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The map label for this gene is hofD [H]

Identifier: 148379295

GI number: 148379295

Start: 1432467

End: 1433234

Strand: Direct

Name: hofD [H]

Synonym: CBO1316

Alternate gene names: 148379295

Gene position: 1432467-1433234 (Clockwise)

Preceding gene: 148379293

Following gene: 148379296

Centisome position: 36.85

GC content: 21.88

Gene sequence:

>768_bases
ATGAATATAATAGTTTTAATTTTAGGCATAATTATAGGAAGTTTTTTAAATGTATGTATCTATAGGATACCTAAAGGAGA
ATCTATAATTTTTCCACCTTCTTATTGTGAAAAATGTGGTGTAAATATAAAAATATATAATTTAATTCCAGTAGTAAGTT
ATATATTTTTAAGGGGAAGATGTAAATGTTGTAAAAATAAAATATCTTTAAGATATCCTCTAGTAGAGTTATTAACAGGA
ATATTATTTTTAAGCATATATCATTTATGTGGTTTGAATTTTAGCTTTATAAAATATATTATATTTGTTTCTTTTATAAT
TGTTATTGGATTTATTGATTTGGATACTACAGATGTATATAGTAAAATTACTATTAGTGCTATGATAATTGGAGTAATTT
ACATACTAATAGAAAAATTTTATTTTGGATATGGTATAAAAACATATATGTATGCAGTGTTATTATGTACTACTGCTATA
GGAACTATAATTTTCACAACTGAAGGAATGGGAAGTGGAGATTTAGATATTTATATAGTAGTTTCCTTATTTTTAGGACT
TAAAATTACTGCTATGACTTTATTTTTTTCTTTTATTTTTGGAGCATTAATAGGAATTTTTCTTATAATTTCAAAAAGAA
AAACTAAAAAAGATTATATGCCCTTTGGACCTTTTATAGCTATGGCTTCTATATTCTCTATATTATTTGGAGATAAAGTA
TCTTTATTATATATATCTTTTATAACAAATTGTTTTTTAAATAGATAA

Upstream 100 bases:

>100_bases
AAAAGTATTATAATAGGGTTATTAAATTCCAACAAATGGCAATTATATAAATATAATATAAAATATAGAATTTTTTAAGA
ATCTTATTGAAAGGTATGAT

Downstream 100 bases:

>100_bases
TGTTATATATTTATATTATAAGCACAGCACCTAATAAAATACATTAATGTCTATTATATTCATAAGTATTTAGAGGTATT
ATTATGGATATAAAAATTAT

Product: type IV leader peptidase family protein

Products: NA

Alternate protein names: Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MNIIVLILGIIIGSFLNVCIYRIPKGESIIFPPSYCEKCGVNIKIYNLIPVVSYIFLRGRCKCCKNKISLRYPLVELLTG
ILFLSIYHLCGLNFSFIKYIIFVSFIIVIGFIDLDTTDVYSKITISAMIIGVIYILIEKFYFGYGIKTYMYAVLLCTTAI
GTIIFTTEGMGSGDLDIYIVVSLFLGLKITAMTLFFSFIFGALIGIFLIISKRKTKKDYMPFGPFIAMASIFSILFGDKV
SLLYISFITNCFLNR

Sequences:

>Translated_255_residues
MNIIVLILGIIIGSFLNVCIYRIPKGESIIFPPSYCEKCGVNIKIYNLIPVVSYIFLRGRCKCCKNKISLRYPLVELLTG
ILFLSIYHLCGLNFSFIKYIIFVSFIIVIGFIDLDTTDVYSKITISAMIIGVIYILIEKFYFGYGIKTYMYAVLLCTTAI
GTIIFTTEGMGSGDLDIYIVVSLFLGLKITAMTLFFSFIFGALIGIFLIISKRKTKKDYMPFGPFIAMASIFSILFGDKV
SLLYISFITNCFLNR
>Mature_255_residues
MNIIVLILGIIIGSFLNVCIYRIPKGESIIFPPSYCEKCGVNIKIYNLIPVVSYIFLRGRCKCCKNKISLRYPLVELLTG
ILFLSIYHLCGLNFSFIKYIIFVSFIIVIGFIDLDTTDVYSKITISAMIIGVIYILIEKFYFGYGIKTYMYAVLLCTTAI
GTIIFTTEGMGSGDLDIYIVVSLFLGLKITAMTLFFSFIFGALIGIFLIISKRKTKKDYMPFGPFIAMASIFSILFGDKV
SLLYISFITNCFLNR

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=259, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR014032
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 28786; Mature: 28786

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIVLILGIIIGSFLNVCIYRIPKGESIIFPPSYCEKCGVNIKIYNLIPVVSYIFLRGR
CHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHCCCCEEEHHHHHHHHHHHHHHH
CKCCKNKISLRYPLVELLTGILFLSIYHLCGLNFSFIKYIIFVSFIIVIGFIDLDTTDVY
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
SKITISAMIIGVIYILIEKFYFGYGIKTYMYAVLLCTTAIGTIIFTTEGMGSGDLDIYIV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHH
VSLFLGLKITAMTLFFSFIFGALIGIFLIISKRKTKKDYMPFGPFIAMASIFSILFGDKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCH
SLLYISFITNCFLNR
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIIVLILGIIIGSFLNVCIYRIPKGESIIFPPSYCEKCGVNIKIYNLIPVVSYIFLRGR
CHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHCCCCEEEHHHHHHHHHHHHHHH
CKCCKNKISLRYPLVELLTGILFLSIYHLCGLNFSFIKYIIFVSFIIVIGFIDLDTTDVY
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
SKITISAMIIGVIYILIEKFYFGYGIKTYMYAVLLCTTAIGTIIFTTEGMGSGDLDIYIV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHH
VSLFLGLKITAMTLFFSFIFGALIGIFLIISKRKTKKDYMPFGPFIAMASIFSILFGDKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCH
SLLYISFITNCFLNR
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]