGCGCTTTCAAAAAAATTAAATGCACCA
ATATTGTTAATTGATGAAAATGTAAATTCTAGTAGAGAAACTATTAATCTTATAAAAAGTAAACTTGCTAAAAATGGTTC
CATATATATATTAGGGGGAGAAGGGGCCGTTGATAGAGTATATGAAGATTGGTTTAAAGATTTTGGATATAAAAATATTA
AAAGGTTAGGTGGAATAAATAGATTTGCTACAAATAAAAATATTGTAAAATCCCTAAATGTAGAAAAAGGAACTCCAATA
GTTATTGTTAATGGTTTTGGATTTGCAGATGCTTTAAGTGTATCTAGTTCTGCAGCATCAAAAGGATATCCAATTTTTAT
GAGTAATGCAGATAAGTTACCTAATGAAATAAAGGATATAATAAAGGATATATCACCTACTAAAGCCTTTATAATAGGTG
GAGAAGGTGTAATGAGAAATAGTATTGTAGATGAATTAAAAAATATTGTACCATCATTAAATAAAGAGGATATAGAAAGA
GTTGAGGGTAAAAATAGATATGAAACATCTTTAAACGTATGTAGCAAGTTTAATTTGTTATCAGATAATGCTATTGTTGC
GAGTGGCGAAAATTTCCCAGATGCTTTATCAGGAAGTGCCTTAGCTTCTAAGATGGATGCTCCTATAATATTGACAGATG
GTGTTAATATATTAAAGCAGAAGGAATATTTAGATAATAATAATTATAAAAACCTTATTTTGCTAGGGGGAACAGGGGCT
ATAAATACAGATTCACAGCGTATACTAGAAAACAAACCAGTTATTTCAGATAAAGATGCTAAAAATTTATTATTTAATGG
AGACGAGGAATTCAAAAAAATCCTTAAAATAGAAGTTCATAAAGAATCTTATATAGATTTAGATGGAAGAAGCTATGCTC
CAGTGAAGGAAGATCTAAGTAAATATGATTCTATAGATGATTACTTAAATAAAAATTTTAAGCTTAGCACTTATTATACA
GAAAATTTTATGAAAAACATGATAAACTTTGAATTTAAAAATATAGATGGACAATGCTACATGGGATATGGAAATCCAGA
GCCAAGACTTATTGTTAAAGATGCCAAAATTATAGAAAAAAAATATGATGGAAATAAAGTAAATGTGTCTTTAAACGGTT
ATTACCCTATTCCAGGACATGTTAGCAATGCAAAGGCTACATTAATATATGATGGAACTAAATGGGTTATAGATGAGTTT
GACAATTGGTTTTAG

Upstream 100 bases:

>100_bases
GAATTCATAAATGATTTATTAGCATTTTTCCGTCTTATACATAATATAGATATGATGTAGTTAGAACTAAAAAATTATTA
TGTTTAGGAGGAACGTTAAA

Downstream 100 bases:

>100_bases
GTTAATTAATAAATAAATTTTAAATGTAAAGGGCTATGGAATATAGGGTTATAACTTAATTTCATAGCTTTTATTTTATA
ATTATAGATGATGTTTAAAA

Product: cell wall hydrolase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MKKIMALVISSAIVLGGKGVAGAKGDYNVNRISGKNRYETSINIAKHYNSEKFENVIIANGNDFPDALAGSALSKKLNAP
ILLIDENVNSSRETINLIKSKLAKNGSIYILGGEGAVDRVYEDWFKDFGYKNIKRLGGINRFATNKNIVKSLNVEKGTPI
VIVNGFGFADALSVSSSAASKGYPIFMSNADKLPNEIKDIIKDISPTKAFIIGGEGVMRNSIVDELKNIVPSLNKEDIER
VEGKNRYETSLNVCSKFNLLSDNAIVASGENFPDALSGSALASKMDAPIILTDGVNILKQKEYLDNNNYKNLILLGGTGA
INTDSQRILENKPVISDKDAKNLLFNGDEEFKKILKIEVHKESYIDLDGRSYAPVKEDLSKYDSIDDYLNKNFKLSTYYT
ENFMKNMINFEFKNIDGQCYMGYGNPEPRLIVKDAKIIEKKYDGNKVNVSLNGYYPIPGHVSNAKATLIYDGTKWVIDEF
DNWF

Sequences:

>Translated_484_residues
MKKIMALVISSAIVLGGKGVAGAKGDYNVNRISGKNRYETSINIAKHYNSEKFENVIIANGNDFPDALAGSALSKKLNAP
ILLIDENVNSSRETINLIKSKLAKNGSIYILGGEGAVDRVYEDWFKDFGYKNIKRLGGINRFATNKNIVKSLNVEKGTPI
VIVNGFGFADALSVSSSAASKGYPIFMSNADKLPNEIKDIIKDISPTKAFIIGGEGVMRNSIVDELKNIVPSLNKEDIER
VEGKNRYETSLNVCSKFNLLSDNAIVASGENFPDALSGSALASKMDAPIILTDGVNILKQKEYLDNNNYKNLILLGGTGA
INTDSQRILENKPVISDKDAKNLLFNGDEEFKKILKIEVHKESYIDLDGRSYAPVKEDLSKYDSIDDYLNKNFKLSTYYT
ENFMKNMINFEFKNIDGQCYMGYGNPEPRLIVKDAKIIEKKYDGNKVNVSLNGYYPIPGHVSNAKATLIYDGTKWVIDEF
DNWF
>Mature_484_residues
MKKIMALVISSAIVLGGKGVAGAKGDYNVNRISGKNRYETSINIAKHYNSEKFENVIIANGNDFPDALAGSALSKKLNAP
ILLIDENVNSSRETINLIKSKLAKNGSIYILGGEGAVDRVYEDWFKDFGYKNIKRLGGINRFATNKNIVKSLNVEKGTPI
VIVNGFGFADALSVSSSAASKGYPIFMSNADKLPNEIKDIIKDISPTKAFIIGGEGVMRNSIVDELKNIVPSLNKEDIER
VEGKNRYETSLNVCSKFNLLSDNAIVASGENFPDALSGSALASKMDAPIILTDGVNILKQKEYLDNNNYKNLILLGGTGA
INTDSQRILENKPVISDKDAKNLLFNGDEEFKKILKIEVHKESYIDLDGRSYAPVKEDLSKYDSIDDYLNKNFKLSTYYT
ENFMKNMINFEFKNIDGQCYMGYGNPEPRLIVKDAKIIEKKYDGNKVNVSLNGYYPIPGHVSNAKATLIYDGTKWVIDEF
DNWF

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 53645; Mature: 53645

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIMALVISSAIVLGGKGVAGAKGDYNVNRISGKNRYETSINIAKHYNSEKFENVIIAN
CHHHHHHHHHHHHEECCCCCCCCCCCCCEEEECCCCCCEEEEEHHHHCCCHHHCEEEEEC
GNDFPDALAGSALSKKLNAPILLIDENVNSSRETINLIKSKLAKNGSIYILGGEGAVDRV
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
YEDWFKDFGYKNIKRLGGINRFATNKNIVKSLNVEKGTPIVIVNGFGFADALSVSSSAAS
HHHHHHHCCHHHHHHHCCCHHHHCCCHHHHHCCCCCCCCEEEEECCCCHHHHHCCCCCCC
KGYPIFMSNADKLPNEIKDIIKDISPTKAFIIGGEGVMRNSIVDELKNIVPSLNKEDIER
CCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHH
VEGKNRYETSLNVCSKFNLLSDNAIVASGENFPDALSGSALASKMDAPIILTDGVNILKQ
HCCCCHHHHHHHHHHHCCEECCCEEEECCCCCCCHHCCCHHHHHCCCCEEEECCCHHHHH
KEYLDNNNYKNLILLGGTGAINTDSQRILENKPVISDKDAKNLLFNGDEEFKKILKIEVH
HHHHCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCEECCCHHHHHHHEEEEE
KESYIDLDGRSYAPVKEDLSKYDSIDDYLNKNFKLSTYYTENFMKNMINFEFKNIDGQCY
CCCEEECCCCCCCCHHHHHHHHCCHHHHHCCCEEEEEEEHHHHHHHHHCEEEECCCCEEE
MGYGNPEPRLIVKDAKIIEKKYDGNKVNVSLNGYYPIPGHVSNAKATLIYDGTKWVIDEF
ECCCCCCCEEEEECHHHHHHCCCCCEEEEEEECEECCCCCCCCCEEEEEECCCCHHHHHC
DNWF
CCCC
>Mature Secondary Structure
MKKIMALVISSAIVLGGKGVAGAKGDYNVNRISGKNRYETSINIAKHYNSEKFENVIIAN
CHHHHHHHHHHHHEECCCCCCCCCCCCCEEEECCCCCCEEEEEHHHHCCCHHHCEEEEEC
GNDFPDALAGSALSKKLNAPILLIDENVNSSRETINLIKSKLAKNGSIYILGGEGAVDRV
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
YEDWFKDFGYKNIKRLGGINRFATNKNIVKSLNVEKGTPIVIVNGFGFADALSVSSSAAS
HHHHHHHCCHHHHHHHCCCHHHHCCCHHHHHCCCCCCCCEEEEECCCCHHHHHCCCCCCC
KGYPIFMSNADKLPNEIKDIIKDISPTKAFIIGGEGVMRNSIVDELKNIVPSLNKEDIER
CCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHH
VEGKNRYETSLNVCSKFNLLSDNAIVASGENFPDALSGSALASKMDAPIILTDGVNILKQ
HCCCCHHHHHHHHHHHCCEECCCEEEECCCCCCCHHCCCHHHHHCCCCEEEECCCHHHHH
KEYLDNNNYKNLILLGGTGAINTDSQRILENKPVISDKDAKNLLFNGDEEFKKILKIEVH
HHHHCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCEECCCHHHHHHHEEEEE
KESYIDLDGRSYAPVKEDLSKYDSIDDYLNKNFKLSTYYTENFMKNMINFEFKNIDGQCY
CCCEEECCCCCCCCHHHHHHHHCCHHHHHCCCEEEEEEEHHHHHHHHHCEEEECCCCEEE
MGYGNPEPRLIVKDAKIIEKKYDGNKVNVSLNGYYPIPGHVSNAKATLIYDGTKWVIDEF
ECCCCCCCEEEEECHHHHHHCCCCCEEEEEEECEECCCCCCCCCEEEEEECCCCHHHHHC
DNWF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]