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The map label for this gene is guaB [C]

Identifier: 148379064

GI number: 148379064

Start: 1185897

End: 1186277

Strand: Direct

Name: guaB [C]

Synonym: CBO1074

Alternate gene names: 148379064

Gene position: 1185897-1186277 (Clockwise)

Preceding gene: 148379063

Following gene: 148379068

Centisome position: 30.51

GC content: 29.4

Gene sequence:

>381_bases
ATGCTTTGTGATATTATGAATACACATGTTATTGTTCTTAATCCTAAGGATAGTATAAAAAAGGCATTAAACCTTATGAA
TGAAAACAATATAAATGGAGCACCTGTAGCTGATGAAGAGGGCAATTTAATAGGAATGATAGTAAAGGCAGATATTTATA
GATTTTTGATGGAAGAGGGTCACTATGATACTTGCCCTGTAGAGTGGGTTATGACTAAAGAGGTTTTTACTGCTTCAGAG
GAAGAGGATGTTATATCTATAGCTAAGAAAATTTTAGATAAAGATATAATAGCTATGCCAATAGTAGATTCTTCAAAAAA
ACTTTTAGGAATAGTATCCGTTGAGGACATATTAAAAAGTTTAATATATAAATTAAAATAA

Upstream 100 bases:

>100_bases
TATAGCAAATATGTGTTATTATTAGACTATGATGATTAATTATAGAATTTTCATAAAACTATTTTCATATGTAAATATAT
GATTTATGGAGGGAATTAAT

Downstream 100 bases:

>100_bases
GTAAAAGGTATTTAACTTTAATGACGCTAGGATAAAAATACACTTAATGAACTAATTCATTTTGCTAAGAAGTTCATTAA
GTGTTTTTTTATCTTTGCTA

Product: CBS domain protein

Products: H+; Nicotinamide adenine dinucleotide - reduced; Xanthosine 5'-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 126; Mature: 126

Protein sequence:

>126_residues
MLCDIMNTHVIVLNPKDSIKKALNLMNENNINGAPVADEEGNLIGMIVKADIYRFLMEEGHYDTCPVEWVMTKEVFTASE
EEDVISIAKKILDKDIIAMPIVDSSKKLLGIVSVEDILKSLIYKLK

Sequences:

>Translated_126_residues
MLCDIMNTHVIVLNPKDSIKKALNLMNENNINGAPVADEEGNLIGMIVKADIYRFLMEEGHYDTCPVEWVMTKEVFTASE
EEDVISIAKKILDKDIIAMPIVDSSKKLLGIVSVEDILKSLIYKLK
>Mature_126_residues
MLCDIMNTHVIVLNPKDSIKKALNLMNENNINGAPVADEEGNLIGMIVKADIYRFLMEEGHYDTCPVEWVMTKEVFTASE
EEDVISIAKKILDKDIIAMPIVDSSKKLLGIVSVEDILKSLIYKLK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0517

COG function: function code R; FOG: CBS domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

None

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR002708
- InterPro:   IPR016426
- ProDom:   PD011569 [H]

Pfam domain/function: PF00571 CBS; PF01837 DUF39 [H]

EC number: 1.1.1.205 [C]

Molecular weight: Translated: 14138; Mature: 14138

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCDIMNTHVIVLNPKDSIKKALNLMNENNINGAPVADEEGNLIGMIVKADIYRFLMEEG
CCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCC
HYDTCPVEWVMTKEVFTASEEEDVISIAKKILDKDIIAMPIVDSSKKLLGIVSVEDILKS
CCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCEEEEECHHHHHHH
LIYKLK
HHHHCC
>Mature Secondary Structure
MLCDIMNTHVIVLNPKDSIKKALNLMNENNINGAPVADEEGNLIGMIVKADIYRFLMEEG
CCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCC
HYDTCPVEWVMTKEVFTASEEEDVISIAKKILDKDIIAMPIVDSSKKLLGIVSVEDILKS
CCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCEEEEECHHHHHHH
LIYKLK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; IMP; Nicotinamide adenine dinucleotide [C]

Specific reaction: H2O + IMP + Nicotinamide adenine dinucleotide --> H+ + Nicotinamide adenine dinucleotide - reduced + Xanthosine 5'-phosphate [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]