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The map label for this gene is metC [H]

Identifier: 148378726

GI number: 148378726

Start: 834670

End: 835812

Strand: Reverse

Name: metC [H]

Synonym: CBO0726

Alternate gene names: 148378726

Gene position: 835812-834670 (Counterclockwise)

Preceding gene: 148378727

Following gene: 148378725

Centisome position: 21.5

GC content: 30.71

Gene sequence:

>1143_bases
ATGAAAATTGAATCATTATTAATTCATGGTGGAATAGACGGAGATAAGCATACAGGTGCAGTAAATGTACCTATTTATCA
AACTTCAACTTACAAGCAATTTAAGTTTGGAGAAAATACAGGTTATGAATATTCAAGAACAGGAAATCCAACAAGGGAAG
CTTTAGAAAAACTTGTAGCAGATTTAGAAAAAGGTTATAAAGGTTTTGCCTTTGCTTCAGGATTGGCTGCTATAACTGCA
GTATTATCACTATTTAAATCAGGAGATGAAATAGTAATTTCAAATAATGTATATGGTGGAACTTTTAGAGTTTTAGATAA
AGTCTTTAACCACTTTGATATTAAATATTCTATAGTTGATACTTCTAACTTAGATGAAGTAAAAAATAGCATAAATGAAA
ATGTAAAAGCTATATATATAGAAACACCAACTAATCCTCTTATGGATATTACAGATATAGAAGAAATATCAAAAATAGCT
AAGGAAAATGATATATATACTATAGTTGATAATACCTTCATGACCCCTTACCTACAGAAGCCAATAAGTCTTGGAGCAGA
TATAGTTATTCATAGTGCTACAAAATATCTAGGAGGGCATAGTGATGTAGTTGCTGGAATTGCTGTTGTAAATAGTGAAG
ATTTAGCTGAAAGACTTCATTTTATACAGAATTCTACTGGCGGGGTTCTAGCTCCTTTTGATTCTTTCCTTTTAATTAGA
GGAATCAAAACATTAGCAATAAGAATGGATAGACATAATTCAAATGCAAAACTTATTGCTGAATTCCTAAGAGAAAGAGA
TGAAGTAGTAAAAGTATATTATCCTGGTTTTGATACTCATCCAGGACATAAAATCCAATCAAAACAAGCTAATGGATATG
GTGGAATGATATCCTTTGTTCTTAAAGATGGTTATGATTATAAAAAGTTTTTTGAAGGTCTTAAGATGGTAACCTTTGGA
GAAAGCTTAGGAGGAGTTGAATCTTTAGCTTGCCATCCAGCTTCTATGACTCACGGTGCTATACCTTATGAATTAAGACA
AAAAGTTGGTATTGTAGATAATTTAATAAGATTATCCGTTGGTATAGAAAATGCTGACGATTTAATAGAAGATTTAAAAA
ATGCATTTAAGGAGAGTAGATAA

Upstream 100 bases:

>100_bases
TAAAATTTTAGATTGAAATAACTGAACAATAAAGTTATTTCAATCTAAAAAAACAAGTAAGAAATGTAATCACAATTAAA
TTCTAAGGAGGAATAAAAAA

Downstream 100 bases:

>100_bases
AATGGTTAAAGTAGAAAGTTTTTCATTAGATCATACAAAGGTTAAGGCTCCTTTTGTAAGGAAATGTGGAACTCAAAAAG
GTGAAATGGGTGATACAATT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKIESLLIHGGIDGDKHTGAVNVPIYQTSTYKQFKFGENTGYEYSRTGNPTREALEKLVADLEKGYKGFAFASGLAAITA
VLSLFKSGDEIVISNNVYGGTFRVLDKVFNHFDIKYSIVDTSNLDEVKNSINENVKAIYIETPTNPLMDITDIEEISKIA
KENDIYTIVDNTFMTPYLQKPISLGADIVIHSATKYLGGHSDVVAGIAVVNSEDLAERLHFIQNSTGGVLAPFDSFLLIR
GIKTLAIRMDRHNSNAKLIAEFLRERDEVVKVYYPGFDTHPGHKIQSKQANGYGGMISFVLKDGYDYKKFFEGLKMVTFG
ESLGGVESLACHPASMTHGAIPYELRQKVGIVDNLIRLSVGIENADDLIEDLKNAFKESR

Sequences:

>Translated_380_residues
MKIESLLIHGGIDGDKHTGAVNVPIYQTSTYKQFKFGENTGYEYSRTGNPTREALEKLVADLEKGYKGFAFASGLAAITA
VLSLFKSGDEIVISNNVYGGTFRVLDKVFNHFDIKYSIVDTSNLDEVKNSINENVKAIYIETPTNPLMDITDIEEISKIA
KENDIYTIVDNTFMTPYLQKPISLGADIVIHSATKYLGGHSDVVAGIAVVNSEDLAERLHFIQNSTGGVLAPFDSFLLIR
GIKTLAIRMDRHNSNAKLIAEFLRERDEVVKVYYPGFDTHPGHKIQSKQANGYGGMISFVLKDGYDYKKFFEGLKMVTFG
ESLGGVESLACHPASMTHGAIPYELRQKVGIVDNLIRLSVGIENADDLIEDLKNAFKESR
>Mature_380_residues
MKIESLLIHGGIDGDKHTGAVNVPIYQTSTYKQFKFGENTGYEYSRTGNPTREALEKLVADLEKGYKGFAFASGLAAITA
VLSLFKSGDEIVISNNVYGGTFRVLDKVFNHFDIKYSIVDTSNLDEVKNSINENVKAIYIETPTNPLMDITDIEEISKIA
KENDIYTIVDNTFMTPYLQKPISLGADIVIHSATKYLGGHSDVVAGIAVVNSEDLAERLHFIQNSTGGVLAPFDSFLLIR
GIKTLAIRMDRHNSNAKLIAEFLRERDEVVKVYYPGFDTHPGHKIQSKQANGYGGMISFVLKDGYDYKKFFEGLKMVTFG
ESLGGVESLACHPASMTHGAIPYELRQKVGIVDNLIRLSVGIENADDLIEDLKNAFKESR

Specific function: The enzymatic degradation of amino acids in cheese is believed to generate aroma compounds and therefore to be essential for flavor development. Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine but is also able to catalyze an alpha

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=357, Percent_Identity=47.3389355742297, Blast_Score=332, Evalue=3e-91,
Organism=Homo sapiens, GI299473759, Length=357, Percent_Identity=42.8571428571429, Blast_Score=281, Evalue=9e-76,
Organism=Homo sapiens, GI25453487, Length=356, Percent_Identity=41.2921348314607, Blast_Score=266, Evalue=3e-71,
Organism=Escherichia coli, GI1790375, Length=380, Percent_Identity=39.2105263157895, Blast_Score=307, Evalue=8e-85,
Organism=Escherichia coli, GI1789383, Length=393, Percent_Identity=26.7175572519084, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17560056, Length=344, Percent_Identity=46.5116279069767, Blast_Score=328, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17538055, Length=345, Percent_Identity=46.9565217391304, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI71980708, Length=370, Percent_Identity=39.4594594594595, Blast_Score=265, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6319307, Length=388, Percent_Identity=44.8453608247423, Blast_Score=320, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6321254, Length=402, Percent_Identity=32.5870646766169, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323333, Length=432, Percent_Identity=34.4907407407407, Blast_Score=182, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6321170, Length=322, Percent_Identity=33.5403726708075, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6321904, Length=393, Percent_Identity=31.5521628498728, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322590, Length=302, Percent_Identity=28.8079470198675, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322970, Length=272, Percent_Identity=26.8382352941176, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323557, Length=336, Percent_Identity=24.702380952381, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922554, Length=374, Percent_Identity=46.7914438502674, Blast_Score=345, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42040; Mature: 42040

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIESLLIHGGIDGDKHTGAVNVPIYQTSTYKQFKFGENTGYEYSRTGNPTREALEKLVA
CCCCEEEEECCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHH
DLEKGYKGFAFASGLAAITAVLSLFKSGDEIVISNNVYGGTFRVLDKVFNHFDIKYSIVD
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEEC
TSNLDEVKNSINENVKAIYIETPTNPLMDITDIEEISKIAKENDIYTIVDNTFMTPYLQK
CCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHC
PISLGADIVIHSATKYLGGHSDVVAGIAVVNSEDLAERLHFIQNSTGGVLAPFDSFLLIR
HHHCCCCEEEEHHHHHHCCCHHHHHHEEEECHHHHHHHHHHHHCCCCCEECCHHHHHHHH
GIKTLAIRMDRHNSNAKLIAEFLRERDEVVKVYYPGFDTHPGHKIQSKQANGYGGMISFV
HHHHEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHH
LKDGYDYKKFFEGLKMVTFGESLGGVESLACHPASMTHGAIPYELRQKVGIVDNLIRLSV
HHCCCCHHHHHHHHEEEEECCHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
GIENADDLIEDLKNAFKESR
CCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIESLLIHGGIDGDKHTGAVNVPIYQTSTYKQFKFGENTGYEYSRTGNPTREALEKLVA
CCCCEEEEECCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHH
DLEKGYKGFAFASGLAAITAVLSLFKSGDEIVISNNVYGGTFRVLDKVFNHFDIKYSIVD
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEEC
TSNLDEVKNSINENVKAIYIETPTNPLMDITDIEEISKIAKENDIYTIVDNTFMTPYLQK
CCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHC
PISLGADIVIHSATKYLGGHSDVVAGIAVVNSEDLAERLHFIQNSTGGVLAPFDSFLLIR
HHHCCCCEEEEHHHHHHCCCHHHHHHEEEECHHHHHHHHHHHHCCCCCEECCHHHHHHHH
GIKTLAIRMDRHNSNAKLIAEFLRERDEVVKVYYPGFDTHPGHKIQSKQANGYGGMISFV
HHHHEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHH
LKDGYDYKKFFEGLKMVTFGESLGGVESLACHPASMTHGAIPYELRQKVGIVDNLIRLSV
HHCCCCHHHHHHHHEEEEECCHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
GIENADDLIEDLKNAFKESR
CCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]