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The map label for this gene is mutM [H]

Identifier: 148360789

GI number: 148360789

Start: 688087

End: 688911

Strand: Reverse

Name: mutM [H]

Synonym: LPC_2743

Alternate gene names: 148360789

Gene position: 688911-688087 (Counterclockwise)

Preceding gene: 148360788

Following gene: 148360790

Centisome position: 19.26

GC content: 40.12

Gene sequence:

>825_bases
ATGCCTGAATTACCCGAAGTTGAAACAACAAAGCAAGGTATTAAACCCCATCTTGAAGGCCGTATGATTACCGCGGTGCA
AGTGCGTAATCGAAAACTTAGATTACCAGTACCTCTAAACCTGAATGAATTATGCCAAGGAAAGCATATAACAGCTATTA
CCCGTAGAGGAAAATACATCTTACTTCATATGGATAAAGGTTATCTTCTCATCCATCTTGGAATGTCCGGACATTTGCGT
ATCGTCTCCCAGACAGCAAATCCTCAAAAACATGATCATATTGATCTGCACATTAATAATGGGCTTGCTCTCAGATTCTG
CGATCCAAGAAGATTTGGCTTATTTATTTACATTGATGAAAATCCTTACCAACACCCACTGCTGGCACATTTAGGCCCGG
AACCTCTGTCTGATGACTTTAATAGCGAGTACTTATTACGTAAAGCTGCGAATAAATCGCAATCCATCAAGTCATTTATT
ATGGATAGCCAAATTGTTGTCGGGATAGGTAATATTTATGCAGCAGAGAGTCTTTTTCTTGCCAAAATCCATCCAAATAC
CTCTGCAAAAAAGATAACTACAGAAGAATTCAATGCTCTGACTGGTCACATCAAAAAGATACTTGAATCTGCCATAGAGG
CAGGAGGGACGACACTTCGTGATTTCTATTCTTCTGATGGTAAACCAGGGTACTTTCGTTTTGCTTTAAAGGTTTATGGC
AGGAAAAATCTCCCCTGTTTGGTATGTGAAAATAAAATAGAAACTGTCGTGATTGCCGGGCGCCACTCCGCATTTTGCCC
GCATTGCCAGCCAATCATTACATAA

Upstream 100 bases:

>100_bases
GAATACTCTGGCTTGGGGCCTTAGCTAAGGAATATTTCTTCCCCAGTAAATCATCCCAAAAAGAACAAGGAAGAATTATA
GAACATGATGATAAAAAATA

Downstream 100 bases:

>100_bases
TAAGTTTAATAATGGCCACCTGGAACCATTTTTGTTTCTTAATTGATTCTGTTGTTGTGACAAAAGGTTAATTTATGGAT
ATTAAAAAACTTAAAAAGGC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MPELPEVETTKQGIKPHLEGRMITAVQVRNRKLRLPVPLNLNELCQGKHITAITRRGKYILLHMDKGYLLIHLGMSGHLR
IVSQTANPQKHDHIDLHINNGLALRFCDPRRFGLFIYIDENPYQHPLLAHLGPEPLSDDFNSEYLLRKAANKSQSIKSFI
MDSQIVVGIGNIYAAESLFLAKIHPNTSAKKITTEEFNALTGHIKKILESAIEAGGTTLRDFYSSDGKPGYFRFALKVYG
RKNLPCLVCENKIETVVIAGRHSAFCPHCQPIIT

Sequences:

>Translated_274_residues
MPELPEVETTKQGIKPHLEGRMITAVQVRNRKLRLPVPLNLNELCQGKHITAITRRGKYILLHMDKGYLLIHLGMSGHLR
IVSQTANPQKHDHIDLHINNGLALRFCDPRRFGLFIYIDENPYQHPLLAHLGPEPLSDDFNSEYLLRKAANKSQSIKSFI
MDSQIVVGIGNIYAAESLFLAKIHPNTSAKKITTEEFNALTGHIKKILESAIEAGGTTLRDFYSSDGKPGYFRFALKVYG
RKNLPCLVCENKIETVVIAGRHSAFCPHCQPIIT
>Mature_273_residues
PELPEVETTKQGIKPHLEGRMITAVQVRNRKLRLPVPLNLNELCQGKHITAITRRGKYILLHMDKGYLLIHLGMSGHLRI
VSQTANPQKHDHIDLHINNGLALRFCDPRRFGLFIYIDENPYQHPLLAHLGPEPLSDDFNSEYLLRKAANKSQSIKSFIM
DSQIVVGIGNIYAAESLFLAKIHPNTSAKKITTEEFNALTGHIKKILESAIEAGGTTLRDFYSSDGKPGYFRFALKVYGR
KNLPCLVCENKIETVVIAGRHSAFCPHCQPIIT

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=270, Percent_Identity=51.1111111111111, Blast_Score=279, Evalue=1e-76,
Organism=Escherichia coli, GI1786932, Length=276, Percent_Identity=23.5507246376812, Blast_Score=74, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30825; Mature: 30694

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS00028 ZINC_FINGER_C2H2_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETTKQGIKPHLEGRMITAVQVRNRKLRLPVPLNLNELCQGKHITAITRRGKYI
CCCCCCCCCHHHCCCCCCCCEEEEEEEECCCEEEECCCCCHHHHHCCCEEEEEECCCCEE
LLHMDKGYLLIHLGMSGHLRIVSQTANPQKHDHIDLHINNGLALRFCDPRRFGLFIYIDE
EEEECCCEEEEEECCCCCEEEEEECCCCCCCCEEEEEECCCEEEEEECCCCEEEEEEECC
NPYQHPLLAHLGPEPLSDDFNSEYLLRKAANKSQSIKSFIMDSQIVVGIGNIYAAESLFL
CCCCCCHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCEEEEEECCEEEECEEEE
AKIHPNTSAKKITTEEFNALTGHIKKILESAIEAGGTTLRDFYSSDGKPGYFRFALKVYG
EEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCCEEEEEEEECC
RKNLPCLVCENKIETVVIAGRHSAFCPHCQPIIT
CCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETTKQGIKPHLEGRMITAVQVRNRKLRLPVPLNLNELCQGKHITAITRRGKYI
CCCCCCCCHHHCCCCCCCCEEEEEEEECCCEEEECCCCCHHHHHCCCEEEEEECCCCEE
LLHMDKGYLLIHLGMSGHLRIVSQTANPQKHDHIDLHINNGLALRFCDPRRFGLFIYIDE
EEEECCCEEEEEECCCCCEEEEEECCCCCCCCEEEEEECCCEEEEEECCCCEEEEEEECC
NPYQHPLLAHLGPEPLSDDFNSEYLLRKAANKSQSIKSFIMDSQIVVGIGNIYAAESLFL
CCCCCCHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCEEEEEECCEEEECEEEE
AKIHPNTSAKKITTEEFNALTGHIKKILESAIEAGGTTLRDFYSSDGKPGYFRFALKVYG
EEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCCEEEEEEEECC
RKNLPCLVCENKIETVVIAGRHSAFCPHCQPIIT
CCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA