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The map label for this gene is mtnA

Identifier: 148379251

GI number: 148379251

Start: 1384793

End: 1385842

Strand: Direct

Name: mtnA

Synonym: CBO1268

Alternate gene names: 148379251

Gene position: 1384793-1385842 (Clockwise)

Preceding gene: 148379250

Following gene: 148379252

Centisome position: 35.63

GC content: 31.9

Gene sequence:

>1050_bases
ATGGCAGAGTTATTAGCTATAAAATGGGATGATAATAGAGATAAGTTAATACTTTTAGACCAAACAATATTACCAAATAA
AATTGAATATATAGAATACGATACTGCAGAAGGTGTATACGATTCCATAAAGGATATGATAGTTAGAGGAGCTCCGGCTA
TAGGAGTTACAGCAGCTTATGGTCTATATTTTGCAGCAAAAGTAGCACCAGAAGATAAATTTGAGAACTTCTTTAAATAT
CTAAAAGAAAAATCATCATATTTAGACTCAAGTAGACCAACAGCTGTAAATTTATCTTGGGCCTTAAAGGTTATGGAAAG
TAAAGCTTTAGAAAATAAAGATAAAGATGTTAAAGAAATAAAGAGTATATTAAGAGAAGAAGCAAAAAGAATTCATGAAG
AAGATATAGAAATATGCAAAACTATAGGGGAAAATCTTATAACTTTATTAAAGGATGGAGTGGGAATATTAACTCATTGT
AATGCTGGACAACTTGCTACATCTAAATACGGAACAGCTACATCTCCTATGTATCTTGCAAAGGAAAAGGGCTGGAATTT
TAAAGTCTATTCAGATGAAACTAGACCAAGGCTTCAAGGATCCACTTTAACGGCTTTAGAGTTATATGAAGCAGGAATAG
ATGTAACTACTATAACAGATAATATGGCAGCTATGGTTATGTCTCAAGGTAAAATTGATGCGGTAATAGTAGGATGCGAT
AGAATAGCAGCTAATGGAGATACTGCTAATAAAATAGGAACCATGGGAGTTTCAATTTTGGCTAAATATTTTGGAATACC
AATGTATATTGCTGCACCAACTCCAAGTATAGATATAAATACAAAAACAGGAGAAGATATACCAATAGAAGAAAGAAATC
CAGAAGAAGTTACTAGTAGATTTGGTGTTTGGACAGCCCCAAAAGGTGTAAAAGTTTATAATCCAGGATTTGATGTTACA
CCACATGAAAACATAACTGCAATTGTTACAGAAAAGGGTATAGTATATCCTCCTTTTAAAGAAAATTTAAAGAAACTTTT
TGAAAAATAA

Upstream 100 bases:

>100_bases
CTTAAAAACAACTGTTTTATATAATAAGATTTTCAAATAAAAAAGGATTAGTAAAGAAGAAATAAGGTAAATAAGATAAA
AGTAAAGAGGAGGATTAAAA

Downstream 100 bases:

>100_bases
GAGGTTAGAAAGGGGCTAAAATAATGGTAGAACTTCTTAATATAAAAAATATAAAAAAGTCCTTTTCAGATGTTCAAGTA
TTACATGAAATAAATAATTT

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MAELLAIKWDDNRDKLILLDQTILPNKIEYIEYDTAEGVYDSIKDMIVRGAPAIGVTAAYGLYFAAKVAPEDKFENFFKY
LKEKSSYLDSSRPTAVNLSWALKVMESKALENKDKDVKEIKSILREEAKRIHEEDIEICKTIGENLITLLKDGVGILTHC
NAGQLATSKYGTATSPMYLAKEKGWNFKVYSDETRPRLQGSTLTALELYEAGIDVTTITDNMAAMVMSQGKIDAVIVGCD
RIAANGDTANKIGTMGVSILAKYFGIPMYIAAPTPSIDINTKTGEDIPIEERNPEEVTSRFGVWTAPKGVKVYNPGFDVT
PHENITAIVTEKGIVYPPFKENLKKLFEK

Sequences:

>Translated_349_residues
MAELLAIKWDDNRDKLILLDQTILPNKIEYIEYDTAEGVYDSIKDMIVRGAPAIGVTAAYGLYFAAKVAPEDKFENFFKY
LKEKSSYLDSSRPTAVNLSWALKVMESKALENKDKDVKEIKSILREEAKRIHEEDIEICKTIGENLITLLKDGVGILTHC
NAGQLATSKYGTATSPMYLAKEKGWNFKVYSDETRPRLQGSTLTALELYEAGIDVTTITDNMAAMVMSQGKIDAVIVGCD
RIAANGDTANKIGTMGVSILAKYFGIPMYIAAPTPSIDINTKTGEDIPIEERNPEEVTSRFGVWTAPKGVKVYNPGFDVT
PHENITAIVTEKGIVYPPFKENLKKLFEK
>Mature_348_residues
AELLAIKWDDNRDKLILLDQTILPNKIEYIEYDTAEGVYDSIKDMIVRGAPAIGVTAAYGLYFAAKVAPEDKFENFFKYL
KEKSSYLDSSRPTAVNLSWALKVMESKALENKDKDVKEIKSILREEAKRIHEEDIEICKTIGENLITLLKDGVGILTHCN
AGQLATSKYGTATSPMYLAKEKGWNFKVYSDETRPRLQGSTLTALELYEAGIDVTTITDNMAAMVMSQGKIDAVIVGCDR
IAANGDTANKIGTMGVSILAKYFGIPMYIAAPTPSIDINTKTGEDIPIEERNPEEVTSRFGVWTAPKGVKVYNPGFDVTP
HENITAIVTEKGIVYPPFKENLKKLFEK

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=347, Percent_Identity=37.463976945245, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI23943880, Length=336, Percent_Identity=35.1190476190476, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI78000156, Length=276, Percent_Identity=22.463768115942, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI78000158, Length=276, Percent_Identity=22.463768115942, Blast_Score=65, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17557462, Length=327, Percent_Identity=36.3914373088685, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17557123, Length=273, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6325375, Length=381, Percent_Identity=36.2204724409449, Blast_Score=186, Evalue=6e-48,
Organism=Drosophila melanogaster, GI21357667, Length=366, Percent_Identity=37.9781420765027, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24651647, Length=366, Percent_Identity=37.9781420765027, Blast_Score=218, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_CLOB1 (A7FTE6)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001383623.1
- ProteinModelPortal:   A7FTE6
- SMR:   A7FTE6
- STRING:   A7FTE6
- GeneID:   5398041
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_1296
- eggNOG:   COG0182
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   PRK05720
- BioCyc:   CBOT441770:CLB_1296-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 38727; Mature: 38596

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: ACT_SITE 240-240 BINDING 92-92 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELLAIKWDDNRDKLILLDQTILPNKIEYIEYDTAEGVYDSIKDMIVRGAPAIGVTAAY
CCCEEEEEECCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHH
GLYFAAKVAPEDKFENFFKYLKEKSSYLDSSRPTAVNLSWALKVMESKALENKDKDVKEI
HHHHHEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHH
KSILREEAKRIHEEDIEICKTIGENLITLLKDGVGILTHCNAGQLATSKYGTATSPMYLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCCCCCCCCCEEEE
KEKGWNFKVYSDETRPRLQGSTLTALELYEAGIDVTTITDNMAAMVMSQGKIDAVIVGCD
ECCCCEEEEECCCCCCCCCCCEEHHHHHHHCCCCEEEECCHHHHHHHCCCCEEEEEEECC
RIAANGDTANKIGTMGVSILAKYFGIPMYIAAPTPSIDINTKTGEDIPIEERNPEEVTSR
CEECCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCCCCCCCHHHHHHH
FGVWTAPKGVKVYNPGFDVTPHENITAIVTEKGIVYPPFKENLKKLFEK
CCCEECCCCCEEECCCCCCCCCCCEEEEEECCCEECCCHHHHHHHHHCC
>Mature Secondary Structure 
AELLAIKWDDNRDKLILLDQTILPNKIEYIEYDTAEGVYDSIKDMIVRGAPAIGVTAAY
CCEEEEEECCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHH
GLYFAAKVAPEDKFENFFKYLKEKSSYLDSSRPTAVNLSWALKVMESKALENKDKDVKEI
HHHHHEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHH
KSILREEAKRIHEEDIEICKTIGENLITLLKDGVGILTHCNAGQLATSKYGTATSPMYLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCCCCCCCCCEEEE
KEKGWNFKVYSDETRPRLQGSTLTALELYEAGIDVTTITDNMAAMVMSQGKIDAVIVGCD
ECCCCEEEEECCCCCCCCCCCEEHHHHHHHCCCCEEEECCHHHHHHHCCCCEEEEEEECC
RIAANGDTANKIGTMGVSILAKYFGIPMYIAAPTPSIDINTKTGEDIPIEERNPEEVTSR
CEECCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCCCCCCCHHHHHHH
FGVWTAPKGVKVYNPGFDVTPHENITAIVTEKGIVYPPFKENLKKLFEK
CCCEECCCCCEEECCCCCCCCCCCEEEEEECCCEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA